International Journal of Peptide Research and Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)
Published: Sept. 30, 2024
Language: Английский
International Journal of Peptide Research and Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)
Published: Sept. 30, 2024
Language: Английский
Bioactive Materials, Journal Year: 2022, Volume and Issue: 20, P. 64 - 80
Published: May 20, 2022
Endowing implant surfaces with combined antibacterial and osteogenic properties by drug-loaded coatings has made great strides, but how to achieve the excellence of infection-triggered bactericidal in vivo-proven activities without causing bacterial resistance still remains a formidable challenge. Herein, antimicrobial peptides (AMPs) fragments were designed complexed on surface silver nanoparticle (AgNP) through hydrogen bonding, collagen structure-bionic silk fibroin (SF) was applied carry AgNPs@ AMPs osteointegration. As verified TEM, contributed dispersion size-regulation AgNPs, particle size about 20 nm, clear protein corona structure observed surface. The release curve ion displayed that SF-based coating owned sensitive pH-responsive properties. In test against S.aureus for up 21 days, rate had always remained above 99%. Meanwhile, underlying mechanism revealed, originating from destruction cell membranes ROS generation. conducive adhesion, diffusion, proliferation bone marrow stem cells (BMSCs) surface, promoted expression genes secretion. vivo implantation results showed compared untreated Ti implants, enhanced osseointegration at week 4 8. Overall, AgNPs@AMPs-loaded presented ability synergistically inhibit bacteria promote osseointegration, possessing tremendous potential application prospects defects related-infection treatments.
Language: Английский
Citations
89Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: July 31, 2024
Nanoparticles play a crucial role in the field of nanotechnology, offering different properties due to their surface area attributed small size. Among them, silver nanoparticles (AgNPs) have attracted significant attention antimicrobial properties, with applications that date back from ancient medicinal practices contemporary commercial products containing ions or nanoparticles. AgNPs possess broad-spectrum biocidal potential against bacteria, fungi, viruses, and Mycobacterium, addition exhibiting synergistic effects when combined certain antibiotics. The mechanisms underlying its action include generation oxygen-reactive species, damage DNA, rupture bacterial cell membranes inhibition protein synthesis. Recent studies highlighted effectiveness various clinically relevant strains through combat antibiotic-resistant pathogens. This review investigates proteomic by which exert effects, special focus on activity planktonic bacteria biofilms. Furthermore, it discusses biomedical non-preparation antibiotic formulations, also addressing issue resistance
Language: Английский
Citations
36Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 489, P. 151485 - 151485
Published: April 20, 2024
Language: Английский
Citations
22Journal of the Egyptian National Cancer Institute, Journal Year: 2025, Volume and Issue: 37(1)
Published: Jan. 6, 2025
Silver nanoparticles (AgNPs) derived from natural sources have garnered significant attention due to their unique properties and eco-friendly production methods. With lung cancer remaining a major global health issue, there is continuous need for novel effective therapeutic approaches beyond conventional treatments such as chemotherapy, immunotherapy, targeted therapies.
Language: Английский
Citations
6Science Bulletin, Journal Year: 2022, Volume and Issue: 67(17), P. 1776 - 1784
Published: July 30, 2022
Language: Английский
Citations
70Antibiotics, Journal Year: 2022, Volume and Issue: 11(7), P. 951 - 951
Published: July 15, 2022
Antibiotics are regarded as a miracle in the medical field it prevents disease caused by pathogenic bacteria. Since discovery of penicillin, antibiotics have become foundation for modern discoveries. However, bacteria soon became resistant to antibiotics, which puts burden on healthcare system. Methicillin-resistant
Language: Английский
Citations
56Antibiotics, Journal Year: 2022, Volume and Issue: 11(9), P. 1205 - 1205
Published: Sept. 6, 2022
The present review focuses on the potential use of silver nanoparticles in therapy diseases caused by antibiotic-resistant bacteria. Such bacteria are known as “superbugs”, and most concerning species Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus (methicillin vancomycin-resistant), some Enterobacteriaceae. According to World Health Organization (WHO), there is an urgent need for new treatments against these “superbugs”. One possible approaches treatment antibacterial nanoparticles. After a short overview nanoparticle usage, mechanisms action, methods synthesis nanoparticles, emphasis has been placed (AgNPs) combat relevant emerging resistant toxicological aspects AgNPs, both vitro using cell cultures vivo have reviewed. It was found that toxic activity AgNPs dependent dose, size, shape, electrical charge. mechanism action involves interactions at various levels such plasma membrane, DNA replication, inactivation protein/enzymes necessary, formation reactive oxygen (ROS) leading death. Researchers do not always agree their conclusions topic more work needed this field before can be effectively applied clinical multi-drug
Language: Английский
Citations
50Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Nov. 15, 2023
Abstract Bacterial wound infections are a serious threat due to the emergence of antibiotic resistance. Herein, we report an innovative hybrid nanozyme independent antibiotics for antimicrobial healing. The nanozymes fabricated from ultra-small Au NPs via in-situ growth on metal-organic framework (MOF)-stabilised Fe 3 O 4 (Fe @MOF@Au NPs, FMA NPs). displayed synergistic peroxidase (POD)-like activities. It showed remarkable level hydroxyl radicals (·OH) in presence low dose H 2 (0.97 mM). Further, exhibited excellent biocompatibility and favourable antibacterial effects against both Gram-negative (Escherichia coli) Gram-positive ( Staphylococcus aureus ) bacteria. animal experiments indicated that promoted repair with adequate biosafety. Thus, well-designed represent potential strategy healing bacterial infections, without any toxic side effects, suggesting possible applications therapy.
Language: Английский
Citations
28Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: Feb. 28, 2023
The use of nanomaterials in several fields science has undergone a revolution the last few decades. It been reported by National Institutes Health (NIH) that 65% and 80% infections are accountable for at least human bacterial infections. One their important applications healthcare is nanoparticles (NPs) to eradicate free-floating bacteria those form biofilms. A nanocomposite (NC) multiphase stable fabric with one or three dimensions much smaller than 100 nm, systems nanoscale repeat distances between unique phases make up material. Using NC materials get rid germs more sophisticated effective technique destroy These biofilms refractory standard antibiotics, mainly chronic non-healing wounds. Materials like graphene chitosan can be utilized forms NCs, addition different metal oxides. ability NCs address issue resistance its main advantage over antibiotics. This review highlights synthesis, characterization, mechanism through which disrupt Gram-positive Gram-negative biofilms, relative benefits drawbacks. There an urgent need develop larger spectrum action due rising prevalence diseases multidrug-resistant
Language: Английский
Citations
24Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: May 22, 2024
Persistent infection caused by biofilm is an urgent in medicine that should be tackled new alternative strategies. Low efficiency of classical treatments and antibiotic resistance are the main concerns persistent due to formation which increases risk morbidity mortality. The gene expression patterns cells differed from those planktonic cells. One promising approaches against biofilms nanoparticle (NP)-based therapy NPs with multiple mechanisms hinder bacterial or forms. For instance, such as silver (Ag), zinc oxide (ZnO), titanium dioxide (TiO 2 ), copper (Cu), iron (Fe 3 O 4 ) through different strategies interfere bacteria associated biofilm. can penetrate into structure affect efflux pump, quorum-sensing, adhesion-related genes, lead inhibit development. Therefore, understanding targeting genes molecular basis point therapeutic targets make possible control infections. In parallel, impact on environment their cytotoxicity avoided controlled exposure safety assessments. This study focuses biofilm-related potential for inhibition highly effective NPs, especially metal NPs.
Language: Английский
Citations
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