Inflammation, Journal Year: 2022, Volume and Issue: 46(1), P. 35 - 46
Published: Aug. 11, 2022
Language: Английский
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Language: Английский
Citations
1
Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2735 - 2735
Published: March 17, 2023
The COVID-19 pandemic caused by SARS-CoV-2 has majorly impacted public health and economies worldwide. Although several effective vaccines drugs are now used to prevent treat COVID-19, natural products, especially flavonoids, showed great therapeutic potential early in the thus attracted particular attention. Quercetin, baicalein, baicalin, EGCG (epigallocatechin gallate), luteolin among most studied flavonoids this field. Flavonoids can directly or indirectly exert antiviral activities, such as inhibition of virus invasion replication viral proteases. In addition, modulate levels interferon proinflammatory factors. We have reviewed previously reported relevant literature researching pharmacological anti-SARS-CoV-2 activity where structures, classifications, synthetic pathways, effects summarized. There is no doubt that treatment COVID-19. However, current research still theoretical stage. More studies recommended evaluate efficacy safety against SARS-CoV-2.
Language: Английский
Citations
22
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 570 - 570
Published: April 10, 2023
Baicalin (7-D-glucuronic acid-5,6-dihydroxyflavone) belongs to natural flavonoids extracted from the roots of Scutellaria baicalensis, plant used in traditional Chinese medicine. It has been proven that baicalin various pharmacological activities, such as antioxidant, anti-inflammatory, anticancer, antibacterial, and anti-apoptotic ones. However, it is essential not only determine medical usefulness baicalin, but also find develop most effective methods for its extraction detection. Therefore, aim this review was summarize current detection identification present applications underlying mechanisms action. Based on latest literature, can be concluded liquid chromatography alone or together with mass spectrometry commonly method determination baicalin. Recently, new electrochemical have established, e.g., biosensors fluorescence, which better limits, sensitivity, selectivity.
Language: Английский
Citations
22
Pharmacological Research - Modern Chinese Medicine, Journal Year: 2023, Volume and Issue: 9, P. 100326 - 100326
Published: Nov. 7, 2023
Chinese Skullcap (Scutellaria baicalensis) is a traditional medicinal herb with rich history of use in Traditional Medicine (TCM). This review aims to provide an updated overview the phytochemical constituents and pharmacological attributes Skullcap, shedding light on its potential therapeutic applications. A comprehensive search scientific databases, including PubMed, Scopus, Web Science, was conducted gather relevant literature published up September 2023. Keywords such as "Scutellaria baicalensis," "phytochemicals," "pharmacological properties" were used identify pertinent studies. found contain diverse array constituents, flavonoids, alkaloids, terpenoids, baicalin baicalein being most prominent bioactive compounds. These compounds have demonstrated wide range activities, anti-inflammatory, antioxidant, anti-cancer, neuroprotective, hepatoprotective effects. Additionally, has been investigated for treating various diseases, cancer, cardiovascular disorders, neurodegenerative conditions. represents compelling avenue future development, emphasizing ongoing need exploration clinical investigation.
Language: Английский
Citations
18
Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(18), P. 53997 - 54021
Published: March 4, 2023
Language: Английский
Citations
17
Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1055 - 1055
Published: Aug. 25, 2024
This comprehensive review investigates the pivotal role of reactive oxygen species (ROS) in cataract formation and evaluates potential antioxidant therapies mitigating this ocular condition. By elucidating mechanisms oxidative stress, article examines how ROS contribute to deterioration lens proteins lipids, leading characteristic aggregation, cross-linking, light scattering observed cataracts. The provides a thorough assessment various strategies aimed at preventing managing cataracts, such as dietary antioxidants (i.e., vitamins C E, lutein, zeaxanthin), well pharmacological agents with antioxidative properties. Furthermore, explores innovative therapeutic approaches, including gene therapy nanotechnology-based delivery systems, designed bolster defenses tissues. Concluding critical analysis current research, offers evidence-based recommendations for optimizing therapies. literature on use prevent is sparse. There lack conclusions; further clinical studies are needed endorse patients cataractogenesis. However, personalized treatment plans considering individual patient factors disease stages can be applied. serves valuable resource, providing insights into alleviate burden
Language: Английский
Citations
8
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 5, 2024
The prevalence of colorectal cancer is increasing worldwide, and despite advances in treatment, (CRC) remains the top three for mortality due to several issues, including drug resistance low efficiency. There evidence that baicalin baicalein, novel small molecule inhibitor extracts Chinese herb Scutellaria baicalensis, have better anti-colorectal effects are less likely induce cells. present review article explains anti-proliferative properties baicalein context against CRC. Additionally, it explores underlying mechanisms by which these compounds modulate diverse signaling pathways associated with apoptosis, cell proliferation, tumor angiogenesis, invasion, metastasis, microenvironment. Moreover, this highlights inhibitory effect inflammatory-cancer transformation near-term therapeutic strategy using them as adjuvant agents chemotherapy.
Language: Английский
Citations
7
Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1487 - 1487
Published: March 27, 2024
Osteoarthritis (OA) is a chronic joint disease that causes pathological changes in articular cartilage, synovial membrane, or subchondral bone. Conventional treatments for OA include surgical and non-surgical methods. Surgical treatment suitable patients the terminal stage of OA. It often last choice because associated risks high cost. Medication mainly includes non-steroidal anti-inflammatory drugs, analgesics, hyaluronic acid, cortico-steroid drugs. However, these drugs have severe side effects cannot meet needs patients. Therefore, safe clinically appropriate long-term are urgently needed. Apoptosis programmed cell death, which kind physiologic suicide determined by heredity conserved evolution. Inhibition apoptosis-related pathways has been found to prevent treat variety diseases. Excessive apoptosis can destroy cartilage homeostasis aggravate process inhibition factors signaling become an effective means Phytochemicals active ingredients from plants, it phytochemicals play important role prevention inhibiting apoptosis. We summarize preclinical clinical studies The results show targeting pathways. On basis improving some with low bioavailability, poor water solubility, toxicity nanotechnology-based drug delivery systems, at same time undergoing strict pharmacological tests, be used as potential therapeutic may applied settings.
Language: Английский
Citations
7
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 6, 2024
, a Gram-positive bacterium, is predominant pathogen associated with various infections. The rapid emergence of antibiotic resistance has intensified the challenge managing fracture-related infections in severe osteoporotic patients. Rifampicin, potent antimicrobial agent employed against fracture and implant-related infections, necessitates combination therapies due to its susceptibility resistance. In this study, we explored potential baicalein, bioactive flavonoid from
Language: Английский
Citations
7
Drug Target Insights, Journal Year: 2024, Volume and Issue: 18(1), P. 30 - 46
Published: June 6, 2024
Aim: Researchers using herbs and natural products to find new drugs often prefer flavonoids because of their potential as antioxidants anti-inflammatories. The planned review addressed baicalein research findings in detail. This manuscript provides a complete baicalein’s pharmacological effects along with several molecular targets for better understanding its therapeutic activities. Materials methods: We targeted the on vitro vivo studies reported baicalein. For this, literature is gathered from database available search engines like PubMed, ScienceDirect, Scopus, Google Scholar up 21 December 2023. keywords “Scutellaria baicalensis”, “Oroxylum indicum”, “Neuroprotective”, “Cardioprotective”, “Toxicity studies”, “Baicalein” were used fetch content. Results: Baicalein’s receptor binding approach has shown anticancer, antidiabetic, antimicrobial, antiaging, neuroprotective, cardioprotective, respiratory protective, gastroprotective, hepatic renal protective effects. synergistic this drug other selective are also contributed towards significant potential. Conclusion: systematic article contemporary scientific perspective offers fresh insight into S. baicalensis, O. indicum, bioactive component complementary medicine. Baicalein may be transformed more efficacious acceptable evidence-based However, we recommend clinical mechanistic approaches confirm safety efficacy
Language: Английский
Citations
6