Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 Treatment DOI Creative Commons

Yuyin Fang,

Peizhen Lao,

Long‐Qian Tang

et al.

Cell Transplantation, Journal Year: 2023, Volume and Issue: 32

Published: Jan. 1, 2023

The 2019 novel coronavirus disease (COVID-19) has lasted for over 3 years and seriously affected the regular life trajectory of human beings. severe acute respiratory syndrome 2 (SARS‑CoV‑2) caused non-negligible harm to people’s systems multiple organs. Although pathogenesis COVID-19 been fully elucidated, there is still a lack effective specific treatment COVID-19. Mesenchymal stem cells (MSCs) or MSC-derived extracellular vesicles (MSC-EVs) by far have become most promising candidates in preclinical studies clinical trials, MSC-related therapies shown their potential treat multidirectional differentiation immunomodulatory function MSCs allowed exert cellular molecular actions on different immune It critical understand therapeutic roles before entering clinics other diseases. This review summarizes recent progress particular mechanisms underlying tissue regenerative effects toward We focused discussing functional MSC-mediated cell responses, survival, organ regeneration. Besides, discoveries findings MSC application patients with were highlighted. will provide an overview current research rapid development MSC-based not only but also immune-mediated/immune-dysregulating

Language: Английский

Two Cases of Graves' Disease Following SARS-CoV-2 Vaccination: An Autoimmune/Inflammatory Syndrome Induced by Adjuvants DOI
Olga Vera‐Lastra, Alberto Ordinola Navarro,

Maria Pilar Cruz Domiguez

et al.

Thyroid, Journal Year: 2021, Volume and Issue: 31(9), P. 1436 - 1439

Published: April 16, 2021

Background: The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) comprises four entities, including the postvaccination phenomenon, which appears after being exposed to in vaccines that increase immune response. There is limited information about autoimmune endocrine diseases and ASIA severe acute respiratory coronavirus 2 (SARS-CoV-2) vaccination. Patient's Findings: Two female health care workers received a SARS-CoV-2 vaccine, three days later developed clinical manifestations of thyroid hyperactivity, with increased hormone levels on function tests, suppressed thyroid-stimulating hormone, elevated antithyroid antibodies. Summary: Vaccines have been shown trigger an response leads broad spectrum diseases, disease. Our patients met diagnostic criteria for ASIA; they were adjuvant (vaccine), hyperfunction within few days, appearance antibodies, despite healthy before Conclusion: Graves' disease can occur

Language: Английский

Citations

195
COVID-19 and the clinical course of rheumatic manifestations DOI Creative Commons
Sakir Ahmed, Olena Zimba, Armen Yuri Gasparyan

et al.

Clinical Rheumatology, Journal Year: 2021, Volume and Issue: 40(7), P. 2611 - 2619

Published: March 17, 2021

Language: Английский

Citations

118
The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication DOI Creative Commons
Qin Ning, Di Wu, Xiaojing Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Feb. 23, 2022

Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) that poses major threat to global public health. Although COVID-19 primarily affects system, causing pneumonia and distress in cases, it can also result multiple extrapulmonary complications. pathogenesis of damage patients with probably multifactorial, involving both direct effects SARS-CoV-2 indirect mechanisms associated host inflammatory response. Recognition features complications has clinical implications for identifying progression designing therapeutic strategies. This review provides an overview from immunological pathophysiologic perspectives focuses on potential targets management COVID-19.

Language: Английский

Citations

73
COVID-19 and Thyroid Diseases: A Bidirectional Impact DOI Creative Commons
Leonidas H. Duntas, Jacqueline Jonklaas

Journal of the Endocrine Society, Journal Year: 2021, Volume and Issue: 5(8)

Published: April 27, 2021

Abstract Context COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has become the most lethal and rapidly moving pandemic since Spanish influenza of 1918-1920, is associated with thyroid diseases. Methods References were identified through searches PubMed MEDLINE for articles published from Jan 1, 2019 to February 19, 2021 use MeSH terms “hypothyroidism”, “hyperthyroidism”, “thyroiditis”, “thyroid cancer”, disease”, in combination “coronavirus” “COVID-19”. Articles resulting these references cited those reviewed. Results Though preexisting autoimmune disease appears unlikely render patients more vulnerable some reports have documented relapse Graves’ (GD) or newly diagnosed GD about 1 month following SARS-CoV-2 infection. Investigations are ongoing investigate molecular pathways permitting virus trigger cause subacute thyroiditis (SAT). While COVID-19 non-thyroidal illness, it not clear whether also increases risk developing hypothyroidism. The possibility that dysfunction may increase susceptibility infection deserves further investigation. Recent data illustrate importance hormone protecting lungs injury, including COVID-19. Conclusion interaction between gland complex bidirectional. triggering SAT, possibly Until understood regarding impact on gland, seems advisable monitor new progression disease.

Language: Английский

Citations

81
Manifestations of thyroid disease post COVID-19 illness: Report of Hashimoto thyroiditis, Graves’ disease, and subacute thyroiditis DOI Creative Commons

Karen Feghali,

Jacqueline Atallah,

Catalina Norman

et al.

Journal of Clinical and Translational Endocrinology Case Reports, Journal Year: 2021, Volume and Issue: 22, P. 100094 - 100094

Published: Aug. 25, 2021

We present three cases of thyroid dysfunction such as Hashimoto thyroiditis, Graves' disease and subacute thyroiditis which developed few weeks after resolution acute phase COVID -19 infection in patients with no prior disease.

Language: Английский

Citations

67
Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches DOI Creative Commons
Ali Attiq, Sheryar Afzal, Habibah A. Wahab

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 4215 - 4240

Published: Sept. 1, 2024

Angiotensin-converting enzyme 2 receptors (ACE2R) are requisite to enter the host cells for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). ACE2R is constitutive and functions as a type I transmembrane metallo-carboxypeptidase in renin-angiotensin system (RAS). On thyroid follicular cells, allows SARS-CoV-2 invade gland, impose cytopathic effects produce endocrine abnormalities, including stiff back, neck pain, muscle ache, lethargy, enlarged, inflamed gland COVID-19 patients. Further damage perpetuated by sudden bursts of pro-inflammatory cytokines, which suggestive life-threatening known "cytokine storm". IL-1β, IL-6, IFN-γ, TNF-α identified key orchestrators cytokine storm. These inflammatory mediators upregulate transcriptional turnover nuclear factor-kappa B (NF-κB), Janus kinase/signal transducer activator transcription (JAK/STAT), mitogen-activated protein kinase (MAPK), paving pathway storm-induced dysfunctions euthyroid sick syndrome, autoimmune diseases, thyrotoxicosis Targeted therapies with corticosteroids (dexamethasone), JAK inhibitor (baricitinib), nucleotide analogue (remdesivir) N-acetyl-cysteine have demonstrated effectiveness terms attenuating severity frequency dysfunctions, morbidity mortality Here, we review pathogenesis storms mechanisms pathways that establish connection between disorder COVID-19. Moreover, cross-talk interactions signalling therapeutic strategies address COVID-19-associated diseases also discussed herein.

Language: Английский

Citations

8
Thyroid Hormone Levels During Hospital Admission Inform Disease Severity and Mortality in COVID-19 Patients DOI
Fabyan Esberard de Lima Beltrão, Daniele Carvalhal de Almeida Beltrão, Giulia Carvalhal

et al.

Thyroid, Journal Year: 2021, Volume and Issue: 31(11), P. 1639 - 1649

Published: July 27, 2021

Background: Illness severity in patients infected with COVID-19 is variable.

Language: Английский

Citations

40
Thyroid sequelae of COVID-19: a systematic review of reviews DOI Creative Commons
Pierpaolo Trimboli, Chiara Camponovo, Lorenzo Scappaticcio

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2021, Volume and Issue: 22(2), P. 485 - 491

Published: April 11, 2021

Abstract The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) has potential to cause multi-organ effects including endocrine disorders. impact of COVID-19 on thyroid gland been described but several aspects have be clarified. systematic review was conceived achieve more solid information about: 1) which or dysfunction should expected in patients; 2) whether patients a higher risk SARS-CoV-2 infection; 3) management adapted patient when infected. literature searched two authors independently. A 5-step search strategy priori adopted. Only reviews focused relationship between and were included. last performed February 21 st 2021. Two-hundred-forty-seven records initially found nine finally identified consequences patients, such as thyrotoxicosis, low-T3 subacute thyroiditis, while no relevant data regarding treatment. present that: diagnosed with can develop dysfunction, frequently non-thyroidal illness hospitalized intensive care unit, having does not increase for infection, do need COVID-19-adapted follow-up. Anyway, factors, critical medications, could affect laboratory tests.

Language: Английский

Citations

36
Correlation between inflammatory parameters and pituitary–thyroid axis in patients with COVID-19 DOI Creative Commons
Verónica Ilera, Laura Delfino, Anabela Zunino

et al.

Endocrine, Journal Year: 2021, Volume and Issue: 74(3), P. 455 - 460

Published: Sept. 13, 2021

Language: Английский

Citations

34
Six-month multidisciplinary follow-up in multisystem inflammatory syndrome in children: An Italian single-center experience DOI Creative Commons
Gian Vincenzo Zuccotti, Valeria Calcaterra, Savina Mannarino

et al.

Frontiers in Pediatrics, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 26, 2023

Background A severe multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 has been described after infection. limited number of reports have analyzed the long-term complications pro-inflammatory status MIS-C. We evaluated multiorgan impairment at 6-month follow-up Methods enrolled 33 pediatric patients consecutively hospitalized for MIS-C and monitored almost 6 months. The inter-relationship patient's features disease severity admission with long term was studied by multivariate analysis. Results Endo-metabolic derangement, cardiac injury, respiratory, renal gastrointestinal manifestations neurological involvement are part initial presentation. most abnormalities appear resolve within first few weeks, without significant dysfunction 6-months follow-up, except endocrine (non-thyroidal illness 12.1%, insulin resistance 21.2%) system (27.3% cognitive or psychological, behavioral, adaptive difficulties). Endocrine heart represent a factor on sequelae; however no association between score outcome noted. Conclusions clinical presentation may be associated organ domain, it is not sequelae. prevalent restoration supports predominant indirect immune-mediated injury triggered systemic response; direct damage due viral entry could excluded. Eventhought our preliminary results seem suggest that risk condition health, longer mandatory confirm this hypothesis.

Language: Английский

Citations

16