Exploring the Diversity and Ecological Dynamics of Palm Leaf Spotting Fungi—A Case Study on Ornamental Palms in Portugal DOI Creative Commons
Diana S. Pereira, Alan J. L. Phillips

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(1), P. 43 - 43

Published: Jan. 7, 2025

Palm trees (Arecaceae) are among the most popular ornamental plants worldwide. Despite extensive research on fungi associated with Arecaceae, diversity and ecological dynamics of affecting palms remain poorly studied, although they have significant impact palm health economic value. Furthermore, while fungal has traditionally focused tropical assemblages, in temperate climates offer a unique opportunity to explore non-native habitats. The present study conducted preliminary assessment ecology potential phytopathogenic foliar lesions various host species Portugal, combining morphological examination, PCR-based genomic fingerprinting, biodiversity data analysis. examination 134 sampled from 100 resulted collection 2064 leaf spotting (PLSF), representing diverse assemblage 320 molecular operational taxonomic units (MOTUs) across 97 genera. overall community composition revealed distinct dominated by Neosetophoma, Alternaria, Phoma, Cladosporium, profusion infrequent rare taxa consistent logseries distribution. Significantly positive co-occurrence (CO) patterns prevalent uncommon suggest synergistic interactions enhancing colonisation, persistence, pathogenicity. structures PLSF contrasted markedly fungi, especially prevalence pleosporalean coelomycetes Didymellaceae Phaeosphaeriaceae, including recently introduced or not previously documented genera Arecaceae. This novel suggests that climatic constraints shape structure communities, resulting distinctive assemblages. In addition, assemblages varied significantly species, temperate-native hosting more diverse, coelomycete-enriched communities. findings highlight as hyperdiverse microhabitats harbouring communities intricate complex interplay climatic, host, factors. With climate change altering environmental conditions, identification thriving inhabiting these becomes crucial for predicting shifts pathogen mitigating future disease outbreaks. Understanding is essential identifying threats developing effective management strategies sustainability plants.

Language: Английский

Evolution of the human pathogenic lifestyle in fungi DOI Creative Commons
Antonis Rokas

Nature Microbiology, Journal Year: 2022, Volume and Issue: 7(5), P. 607 - 619

Published: May 4, 2022

Fungal pathogens cause more than a billion human infections every year, resulting in 1.6 million deaths annually. Understanding the natural history and evolutionary ecology of fungi is helping us understand how disease-relevant traits have repeatedly evolved. Different types mechanisms genetic variation contributed to evolution fungal pathogenicity specific differences distinguish from non-pathogens. Insights into traits, elements, ecological that contribute are crucial for developing strategies both predict emergence develop drugs combat them.

Language: Английский

Citations

155
Microbes and Climate Change: a Research Prospectus for the Future DOI
James M. Tiedje, Mary Ann Bruns, Arturo Casadevall

et al.

mBio, Journal Year: 2022, Volume and Issue: 13(3)

Published: April 19, 2022

Climate change is the most serious challenge facing humanity. Microbes produce and consume three major greenhouse gases-carbon dioxide, methane, nitrous oxide-and some microbes cause human, animal, plant diseases that can be exacerbated by climate change. Hence, microbial research needed to help ameliorate warming trajectory cascading effects resulting from heat, drought, severe storms. We present a brief summary of what known about responses in ecosystems: terrestrial, ocean, urban. also offer suggestions for new directions reduce gases mitigate pathogenic impacts microbes. These include performing more controlled studies on impact processes, system interdependencies, human interventions, using their carbon nitrogen transformations useful stable products, improving process data models, taking One Health approach study

Language: Английский

Citations

131
The rapid emergence of antifungal-resistant human-pathogenic fungi DOI
Shawn R. Lockhart, Anuradha Chowdhary, Jeremy A.W. Gold

et al.

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(12), P. 818 - 832

Published: Aug. 30, 2023

Language: Английский

Citations

127
Cryptococcus neoformans, a global threat to human health DOI Creative Commons
Youbao Zhao, Leixin Ye, Fujie Zhao

et al.

Infectious Diseases of Poverty, Journal Year: 2023, Volume and Issue: 12(1)

Published: March 17, 2023

Abstract Background Emerging fungal pathogens pose important threats to global public health. The World Health Organization has responded the rising threat of traditionally neglected infections by developing a Fungal Priority Pathogens List (FPPL). Taking highest-ranked pathogen in FPPL, Cryptococcus neoformans , as paradigm, we review progress made over past two decades on its burden, clinical manifestation and management cryptococcal infection, antifungal resistance. purpose this is drive research efforts improve future diagnoses, therapies, interventions associated with infections. Methods We first reviewed trends burden HIV-associated mainly based series systematic studies. next conducted scoping reviews accordance guidelines described Preferred Reporting Items for Systematic Reviews Meta-analyses extension Scoping using PubMed ScienceDirect keyword identify case reports published since 2000. then recent updates diagnosis treatment Finally, summarized knowledge regarding resistance tolerance C. approved drugs. Results There been general reduction estimated meningitis 2009, probably due improvements highly active antiretroviral therapies. However, still accounts 19% AIDS-related deaths annually. incidences CM Europe North America Latin region have increased approximately two-fold while other regions showed either reduced or stable numbers cases. Unfortunately, diagnostic options are limited, emerging exacerbates health burden. Conclusion compounded accumulating evidence ability infect immunocompetent individuals emergence antifungal-resistant variants. Emphasis should be placed further understanding mechanisms pathogenicity tolerance. development novel strategies through identification new drug targets discovery optimization existing diagnostics therapeutics key reducing

Language: Английский

Citations

105
Artificial nanovesicles for dsRNA delivery in spray‐induced gene silencing for crop protection DOI Creative Commons
Lulu Qiao, Jonatan Niño‐Sánchez,

Rachael Hamby

et al.

Plant Biotechnology Journal, Journal Year: 2023, Volume and Issue: 21(4), P. 854 - 865

Published: Jan. 5, 2023

Summary Spray‐induced gene silencing (SIGS) is an innovative and eco‐friendly technology where topical application of pathogen gene‐targeting RNAs to plant material can enable disease control. SIGS applications remain limited because the instability RNA, which be rapidly degraded when exposed various environmental conditions. Inspired by natural mechanism cross‐kingdom RNAi through extracellular vesicle trafficking, we describe herein use artificial nanovesicles (AVs) for RNA encapsulation control against fungal pathogen, Botrytis cinerea . AVs were synthesized using three different cationic lipid formulations, DOTAP + PEG, DODMA, examined their ability protect deliver double stranded (dsRNA). All formulations enabled dsRNA delivery uptake B Further, encapsulating in provided strong protection from nuclease degradation removal leaf washing. This improved stability led prolonged RNAi‐mediated both on pre‐ post‐harvest AVs. Specifically, extended duration conferred 10 days tomato grape fruits 21 leaves. The results this work demonstrate how used as a new nanocarrier overcome crop protection.

Language: Английский

Citations

63
Impact of climate change and natural disasters on fungal infections DOI Creative Commons
Danila Seidel, Sebastian Wurster, Jeffrey D. Jenks

et al.

The Lancet Microbe, Journal Year: 2024, Volume and Issue: 5(6), P. e594 - e605

Published: March 19, 2024

The effects of climate change and natural disasters on fungal pathogens the risks for diseases remain incompletely understood. In this literature review, we examined how fungi are adapting to an increase in Earth's temperature becoming more thermotolerant, which is enhancing fitness virulence. Climate creating conditions conducive emergence new priming adapt previously inhospitable environments, such as polluted habitats urban areas, leading geographical spread some traditionally non-endemic areas. also contributing increases frequency severity disasters, can trigger outbreaks pathogens. populations mostly affected socially vulnerable. More awareness, research, funding, policies part key stakeholders needed mitigate disaster-related diseases.

Language: Английский

Citations

60
The plant disease triangle facing climate change: a molecular perspective DOI
Charles Roussin‐Léveillée,

Christina A. M. Rossi,

Christian Danve M. Castroverde

et al.

Trends in Plant Science, Journal Year: 2024, Volume and Issue: 29(8), P. 895 - 914

Published: April 4, 2024

Language: Английский

Citations

24
Microfluidic systems for infectious disease diagnostics DOI Creative Commons
Thomas Lehnert, Martin A. M. Gijs

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1441 - 1493

Published: Jan. 1, 2024

This review explores emerging microfluidic-based technologies incorporating innovative assay strategies for infectious disease diagnostics. Our classification scheme is based on the human body systems or pathogen transmission modes.

Language: Английский

Citations

19
Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature DOI
Jingjing Huang, Pengjie Hu, Leixin Ye

et al.

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(7), P. 1686 - 1699

Published: June 19, 2024

Language: Английский

Citations

19
Editorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Fungal Pathogens During the COVID-19 Pandemic DOI

Dinah V. Parums

Medical Science Monitor, Journal Year: 2022, Volume and Issue: 28

Published: Dec. 1, 2022

The COVID-19 pandemic, climate change, increased resistance to antifungal drugs, and an number of immunocompromised patients have driven a recent global surge in pathogenic fungal infections, including aspergillosis, candidiasis, mucormycosis. On 25 October 2022, the World Health Organization (WHO) released list 19 priority pathogens identified as having greatest threat public health. WHO Fungal Priority Pathogens List represents first response identify prioritize their impact on health consider unmet research development needs. has grouped into those critical, high, medium priority. This Editorial aims highlight importance identifying prioritizing emerging factors driving changing patterns infection.

Language: Английский

Citations

61