Molecular Findings Before Vision Loss in the Streptozotocin-Induced Rat Model of Diabetic Retinopathy DOI Creative Commons
Mădălina Anca Moldovan, Roxana-Denisa Capraş, Raluca Paşcalău

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(1), P. 28 - 28

Published: Jan. 4, 2025

The streptozotocin-induced rat model of diabetic retinopathy presents similarities to the disease observed in humans. After four weeks following induction diabetes, rats experience vision impairment. During this crucial four-week period, significant changes occur, with vascular damage standing out as a clinically factor, alongside neovascularization. While redox imbalance, activation microglia, secretion pro-inflammatory cytokines, and neuronal cell death are also observed, latter remains an emerging hypothesis requiring further exploration. This review is comprehensive up-to-date chronological depiction progression within initial hyperglycemia, which precede onset loss. data structured weekly changes. In first week, oxidative stress triggers retinal produces inflammation, leading altered neurotransmission. second week characterized by leukostasis, promotes ischemia, while neural degeneration begins accompanied simultaneous increase vessel permeability. inflammatory imbalances third week. Finally, fourth developments occur vessels dilate become tortuous, neovascularization develops, thickness diminishes, ultimately Through clearly outline, aims delineate framework for retinopathy.

Language: Английский

Mechanisms and early efficacy data of caloric restriction and caloric restriction mimetics in neurodegenerative disease DOI Creative Commons

Anchal Trisal,

Abhishek Kumar Singh

Neuroscience, Journal Year: 2025, Volume and Issue: 567, P. 235 - 248

Published: Jan. 5, 2025

Language: Английский

Citations

3
Recent advances in electrochemical non-enzymatic glucose sensor for the detection of glucose in tears and saliva: A Review DOI

Kermue Vasco Jarnda,

Danqi Wang, Qurrat-ul-Ain Qurrat-ul-Ain

et al.

Sensors and Actuators A Physical, Journal Year: 2023, Volume and Issue: 363, P. 114778 - 114778

Published: Oct. 30, 2023

Language: Английский

Citations

36
Biopolymer-based hydrogels for biomedical applications: Bioactivity and wound healing properties DOI
Fariba Mehvari, Vahid Ramezanzade, Jusung An

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216093 - 216093

Published: July 25, 2024

Language: Английский

Citations

14
Polyphenol-Standardized Aphanamixis polystachya Leaf Extract Ameliorates Diabetes, Oxidative Stress, Inflammation, and Fibrosis in Streptozotocin-Induced Diabetic Rats DOI Creative Commons
Manik Chandra Shill,

Abdullah All Rakib,

Sabrin Islam Khan

et al.

Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 18

Published: Jan. 2, 2024

Background. Diabetes is a rising disorder that affects millions of people annually. It also creates more complications, such as neuropathy, oxidative stress, and hepatic kidney impairment. Aphanamixis polystachya plant, which possesses multiple medicinal values, used in this study to explore its potential treating diabetes. Methods. A single dose (65 mg/kg) intraperitoneal streptozotocin injection was utilized mediate diabetes Sprague-Dawley rats. Diabetic animals were treated orally with 250 or 500 mg/kg standardized leaves’ extract A. (AP) for 28 days evaluate the antidiabetic organ-protective effects plant. Different biochemical histological markers are measured according established protocol. Results. Our results demonstrated significant decrease blood glucose ( p <0.001 ) HbA1c p <0.05 levels diabetic animal after administering AP (250 doses) compared control groups. can regularize lipids, glycogen, alanine aminotransferase, aspartate aminotransferase. Furthermore, serum urea nitrogen creatinine decreased treatment reduced stress showed substantial elevation antioxidant enzymes animals. Overall, at revealed comparable against standard drug glyburide. Besides, investigation AP’s efficacy attenuating tissue inflammation damage. HPLC data elucidated leaf contains polyphenols antioxidant, antidiabetic, organ protective agents: gallic acid, rutin hydrate, quercetin hydrate. Conclusion. Taken together, may be one sources agents.

Language: Английский

Citations

13
Effect of cubebin against streptozotocin-induced diabetic nephropathy rats via inhibition TNF-α/NF-κB/TGF-β: in vivo and in silico study DOI Creative Commons
Rahamat Unissa Syed, Sivakumar S. Moni, Weiam Hussein

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 5, 2025

Language: Английский

Citations

1
Comparative Evaluation of the Antidiabetic potential of three varieties of Ipomoea batatas L. DOI Creative Commons
Seun F. Akomolafe, Oluwadamilare Ajayi, Oluwaseun Emmanuel Agboola

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 102015 - 102015

Published: March 28, 2025

Sweet potato (Ipomoea batatas L.) is a nutrient-dense tuber often used in traditional diabetic treatment. This research compares the antidiabetic potential of three sweet varieties: orange-fleshed (OFSP), purple-peel white-fleshed (PPWSP), and white-peel (WPWSP), utilising vitro vivo techniques. potatoes (OFSP, PPWSP, WPWSP) boiled at 100°C for 20 minutes were incorporated into formulated diets administered to streptozotocin-induced rats 14 days. Aqueous extracts tested antioxidants phytochemicals. Glycaemic control parameters, lipid profiles, oxidative stress indicators, pancreatic histology investigated. Gene expression analysis was performed on critical diabetes-related pathways. OFSP showed significant strong anti-diabetic benefits, including better glycemic control, weight maintenance, lower HOMA-IR scores, lowered α-amylase α-glucosidase activity. OFSP-fed had higher insulin, glycogen, hexokinase activity than those given PPWSP WPWSP. decreased mRNA DPP-4 while increasing GLP-1 expression. also improved HDLc decreasing LDLc triglycerides more other varieties. Histopathological examination revealed restorative effects beta cells. demonstrated pronounced compared WPWSP, particularly terms insulin regulation, profile improvement. These findings suggest that may offer diabetes management. However, further clinical studies are needed validate these results explore practical dietary applications control.

Language: Английский

Citations

1
Application of Self Powered Black Phosphorus Nanosheets-Based Hydrogel Skin Patch in Wound Healing of Diabetes DOI

Xiaohan Ge,

Meiru Mao,

Hongrui Yu

et al.

Nano Energy, Journal Year: 2024, Volume and Issue: unknown, P. 110289 - 110289

Published: Sept. 1, 2024

Language: Английский

Citations

9
The rat as an animal model in chronic wound research: An update DOI

Mahboubeh Ghanbari,

Yury Salkovskiy, Mark A. Carlson

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122783 - 122783

Published: June 5, 2024

Language: Английский

Citations

8
Curcumin Analog J7 Attenuates Liver Fibrosis and Metabolic Dysregulation in a Rat Model of Type 2 Diabetes via Modulation of TGF-β/Smad and NF-κB/BCL-2/BAX Pathways DOI Creative Commons
Jun Ma, Wei C., Deep K Vaishnani

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 2411 - 2432

Published: April 1, 2025

Objective: To evaluate the therapeutic potential of curcumin analog J7 in protecting liver and regulating glucose lipid metabolism rats with type 2 diabetes. Methods: Bioinformatics methods were used to identify signaling pathways linked diabetic disease. Diabetic treated curcumin, low-dose J7, or high-dose function fibrosis assessed through biochemical analyses, histopathology, immunohistochemistry, ELISA. Results: administration significantly improved lisver function, reduced fibrosis, regulated metabolic profiles rats. downregulated TGF-β 1, NF-κB p65, BAX, while upregulating BCL-2, showing superior effects traditional reducing 1 inhibiting α-SMA expression. Conclusion: demonstrates as a agent for managing complications diabetes, effectively attenuating modulation key proteins. Plain Language Summary: Diabetes is common condition that can cause serious problems liver, such damage scarring (fibrosis). These are how body handles sugar fat. Right now, there not many effective treatments diabetes-related issues. Our study looked at new drug called which based on natural compound found turmeric, see if it could help protect improve fat metabolism. We rat model diabetes test J7. Rats given either low dose high then measured well their livers working examined tissue under microscope. also levels specific molecules involved inflammation, scarring, cell survival. worked better than regular curcumin. It damage, handled fat, lessened scarring. achieved this by affecting certain biological pathways, like TGF-β/Smad pathway signaling, players inflammation. results suggest be promising treatment people This highlights improving compounds make them more medicines. Further research needed explore might Keywords: insulin resistance, dysfunction-associated fatty disease, MAFLD, analog, pathway, NF-κB-BCL-2/BAX axis

Language: Английский

Citations

1
Pistacia lentiscus: Phytochemistry and Antidiabetic Properties DOI Open Access
Sonia Floris, Amalia Di Petrillo, Francesca Pintus

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1638 - 1638

Published: May 27, 2024

Pistacia lentiscus L. (P. lentiscus) is an evergreen shrub (Anacardiaceae family) primarily found in the Mediterranean region. The plant has been thoroughly characterized, resulting a high concentration of bioactive compounds as flavonoids and phenolics. Moreover, P. was revealed to possess great nutritional industrial importance because its variety biological activities, including antibacterial, anti-inflammatory, anti-atherogenic antioxidant properties. Many beneficial health properties applications date back antiquity, European Medicines Agency officially acknowledged it herbal medicinal product. Indeed, widely employed conventional medicine treat several diseases, type 2 diabetes (T2D). On this basis, review aims summarize describe chemical composition different parts highlight potential lentiscus, focusing on antidiabetic activities. kingdom drawing increasing attention complexity natural molecules research novel for drug development. In context, demonstrated vitro vivo effects, acting upon many therapeutic T2D targets. Therefore, information available highlighted multitarget effects treatment.

Language: Английский

Citations

6