Nutrition, Journal Year: 2024, Volume and Issue: 131, P. 112669 - 112669
Published: Dec. 7, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694
Published: March 26, 2024
Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.
Language: Английский
Citations
12
Biology, Journal Year: 2023, Volume and Issue: 12(5), P. 662 - 662
Published: April 27, 2023
There is growing evidence that gut microbiota dysbiosis linked to the etiopathogenesis of nonalcoholic fatty liver disease (NAFLD), from initial stage until progressive steatohepatitis (NASH) and final cirrhosis. Conversely, probiotics, prebiotics, synbiotics have shown promise in restoring lowering clinical indicators a number both preclinical studies. Additionally, postbiotics parabiotics recently garnered some attention. The purpose this bibliometric analysis assess recent publishing trends concerning role microbiome progression NAFLD, NASH cirrhosis its connection with biotics. free access version Dimensions scientific research database was used find publications field 2002 2022. VOSviewer Dimensions' integrated tools were analyze current trends. Research into following topics expected emerge field: (1) evaluation risk factors which are correlated such as obesity metabolic syndrome; (2) pathogenic mechanisms, inflammation through toll-like receptors activation, or alteration short-chain acids metabolisms, contribute NAFLD development more severe forms, cirrhosis; (3) therapy for reduction, on hepatic encephalopathy common consequence (4) diversity, composition under it varies by rRNA gene sequencing, tool can also be new probiotics explore impact biotics microbiome; (5) treatments reduce Akkermansia, fecal transplantation.
Language: Английский
Citations
17
World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(37), P. 5339 - 5360
Published: Sept. 25, 2023
Nonalcoholic fatty liver disease (NAFLD) is chronic, with its progression leading to fibrosis and end-stage cirrhosis. Although NAFLD increasingly common, no treatment guideline has been established. Many mechanistic studies drug trials have conducted for new development treat NAFLD. An up-to-date overview on the knowledge structure of through bibliometrics, focusing research hotspots, necessary reveal rational timely directions in this field.To latest literature determine current trends NAFLD.Publications related were searched Web Science Core Collection database, from 2010 2023. VOSviewers, CiteSpace, R package "bibliometrix" used conduct bibliometric analysis. The key information was extracted, results cluster analysis based network data generating investigating maps country, institution, journal, author. Historiography analysis, bursts co-occurrence trend topic revealed hotspots field. GraphPad Prism 9.5.1.733 Microsoft Office Excel 2019 visualization.In total, 10829 articles 120 countries (led by China United States) 8785 institutions included. number publications increased annually. While produced most publications, States cited Kingdom collaborated an international standpoint. University California-San Diego, Shanghai Jiao Tong University, Traditional Chinese Medicine all institutions. International Journal Molecular Sciences frequent journal out 1523 total journals, Hepatology co-cited journal. Sanyal AJ author, author Younossi ZM, influential Loomba R. studied topics included epidemiology mechanism NAFLD, accurate diagnosis, precise management patients associated metabolic comorbidities. major "emerging drug," "glucagon-like peptide-1 receptor agonist," "metabolic dysfunction-associated disease," "gut microbiota," "glucose metabolism."The study identified recent frontiers hot directions, which can provide a valuable reference scholars researching treatments
Language: Английский
Citations
17
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11
Published: Jan. 7, 2025
Numerous studies have shown a link between circadian rhythms disruptions and higher risk of obesity. This article aims to conduct an extensive bibliometric analysis deepen our understanding the relationship The literature related rhythm obesity, published from inception Web Science Core Collection (WoSCC) until June 30, 2024, was extracted WoSCC databases (SCIE, SSCI, ESCI). Using CiteSpace, Vosviewer, WPS, other software, this paper examines publication trends, including number papers, countries/regions, institutions, authors, journals, references, keywords. A total 2,870 articles were included in analysis, revealing consistent year by increase research on These publications originate 460 institutions 88 countries. Among authors Garaulet, Marta most prolific, Turek FW co-cited. Proceedings National Academy Sciences United States America emerged as journal with highest publications, American Journal Physiology had centrality. frequently used keywords "obesity," "circadian rhythm," clock," "metabolic syndrome," "metabolism." Additionally, areas involving intermittent fasting, restricted feeding, gut microbiota rapidly developing represented forefront Our study demonstrates that obesity has been expanding, increasingly in-depth exploration topic. It is recommended strengthen cooperation countries jointly promote field. gene expression early hotspot emerging such endothelial nitric oxide synthase will become significant hotspots trends field findings provide researchers critical directions for future may implications clinical practice public health policy.
Language: Английский
Citations
0
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 17, 2025
Despite significant advancements in prevention and treatment, cardiometabolic diseases continue to pose a high burden of incidence mortality. The chronic progression these necessitates the identification early complementary therapeutic targets elucidate mitigate residual risks patient care. gut microbiota acts as sentinel between internal external environments, transmitting modified associated with factors host. Imidazole propionate (ImP), histidine metabolite originating from microbiota, gained attention after being found impair glucose tolerance insulin signaling several years ago. Epidemiological studies over past five have demonstrated robust correlation ImP an increased risk onset type 2 diabetes (T2D) obesity, exacerbation kidney traits disease (CKD), atherosclerotic plaques, elevated mortality rates heart failure (HF). These findings suggest that may serve pivotal target for treatment diseases. Mechanistic insights uncovered associations resistance, impaired metabolism, inflammation, intestinal barrier damage. This review provides comprehensive summary current evidence regarding association impairment, highlighting its potential advancing personalized approaches management, exploring intricate interplay diet, cardiovascular metabolic impairment. Overall, this offers valuable into multifaceted roles diseases, identifies knowledge gaps, discusses future research directions.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 5, 2025
Hypertension continues to be a global health and economic burden, conventionally characterized by chronic inflammatory state. Macrophages are critical for the initiation, progression manifestation of hypertension. As studies on relationship between macrophages hypertension increase substantially, identifying research areas unraveling potential interaction mechanisms become increasingly essential. Articles associated with in recent 10 years were retrieved from Web Science Core Collection analysis, using Microsoft Excel, VOSviewer, CiteSpace Scimago Graphica. After excluding that did not meet inclusive standard based time (2015-2024) type (article or reviews), 2,013 original articles related included. The number publications has been increasing annually. These records consisted English language papers published 351 journals 315 institutions regions 83 countries/regions 2015 2024. We analyzed co-cited references clusters objectively outline current state research, including regulatory hypertension, diseases lifestyle factor. Inflammation remains one most popular hot-spot. publishing journal this field is PLOS ONE prolific writer Li, Hui-Hua. primary keywords cluster inflammation, highest occurrences TLS among top keywords. comprehensive visualized bibliometric results summarized significant findings macrophage-related over past years. appear effective treatment as targets, but further needed clarify specific pathophysiological involved.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 19, 2024
An increasing number of studies have demonstrated that immunotherapy may play a significant role in treating Atherosclerosis and has emerged as promising therapy this field. The aim study is to provide comprehensive perspective through bibliometric analysis investigate the existing hotspots frontiers.
Language: Английский
Citations
3
Gut Pathogens, Journal Year: 2024, Volume and Issue: 16(1)
Published: July 3, 2024
Nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as a significant health issue. Emerging research has focused on the role of gut microbiota in NAFLD, emphasizing gut-liver axis. This study aimed to identify key trends and guide future investigations this evolving area.
Language: Английский
Citations
2
Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e35498 - e35498
Published: Aug. 1, 2024
The increasing scientific interest in antioxidants and naturally derived compounds as potential remedies for obesity non-alcoholic fatty liver disease (NAFLD) has led to extensive research. objective of this bibliometric analysis is present an updated perspective on the topic antioxidants, herbs, phytochemicals, natural compounds, control NAFLD, identify new areas future Publications from years 2012-2022 were retrieved using Scopus database. research trends analyzed Biblioshiny VOSviewer tools. field seen a significant increase activity, indicated by annual growth rate 10 % number published manuscripts. China, Korea, USA emerged most prominent contributors specific field, supported their notable volumes publications citations. density revealed that frequently occurring authors' keywords related herbal species are, rank order
Language: Английский
Citations
2
Animal Science Papers and Reports, Journal Year: 2023, Volume and Issue: 41(3), P. 179 - 194
Published: Sept. 1, 2023
Abstract Non-alcoholic fatty liver disease (NAFLD) is defined as a clinical syndrome characterized by excessive fat accumulation in liver, predominantly influenced dietary choices. This study provides an extensive quantitative literature analysis on influences NAFLD. Bibliometric data were collected through the search string TOPIC = (“NAFLD*” OR “nonalcoholic liver*” “non-alcoholic liver*”) AND (“diet*” “nutrition*” “food*” “feed*”), which yielded 12,445 publications indexed within Web of Science Core Collection. Utilizing VOSviewer software, term maps generated to visually illustrate recurring phrases alongside citation data. The literature, has seen exponential growth since 2010s, consists original articles, with ratio 4.7:1 compared reviews. Notably, significant contributors this field China and United States. majority found journals specialized Gastroenterology & Hepatology, Nutrition Dietetics, Biochemistry Molecular Biology, Endocrinology Metabolism, Pharmacology Pharmacy. Key compounds/compounds classes such resveratrol, polyphenols, curcumin, berberine, quercetin, flavonoids, omega-3 acids, docosahexaenoic acid (DHA), genistein, palmitic frequently mentioned cited. Many them demonstrated have some potential benefits NAFLD, both human animal studies.
Language: Английский
Citations
5