Electrospun Nanofibers for the Delivery of Endolysin/Dendronized Ag-NPs Complex Against Pseudomonas aeruginosa DOI Creative Commons
Magdalena Lasak, Małgorzata Łysek-Gładysińska, Karolina Lach

et al.

Nanotechnology Science and Applications, Journal Year: 2025, Volume and Issue: Volume 18, P. 57 - 70

Published: Feb. 1, 2025

As bacterial resistance to antibiotics increases, there is an urgent need identify alternative antibacterial agents and improve materials. One the controlled transport of that prevents infection with drug-resistant bacteria, especially in treatment difficult-to-heal wounds. This work presents use electrospun PLCL/PVP (poly(L-lactide-co-ε-caprolactone/polyvinylpyrrolidone) nanofibers modified two properties but different mechanisms action, is, dendritic silver nanoparticles (Dend-AgNPs) endolysin. The nanomat prepared this manner showed significant activity against antibiotic-resistant Pseudomonas aeruginosa strains, inhibiting their growth production key pigments virulence factors. Moreover, as carriers selected factors significantly reduced cytotoxicity towards human fibroblasts. results confirmed possibility using presented product innovative dressing material, opening new perspectives for wounds combating infections bacteria.

Language: Английский

Exploring Electrospun Scaffold Innovations in Cardiovascular Therapy: A Review of Electrospinning in Cardiovascular Disease DOI Creative Commons
Mark Broadwin,

Frances Imarhia,

Amy Oh

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(3), P. 218 - 218

Published: Feb. 25, 2024

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. In particular, patients who suffer from ischemic heart (IHD) that is not amenable to surgical or percutaneous revascularization techniques have limited treatment options. Furthermore, after successfully implemented, there are a number pathophysiological changes myocardium, including but ischemia-reperfusion injury, necrosis, altered inflammation, tissue remodeling, and dyskinetic wall motion. Electrospinning, nanofiber scaffold fabrication technique, has recently emerged as an attractive option potential therapeutic platform for cardiovascular disease. Electrospun scaffolds made biocompatible materials ability mimic native extracellular matrix compatible with drug delivery. These inherent properties, combined ease customization low cost production, electrospun active area research this review, we aim discuss current state electrospinning fundamentals creation role both bioengineered matrices delivery vehicles in CVD, special emphasis on clinical applications myocardial ischemia.

Language: Английский

Citations

12
Electrospun Polymeric Nanofibers: Current Trends in Synthesis, Surface Modification, and Biomedical Applications DOI

Abdurohman Mengesha Yessuf,

Mohamed Bahri,

Tibebu Shiferaw Kassa

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 4231 - 4253

Published: June 10, 2024

Electrospun polymeric nanofibers are essential in various fields for applications because of their unique properties. Their features similar to extracellular matrices, which suggests them healthcare fields, such as antimicrobials, tissue engineering, drug delivery, wound healing, bone regeneration, and biosensors. This review focuses on the synthesis electrospun nanofibers, surface modification, biomedical applications. Nanofibers can be fabricated from both natural synthetic polymers composites. Even though they mimic (physicochemical characteristics) not always capable fulfilling purpose target application. Therefore, need improved via modification techniques. Both needle-based needleless electrospinning thoroughly discussed. Various techniques setups employed each method also reviewed. Furthermore, pre- postspinning approaches including instrument design targeted applications, extensively In this way, remarkable potential highlighted reveal future research directions dynamic field.

Language: Английский

Citations

12
Recent advancement in fabrication of electrospun nanofiber and its biomedical and drug delivery application – an paradigm shift DOI
Abhay Raizaday, Marjita Chakma

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 94, P. 105482 - 105482

Published: Feb. 15, 2024

Language: Английский

Citations

11
Bioactive chitosan/poly(ethyleneoxide)/CuFe2O4 nanofibers for potential wound healing DOI
Esmaeel Sharifi, Rezvan Jamaledin, Fatemeh Familsattarian

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 239, P. 117448 - 117448

Published: Oct. 18, 2023

Language: Английский

Citations

22
Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids DOI Creative Commons
Huan Liu,

Yelin Dai,

Jia Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: April 6, 2023

As an interdisciplinary field, drug delivery relies on the developments of modern science and technology. Correspondingly, how to upgrade traditional dosage forms for a more efficacious, safer, convenient poses continuous challenge researchers.

Language: Английский

Citations

20
Electrospun fibers for the treatment of skin diseases DOI Creative Commons

A. Gürtler,

Thomas Rades, Andrea Heinz

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 621 - 640

Published: Oct. 12, 2023

Skin diseases are among the most common in global population and with growth of aging population, they represent an increasing burden to healthcare systems worldwide. Even though rarely life-threatening, suffering for those affected is high due visibility physical discomfort related these diseases. Typical symptoms skin include inflamed, swollen or itchy skin, therefore, there a demand effective therapy options. In recent years, electrospinning has attracted considerable interest field drug delivery. The technique allows producing multifunctional drug-loaded fibrous patches from various natural synthetic polymers fiber diameters nano- micrometer range, suitable treatment wide variety great potential electrospun not only lies their tunable release properties possibility entrap therapeutic compounds, but also provide mechanical protection impaired area, exhibit surface allow gas exchange, absorb exudate porous structure cytocompatible biodegradable. case wound healing, cell adhesion promoted resemblance fibers native extracellular matrix. This review gives overview applications therapy. addition bacterial, diabetic burn wounds, focus placed on inflammatory such as atopic dermatitis psoriasis, options cancer, acne vulgaris herpes labialis discussed. While we aim emphasize this paper, highlight challenges limitations current research field.

Language: Английский

Citations

20
Electrospinning of cellulose acetate for methylene blue dye removal DOI Creative Commons

S. V. Anulaya,

Alsha Subash,

Vishwanath Gholap

et al.

Hybrid Advances, Journal Year: 2024, Volume and Issue: 6, P. 100205 - 100205

Published: April 25, 2024

Textile industries plays a vital role in the augmentation of global economy attributed to high-end demand for textiles and fabrics demonstrated vast pace growth post-pandemic period. The escalated production not only resulted development but also led large-scale liberation textile effluents (dyes pigments) which poses as severe threat human environmental health. Methylene Blue (MB) is one among most widely utilized dye ascribed mutagenic, carcinogenic, persistent nature MB, sequestration MB from waterways are explored. This review focuses on application cellulose acetate (CA) nanofibers, fabricated by electrospinning removal methylene blue wastewater. A comprehensive overview processing parameters, isotherm models, kinetics, efficiencies achieved different CA nanocomposites with various fillers discussed. study extends desorption reusability emphasizing significance regeneration sustainability waste reduction. Furthermore, insights into industrial scaling future directions highlight potential electro-spun applications.

Language: Английский

Citations

6
Advances in Light-Responsive Smart Multifunctional Nanofibers: Implications for Targeted Drug Delivery and Cancer Therapy DOI Creative Commons
Ahmed M. Agiba, Nihal Mohamed Elmahdy Elsayyad, Hala N. ElShagea

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1017 - 1017

Published: July 31, 2024

Over the last decade, scientists have shifted their focus to development of smart carriers for delivery chemotherapeutics in order overcome problems associated with traditional chemotherapy, such as poor aqueous solubility and bioavailability, low selectivity targeting specificity, off-target drug side effects, damage surrounding healthy tissues. Nanofiber-based systems recently emerged a promising system cancer therapy owing unique structural functional properties, including tunable interconnected porosity, high surface-to-volume ratio entrapment efficiency loading capacity, mass transport which allow controlled targeted delivery. In addition, they are biocompatible, biodegradable, capable surface functionalization, allowing target-specific release. One most common fiber production methods is electrospinning, even though relatively two-dimensional (2D) tightly packed structures rates limited its performance. Forcespinning an alternative spinning technology that generates high-throughput, continuous polymeric nanofibers 3D structures. Unlike forcespinning fibers by centrifugal forces rather than electrostatic forces, resulting significantly higher production. The functionalization nanocarriers on can result anticancer capabilities be activated external stimuli, light. This review addresses current trends potential applications light-responsive dual-stimuli-responsive electro- forcespun therapy, particular emphasis functionalizing nanofiber surfaces developing nano-in-nanofiber emerging dual-controlled release high-precision tumor targeting. progress prospective diagnostic therapeutic discussed context combination therapy.

Language: Английский

Citations

5
Hybrid Polyvinyl Alcohol-Silica Antibacterial Nanofiber Fabricated by Combined Sol-Gel and Electrospinning Techniques DOI
Khadija El kalaaoui,

Aïcha Boukhriss,

O. Bili

et al.

Journal of Sol-Gel Science and Technology, Journal Year: 2024, Volume and Issue: 112(1), P. 69 - 83

Published: Aug. 11, 2024

Language: Английский

Citations

5
Electrospun nanofibers based on plant extract bioactive materials as functional additives: possible sources and prospective applications DOI Creative Commons
Md Nur Uddin, Ayub Ali,

Md Jobaer

et al.

Materials Advances, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Bioactive plant compounds are combined with polymers and electrospun into nanofibers. These fibers, antioxidant antibacterial properties, used in drug delivery, tissue engineering, food packaging.

Language: Английский

Citations

5