Journal of Oral Biology and Craniofacial Research, Journal Year: 2024, Volume and Issue: 14(6), P. 773 - 781
Published: Oct. 20, 2024
Language: Английский
Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 102(6), P. 733 - 750
Published: April 11, 2024
Abstract The accumulation of senescent cells within tissues is a hallmark the aging process. Senescent are also commonly present in many age-related diseases and cancer microenvironment. escape abnormal from immune surveillance indicates that there some defect function cytotoxic cells, e.g., CD8 + T natural killer (NK) cells. Recent studies have revealed expression programmed death-ligand 1 (PD-L1) protein abundantly increased An increase amount PD-L1 protects clearance by PD-1 checkpoint receptor In fact, activation suppresses properties NK promoting state immunosenescence. inhibitory PD-1/PD-L1 pathway acts cooperation with immunosuppressive cells; for example, can enhance differentiation regulatory (Treg), myeloid-derived suppressor (MDSC), M2 macrophages, whereas cytokines secreted stimulate protein. Interestingly, signaling pathways known to promote cellular senescence process crucial stimulators protein, epigenetic regulation, inflammatory mediators, mTOR-related signaling, cGAS-STING pathway, AhR signaling. It seems axis has role thus it promotes tissues. Thus, blockade might be potential anti-aging senolytic therapy. Key messages accumulate during diseases. able Expression markedly increases Age-related stimulates Inhibitory
Language: Английский
Citations
23
Cancer Letters, Journal Year: 2024, Volume and Issue: 593, P. 216969 - 216969
Published: May 19, 2024
Language: Английский
Citations
11
Livers, Journal Year: 2025, Volume and Issue: 5(1), P. 5 - 5
Published: Jan. 27, 2025
Liver fibrosis is a very complicated dynamic process where several immune cells are involved. Both innate and adaptive immunity implicated, their interplay always present. Multi-directional interactions between liver macrophages, hepatic stellate (HSCs), cells, cytokines important for the induction perpetuation of fibrosis. Detailed studies proteomics transcriptomics have produced new evidence role individual in cirrhosis. Most these controlled by various checkpoints whose main function to maintain homeostasis implicated cells. Recent indicates that involved In particular, programmed cell death protein 1 (PD-1), death-ligand (PD-L1), cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) been investigated, particularly after availability checkpoint inhibitors. Their activation leads exhaustion CD4+ve CD8+ve promotion this review, current pathogenesis immunological abnormalities discussed. The recent data on involvement identified as possible targets future interventions.
Language: Английский
Citations
1
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102694 - 102694
Published: Feb. 1, 2025
Language: Английский
Citations
1
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 97, P. 102296 - 102296
Published: April 7, 2024
Fibroblasts are abundant stromal cells which not only control the integrity of extracellular matrix (ECM) but also act as immune regulators. It is known that structural within tissues can establish an organ-specific immunity expressing many immune-related genes and closely interact with cells. In fact, fibroblasts modify their properties to display both pro-inflammatory immunosuppressive activities in a context-dependent manner. After acute insults, promote tissue inflammation although they concurrently recruit enhance resolution inflammation. chronic pathological states, fibroblasts, especially senescent stimulate different return, cells, such M2 macrophages myeloid-derived suppressor (MDSC), evoke excessive conversion into myofibroblasts, thus aggravating severity fibrosis. Single-cell transcriptome studies on isolated from aged have confirmed express coding for cytokines, chemokines, complement factors, whereas lose some fibrogenic properties. The versatile close cooperation indicate crucial role aging process age-related diseases.
Language: Английский
Citations
8
Biomaterials Research, Journal Year: 2024, Volume and Issue: 28
Published: Jan. 1, 2024
Language: Английский
Citations
6
Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 630 - 630
Published: March 12, 2024
Pulmonary fibrosis is an irreversible condition that may be caused by known (including viral triggers such as SARS-CoV-2) and unknown insults. The latter group includes idiopathic pulmonary (IPF), which a chronic, progressive fibrosing interstitial pneumonia of cause. longer the insult acts on lung tissue, lower probability complete resolution damage. An emerging clinical entity post-COVID-19 (PCPF), shares many pathological, clinical, immunological features with IPF. fibrotic response in both diseases-IPF PCPF-is orchestrated part immune system. important role regarding inhibitory or stimulatory effects responses exerted checkpoints (ICs). aim present study was to analyse similarities differences between CD4+, CD8+, NK cells peripheral blood patients affected disease, IPF, PCPF compared sarcoidosis healthy controls. second evaluate expression co-expression PD-1 TIGIT CD4, CD8, from our patient cohort.
Language: Английский
Citations
5
Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(5), P. 593 - 603
Published: June 25, 2024
Summary Background and Aims For chronic hepatitis B (CHB) patients, there is still a need to improve surface antigen (HBsAg) clearance rates. This study aimed assess the predictive effectiveness of soluble programmed cell death‐1 (sPD‐1) death ligand‐1 (sPD‐L1) for HBsAg in HBeAg‐negative CHB patients undergoing peginterferon (Peg‐IFN)‐based antiviral treatment. Methods encompassed 280 treatment with Peg‐IFNα. Serum levels sPD‐1 sPD‐L1 were measured using ELISA kits at baseline, as well 12, 24 48 weeks. The primary endpoint was determination Logistic regression analysis employed identify predictors clearance. Results group demonstrated significantly lower serum compared non‐clearance group. While both groups exhibited an increase levels, only showed rise levels. Multivariate identified weeks, decline weeks combined use these indicators performance AUROC 0.907 (95% CI: 0.861–0.953, p < 0.001). Conclusions revealed inverse relationship between trends sPD‐1/sPD‐L1 during IFN NAs Moreover, magnitude reduction emerged significant
Language: Английский
Citations
4
Biogerontology, Journal Year: 2024, Volume and Issue: 25(5), P. 749 - 773
Published: July 1, 2024
Abstract The accumulation of pro-inflammatory senescent cells within tissues is a common hallmark the aging process and many age-related diseases. This modification has been called senescence-associated secretory phenotype (SASP) observed in cultured isolated from aged tissues. Currently, there debate whether should be attributed to increased generation or defect their elimination Emerging studies have revealed that display an expression several inhibitory immune checkpoint ligands, especially those programmed cell death protein-1 (PD-1) ligand-1 (PD-L1) proteins. It known PD-L1 cancer cells, target PD-1 receptor cytotoxic CD8 + T natural killer (NK) disturbing functions, e.g., evoking decline activity promoting exhaustion even apoptosis. An increase level protein was able suppress surveillance inhibit by NK cells. Senescent are express ligands for receptors, i.e., PD-1, LILRB4, NKG2A, TIM-3, SIRPα receptors. Here, I will briefly describe pathways examine these checkpoints could involved evasion with seems plausible enhanced signaling can prevent thus promote process.
Language: Английский
Citations
3
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113186 - 113186
Published: Sept. 19, 2024
Language: Английский
Citations
3