Movement Disorders, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 31, 2024
Reduced step length is a hallmark of gait disturbance in people with Parkinson's disease (PD). Although treadmill training effective for improving length, the associated neural mechanisms have not been fully investigated. Moreover, exploring baseline neurophysiological predictors improvement after could facilitate personalized rehabilitation PD.
Language: Английский
Stroke, Journal Year: 2024, Volume and Issue: 55(4), P. 812 - 821
Published: Feb. 27, 2024
Vascular contributions to cognitive impairment and dementia, specifically cerebral small vessel disease (CSVD), are the second most common cause of dementia. Currently, there no specific pharmacological treatments for CSVD, use conventional antidementia drugs is not recommended. Exercise has potential prevent mitigate CSVD-related brain damage improve function. Mechanistic pathways underlying neurocognitive benefits exercise include control vascular risk factors, improving endothelial function, upregulating exerkines. Notably, therapeutic efficacy may vary by type (ie, aerobic versus resistance training) biological sex; thus, studies designed examine these moderating factors within a CSVD context needed. Furthermore, future research should prioritize training interventions, given their tremendous potential. Addressing knowledge gaps will help us refine recommendations maximize impact in prevention mitigation CSVD.
Language: Английский
Citations
10
Cell Reports, Journal Year: 2023, Volume and Issue: 42(11), P. 113436 - 113436
Published: Nov. 1, 2023
Skeletal muscle has recently arisen as a regulator of central nervous system (CNS) function and aging, secreting bioactive molecules known myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here, we report generation transgenic mouse enhanced skeletal lysosomal mitochondrial via overexpression transcription factor E-B (TFEB). We discovered that resulting geroprotective effects reduce neuroinflammation accumulation tau-associated pathological hallmarks model tauopathy. Muscle-specific TFEB significantly ameliorates proteotoxicity, reduces neuroinflammation, promotes transcriptional remodeling aged CNS, preserving cognition memory mice. Our results implicate maintenance throughout aging direct regulation CNS health disease suggest originating factors may act therapeutic targets against age-associated neurodegenerative disorders.
Language: Английский
Citations
16
Frontiers in Aging, Journal Year: 2023, Volume and Issue: 4
Published: June 1, 2023
In the last decades, important progress has been achieved in understanding of neurotrophic effects intermittent fasting (IF), calorie restriction (CR) and exercise. Improved neuroprotection, synaptic plasticity adult neurogenesis (NSPAN) are essential examples these effects. The importance this respect metabolic switch from glucose to ketone bodies as cellular fuel highlighted. More recently, mimetics (CRMs; resveratrol other polyphenols particular) have investigated thoroughly relation NSPAN. narrative review sections manuscript, recent findings on functions synthesized most molecules involved presented. researched signaling pathways (PI3K, Akt, mTOR, AMPK, GSK3β, ULK, MAPK, PGC-1α, NF-κB, sirtuins, Notch, Sonic hedgehog Wnt) processes (e.g., anti-inflammation, autophagy, apoptosis) that support or thwart then briefly This provides an accessible entry point literature. annotated bibliography section contribution, brief summaries provided about 30 literature reviews relating interest IF, CR, CRMs Most selected address perspective healthier aging (sometimes discussing epigenetic factors) reduction risk for neurodegenerative diseases (Alzheimer’s disease, Huntington’s Parkinson’s disease) depression improvement cognitive function.
Language: Английский
Citations
13
Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)
Published: Aug. 9, 2024
Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain-gut-bone axis, a complex network that modulates multiple physiological systems, has gained increasing attention owing its profound effects on occurrence development neurodegenerative diseases. No comprehensive review been conducted clarify triangular relationship involving axis potential for innovative therapies disorders. In light this, new perspective is aimed propose interplay between brain, gut, bone highlighting their dynamic communication in diseases, as they modulate including nervous, immune, endocrine, metabolic systems. Therapeutic strategies maintaining balance brain regulation, intestinal microbiota improving skeletal health, also explored. intricate interactions within pose challenge effective treatments can comprehensively target this system. Furthermore, safety these requires further evaluation. This offers novel insights prevention treatment which have important implications clinical practice patient well-being.
Language: Английский
Citations
4
GeroScience, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 13, 2024
Language: Английский
Citations
2
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 31, 2024
Ovarian cancer continues to be a major cause of morbidity and mortality in women, with immune regulation playing critical role its progression treatment response. This review explores the interplay between sex hormones, particularly estrogen progesterone, ovarian cancer. We delve into mechanisms by which these hormones influence cell function, modulate checkpoints, alter tumor microenvironment. Key pathways involving progesterone receptors are examined, highlighting their impact on growth evasion. The also discusses therapeutic implications interactions, including potential for combining hormone-based therapies checkpoint inhibitors. Personalized medicine approaches, leveraging biomarkers predicting response, considered essential optimizing patient outcomes. Finally, we address current research gaps future directions, emphasizing need advanced technologies novel strategies improve through better understanding hormone-immune interactions.
Language: Английский
Citations
2
Archives of Physical Medicine and Rehabilitation, Journal Year: 2023, Volume and Issue: 105(3), P. 525 - 530
Published: Sept. 25, 2023
Language: Английский
Citations
5
iScience, Journal Year: 2023, Volume and Issue: 26(8), P. 107298 - 107298
Published: July 10, 2023
Physical exercise can lower lung cancer incidence. However, its effect on progression is less understood. Studies exercising mice have shown decreased ectopic growth through the secretion of interleukin-6 from muscles and recruitment natural killer (NK) cells to tumors. We asked if suppresses in an orthotopic model also. Single-housed C57Bl/6 male cages with running wheels were tail vein-injected LLC1.1 cells, tumor nodules analyzed. Exercise did not affect cancer. Therefore, we also tested a subcutaneous LLC1 B16F10 melanoma model. Except for one case excessive exercise, was influenced. Moderately increase IL-6 or recruit NK tumor. Our data suggest that dose may dictate how efficiently immune system stimulated controls progression.
Language: Английский
Citations
4
European Journal of Applied Physiology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 3, 2024
Abstract When considering the acute effects of different modalities endurance training on cellular immune components, matching duration and mean intensity consideration sex-dependent differences have received less attention so far. The aim study was to compare interval running (IR) vs. continuous (CR) circulating cells inflammation markers. Additionally, we analyze in these effects. In a cross-over design, 24 recreational runners completed duration-matched session IR CR. Blood samples were taken immediately before, after, 1 h after exercise cessation for cell counts cortisol level quantification. Neutrophil showed sustained increase both with significantly greater values compared CR at increases females. Neutrophil-to-lymphocyte ratio systemic immune-inflammation index increased higher Platelet-to-lymphocyte decreased sexes modalities. shows lower value no differences. protocol induces mobilizations comparison CR, which is primarily based neutrophil counts. are suitable distinguish this effect between Sex-dependent confirm that biological sex influences response exercise. Protocol registration: German Clinical Trials Register, DRKS00017686, Date 11.02.2020.
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown
Published: March 8, 2022
Summary Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report generation transgenic mouse enhanced skeletal lysosomal mitochondrial via overexpression Transcription Factor E-B (TFEB). We have discovered that resulting geroprotective effects reduce neuroinflammation accumulation tau-associated pathological hallmarks model tau pathology. Muscle-specific TFEB also significantly ameliorates proteotoxicity, reduces promotes transcriptional remodeling aged CNS, preserving cognition memory mice. Our results implicate maintenance throughout aging to direct regulation CNS health disease, suggest skeletal-muscle originating factors may act therapeutic targets against age-associated neurodegenerative disorders.
Language: Английский
Citations
6