Joining Forces against Antibiotic Resistance: The One Health Solution

Pathogens, Journal Year: 2023, Volume and Issue: 12(9), P. 1074 - 1074

Published: Aug. 23, 2023

Antibiotic resistance is a significant global health concern that affects both human and animal populations. The One Health approach acknowledges the interconnectedness of health, environment. It emphasizes importance collaboration coordination across these sectors to tackle complex challenges such as antibiotic resistance. In context Health, refers ability bacteria withstand efficacy antibiotics, rendering them less effective or completely ineffective in treating infections. emergence spread antibiotic-resistant pose threat well effectiveness medical treatments veterinary interventions. particular, recognizes use medicine, agriculture, environment are interconnected factors contributing development For example, misuse overuse antibiotics healthcare, including inappropriate prescribing patient non-compliance, can contribute selection resistant bacteria. Similarly, livestock production for growth promotion disease prevention animals subsequent transmission humans through food chain. Addressing requires collaborative involves multiple participants, healthcare professionals, veterinarians, researchers, policymakers.

Language: Английский

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Bioactive Metabolites from Terrestrial and Marine Actinomycetes

Molecules, Journal Year: 2023, Volume and Issue: 28(15), P. 5915 - 5915

Published: Aug. 6, 2023

Actinomycetes inhabit both terrestrial and marine ecosystems are highly proficient in producing a wide range of natural products with diverse biological functions, including antitumor, immunosuppressive, antimicrobial, antiviral activities. In this review, we delve into the life cycle, ecology, taxonomy, classification actinomycetes, as well their varied bioactive metabolites recently discovered between 2015 2023. Additionally, explore promising strategies to unveil investigate new metabolites, encompassing genome mining, activation silent genes through signal molecules, co-cultivation approaches. By presenting comprehensive up-to-date hope offer potential solution uncover novel compounds essential

Language: Английский

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Safety and Tolerability of Antimicrobial Agents in the Older Patient

Drugs & Aging, Journal Year: 2023, Volume and Issue: 40(6), P. 499 - 526

Published: March 28, 2023

Language: Английский

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Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action

World Journal of Emergency Surgery, Journal Year: 2023, Volume and Issue: 18(1)

Published: Oct. 16, 2023

Abstract Antibiotics are recognized widely for their benefits when used appropriately. However, they often inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component universal healthcare, and it a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive develop new antibiotics due scientific, regulatory, financial barriers, further emphasizing To address this issue, Global Alliance Infections in Surgery established international multidisciplinary task force 295 experts from 115 countries with different backgrounds. The developed position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness antimicrobial resistance improving prescribing practices worldwide. outlined 10 axioms, or “golden rules,” that all healthcare workers should consistently adhere

Language: Английский

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Methicillin Resistant Staphylococcus aureus: Molecular Mechanisms Underlying Drug Resistance Development and Novel Strategies to Combat

Infection and Drug Resistance, Journal Year: 2023, Volume and Issue: Volume 16, P. 7641 - 7662

Published: Dec. 1, 2023

Antimicrobial resistance (AMR) represents a major threat to global health. Infection caused by Methicillin-resistant Staphylococcus aureus (MRSA) is one of the well-recognized public health problem globally. In some regions, as many 90% S. infections are reported be MRSA, which cannot treated with standard antibiotics. WHO reports indicated that MRSA circulating in every province worldwide, significantly increasing risk death 64% compared drug-sensitive forms infection attributed its antibiotic resistance. The emergence and spread antibiotic-resistant strains have contributed increased prevalence both healthcare community settings. methicillin due expression penicillin-binding protein 2a (PBP2a), renders it impervious action β-lactam antibiotics including methicillin. other through production beta-lactamases. Although treatment options for limited, there promising alternatives combat infections. Innovative therapeutic strategies wide range activity modes yet explored. review highlights challenges posed elucidates mechanisms underlying development, explores mitigation strategies. Furthermore, focuses on alternative therapies such bacteriophages, immunotherapy, nanobiotics, antimicrobial peptides, emphasizing their synergistic effects efficacy against MRSA. By examining these approaches, this provides insights into potential tackling combatting escalating AMR. Ultimately, multifaceted approach encompassing conventional novel interventions imperative mitigate impact ensure sustainable future healthcare.

Language: Английский

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Multidrug-Resistant Sepsis: A Critical Healthcare Challenge

Antibiotics, Journal Year: 2024, Volume and Issue: 13(1), P. 46 - 46

Published: Jan. 4, 2024

Sepsis globally accounts for an alarming annual toll of 48.9 million cases, resulting in 11 deaths, and inflicts economic burden approximately USD 38 billion on the United States healthcare system. The rise multidrug-resistant organisms (MDROs) has elevated urgency surrounding management (MDR) sepsis, evolving into a critical global health concern. This review aims to provide comprehensive overview current epidemiology sepsis its associated challenges, particularly critically ill hospitalized patients. Highlighted findings demonstrated complex nature pathophysiology immune responses, which significantly hinder treatment. Studies also revealed that aging, antibiotic overuse or abuse, inadequate empiric therapy, underlying comorbidities contribute recurrent thereby leading septic shock, multi-organ failure, ultimately paralysis, all high mortality rates among Moreover, studies confirmed correlation between readmission increased risk cognitive organ dysfunction patients, amplifying hospital-associated costs. To mitigate impact burden, researchers have directed their efforts towards innovative diagnostic methods like point-of-care testing (POCT) devices rapid, accurate, bedside detection sepsis; however, these are currently limited detecting only few resistance biomarkers, thus warranting further exploration. Numerous interventions been introduced treat MDR including combination therapy with antibiotics from two different classes precision involves personalized treatment strategies tailored individual needs. Finally, addressing MDR-associated challenges at regional levels based local pathogen patterns emerges as strategy effective minimizing adverse effects.

Language: Английский

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Ionic Liquids in Pharmaceutical and Biomedical Applications: A Review

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(1), P. 151 - 151

Published: Jan. 22, 2024

The unique properties of ionic liquids (ILs), such as structural tunability, good solubility, chemical/thermal stability, favorable biocompatibility, and simplicity preparation, have led to a wide range applications in the pharmaceutical biomedical fields. ILs can not only speed up chemical reaction process, improve yield, reduce environmental pollution but also many problems field medicine, poor drug product crystal instability, biological activity, low delivery efficiency. This paper presents systematic concise analysis recent advancements further from aspects synthesis, analysis, solubilization, engineering. Additionally, it explores field, covering carriers, stabilization proteins, antimicrobials, bioactive liquids.

Language: Английский

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An Overview of the Recent Advances in Antimicrobial Resistance

Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1920 - 1920

Published: Sept. 21, 2024

Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by widespread prevalence constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every day. The most common mechanisms underlying AMR (i.e., genetic mutations, horizontal gene transfer, selective pressure) contribute to the emergence dissemination resistant strains. Therefore, mitigation strategies (e.g., antibiotic stewardship programs—ASPs—and infection prevention control strategies—IPCs) emphasize importance responsible antimicrobial use surveillance. A One Health approach interconnectedness human, animal, environmental health) highlights necessity for interdisciplinary collaboration holistic in combating AMR. Advancements novel therapeutics alternative agents vaccines) offer promising avenues addressing challenges. Policy interventions at international national levels also promote ASPs aiming regulate use. Despite all observed progress, remains pressing concern, demanding sustained efforts address emerging threats sustainability. Future research must prioritize innovative approaches complex socioecological dynamics This manuscript resource researchers, policymakers, healthcare professionals seeking navigate develop effective mitigation.

Language: Английский

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Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 16, 2024

Antibacterial drug resistance poses a significant challenge to modern healthcare systems, threatening our ability effectively treat bacterial infections. This review aims provide comprehensive overview of the types and mechanisms antibacterial resistance. To achieve this aim, thorough literature search was conducted identify key studies reviews on mechanisms, strategies next-generation antimicrobials contain antimicrobial In review, major with examples including target site modifications, decreased influx, increased efflux pumps, enzymatic inactivation antibacterials has been discussed. Moreover, biofilm formation, horizontal gene transfer methods also included. Furthermore, measures (interventions) taken control have discussed in detail. Overall, provides valuable insights into diverse employed by bacteria resist effects drugs, aim informing future research guiding stewardship efforts.

Language: Английский

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Effect of the COVID-19 pandemic on antibiotic consumption: A systematic review comparing 2019 and 2020 data

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Oct. 18, 2022

The coronavirus disease 2019 (COVID-19) pandemic has influenced antibiotic consumption over a long period, with variability in trends among studies. We conducted this systematic review to explore and compare the effect of on overall individual 2020 that 2019.

Language: Английский

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