Indian Journal of Orthopaedics, Journal Year: 2024, Volume and Issue: 58(7), P. 876 - 886
Published: May 2, 2024
Language: Английский
Materials & Design, Journal Year: 2024, Volume and Issue: 240, P. 112853 - 112853
Published: March 19, 2024
3D bioprinting techniques have emerged as a flexible tool in tissue engineering and regenerative medicine to fabricate or pattern functional bio-structures with precise geometric designs, bridging the divergence between engineered natural constructs. A significantly increasing development has been achieved understanding relationship 3D-printing process structures, properties, applications of objects created. The ongoing advancement novel biomaterial inks enabled manufacturing models vitro implants capable achieving some level success preclinical trials. Remarkable progress cell biology biology-inspired computational design assisted latest milestone planned tissue- organ-like constructs having specific levels functionality. However, biofabricated still long way go before reaching clinics. This review presents picture context medicine, focus on biomaterials-related design-centred aspects. Biomedical are described detail relation major tissues organs considered human body. Current technical limitations, challenges, future prospects improvements critically outlined discussed.
Language: Английский
Citations
43
Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 37, P. 102016 - 102016
Published: April 1, 2024
Tissue-engineered constructs can replicate the structural and physiological properties of natural tissues. The be designed to address transplantation issues affected by shortage donor tissues organs. One major concerns in tissue engineering is design development structures that improve interaction between materials cells provide an ideal platform for form functional tissue. Several contributing factors need considered fabricate constructs, including biomaterials, biological, topographical, biophysical, morphological either alone or combination. Here, we review application, advancement, future directions these essential designing developing regeneration. In particular, focus on original approaches tools construct parameters engineering.
Language: Английский
Citations
14
Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. 333 - 353
Published: Jan. 1, 2025
Bone and soft tissues are connected by a complex interface that is crucial for the smooth transfer of mechanical stress. Effective repair this requires bio-scaffolds specifically designed to support regeneration diverse cell types signalling molecules. With advances in micro- nanotechnologies, gradient biomaterial scaffolds have demonstrated significant potential tissue regeneration. This paper reviews structure bone-soft interface, various scaffold types, construction methods. It also discusses recent developments future directions engineering, emphasizing restore natural function interfaces. Overall, provides valuable insights into application offering inspiration biomimetic approaches soft-hard medical engineering. First, emphasis on could significantly impact clinical practices related integration, ultimately improving patient outcomes quality life. Second, it aligns with growing trend potentially inspiring new innovations strategies.
Language: Английский
Citations
1
Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 859 - 859
Published: April 12, 2024
Tendon regeneration has emerged as an area of interest due to the challenging healing process avascular tendon tissue. During after injury, formation a fibrous scar can limit strength and lead subsequent complications. The specific biological mechanisms that cause fibrosis across different cellular subtypes within tendons in body continue remain unknown. Herein, we review current understanding healing, mechanisms, future directions for treatments. We summarize recent research on role fibroblasts throughout describe functional heterogeneity tendons. notes gaps research, with focus characterizing distinct fibroblast subpopulations tendon. highlight new techniques field be used enhance our complex pathologies such fibrosis. Finally, explore bioengineering tools discuss areas innovation. Exploring level inform therapeutic strategies addressing ultimately reduce its clinical burden.
Language: Английский
Citations
8
Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(6), P. 299 - 299
Published: May 28, 2023
Exosomes have been proven to play a positive role in tendon and tendon–bone healing. Here, we systematically review the literature evaluate efficacy of exosomes Following Preferred Reporting Items for Systematic Reviews Meta-Analyses guidelines, systematic comprehensive was performed on 21 January 2023. The electronic databases searched included Medline (through PubMed), Web Science, Embase, Scopus, Cochrane Library Ovid. In end, total 1794 articles were reviewed. Furthermore, “snowball” search also carried out. Finally, forty-six studies analysis, with sample size being 1481 rats, 416 mice, 330 rabbits, 48 dogs, 12 sheep. these studies, promoted healing displayed improved histological, biomechanical morphological outcomes. Some suggested mechanism promoting healing, mainly through following aspects: (1) suppressing inflammatory response regulating macrophage polarization; (2) gene expression, reshaping cell microenvironment reconstructing extracellular matrix; (3) angiogenesis. risk bias low whole. This provides evidence effect preclinical studies. unclear-to-low highlights significance standardization outcome reporting. It should be noted that most suitable source, isolation methods, concentration administration frequency are still unknown. Additionally, few used large animals as subjects. Further may required comparing safety different treatment parameters animal models, which would conducive design clinical trials.
Language: Английский
Citations
16
Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100977 - 100977
Published: Jan. 28, 2024
Although human tenocytes and dermal fibroblasts have shown promise in tendon engineering, no tissue engineered medicine has been developed due to the prolonged
Language: Английский
Citations
6
Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(5), P. 190 - 190
Published: April 26, 2024
Musculoskeletal injuries such as equine osteoarthritis, osteoarticular defects, tendonitis/desmitis, and muscular disorders are prevalent among sport horses, with a fair prognosis for returning to exercise or previous performance levels. The field of medicine has witnessed rapid fruitful development, resulting in diverse range therapeutic options musculoskeletal problems. Staying abreast these advancements can be challenging, prompting the need comprehensive review commonly used recent treatments. aim is compile current managing injuries, spanning from simple complex physiotherapy techniques, conservative treatments including steroidal non-steroidal anti-inflammatory drugs, hyaluronic acid, polysulfated glycosaminoglycans, pentosan polysulfate, polyacrylamides, promising regenerative therapies hemoderivatives stem cell-based therapies. Each modality scrutinized its benefits, limitations, potential synergistic actions facilitate their most effective application intended healing/regeneration injured tissue/organ subsequent patient recovery. While have emerged particularly multidisciplinary approach underscored throughout discussion, emphasizing importance considering various modalities tandem.
Language: Английский
Citations
5
Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)
Published: May 13, 2024
Tendons are fibroblastic structures that link muscle and bone. There two kinds of tendon injuries, including acute chronic. Each form injury or deterioration can result in significant pain loss function. The recovery damage is a complex time-consuming process. Depending on the anatomical location tissue, clinical outcomes not same. healing wound process divided into three stages overlap: inflammation, proliferation, tissue remodeling. Furthermore, curing has high re-tear rate. Faced with challenges, management still issue must be resolved as soon possible. Several newer directions breakthroughs have emerged recent years. This article describes summarizes advances recovery, along stem cell therapy, gene Platelet-rich plasma remedy, growth factors, drug treatment, engineering. Despite fast-growing research still, none them translated to setting. review provides detailed overview injuries potential preclinical approaches for treating injuries.
Language: Английский
Citations
5
Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101342 - 101342
Published: Nov. 14, 2024
Hydrogels, that are crosslinked polymer networks, can absorb huge quantities of water and/or biological fluids. Their physical properties, such as elasticity and soft tissue, together with their biocompatibility biodegradability, closely resemble living tissues. The versatility hydrogels has fuelled application in various fields, agriculture, biomaterials, the food industry, drug delivery, tissue engineering, regenerative medicine. combination nanoparticles, specifically Mesoporous Silica Nanoparticles (MSNs), have elevated these composites to next level, since MSNs could improve hydrogel mechanical ability encapsulate controlled release great amounts different therapeutic agents, responsiveness a variety external internal stimuli. In this review, main features both introduced, followed by discussion hydrogels-MSNs structures an overview use applications, delivery technologies engineering.
Language: Английский
Citations
4
European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113716 - 113716
Published: Jan. 1, 2025
Language: Английский
Citations
0