Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 2327 - 2346
Published: June 1, 2024
Vascular calcification is a major cause of cardiovascular accidents in patients with type 2 diabetes mellitus. This study aimed to investigate the impact carbohydrates on gut microbiota and aortic diabetic ApoE
Language: Английский
Microorganisms, Journal Year: 2022, Volume and Issue: 10(12), P. 2507 - 2507
Published: Dec. 18, 2022
Dietary fiber is fermented by the human gut microbiota, producing beneficial microbial metabolites, such as short-chain fatty acids. Over last few centuries, dietary intake has decreased tremendously, leading to detrimental alternations in microbiota. Such changes consumption have contributed global epidemic of obesity, type 2 diabetes, and other metabolic disorders. The responses microbiota are specific type, amount, duration intake. intricate interplay between may provide clues for optimal intervention strategies patients with diabetes noncommunicable diseases. In this review, we summarize current evidence regarding intake, modulation, modification health, highlighting type-specific cutoff thresholds outcomes.
Language: Английский
Citations
134
Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 20(1), P. 27 - 49
Published: Oct. 16, 2023
Language: Английский
Citations
98
Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1714 - 1714
Published: June 30, 2023
Recently, probiotics are increasingly being used for human health. So far, only lactic acid bacteria isolated from the gastrointestinal tract were recommended use as probiotics. However, more authors suggest that can be also unconventional sources, such fermented food products of animal and plant origin. Traditional a rich source microorganisms, some which may have probiotic properties. A novel category recently microorganisms with great potential health benefits next-generation (NGPs). In this review, general information "beneficial microbes", including NGPs acetic bacteria, presented well essential mechanisms microbe host interactions. Many reports showed NGP selected strains sources exhibit positive properties when it comes to (i.e., they effect on metabolic, gastrointestinal, neurological, cardiovascular, immune system diseases). Here we briefly present current regulatory framework requirements should followed introduce new use. The term "probiotic" herein is not limited conventional Innovation will undoubtedly result in isolation fascinating advantages hitherto unforeseen functionalities.
Language: Английский
Citations
29
Foods, Journal Year: 2024, Volume and Issue: 13(6), P. 853 - 853
Published: March 11, 2024
Polysaccharides are functional foods or drugs that can be used to alleviate heavy metal poisoning by cadmium, lead, mercury, and arsenic. Industries generate substantial quantities of toxic wastes, such as wastewater discharges, paints, electronic waste, batteries, pigments, plastics, into the environment pose a risk human health. Therefore, it is imperative eliminate accumulated ions from body environment. Heavy toxicity lead decreased energy levels impair functioning vital organs, brain, lungs, kidneys, liver, blood. Prolonged exposure result in progressive physical, muscular, neurological degeneration resembles conditions multiple sclerosis, Parkinson’s disease, Alzheimer’s muscular dystrophy. operate through mechanisms chelation, antioxidant defense, immunomodulation, tissue repair. involved removal include methionine cysteine, together with N-acetylcysteine, an acetylated form S-adenosylmethionine, metabolite methionine, α-lipoic acid, tripeptide glutathione (GSH). These compounds effectively bind harmful metals create stable complex defend biological targets ions, thus decreasing their effects causing them excreted body. This review also highlights importance polysaccharides’ ability mitigate oxidative stress, enhance immune responses, support repair processes. ubiquitous nature take part diverse processes, making potential natural therapies for metal-related diseases. discusses effectiveness polysaccharides allow have inherent features enable function pharmacological agents regulate response.
Language: Английский
Citations
12
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3540 - 3540
Published: March 21, 2024
The intestinal microbiota refers to the collection of microorganisms that exist in human gut. It has been said bacteria influence development metabolic diseases, such as diabetes mellitus, they have roles immunomodulation, protection against pathogens, blood vessel growth, repairing wall, and neurological system. In this review, we look at latest research regarding interactions between gut oral antihyperglycemic drugs present data suggesting microbiome may help counteract reduced glucose tolerance insulin resistance associated with disorders. We found antidiabetic can significant impacts on composition function, potentially influencing both efficacy side effects these medications. Additionally, discovered microbial-based therapeutics, including probiotics, prebiotics, postbiotics, fecal be considered when discussing preventive measures personalized treatment options for type 2 mellitus. Understanding how modulate function is essential optimizing their therapeutic minimizing potential adverse effects. relationship glycemic agents, not fully understood, currently subject increasing discussion. proven impact effectiveness medications, but further field uncover novel strategies other disorders by targeting microbiota.
Language: Английский
Citations
10
Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 127 - 127
Published: Feb. 13, 2025
Numerous recent studies have suggested that the composition of intestinal microbiota can trigger metabolic disorders, such as diabetes, prediabetes, obesity, syndrome, sarcopenia, dyslipidemia, hyperhomocysteinemia, and non-alcoholic fatty liver disease. Since then, considerable effort has been made to understand link between well role probiotics in modulation microbiota. The aim this review was summarize reviews individual articles on state art regarding ideal therapy with prebiotics order obtain reversion dysbiosis (alteration microbiota) eubiosis during diseases, diseases. This includes 245 eligible studies. In conclusion, a condition dysbiosis, or general, alteration microbiota, could be implicated development disorders through different mechanisms, mainly linked release pro-inflammatory factors. Several already demonstrated potential using treatment condition, detecting significant improvements specific symptoms These findings reinforce hypothesis lead generalized inflammatory picture negative consequences organs systems. Moreover, confirms beneficial effects diseases are promising, but more research is needed determine optimal probiotic strains, doses, administration forms for conditions.
Language: Английский
Citations
1
Diagnostics, Journal Year: 2024, Volume and Issue: 14(6), P. 614 - 614
Published: March 14, 2024
The incidence of pancreatitis and pancreatic cancer is on the upswing in USA. These conditions often lead to higher healthcare costs due complex nature diagnosis need for specialized medical interventions, surgical procedures, prolonged management. economic ramification encompasses direct expenses indirect related productivity losses, disability, potential long-term care requirements. Increasing evidence underscores importance a healthy lifestyle preventing managing these conditions. Lifestyle medicine employs evidence-based interventions promote health through six key pillars: embracing whole-food, plant-predominant dietary pattern; regular physical activity; ensuring restorative sleep; stress effectively; removing harmful substances; fostering positive social connections. This review provides comprehensive overview development cancer.
Language: Английский
Citations
4
Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 16, 2023
Weining cattle is a precious species with high tolerance to cold, disease, and stress, accounts for large proportion of agricultural economic output in Guizhou, China. However, there are gaps information about the intestinal flora cattle. In this study, high-throughput sequencing were employed analyze (WN), Angus (An), diarrheal (DA), explore potential bacteria associated diarrhea. We collected 18 fecal samples from Weining, including cattle, Healthy Angus, Diarrheal Angus. The results microbiota analysis showed no significant differences diversity richness among groups (p > 0.05). abundance beneficial (Lachnospiraceae, Rikenellaceae, Coprostanoligenes, Cyanobacteria) significantly higher than < pathogens Anaerosporobacter Campylobacteria enriched DA group. Furthermore, Lachnospiraceae was very WN group 0.05), which might explain why less prone This first report on furthering understanding relationship between health.
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7184 - 7184
Published: April 13, 2023
As the pathophysiologic mechanisms of type 2 diabetes mellitus (T2DM) are discovered, there is a switch from glucocentric to more comprehensive, patient-centered management. The holistic approach considers interlink between T2DM and its complications, finding best therapies for minimizing cardiovascular (CV) or renal risk benefitting treatment‘s pleiotropic effects. Sodium-glucose cotransporter inhibitors (SGLT-2i) glucagon-like peptide-1 receptor agonists (GLP-1 RA) fit in because their effects reducing CV events obtaining better metabolic control. Additionally, research on SGLT-2i GLP-1 RA modification gut microbiota accumulating. plays significant role relation diet disease some intestinal bacteria lead an increase short-chain fatty acids (SCFA) consequent positive Thus, our review aims describe antidiabetic non-insulin therapy (SGLT-2i with CV-proven benefits patients T2DM. We identified five randomized clinical trials including dapagliflozin, empagliflozin, liraglutide, loxenatide, different results. There were differences empagliflozin metformin regarding despite similar glucose control both study groups. One demonstrated that liraglutide induced alterations treated initially metformin, but another failed detect any when same molecule was compared sitagliptin. established protection exert could be partly due action microbiota. individual cumulative drugs need further research.
Language: Английский
Citations
11
Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 11(3)
Published: May 4, 2023
MALDI-TOF MS is well-recognized for single microbial identification and widely used in research clinical fields due to its specificity, speed of analysis, low cost consumables. Multiple commercial platforms have been developed approved by the U.S. Food Drug Administration. Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) has identification. However, microbes can present as a specific microbiota, detection classification remain challenge. Here, we constructed several microbiotas tried classify them using MS. Different concentrations nine bacterial strains (belonging eight genera) constituted 20 microbiotas. Using MS, overlap spectrum each microbiota (MS spectra with component percentages) could be classified hierarchical clustering analysis (HCA). real was different than that bacteria. The showed excellent repeatability were easier HCA, an accuracy close 90%. These results indicate method individual bacteria expanded microbiota. IMPORTANCE model actual not simple superposition every bacterium certain proportion but had spectral fingerprint. specificity this fingerprint enhance classification.
Language: Английский
Citations
10