Food Chemistry, Journal Year: 2025, Volume and Issue: 478, P. 143674 - 143674
Published: March 1, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6022 - 6022
Published: May 30, 2024
The role of probiotics in regulating intestinal flora to enhance host immunity has recently received widespread attention. Altering the human gut microbiota may increase predisposition several disease phenotypes such as inflammation and metabolic disorders. converts dietary nutrients into metabolites that serve biologically active molecules modulating regulatory functions host. Probiotics, which are microorganisms, play a versatile restoring composition microbiota, helping improve prevent phenotypes. This comprehensive review provides firsthand information on their influence health, effects diet how alter function along with corresponding building healthy intestine. We also discuss implications some most important diseases. In summary, significant boosting overall immunity, increasing abundance beneficial bacteria, ameliorate symptoms multiple
Language: Английский
Citations
65
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3148 - 3148
Published: March 28, 2025
Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing
Language: Английский
Citations
3
Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2259 - 2259
Published: July 13, 2024
Dietary components, including dietary fiber, unsaturated fatty acids, and polyphenols, along with meal timing spacing, significantly affect the microbiota’s capacity to produce various metabolites essential for quality sleep overall health. This review explores role of gut microbiota in regulating through such as short-chain tryptophan, serotonin, melatonin, gamma-aminobutyric acid. A balanced diet rich plant-based foods enhances production these sleep-regulating metabolites, potentially benefiting aims investigate how habits composition, it produces, subsequent impact on related health conditions.
Language: Английский
Citations
10
Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10
Published: Sept. 28, 2023
An imbalance in microbial homeostasis, referred to as dysbiosis, is critically associated with the progression of obesity-induced metabolic disorders including type 2 diabetes (T2D). Alteration gut diversity and abundance pathogenic bacteria disrupt homeostasis potentiate chronic inflammation, due intestinal leakage or release a diverse range metabolites. The obesity-associated shifts worsen triglyceride cholesterol level that regulates adipogenesis, lipolysis, fatty acid oxidation. Moreover, an intricate interaction gut-brain axis coupled altered microbiome profile microbiome-derived metabolites bidirectional communication for instigating insulin resistance. Furthermore, distinct community within visceral adipose tissue its dysfunction obese T2D individuals. specific bacterial signature was found mesenteric patients. Recently, it has been shown Crohn's disease, gut-derived bacterium Clostridium innocuum translocated modulates function by inducing M2 macrophage polarization, increasing promoting surveillance. Considering these facts, modulation microbiota could serve one contemporary approaches manage using prebiotics, probiotics, faecal transplantation. Altogether, this review consolidates current knowledge on dysbiosis role development T2D. It emphasizes significance well alteration dysfunction, identifying novel therapeutic strategies, providing valuable insights directions future research potential clinical interventions.
Language: Английский
Citations
22
Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: Nov. 16, 2023
Background Non-alcoholic steatohepatitis (NASH) has become a major public health issue as one of the leading causes liver disease and transplantation worldwide. The instrumental role gut microbiota is emerging but still under investigation. Endogenous ethanol (EtOH) production by bacteria yeasts an putative mechanism. Microbial metagenomics culture studies targeting enterobacteria or have been reported, no culturomics conducted so far. Aim To assess fecal EtOH other biochemical parameters, characterize NASH-associated dysbiosis identify EtOH-producing microbes associated with disease, samples from 41 NASH patients 24 controls were analyzed. High-performance liquid chromatography (HPLC) was used for EtOH, glucose, total proteins, triglyceride cholesterol. Viable assessed microbial culturomics. genetic material using 16S hypervariable V3V4 region. Results Fecal glucose elevated in stools (p < 0.05) not triglyceride, cholesterol proteins. In culturomics, Enterocloster bolteae Limosilactobacillus fermentum enriched NASH. rRNA amplicon sequencing confirmed enrichment including L. , Mediterraneibacter gnavus Streptococcus mutans species previously dysbiosis-associated diseases. Strikingly, E. identified only well-known Lacticaseibacillus casei never isolated 0.05). Conclusion Elevated feature Several different may play disease. Culturomics metagenomics, two complementary methods, will be critical to future diagnostic markers therapeutic targets Suppression administration are options tested treatment.
Language: Английский
Citations
19
Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 112, P. 105991 - 105991
Published: Jan. 1, 2024
The study aimed to explore the effects of Ganoderma atrum polysaccharide (PSG) on diabetic cardiomyopathy in type 2 rats. Results suggested that PSG significantly attenuated cardiomyopathy, as evidenced by alleviating heart histopathological changes and LDH release, mitigating weight loss, improving fasting blood glucose serum insulin levels. could also reduce ROS generation malondialdehyde contents, while enhancing antioxidant enzyme activities Nrf2 expression. Furthermore, reduced inflammation suppressing NLRP3 inflammasome, caspase-1, TLR4, NF-κB p65 expression, IL-1β IL-6 secretion. Moreover, treatment manipulated intestinal microbiota metabolites, including short-chain fatty acids, plasma lipopolysaccharide, trimethylamine N-oxide. These metabolites might mediate gut-heart communication through interaction with inflammasome. Collectively, activating pathway, controlling via NLRP3/Caspase-1/IL-1β signaling, using gut microbial alternative biomarkers for predicting mechanisms assessing interventions.
Language: Английский
Citations
7
Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3447 - 3447
Published: Oct. 11, 2024
The gut microbiota, a complex ecosystem of microorganisms in the human gastrointestinal tract (GI), plays crucial role maintaining metabolic health and influencing disease susceptibility. Dysbiosis, or an imbalance has been linked to development type 2 diabetes mellitus (T2DM) through mechanisms such as reduced glucose tolerance increased insulin resistance. A balanced eubiosis, is associated with improved metabolism sensitivity, potentially reducing risk diabetes-related complications. Various strategies, including use prebiotics like inulin, fructooligosaccharides, galactooligosaccharides, resistant starch, pectic oligosaccharides, polyphenols, β-glucan, Dendrobium officinale have shown improve microbial composition support glycemic control T2DM patients. These can directly impact blood sugar levels while promoting growth beneficial bacteria, thus enhancing control. Studies that patients often exhibit decrease butyrate-producing Roseburia Faecalibacterium, increase harmful Escherichia Prevotella. This review aims explore effects different on T2DM, their microbiota composition, potential for personalized dietary interventions optimize management overall outcomes.
Language: Английский
Citations
7
Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 22 - 22
Published: Jan. 6, 2025
Background/Objectives: Managing type 2 diabetes mellitus (T2DM) and obesity requires a multidimensional, patient-centered approach including nutritional interventions (NIs) physical activity. Changes in the gut microbiota (GM) have been linked to metabolic alterations typical of T2DM obesity, they are strongly influenced by diet. However, few studies evaluated effects on GM very-low-calorie ketogenic diet (VLCKD) patients with T2DM, especially mid-term long-term. This longitudinal study is aimed at evaluating long-term impact VLCKD Mediterranean (MD) anthropometric, metabolic, lifestyle parameters 11 (diabesity). extends previously published results short-term (three months) these NIs same patients. Methods: At baseline, were randomly assigned either (KETO group) or (MEDI group). After two months, KETO group gradually shifted (VLCKD-MD), according current guidelines. From fourth month until end both groups followed similar MD. Previous showed that had more beneficial than MD several variables for 3 months NI. In this study, analyses extended six (T6) twelve (T12) NI comparing data prospectively against baseline (T0). The analysis was performed through next-generation sequencing. Results: Improvements anthropometric pronounced T6, particularly body mass index (−5.8 vs. −1.7 kg/m2; p = 0.006) waist circumference (−15.9 −5.2 cm; 0.011). significant improvement HbA1c (6.7% 5.5% 0.02) triglyceride (158 95 mg/dL 0.04) values compared T0 observed only group, which maintained achieved T3. VLCKD-MD phenotype. A substantial positive modulatory effect up sixth due progressive increase bacterial markers human health. month, most health decreased, though still increased baseline. Among them, Verrucomicrobiota phylum identified as main biomarker together its members Verrucomicrobiae, Akkermansiaceae, Verrucomicrobiales, Akkermansia T6 Conclusions: Both dietary approaches ameliorated status, but VLCKD, support MD, has shown greater improvements parameters, well profile,
Language: Английский
Citations
1
Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(2)
Published: Feb. 8, 2025
Language: Английский
Citations
1
Biomolecules, Journal Year: 2023, Volume and Issue: 13(9), P. 1307 - 1307
Published: Aug. 25, 2023
Hypoglycemic medications that could be co-administered with prebiotics and functional foods can potentially reduce the burden of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM). The efficacy drugs metformin sulfonylureas enhanced by activity intestinal microbiome elaborated metabolites. Functional (e.g., oligofructose) dietary fibers treat a dysbiotic gut enhancing diversity microbial niches in gut. These beneficial shifts profiles include an increased abundance bacteria Faecalibacterium prauznitzii, Akkermancia muciniphila, Roseburia species, Bifidobacterium species. An important net effect is increase levels luminal SCFAs butyrate) provide energy carbon sources for cross-feeding activities, concomitant improvement dysbiosis attenuation inflammatory sequalae improved barrier integrity, which alleviates morbidity T2DM. Oligosaccharides administered adjunctively pharmacotherapy to ameliorate T2DM represent current plausible treatment modalities.
Language: Английский
Citations
17