Frontiers of Optoelectronics,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Dec. 9, 2024
Abstract
Achilles
tendon
injuries,
as
a
widely
existing
disease,
have
attracted
lot
of
research
interest.
Mueller
matrix
polarimetry,
novel
label-free
quantitative
imaging
method,
has
been
used
in
various
applications
lesion
identification
and
pathological
diagnosis.
However,
focusing
on
the
recovery
process
current
optical
methods
not
yet
achieved
precise
evaluation.
In
this
study,
using
injury
samples
were
characterized
specifically,
efficacy
different
schemes
was
evaluated
accordingly.
Experiments
indicate
that
injured
tendons
show
less
phase
retardance,
larger
diattenuation,
relatively
disordered
orientation.
The
combination
experiments
with
Monte
Carlo
simulation
results
illustrate
microscopic
mechanism
from
three
aspects,
is,
increased
fiber
diameter,
more
consistent
orientation,
greater
birefringence
induced
by
collagen
protein.
Finally,
based
statistical
distribution
polarization
measurements,
specific
characterization
parameter
extracted
to
construct
image,
which
cannot
only
intuitively
samples,
but
also
give
evaluation
treatment.
Graphical
Materials & Design,
Journal Year:
2024,
Volume and Issue:
240, P. 112853 - 112853
Published: March 19, 2024
3D
bioprinting
techniques
have
emerged
as
a
flexible
tool
in
tissue
engineering
and
regenerative
medicine
to
fabricate
or
pattern
functional
bio-structures
with
precise
geometric
designs,
bridging
the
divergence
between
engineered
natural
constructs.
A
significantly
increasing
development
has
been
achieved
understanding
relationship
3D-printing
process
structures,
properties,
applications
of
objects
created.
The
ongoing
advancement
novel
biomaterial
inks
enabled
manufacturing
models
vitro
implants
capable
achieving
some
level
success
preclinical
trials.
Remarkable
progress
cell
biology
biology-inspired
computational
design
assisted
latest
milestone
planned
tissue-
organ-like
constructs
having
specific
levels
functionality.
However,
biofabricated
still
long
way
go
before
reaching
clinics.
This
review
presents
picture
context
medicine,
focus
on
biomaterials-related
design-centred
aspects.
Biomedical
are
described
detail
relation
major
tissues
organs
considered
human
body.
Current
technical
limitations,
challenges,
future
prospects
improvements
critically
outlined
discussed.
Materials Today Chemistry,
Journal Year:
2024,
Volume and Issue:
37, P. 102016 - 102016
Published: April 1, 2024
Tissue-engineered
constructs
can
replicate
the
structural
and
physiological
properties
of
natural
tissues.
The
be
designed
to
address
transplantation
issues
affected
by
shortage
donor
tissues
organs.
One
major
concerns
in
tissue
engineering
is
design
development
structures
that
improve
interaction
between
materials
cells
provide
an
ideal
platform
for
form
functional
tissue.
Several
contributing
factors
need
considered
fabricate
constructs,
including
biomaterials,
biological,
topographical,
biophysical,
morphological
either
alone
or
combination.
Here,
we
review
application,
advancement,
future
directions
these
essential
designing
developing
regeneration.
In
particular,
focus
on
original
approaches
tools
construct
parameters
engineering.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 859 - 859
Published: April 12, 2024
Tendon
regeneration
has
emerged
as
an
area
of
interest
due
to
the
challenging
healing
process
avascular
tendon
tissue.
During
after
injury,
formation
a
fibrous
scar
can
limit
strength
and
lead
subsequent
complications.
The
specific
biological
mechanisms
that
cause
fibrosis
across
different
cellular
subtypes
within
tendons
in
body
continue
remain
unknown.
Herein,
we
review
current
understanding
healing,
mechanisms,
future
directions
for
treatments.
We
summarize
recent
research
on
role
fibroblasts
throughout
describe
functional
heterogeneity
tendons.
notes
gaps
research,
with
focus
characterizing
distinct
fibroblast
subpopulations
tendon.
highlight
new
techniques
field
be
used
enhance
our
complex
pathologies
such
fibrosis.
Finally,
explore
bioengineering
tools
discuss
areas
innovation.
Exploring
level
inform
therapeutic
strategies
addressing
ultimately
reduce
its
clinical
burden.
Journal of Orthopaedic Translation,
Journal Year:
2025,
Volume and Issue:
50, P. 333 - 353
Published: Jan. 1, 2025
Bone
and
soft
tissues
are
connected
by
a
complex
interface
that
is
crucial
for
the
smooth
transfer
of
mechanical
stress.
Effective
repair
this
requires
bio-scaffolds
specifically
designed
to
support
regeneration
diverse
cell
types
signalling
molecules.
With
advances
in
micro-
nanotechnologies,
gradient
biomaterial
scaffolds
have
demonstrated
significant
potential
tissue
regeneration.
This
paper
reviews
structure
bone-soft
interface,
various
scaffold
types,
construction
methods.
It
also
discusses
recent
developments
future
directions
engineering,
emphasizing
restore
natural
function
interfaces.
Overall,
provides
valuable
insights
into
application
offering
inspiration
biomimetic
approaches
soft-hard
medical
engineering.
First,
emphasis
on
could
significantly
impact
clinical
practices
related
integration,
ultimately
improving
patient
outcomes
quality
life.
Second,
it
aligns
with
growing
trend
potentially
inspiring
new
innovations
strategies.
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
14(6), P. 299 - 299
Published: May 28, 2023
Exosomes
have
been
proven
to
play
a
positive
role
in
tendon
and
tendon–bone
healing.
Here,
we
systematically
review
the
literature
evaluate
efficacy
of
exosomes
Following
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
guidelines,
systematic
comprehensive
was
performed
on
21
January
2023.
The
electronic
databases
searched
included
Medline
(through
PubMed),
Web
Science,
Embase,
Scopus,
Cochrane
Library
Ovid.
In
end,
total
1794
articles
were
reviewed.
Furthermore,
“snowball”
search
also
carried
out.
Finally,
forty-six
studies
analysis,
with
sample
size
being
1481
rats,
416
mice,
330
rabbits,
48
dogs,
12
sheep.
these
studies,
promoted
healing
displayed
improved
histological,
biomechanical
morphological
outcomes.
Some
suggested
mechanism
promoting
healing,
mainly
through
following
aspects:
(1)
suppressing
inflammatory
response
regulating
macrophage
polarization;
(2)
gene
expression,
reshaping
cell
microenvironment
reconstructing
extracellular
matrix;
(3)
angiogenesis.
risk
bias
low
whole.
This
provides
evidence
effect
preclinical
studies.
unclear-to-low
highlights
significance
standardization
outcome
reporting.
It
should
be
noted
that
most
suitable
source,
isolation
methods,
concentration
administration
frequency
are
still
unknown.
Additionally,
few
used
large
animals
as
subjects.
Further
may
required
comparing
safety
different
treatment
parameters
animal
models,
which
would
conducive
design
clinical
trials.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 12, 2025
Rotator
cuff
injury
(RCI),
characterized
by
shoulder
pain
and
restricted
mobility,
represents
a
subset
of
tendon-bone
insertion
injuries
(TBI).
In
the
majority
cases,
surgical
reconstruction
affected
tendons
or
ligaments
is
required
to
address
damage.
However,
numerous
clinical
failures
have
underscored
suboptimal
outcomes
associated
with
such
procedures.
Further
investigations
revealed
that
these
are
largely
attributable
delayed
healing
at
interface,
excessive
formation
vascularized
scar
tissue,
inadequate
integration
tendon
grafts
within
bone
tunnels.
As
result,
process
rotator
faces
significant
challenges.Bone
marrow-derived
mesenchymal
stem
cell
exosomes
(BMSC-exos)
emerged
as
prominent
focus
research
field
bioengineering,
owing
their
remarkable
potential
regulate
cellular
proliferation
differentiation,
modulate
immune
responses,
facilitate
tissue
repair
regeneration
following
this
review,
we
explore
anti-inflammatory,
angiogenic,
anti-scarring,
metabolism-modulating
effects
BMSC-exos
in
context
injury.
Additionally,
limitations
ongoing
challenges
current
research,
offering
insights
could
guide
application
treatment
future.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Despite
advances
in
surgical
techniques
for
tendon
injuries
and
improvements
rehabilitation,
the
challenge
of
achieving
sufficient
regeneration
preventing
postoperative
tissue
adhesions
persists
orthopedic
surgeons.
In
this
study,
we
developed
a
multilayer
film
with
platelet-derived
growth
factor-BB
(PDGF-BB)-immobilized
leaf-stacked
structure
(LSS)
layer
(bioactive
layer)
an
alginate
(antiadhesive
on
both
sides
PCL
(PDGF/FLSS-Alg).
The
porous
LSS
was
fabricated
using
heating-cooling
method
tetraglycol,
where
PDGF-BB
adsorbed
onto
layer.
An
coating
applied
opposite
side
to
form
antiadhesion
loaded
provided
sustained
release
at
effective
concentrations
over
29
days.
From
vitro
cell
culture
vivo
animal
studies,
proved
cell/tissue
adhesion;
meanwhile,
bioactive
facilitated
tenogenic
differentiation
hBMSCs
supported
regeneration.
Accordingly,
propose
that
PDGF/FLSS-Alg
offers
viable
strategy
clinical
practice.
The Journal of Physiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 11, 2025
Abstract
Tendon
injuries
are
a
common
and
significant
health
burden
around
the
world.
Current
treatment
strategies
unable
to
fully
restore
tendon
structure
function.
To
address
these
critical
clinical
needs,
stem
cell
therapy
has
recently
emerged
as
promising
approach
for
better
repair.
In
this
review,
we
discuss
efficacy
of
in
repair
by
summarizing
its
advantages
disadvantages
both
preclinical
settings.
We
highlight
recent
advances
improving
cell‐based
treatment,
with
focus
on
research
efforts
identification
appropriate
sources,
modification
effective
transplantation,
development
carriers,
standardization
protocols.
Finally,
provide
insights
into
future
directions
therapy,
emphasis
necessity
employing
patient
screening
criteria
before
establishing
comprehensive
outcome
measurements
ensure
rigor
trials.
image
Veterinary Medicine and Science,
Journal Year:
2025,
Volume and Issue:
11(3)
Published: April 11, 2025
ABSTRACT
Background
Low‐level
laser
therapy
(LLLT)
has
been
utilized
to
treat
tendinitis
and
various
other
musculoskeletal
conditions.
The
current
study
assessed
the
impact
of
LLLT
(650
750
nm)
on
tendon
repair
in
rabbits.
Materials
methods
Fifteen
2‐year‐old
male
New
Zealand
White
rabbits
were
divided
into
three
groups:
control,
650
nm
therapy.
After
applying
Achilles
tendon‐destructive
surgery
their
right
legs,
underwent
LLLT,
was
using
histopathology
immunohistochemistry
(IHC)
findings.
All
data
analysed
SPSS
version
21,
considering
a
significant
level
<0.05.
Results
study's
histopathological
immunohistochemical
analysis
revealed
that
at
significantly
improved
healing
compared
control
group
(
p
<
0.05).
treated
groups
exhibited
better
organized
fibres
with
reduced
discontinuity,
collagen
fibre
waviness,
inflammatory
response
Both
wavelengths
showed
similar
results
no
differences
between
them
>
0.05),
but
both
notably
than
reducing
inflammation,
enhancing
structure,
lowering
levels
type
I
(Col‐I);
III
(Col‐III);
transformer
growth
factor
beta
(TGF‐β);
galectin‐3
(galectin‐3);
VGF
nerve
inducible;
vascular
endothelial
(VEGF),
indicating
more
effective
process
LLLT.
Conclusion
Due
our
findings,
effectively
structural
integrity,
enhanced
organization
for
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
25, P. 100977 - 100977
Published: Jan. 28, 2024
Although
human
tenocytes
and
dermal
fibroblasts
have
shown
promise
in
tendon
engineering,
no
tissue
engineered
medicine
has
been
developed
due
to
the
prolonged
