Effect of nutrition in Alzheimer’s disease: A systematic review

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: May 4, 2023

Background and objective Alzheimer’s disease (AD) is a progressive neurodegenerative characterized by declining cognitive ability. Currently, there are no effective treatments for this condition. However, certain measures, such as nutritional interventions, can slow progression. Therefore, the of systematic review was to identify map updates last 5 years regarding status interventions associated with AD patients. Study design A review. Methods search conducted randomized clinical trials, reviews, meta-analyses investigating association between published 2018 2022 in PubMed, Web Science, Scopus, Cochrane Library databases. total 38 studies were identified, which 17 21 reviews and/or meta-analyses. Results The results show that western diet pattern risk factor developing AD. In contrast, Mediterranean diet, ketogenic supplementation omega-3 fatty acids probiotics protective factors. This effect significant only cases mild-to-moderate Conclusion Certain may progression improve function quality life. Further research required draw more definitive conclusions.

Language: Английский

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Improving Cognitive Function with Nutritional Supplements in Aging: A Comprehensive Narrative Review of Clinical Studies Investigating the Effects of Vitamins, Minerals, Antioxidants, and Other Dietary Supplements

Nutrients, Journal Year: 2023, Volume and Issue: 15(24), P. 5116 - 5116

Published: Dec. 15, 2023

Cognitive impairment and dementia are burgeoning public health concerns, especially given the increasing longevity of global population. These conditions not only affect quality life individuals their families, but also pose significant economic burdens on healthcare systems. In this context, our comprehensive narrative review critically examines role nutritional supplements in mitigating cognitive decline. Amidst growing interest non-pharmacological interventions for enhancement, delves into efficacy vitamins, minerals, antioxidants, other dietary supplements. Through a systematic evaluation randomized controlled trials, observational studies, meta-analysis, focuses outcomes such as memory attention improvement, executive function support, neuroprotection. The findings suggest complex interplay between supplementation health, with some showing promising results others displaying limited or context-dependent effectiveness. highlights importance dosage, bioavailability, individual differences response to supplementation. Additionally, it addresses safety concerns potential interactions conventional treatments. By providing clear overview current scientific knowledge, aims guide professionals researchers making informed decisions about use health.

Language: Английский

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A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer’s Disease: A Focus on Probiotic and Vitamin Co-Supplementation

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 202 - 202

Published: Feb. 5, 2024

Alzheimer’s disease is a progressive neurodegenerative disorder with complex etiology, and effective interventions to prevent or delay its onset remain global health challenge. In recent years, there has been growing interest in the potential role of probiotic vitamin supplementation as complementary strategies for prevention. This review paper explores current scientific literature on use probiotics vitamins, particularly A, D, E, K, B-complex context prevention management. We delve into mechanisms through which may modulate gut–brain interactions neuroinflammation while vitamins play crucial roles neuronal cognitive function. The also examines collective impact this combinational therapy reducing risk factors associated disease, such oxidative stress, inflammation, gut dysbiosis. By providing comprehensive overview existing evidence mechanisms, aims shed light promise co-supplementation multifaceted approach combat offering insights possible avenues future research clinical application.

Language: Английский

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From Brain to Muscle: The Role of Muscle Tissue in Neurodegenerative Disorders

Biology, Journal Year: 2024, Volume and Issue: 13(9), P. 719 - 719

Published: Sept. 12, 2024

Neurodegenerative diseases (NDs), like amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's (PD), primarily affect the central nervous system, leading to progressive neuronal loss motor cognitive dysfunction. However, recent studies have revealed that muscle tissue also plays a significant role in these diseases. ALS is characterized by severe wasting as result of neuron degeneration, well alterations gene expression, protein aggregation, oxidative stress. Muscle atrophy mitochondrial dysfunction are observed AD, which may exacerbate decline due systemic metabolic dysregulation. PD patients exhibit fiber atrophy, altered composition, α-synuclein aggregation within cells, contributing symptoms progression. Systemic inflammation impaired degradation pathways common among disorders, highlighting key player Understanding muscle-related changes offers potential therapeutic avenues, such targeting function, reducing inflammation, promoting regeneration with exercise pharmacological interventions. This review emphasizes importance considering an integrative approach neurodegenerative research, both peripheral pathological mechanisms, order develop more effective treatments improve patient outcomes.

Language: Английский

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Tetraselmis chuii Edible Microalga as a New Source of Neuroprotective Compounds Obtained Using Fast Biosolvent Extraction

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3897 - 3897

Published: March 31, 2024

Tetraselmis chuii is an EFSA-approved novel food and dietary supplement with increasing use in nutraceutical production worldwide. This study investigated the neuroprotective potential of bioactive compounds extracted from T. using green biobased solvents (ethyl acetate, AcOEt, cyclopentyl methyl ether, CPME) under pressurized liquid extraction (PLE) conditions supercritical fluid (SFE). Response surface optimization was used to effect temperature solvent composition on properties PLE extracts, including anticholinergic activity, reactive oxygen/nitrogen species (ROS/RNS) scavenging capacity, anti-inflammatory activity. Optimized 40 °C 34.9% AcOEt CPME resulted extracts high ROS/RNS while operation at 180 54.1% yielded potent only 20 min. Chemical characterization revealed presence carotenoids (neoxanthin, violaxanthin, zeaxanthin, α- β-carotene) known for their anti-cholinesterase, antioxidant, potential. The also exhibited levels omega-3 polyunsaturated fatty acids (PUFAs) a favorable ω-3/ω-6 ratio (>7), contributing effects. Furthermore, were found be safe use, as cytotoxicity assays showed no observed toxicity HK-2 THP-1 cell lines or below concentration μg mL-1. These results highlight making them valuable field emphasize interest studying new alternatives conventional toxic solvents.

Language: Английский

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Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12155 - 12155

Published: Nov. 12, 2024

The interplay between functional food nutrients and neurosteroids has garnered significant attention for its potential to enhance stress resilience in health and/or disease. Several bioactive nutrients, including medicinal herbs, flavonoids, bioavailable polyphenol-combined nanoparticles, as well probiotics, vitamin D omega-3 fatty acids, have been shown improve blood-brain barrier (BBB) dysfunction, endogenous neurosteroid homeostasis brain function. These can inhibit oxidative neuroinflammation, which are linked the pathogenesis of various neurological disorders. Interestingly, flavonoids exhibit dose-dependent effects, activating nuclear factor erythroid 2-related 2 (Nrf2) pathway at physiological/low dose (neurohormesis). This leads upregulation antioxidant phase II genes proteins such heme oxygenase-1 (HO-1) sirtuin-1 (Sirt1), activated by curcumin resveratrol, respectively. adaptive neuronal response mechanisms help protect against reactive oxygen species (ROS) neurotoxicity. Impaired Nrf2 hormone signaling exacerbate selective vulnerability neuroinflammatory conditions, contributing onset progression neurodegenerative psychiatric disorders, Alzheimer's disease, anxiety depression other due neurons stress. review focuses on targeting redox regulate BBB damage associated with altered GABAergic neurotransmission. By exploring underlying molecular using innovative technologies, we aim develop promising neuroprotective strategies personalized nutritional neuroregenerative therapies prevent or attenuate ultimately promoting health.

Language: Английский

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Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer’s Disease: A Review

The Yale Journal of Biology and Medicine, Journal Year: 2024, Volume and Issue: 97(2), P. 205 - 224

Published: June 28, 2024

Neuroinflammation, toxic protein aggregation, oxidative stress, and mitochondrial dysfunction are key pathways in neurodegenerative diseases like Alzheimer's disease (AD). Targeting these mechanisms with antioxidants, anti-inflammatory compounds, inhibitors of Aβ formation aggregation is crucial for treatment. Marine algae rich sources bioactive including carbohydrates, phenolics, fatty acids, phycobiliproteins, carotenoids, vitamins. In recent years, they have attracted interest from the pharmaceutical nutraceutical industries due to their exceptional biological activities, which include anti-inflammation, antioxidant, anticancer, anti-apoptosis properties. Multiple lines evidence unveiled potential neuroprotective effects multifunctional algal compounds application treating managing AD. This article will provide insight into molecular underlying derived based on vitro vivo models neuroinflammation We also discuss as disease-modifying symptomatic treatment strategies AD.​AD.Open a separate windowGraphical Abstract.

Language: Английский

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A systematic review of lifestyle-based interventions for managing Alzheimer's disease: Insights from randomized controlled trials

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Background Alzheimer's disease (AD) presents a significant challenge in healthcare, prompting exploration into non-pharmacological interventions to complement traditional treatments. Objective This systematic review explores the efficacy of lifestyle-based managing AD. Methods A comprehensive literature search was conducted PubMed, Web Science, and Scopus between 2018 2023, selecting randomized controlled trials examining factors such as exercise, diet, stress, cognitive training AD patients. Results The revealed physical exercise predominant intervention, accompanied by dietary modifications, training, therapies mindfulness music. While demonstrated improvements quality life, its benefits were limited. Modified diets, Atkins ketogenic, displayed inconsistent effects on function but influenced other health-related parameters. Additionally, probiotic therapy novel technologies explored. Conclusions Despite some showing promise enhancing slowing progression, uncertainties remain regarding dose-response relationship, underlying mechanisms, potential synergistic effects. Moreover, consideration genetic sex-based disparities is warranted. synthesis underscores need for further research elucidate nuances effectively. PROSPERO registration number CRD42023432823

Language: Английский

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The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer’s Disease Treatment

Metabolites, Journal Year: 2023, Volume and Issue: 13(3), P. 438 - 438

Published: March 17, 2023

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline and characterized by amyloid-β plaques neurofibrillary tau tangles. Although AD’s exact pathophysiology remains unclear, oxidative stress known to play role in the process. Since no curative treatment exists, antioxidants represent potential for AD due their ability modulate stress. Therefore, this review aims examine impact of antioxidant supplementation its mechanisms on function. The primarily discusses research articles published between 2012 2022 reporting results clinical trials involving function individuals AD. Antioxidant included probiotics, selenium, melatonin, resveratrol, rosmarinic acid, carotenoids, curcumin, vitamin E, coenzyme Q. While studies did not provide much evidence beneficial supplements AD, varied from among examining same antioxidant. Furthermore, many studies’ findings face several limitations, including short trial durations, small sample sizes, lack diversity study participants. As result, more required

Language: Английский

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Associations of Microbiota and Nutrition with Cognitive Impairment in Diseases

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3570 - 3570

Published: Oct. 21, 2024

Recent research highlights the growing interest in impact of nutrition on cognitive health and function disease, as dietary habits are increasingly recognized crucial factors relation to brain function. This focus is especially important given rising prevalence neurodegenerative diseases decline associated with poor choices. Links now being sought between microbiota gut-brain axis. Mechanisms proposed that include low-grade chronic neuroinflammation, influence short-chain fatty acids, or disruption glial cells transmitters brain.

Language: Английский

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