Journal of Dentistry,
Journal Year:
2024,
Volume and Issue:
145, P. 104991 - 104991
Published: April 11, 2024
This
study
aimed
to
investigate
the
association
between
number
of
teeth,
food
intake,
and
cognitive
function
in
Japanese
community-dwelling
older
adults.
Nutrition & Metabolism,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: March 19, 2024
Abstract
Context
Resveratrol
(RV),
a
natural
compound
found
in
grapes,
berries,
and
peanuts,
has
been
extensively
studied
for
its
potential
treating
Alzheimer’s
disease
(AD).
RV
shown
promise
inhibiting
the
formation
of
beta-amyloid
plaques
(Aβ)
neurofibrillary
tangles
(NFTs),
protecting
against
neuronal
damage
oxidative
stress,
reducing
inflammation,
promoting
neuroprotection,
improving
function
blood–brain
barrier
(BBB).
However,
conflicting
results
have
reported,
necessitating
comprehensive
umbrella
review
systematic
reviews
to
provide
an
unbiased
conclusion
on
therapeutic
effectiveness
AD.
Objective
The
objective
this
study
was
systematically
synthesize
evaluate
meta-analysis
investigating
role
AD
using
data
from
both
human
animal
studies.
Data
sources
extraction
Of
34
examining
association
between
that
were
collected,
six
included
based
specific
selection
criteria.
To
identify
pertinent
studies,
search
conducted
English-language
peer-reviewed
journals
without
any
restrictions
publication
date
until
October
15,
2023.
carried
out
across
multiple
databases,
including
Embase,
MEDLINE
(PubMed),
Cochrane
Library,
Web
Science,
Google
Scholar,
utilizing
appropriate
terms
relevant
research
field.
AMSTAR-2
ROBIS
tools
also
used
quality
risk
bias
reviews,
respectively.
Two
researchers
independently
extracted
analyzed
data,
resolving
discrepancies
through
consensus.
note,
adhered
PRIOR
checklist.
analysis
This
presented
robust
evidence
supporting
positive
impacts
AD,
irrespective
mechanisms
involved.
It
indeed
indicated
all
unanimously
concluded
consumption
can
be
effective
treatment
Conclusion
exhibits
promising
benefiting
individuals
with
various
mechanisms.
observed
enhance
cognitive
function,
reduce
Aβ
accumulation,
protect
BBB,
support
mitochondrial
facilitate
synaptic
plasticity,
stabilize
tau
proteins,
mitigate
neuroinflammation
commonly
associated
Graphical
abstract
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: June 29, 2023
Dementia
is
a
growing
public
health
concern,
with
an
estimated
prevalence
of
57
million
adults
worldwide.
Alzheimer’s
disease
(AD)
accounts
for
60–80%
the
cases.
Clinical
trials
testing
potential
drugs
and
neuroprotective
agents
have
proven
futile,
currently
approved
only
provide
symptomatic
benefits.
Emerging
epidemiological
clinical
studies
suggest
that
lifestyle
changes,
including
diet
physical
activity,
offer
alternative
therapeutic
route
slowing
preventing
cognitive
decline
dementia.
Age
single
most
common
risk
factor
dementia,
it
associated
cellular
bioenergetics
metabolic
processes.
Therefore,
nutrient-rich
critical
optimal
brain
health.
Furthermore,
type
2
diabetes
(T2D)
AD,
diets
reduce
T2D
may
confer
neuroprotection.
Foods
predominant
in
Mediterranean,
MIND,
DASH
diets,
fruits,
leafy
green
vegetables,
fish,
nuts,
olive
oil,
prevent
or
slow
decline.
The
mechanisms
by
which
these
nutrients
promote
health,
however,
are
not
yet
completely
understood.
Other
dietary
approaches
eating
regimes,
ketogenic
intermittent
fasting,
also
emerging
as
beneficial
This
review
summarizes
pathophysiology,
factors,
pathways
activated
several
regimes
shown
promising
results
promoting
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(16), P. 2646 - 2646
Published: Aug. 10, 2024
This
narrative
review
synthesizes
current
evidence
regarding
anti-inflammatory
dietary
patterns
and
their
potential
benefits
for
individuals
with
mental
disorders
neurodegenerative
diseases.
Chronic
low-grade
inflammation
is
increasingly
recognized
as
a
key
factor
in
the
etiology
progression
of
these
conditions.
The
examines
neuroprotective
properties
components
food
groups,
focusing
on
whole
foods
rather
than
specific
nutrients
or
supplements.
Key
showing
include
fruits
vegetables
(especially
berries
leafy
greens),
grains,
legumes,
fatty
fish
rich
omega-3,
nuts
(particularly
walnuts),
olive
oil,
fermented
foods.
These
are
generally
antioxidants,
fiber,
bioactive
compounds
that
may
help
modulate
inflammation,
support
gut
health,
promote
neuroprotection.
Conversely,
ultra-processed
foods,
red
meat,
sugary
beverages
be
harmful.
Based
this
evidence,
we
designed
Brain
Anti-Inflammatory
Nutrition
(BrAIN)
diet.
mechanisms
diet
modulation
microbiota
gut-brain
axis,
regulation
inflammatory
pathways,
reduction
oxidative
stress,
promotion
neuroplasticity.
BrAIN
shows
promise
an
aid
to
manage
disorders.
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Dec. 16, 2024
Alzheimer's
disease
(AD)
is
a
chronic,
progressive
neurodegenerative
disorder
characterized
by
cognitive
decline,
memory
loss,
and
impaired
reasoning.
It
the
leading
cause
of
dementia
in
older
adults,
marked
pathological
accumulation
amyloid-beta
plaques
neurofibrillary
tangles.
These
changes
lead
to
widespread
neuronal
damage,
significantly
impacting
daily
functioning
quality
life.
Annals of Neurology,
Journal Year:
2024,
Volume and Issue:
96(4), P. 633 - 649
Published: Aug. 17, 2024
Alzheimer's
disease
(AD)
is
a
devastating,
age‐associated
neurodegenerative
disorder
and
the
most
common
cause
of
dementia.
The
clinical
continuum
AD
spans
from
preclinical
to
subjective
cognitive
decline,
mild
impairment,
dementia
stages
(mild,
moderate,
severe).
Neuropathologically,
defined
by
accumulation
amyloid
β
(Aβ)
into
extracellular
plaques
in
brain
parenchyma
cerebral
vasculature,
abnormally
phosphorylated
tau
that
accumulates
intraneuronally
forming
neurofibrillary
tangles
(NFTs).
Development
treatment
approaches
prevent
or
even
reduce
decline
because
has
been
slow
compared
other
major
causes
death.
Recently,
United
States
Food
Drug
Administration
gave
full
approval
2
different
Aβ‐targeting
monoclonal
antibodies.
However,
this
breakthrough
modifying
approach
only
applies
limited
subset
patients
there
are
stringent
eligibility
criteria.
Furthermore,
these
do
not
progression
disease,
AD‐related
pathologies,
such
as
NFTs,
directly
targeted.
A
non‐mutually
exclusive
alternative
address
lifestyle
interventions
can
help
risk
dementias
(ADRD).
It
estimated
addressing
modifiable
factors
could
potentially
delay
up
40%
AD/ADRD
cases.
In
review,
we
discuss
some
many
may
be
associated
with
prevention
and/or
increasing
resilience,
well
interact
influence
progression.
[Color
figure
viewed
at
www.annalsofneurology.org
]
ANN
NEUROL
2024;96:633–649
Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Abstract
Alzheimer's
disease
(AD)
is
a
degenerative
characterized
by
progressive
cognitive
dysfunction.
The
strong
link
between
nutrition
and
the
occurrence
progression
of
AD
pathology
has
been
well
documented.
Poor
nutritional
status
accelerates
progress
potentially
aggravating
amyloid
beta
(Aβ)
tau
deposition,
exacerbating
oxidative
stress
response,
modulating
microbiota–gut–brain
axis,
disrupting
blood–brain
barrier
function.
advanced
stage
tends
to
lead
malnutrition
due
impairments,
sensory
dysfunctions,
brain
atrophy,
behavioral
psychological
symptoms
dementia
(BPSD).
This,
in
turn,
produces
vicious
cycle
AD.
This
review
discusses
how
factors
deteriorate
each
other
from
early
terminal
stages
AD,
focusing
on
potential
different
levels
factors,
ranging
micronutrients
diet
patterns.
provides
novel
insights
into
reducing
risk
delaying
its
progression,
improving
prognosis.
Highlights
Two‐fifths
cases
worldwide
have
attributed
modifiable
factors.
Up
≈26%
community‐dwelling
patients
with
are
malnourished,
compared
7%∼76%
institutionalized
patients.
Undernutrition
effects
onset,
prognosis
through
multiple
mechanisms.
Various
supports
were
confirmed
be
protective
for
via
specific
Journal of Alzheimer s Disease,
Journal Year:
2024,
Volume and Issue:
99(4), P. 1173 - 1186
Published: May 17, 2024
Background:
Early
intervention
is
essential
for
meaningful
disease
modification
in
Alzheimer’s
(AD).
Objective:
We
aimed
to
determine
the
efficacy
and
safety
of
pharmacologic
nutritional
interventions
early
AD.
Methods:
PubMed,
Embase,
Cochrane
Library,
ClinicalTrials.gov
were
searched
from
database
inception
until
1
September
2023.
included
randomized
controlled
trials
that
evaluated
Only
demonstrated
compared
placebo
network
meta-analysis
(NMA).
Then
we
performed
frequentist
fixed-effects
NMA
rank
interventions.
GRADE
criteria
used
evaluate
level
evidence.
Results:
Fifty-eight
including
a
total
33,864
participants
48
eligible
inclusion.
Among
analyzed,
only
6
(12.5%)
treatments—
ranging
low
high
certainty—
showed
significant
improvement
cognitive
decline
placebo.
High
certainty
evidence
indicated
donanemab
(standardized
mean
difference
[SMD]
–0.239,
95%
confidence
interval
[CI]
–0.343
–0.134)
lecanemab
(SMD
–0.194,
CI
–0.279
–0.108)
moderately
slowed
clinical
progression
patients
with
amyloid
pathology.
Additionally,
methylphenidate,
donepezil,
LipiDiDiet,
aducanumab
However,
there
was
no
serious
adverse
events
as
reported
between
six
Conclusions:
12.5%
studied
reducing
impairment
Donanemab
have
potential
slow
Further
required
Journal of Alzheimer s Disease,
Journal Year:
2024,
Volume and Issue:
100(s1), P. S165 - S178
Published: Aug. 6, 2024
The
two
major
determining
factors
for
Alzheimer's
disease
(AD)
are
genetics
and
lifestyle.
Alleles
of
the
apolipoprotein
E
(APOE)
gene
play
important
roles
in
development
late-onset
AD,
with
APOEɛ4
increasing
risk,
APOEɛ3
being
neutral,
APOEɛ2
reducing
risk.
Several
modifiable
lifestyle
have
been
studied
terms
how
they
can
modify
risk
AD.
Among
these
dietary
pattern,
nutritional
supplements
such
as
omega-3
fatty
acids,
B
vitamins,
physical
exercise,
obesity,
vitamin
D.
Western
diet
increases
while
patterns
Mediterranean
vegetarian/vegan
diets
reduce
Foods
associated
reduced
include
coffee,
fruits
vegetables,
whole
grains
legumes,
fish,
meat
ultraprocessed
foods
increased
especially
when
lead
to
obesity.
In
multi-country
ecological
studies,
amount
national
has
highest
correlation
history
research
regarding
on
AD
is
emphasized
this
review.
be
modified
starting
at
least
by
mid-life.
People
greater
genetic
would
benefit
more
choosing
and/or
delay
incidence
European Journal of Nutrition,
Journal Year:
2023,
Volume and Issue:
62(S1), P. 1 - 16
Published: Nov. 28, 2023
Populations
in
crisis!A
global
overview
of
health
challenges
and
policy
efforts
within
the
scope
current
nutrition
issues,
from
persistent
forms
undernutrition,
including
micronutrient
deficiency,
to
diet-related
chronic
diseases.
Nutrition
science
has
evolved
a
therapeutic
prevention
emphasis
include
focus
on
diets
food
systems.
Working
consensus
definitions
are
needed,
as
well
guidance
related
healthy
emerging
issues
that
require
further
research
building.
Between
nutrient
deficiency
disease,
focusing
exclusively
extremes
overt
disease
prevention,
equipping
bodies
with
ability
cope
physiologic,
metabolic,
psychological
stress.
Just
what
is
'optimal
nutrition',
valid
public
goal,
terminology
being
provided
by
community?
'healthspan',
resilience,
intrinsic
capacity
may
provide
evidence
support
optimal
nutrition.
Finally,
experts
views
ongoing
achieving
or
acceptance
various
interventions
for
promotion,
how
these
can
inform
government
policies.Nutrition
topics
receive
particular
proceedings
choline,
NAD-replenishment
neurodegenerative
diseases,
xanthophyll
carotenoids.
Choline
crucial
essential
cellular
metabolism,
requiring
consumption
foods
supplements
due
inadequate
endogenous
synthesis.
Maternal
choline
intake
vital
fetal
infant
development
prevent
neural
tube
defects.
Neurodegenerative
diseases
pose
growing
challenge,
lacking
effective
therapies.
Nutrition,
NAD-replenishing
nutrients,
might
aid
prevention.
Emerging
indicates
carotenoids
enhance
vision
cognition,
potentially
impacting
age-related
Alzheimer’s
disease,
a
progressive
and
irreversible
neurodegenerative
disorder,
is
the
most
prevalent
form
of
dementia
with
an
increasingly
growing
incidence
rate
worldwide.
As
no
effective
therapeutic
modalities
are
still
available
for
treatment
this
serious
disabling
condition,
lifestyle
modifications,
especially
nutritional
interventions,
have
been
shown
to
be
important
in
its
prevention
symptomatic
alleviation.
In
short
perspective
article,
inverse
association
between
intake
sunflower
seeds
mortality
from
disease
proposed,
showing
that
countries
highest
consumption
seeds,
death
disorder
low.
The
bioactive
ingredients
their
possible
neuroprotective
mechanisms
further
unraveled,
highlighting
potent
antioxidant,
antiinflammatory
neurotrophic
effects
tocopherols,
unsaturated
fatty
acids
phytosterols.
Among
latter
agents,
β-sitosterol
might
particularly
combating
by
enhancing
levels
nerve
growth
factor
thereby
promoting
neurite
formation.
If
future
epidemiological
studies
will
confirm
proposed
development
dementia,
it
easy
include
appropriate
seed
products
everyday
diet
protect
against
pathogenesis
progression
individuals
genetic
predisposition.
Considering
rather
long
latency
period
before
clinical
manifestation
approaches
specific
foods
promising
strategy
fighting
dementia.