Unraveling the therapeutic efficacy of resveratrol in Alzheimer’s disease: an umbrella review of systematic evidence

Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)

Published: March 19, 2024

Abstract Context Resveratrol (RV), a natural compound found in grapes, berries, and peanuts, has been extensively studied for its potential treating Alzheimer’s disease (AD). RV shown promise inhibiting the formation of beta-amyloid plaques (Aβ) neurofibrillary tangles (NFTs), protecting against neuronal damage oxidative stress, reducing inflammation, promoting neuroprotection, improving function blood–brain barrier (BBB). However, conflicting results have reported, necessitating comprehensive umbrella review systematic reviews to provide an unbiased conclusion on therapeutic effectiveness AD. Objective The objective this study was systematically synthesize evaluate meta-analysis investigating role AD using data from both human animal studies. Data sources extraction Of 34 examining association between that were collected, six included based specific selection criteria. To identify pertinent studies, search conducted English-language peer-reviewed journals without any restrictions publication date until October 15, 2023. carried out across multiple databases, including Embase, MEDLINE (PubMed), Cochrane Library, Web Science, Google Scholar, utilizing appropriate terms relevant research field. AMSTAR-2 ROBIS tools also used quality risk bias reviews, respectively. Two researchers independently extracted analyzed data, resolving discrepancies through consensus. note, adhered PRIOR checklist. analysis This presented robust evidence supporting positive impacts AD, irrespective mechanisms involved. It indeed indicated all unanimously concluded consumption can be effective treatment Conclusion exhibits promising benefiting individuals with various mechanisms. observed enhance cognitive function, reduce Aβ accumulation, protect BBB, support mitochondrial facilitate synaptic plasticity, stabilize tau proteins, mitigate neuroinflammation commonly associated Graphical abstract

Language: Английский

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Diet and lifestyle impact the development and progression of Alzheimer’s dementia

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: June 29, 2023

Dementia is a growing public health concern, with an estimated prevalence of 57 million adults worldwide. Alzheimer’s disease (AD) accounts for 60–80% the cases. Clinical trials testing potential drugs and neuroprotective agents have proven futile, currently approved only provide symptomatic benefits. Emerging epidemiological clinical studies suggest that lifestyle changes, including diet physical activity, offer alternative therapeutic route slowing preventing cognitive decline dementia. Age single most common risk factor dementia, it associated cellular bioenergetics metabolic processes. Therefore, nutrient-rich critical optimal brain health. Furthermore, type 2 diabetes (T2D) AD, diets reduce T2D may confer neuroprotection. Foods predominant in Mediterranean, MIND, DASH diets, fruits, leafy green vegetables, fish, nuts, olive oil, prevent or slow decline. The mechanisms by which these nutrients promote health, however, are not yet completely understood. Other dietary approaches eating regimes, ketogenic intermittent fasting, also emerging as beneficial This review summarizes pathophysiology, factors, pathways activated several regimes shown promising results promoting

Language: Английский

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An Anti-Inflammatory Diet and Its Potential Benefit for Individuals with Mental Disorders and Neurodegenerative Diseases—A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2646 - 2646

Published: Aug. 10, 2024

This narrative review synthesizes current evidence regarding anti-inflammatory dietary patterns and their potential benefits for individuals with mental disorders neurodegenerative diseases. Chronic low-grade inflammation is increasingly recognized as a key factor in the etiology progression of these conditions. The examines neuroprotective properties components food groups, focusing on whole foods rather than specific nutrients or supplements. Key showing include fruits vegetables (especially berries leafy greens), grains, legumes, fatty fish rich omega-3, nuts (particularly walnuts), olive oil, fermented foods. These are generally antioxidants, fiber, bioactive compounds that may help modulate inflammation, support gut health, promote neuroprotection. Conversely, ultra-processed foods, red meat, sugary beverages be harmful. Based this evidence, we designed Brain Anti-Inflammatory Nutrition (BrAIN) diet. mechanisms diet modulation microbiota gut-brain axis, regulation inflammatory pathways, reduction oxidative stress, promotion neuroplasticity. BrAIN shows promise an aid to manage disorders.

Language: Английский

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Nutrition: A non‐negligible factor in the pathogenesis and treatment of Alzheimer's disease

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract Alzheimer's disease (AD) is a degenerative characterized by progressive cognitive dysfunction. The strong link between nutrition and the occurrence progression of AD pathology has been well documented. Poor nutritional status accelerates progress potentially aggravating amyloid beta (Aβ) tau deposition, exacerbating oxidative stress response, modulating microbiota–gut–brain axis, disrupting blood–brain barrier function. advanced stage tends to lead malnutrition due impairments, sensory dysfunctions, brain atrophy, behavioral psychological symptoms dementia (BPSD). This, in turn, produces vicious cycle AD. This review discusses how factors deteriorate each other from early terminal stages AD, focusing on potential different levels factors, ranging micronutrients diet patterns. provides novel insights into reducing risk delaying its progression, improving prognosis. Highlights Two‐fifths cases worldwide have attributed modifiable factors. Up ≈26% community‐dwelling patients with are malnourished, compared 7%∼76% institutionalized patients. Undernutrition effects onset, prognosis through multiple mechanisms. Various supports were confirmed be protective for via specific

Language: Английский

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Factors Affecting Resilience and Prevention of Alzheimer's Disease and Related Dementias

Annals of Neurology, Journal Year: 2024, Volume and Issue: 96(4), P. 633 - 649

Published: Aug. 17, 2024

Alzheimer's disease (AD) is a devastating, age‐associated neurodegenerative disorder and the most common cause of dementia. The clinical continuum AD spans from preclinical to subjective cognitive decline, mild impairment, dementia stages (mild, moderate, severe). Neuropathologically, defined by accumulation amyloid β (Aβ) into extracellular plaques in brain parenchyma cerebral vasculature, abnormally phosphorylated tau that accumulates intraneuronally forming neurofibrillary tangles (NFTs). Development treatment approaches prevent or even reduce decline because has been slow compared other major causes death. Recently, United States Food Drug Administration gave full approval 2 different Aβ‐targeting monoclonal antibodies. However, this breakthrough modifying approach only applies limited subset patients there are stringent eligibility criteria. Furthermore, these do not progression disease, AD‐related pathologies, such as NFTs, directly targeted. A non‐mutually exclusive alternative address lifestyle interventions can help risk dementias (ADRD). It estimated addressing modifiable factors could potentially delay up 40% AD/ADRD cases. In review, we discuss some many may be associated with prevention and/or increasing resilience, well interact influence progression. [Color figure viewed at www.annalsofneurology.org ] ANN NEUROL 2024;96:633–649

Language: Английский

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A Brief History of the Progress in Our Understanding of Genetics and Lifestyle, Especially Diet, in the Risk of Alzheimer’s Disease

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 100(s1), P. S165 - S178

Published: Aug. 6, 2024

The two major determining factors for Alzheimer's disease (AD) are genetics and lifestyle. Alleles of the apolipoprotein E (APOE) gene play important roles in development late-onset AD, with APOEɛ4 increasing risk, APOEɛ3 being neutral, APOEɛ2 reducing risk. Several modifiable lifestyle have been studied terms how they can modify risk AD. Among these dietary pattern, nutritional supplements such as omega-3 fatty acids, B vitamins, physical exercise, obesity, vitamin D. Western diet increases while patterns Mediterranean vegetarian/vegan diets reduce Foods associated reduced include coffee, fruits vegetables, whole grains legumes, fish, meat ultraprocessed foods increased especially when lead to obesity. In multi-country ecological studies, amount national has highest correlation history research regarding on AD is emphasized this review. be modified starting at least by mid-life. People greater genetic would benefit more choosing and/or delay incidence

Language: Английский

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Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 16, 2024

Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired reasoning. It the leading cause of dementia in older adults, marked pathological accumulation amyloid-beta plaques neurofibrillary tangles. These changes lead to widespread neuronal damage, significantly impacting daily functioning quality life.

Language: Английский

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Non-coding RNAs involved in the molecular pathology of Alzheimer’s disease: a systematic review

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: June 28, 2024

Alzheimer's disease (AD) is the leading cause of dementia globally, having a pathophysiology that complex and multifactorial. Recent findings highlight significant role non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), piwi-interacting (piRNAs) in molecular mechanisms underlying AD. These ncRNAs are involved critical biological processes such as cell proliferation, apoptosis, oxidative stress, amyloid-beta aggregation, tau phosphorylation, neuroinflammation, autophagy, which pivotal AD development progression. This systematic review aims to consolidate current scientific knowledge on AD, making it first encompass four types associated with disease. Our comprehensive search analysis reveal not only play crucial roles pathogenesis but also hold potential biomarkers for its early detection novel therapeutic targets. Specifically, underscore significance miRNAs regulating genes key pathways activin receptor signaling pathway, actomyosin contractile ring organization, advanced glycation endproducts-receptor endproducts (AGE-RAGE) pathway. highlights unveiling diagnostic strategies, emphasizing need further research validate their clinical utility. exploration provides foundation future bioinformatic analyses ncRNA-based precision medicine approaches offering new insights into disease's pathology paving way innovative treatment strategies.

Language: Английский

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Western diet-induced cognitive and metabolic dysfunctions in aged mice are prevented by rosmarinic acid in a sex-dependent fashion

Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(10), P. 2236 - 2248

Published: Aug. 18, 2024

Unhealthy lifestyles, such as chronic consumption of a Western Diet (WD), have been associated with increased systemic inflammation and oxidative stress (OS), condition that may favour cognitive dysfunctions during aging. Polyphenols, rosmarinic acid (RA) buffer low-grade OS, characterizing the aging brain is sustained by WD, promoting healthspan. The aim this study was to evaluate ability RA prevent decline in mouse model WD-driven unhealthy gain knowledge on specific molecular pathways modulated within brain.

Language: Английский

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Impact of dietary nutrition regimens based on body composition analysis on bone metabolism in Alzheimer’s disease patients

World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(2)

Published: Jan. 14, 2025

BACKGROUND Body composition analysis (BCA) is primarily used in the management of conditions such as obesity and endocrine disorders. However, its potential providing nutritional guidance for patients with Alzheimer’s disease (AD) remains relatively unexplored. AIM To explore clinical efficacy BCA-based dietary nutrition scheme on bone metabolism AD patients. METHODS This retrospective study included 96 complicated by osteoporosis who were admitted to The Third Hospital Quzhou between January 2023 December 2024. Based data from previous similar studies, randomly assigned either a routine diet (RD) group (n = 48) or personalized (PN) 48). RD received conventional guidance, while PN individualized intervention measures based human BCA. period lasted 12 weeks. Bone mineral density (BMD), body mass index (BMI), muscle mass, content, osteocalcin, 25-hydroxyvitamin D, procollagen type I N-terminal propeptide (PINP), beta C-terminal telopeptide collagen (β-CTX), serum calcium measured compared two groups before weeks after intervention. RESULTS No significant differences observed terms age, sex, height, BMI, other baseline (P > 0.05). In both groups, BMI did not show changes 0.05), whereas content significantly increased < After intervention, differ that group, but higher proportion had T score -1 mini-mental state examination (MMSE) was MMSE than post-intervention pre-intervention levels Before calcium, PINP, β-CTX, D different exhibited well lower PINP higher, β-CTX CONCLUSION regimen plays crucial role improving BMD metabolism, effects surpass those strategies. findings this provide strong evidence

Language: Английский

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