Tolerance to ethanol: cerebellar apoptotic parameters and circulating miRNAs in senile UChB rats (voluntary ethanol consumers) DOI Creative Commons

M. Martinez,

Isabela Maria Urra Rossetto,

F.S.N. Lizarte

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 9, 2023

Abstract Background Despite the absence of scientific data supporting real impact drinking on elderly individuals, alcohol abuse is a common feature older people. Because aging associated with biological changes that include reduced water volume in body, lower efficiency liver enzymes and hepatic blood flow, altered brain responsiveness due to drug interactions, individuals are more prone harmful effects consumption. The adverse acute or chronic exposure ethanol have been extensively recognized cerebellar circuits, impairment movement balance. In addition motor deterioration, degeneration contributes distinct neuropsychological deficits alcoholics children prenatal ethanol. However, senile unclear. This study determines pattern MicroRNAs, gene expressions, apoptotic anti-apoptotic protein levels, ultrastructural analysis neurons contribute understanding consequences cerebellum. Methods Results results immunohistochemical expressions for Caspase-3, XIAP, IGFR-1 were similar both groups. Serum levels miR-9-3p, -15b-5p, -16-5p, -21, − 200a, 222-3p upregulated presence aging. Conclusions suggest an important tolerance development by UChB rats consumption aged cerebellum, miRNAs may be potentially involved this mechanism.

Language: Английский

Stress, diet, exercise: Common environmental factors and their impact on epigenetic age DOI Creative Commons
Fedor Galkin, Olga Kovalchuk, Diana Koldasbayeva

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101956 - 101956

Published: May 20, 2023

Epigenetic aging clocks have gained significant attention as a tool for predicting age-related health conditions in clinical and research settings. They enabled geroscientists to study the underlying mechanisms of assess effectiveness anti-aging therapies, including diet, exercise environmental exposures. This review explores effects modifiable lifestyle factors' on global DNA methylation landscape, seen by clocks. We also discuss through which these factors contribute biological provide comments what findings mean people willing build an evidence-based pro-longevity lifestyle.

Language: Английский

Citations

50
The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES DOI Open Access

MA Jian-hua,

Ping-An Li, Yue Jiang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1635 - 1635

Published: May 27, 2024

The acceleration of aging is a risk factor for numerous diseases, and diet has been identified as an especially effective anti-aging method. Currently, research on the relationship between dietary nutrient intake accelerated remains limited, with existing studies focusing small number individual nutrients. Comprehensive single mixed effects nutrients not conducted. This study aimed to comprehensively explore intakes, both singly in combination, aging. Data this were extracted from 2015–2018 National Health Nutrition Examination Surveys (NHANES). was measured by phenotypic age acceleration. Linear regression (linear), restricted cubic spline (RCS) (nonlinear), weighted quantile sum (WQS) (mixed effect) models used association A total 4692 participants aged ≥ 20 included study. In fully adjusted models, intakes 16 negatively associated (protein, vitamin E, A, beta-carotene, B1, B2, B6, K, phosphorus, magnesium, iron, zinc, copper, potassium, fiber, alcohol). Intakes sugars, C, caffeine, alcohol showed significant nonlinear associations Additionally, Single well may mitigate Moderately increasing specific maintaining balance be key strategies prevent

Language: Английский

Citations

6
Alcohol consumption and accelerated biological ageing in middle‐aged and older people: A longitudinal study from two cohorts DOI
Hongxiang Chen,

Jianzhong Yin,

Yi Xiang

et al.

Addiction, Journal Year: 2024, Volume and Issue: 119(8), P. 1387 - 1399

Published: April 28, 2024

Abstract Background and aims The relationship between alcohol consumption age‐related diseases is inconsistent. Biological age (BA) serves as both a precursor predictor of diseases; however, longitudinal associations BA in middle‐aged older people remain unclear. We measured whether there was association drinking frequency pure intake with among people. Design setting participants This study involved two prospective cohort studies, set Southwestern China the United Kingdom. A total 8046 from Multi‐Ethnic Cohort (CMEC) 5412 UK Biobank (UKB), aged 30–79 years, took part, complete data waves clinical biomarkers. Measurements calculated by Klemera Doubal's method. Accelerated equalled minus chronological age. Drinking were obtained through self‐reported questionnaires. past year classified current non‐drinking, occasional (monthly drinking) regular (weekly drinking). Findings Compared consistent non‐drinkers, more frequent drinkers [CMEC: β = 0.46, 95% confidence interval (CI) 0.13–0.80; UKB: 0.65, CI 0.01–1.29)], less (CMEC: 0.62, 0.37–0.87; 0.54, −0.01–1.09), 0.51, 0.23–0.79; 0.63, 0.13–1.13) 0.56, 0.17–0.95; 0.00–0.91) exhibited increased accelerated BA. non‐linear observed drinkers. Conclusions In people, any change amount seem to be positively associated acceleration biological ageing, compared maintaining abstinence.

Language: Английский

Citations

5
Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder DOI

Camila N. C. Lima,

Emese H.C. Kovács,

Salahudeen Mirza

et al.

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 48(6), P. 954 - 962

Published: March 6, 2023

Language: Английский

Citations

11
Is There a Safe Alcohol Consumption Limit for the General Population and in Patients with Liver Disease? DOI
Manuel Romero‐Gómez, Juan Pablo Arab, Cláudia P. Oliveira

et al.

Seminars in Liver Disease, Journal Year: 2024, Volume and Issue: 44(01), P. 069 - 078

Published: Feb. 1, 2024

Excessive alcohol consumption represents an important burden for health systems worldwide and is a major cause of liver- cancer-related deaths. Alcohol mostly assessed by self-report that often underestimates the amount drinking. While use disorders identification test - version C most widely used screening, in patients with liver disease biomarker could help objective assessment. The leads to significant depends on gender, genetic background, coexistence comorbidities (i.e., metabolic syndrome factors). All alcohol-associated are recommended follow complete abstinence they should be treated within multidisciplinary teams. Abstinence slows down even reverses progression fibrosis can recompensate complicated cirrhosis. Whether there safe general population matter intense debate. Large epidemiological studies showed avoid overall health-related risks lower than expected population. Even one drink per day increase death. In any kind chronic disease, especially those metabolic-associated steatotic no intake recommended. This review article discusses current evidence supporting deleterious effects small-to-moderate amounts underlying disease.

Language: Английский

Citations

4
Dietary carbohydrate quality is associated with epigenetic age acceleration: a cross-sectional study of the CARDIA cohort DOI Creative Commons
So-Yun Yi, Lyn M. Steffen, David R. Jacobs

et al.

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Chronic alcohol consumption accelerates cardiovascular aging and decreases cardiovascular reserve capacity DOI Creative Commons
Partha Mukhopadhyay,

Burhan Yokus,

Bruno Paes‐Leme

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract The pathology of cardiovascular aging is complex, involving mitochondrial dysfunction, oxidative and nitrative stress, DNA injury, impaired lipid metabolism, cell death, senescence, chronic inflammation. These processes lead to remodeling structural changes in the system, resulting a progressive decline reserve capacity health, an increased risk diseases mortality. Excessive alcohol consumption exacerbates these risks by promoting hypertension, stroke, arrhythmias, coronary artery disease, cardiomyopathy, sudden cardiac yet effects on remain unclear. Herein, we explored impact 6-month 5% Lieber-DeCarli diet young (3 months old) (24–26 Fisher F344BNF1 rats. We assessed detailed hemodynamics, function, oxidative/nitrative inflammation, myocardial fibrosis using pressure–volume isolated vascular rings, various histological, biochemical, molecular biology methods. Alcohol both rats disrupted cholesterol triglyceride leading systolic contractile function. In rats, further exacerbated diastolic dysfunction fibrosis. also apoptosis, senescence vasculature, contributing endothelial total peripheral resistance. Additionally, aging-related ventriculo-arterial uncoupling diminished efficiency, reducing capacity. conclusion, promotes diminishes already associated with aging.

Language: Английский

Citations

0
Objective Assessments of Smoking and Drinking Outperform Clinical Phenotypes in Predicting Variance in Epigenetic Aging DOI Open Access
Robert A. Philibert, Man‐Kit Lei, Mei Ling Ong

et al.

Genes, Journal Year: 2024, Volume and Issue: 15(7), P. 869 - 869

Published: July 2, 2024

The reliability of the associations acceleration epigenetic aging (EA) indices with clinical phenotypes other than for smoking and drinking is poorly understood. Furthermore, majority phenotyping studies have been conducted using data from subjects European ancestry. In order to address these limitations, we clinical, physiologic, assessments a cohort 278 middle-aged African American adults analyzed recently described principal-components-trained version GrimAge (i.e., PC-GrimAge) DunedinPACE (PACE) index regression analyses. We found that 74% PC-GrimAge accelerated could be predicted by simple baseline model consisting age, sex, methylation-sensitive digital PCR (MSdPCR) drinking. addition serological, demographic, medical history variables or PACE values did not meaningfully improve prediction, although some significantly fit. contrast, mapping cardiometabolic syndrome independently contribute prediction beyond model. were correlated (r = 0.2), little overlap in variance explained conveyed results suggest EA may differ information they provide significant limitations as screening tools guide patient care.

Language: Английский

Citations

3
Alcohol consumption and epigenetic age acceleration across human adulthood DOI Creative Commons
Mengyao Wang, Yi Li, M M Lai

et al.

Aging, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 26, 2023

The alcohol-associated biological aging remains to be studied across adulthood. We conducted linear regression analyses investigate the associations between alcohol consumption and two DNA methylation-based age acceleration metrics in 3823 Framingham Heart Study participants (24–92 years 53.8% women) adjusting for covariates. also investigated whether epigenetic mediated association of with hypertension. found that higher long-term average was significantly associated assessed by GrimAge (GAA) PhenoAge (PAA) middle-aged (45–64 years, n = 1866) older (65–92 1267) while not young (24–44 690). For example, one additional standard drink (~14 grams ethanol per day) a 0.71 ± 0.15-year (p 2.1e-6) 0.60 0.18-year 7.5e-4) increase PAA participants, respectively, but significant 0.23). One serving liquor ethanol) greater GAA (0.82-year, p 4.8e-4) (1.45-year, 7.4e-5) than beer (GAA: 0.45-year, 5.2e-4; PAA: 0.48-year, 0.02) wine 0.51-year, 0.02; 0.91-year, 0.008) participant group. observed up 28% hypertension or pooled sample. Our findings suggest is quantified metrics, which may mediate quantitative traits, such as

Language: Английский

Citations

7
Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model DOI Creative Commons
Alison Basel, Sanat S. Bhadsavle,

Katherine Z. Scaturro

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Although detrimental changes in mitochondrial morphology and function are widely described symptoms of fetal alcohol exposure, no studies have followed these deficits into adult life or determined if they predispose individuals with spectrum disorders (FASDs) to accelerated biological aging. Here, we used a multiplex preclinical mouse model compare markers cellular senescence age-related outcomes induced by maternal, paternal, dual-parental exposures. We find that even middle (postnatal day 300), the offspring alcohol-exposed parents exhibited significant increases stress-induced premature brain liver, including an upregulation cell cycle inhibitory proteins increased senescence-associated β-galactosidase activity. Strikingly, male offspring, observe interaction between maternal paternal use, histological indicators liver disease exceeding those either use alone. Our indicate chronic parental causes enduring dysfunction resulting reduced NAD+/NAHD ratio altered expression NAD+-dependent deacetylases SIRT1 SIRT3. These observations suggest some aspects FASDs may be linked aging due programmed regulation bioenergetics.

Language: Английский

Citations

1