Cell-derived biomimetic drug delivery system for inflammatory bowel disease therapy DOI Creative Commons
Wenjing Yang, Peihong Lin, Rui Gao

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101332 - 101332

Published: Nov. 8, 2024

Inflammatory bowel disease (IBD) is a chronic recurrent with an increasing incidence year by year. At present, no safe and effective treatment for IBD exists. Thus, there urgent need to create new therapeutic options that have decreased adverse effects positive clinical efficacy. A range of nanomaterials fueled the advancement nanomedicine in recent years, which establishing more appealing prospective approaches IBD. However, traditional synthetic still some problems drug delivery process, such as weak targeting ability vectors, difficulty escaping immune surveillance, poor biosecurity. Natural sources biological been identified solve above problems. system based on bionic technology expected achieve breakthrough targeted therapy nanotechnology due its organic integration low immunogenicity natural materials controllability versatility nanocarrier design. We begin this review outlining fundamental traits both inflammatory healthy intestinal microenvironments. Subsequently, we latest application cell-derived therapy. Finally, discuss development prospects challenges translation. Biomimetic nanotherapy believed offer strategy

Language: Английский

Cell membrane-coated nanomaterials for cancer therapy DOI Creative Commons
Shiying Zeng,

Qinglai Tang,

Minna Xiao

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100633 - 100633

Published: April 12, 2023

With the development of nanotechnology, nanoparticles have emerged as a delivery carrier for tumor drug therapy, which can improve therapeutic effect by increasing stability and solubility prolonging half-life drugs. However, are foreign substances humans, easily cleared immune system, less targeted to tumors, may even be toxic body. As natural biological material, cell membranes unique properties, such good biocompatibility, strong targeting ability, ability evade surveillance, high drug-carrying capacity. In this article, we review membrane-coated (CMNPs) their applications therapy. First, briefly describe CMNP characteristics applications. Second, present advantages different well nanoparticles, provide brief description process CMNPs, discuss current status application summarize shortcomings use in cancer propose future research directions. This summarizes progress on CMNPs therapy recent years assesses remaining problems, providing scholars with new ideas

Language: Английский

Citations

53
Rational Designs of Biomaterials for Combating Oral Biofilm Infections DOI

Zhengrong Yin,

Yaxi Liu,

Annikaer Anniwaer

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 11, 2023

Oral biofilms, which are also known as dental plaque, the culprit of a wide range oral diseases and systemic diseases, thus contributing to serious health risks. The manner how achieve good control biofilms has been an increasing public concern. Novel antimicrobial biomaterials with highly controllable fabrication functionalization have proven be promising candidates. However, previous reviews generally emphasized physicochemical properties, action mode, application effectiveness those biomaterials, whereas insufficient attention given design rationales tailored different infection types scenarios. To offer guidance for better diversification anti-oral-biofilm this review details up-to-date in three aspects: core strategies combating biofilm, well advanced antibiofilm capacity multiple functions based on improvement or combination abovementioned strategies. Thereafter, insights existing challenges future biomaterial-assisted biofilm treatments proposed, hoping provide theoretical basis reference subsequent biomaterials.

Language: Английский

Citations

30
Chitosan in Oral Drug Delivery Formulations: A Review DOI Creative Commons
Tanikan Sangnim, Divya Dheer,

Nitin Jangra

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2361 - 2361

Published: Sept. 21, 2023

Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common method, although it not always effective route because of challenges with swallowing, gastrointestinal discomfort, low solubility, and poor absorption. One significant barriers that medications must overcome to exert a therapeutic effect impact first hepatic transit. Studies shown controlled-release systems using nanoparticles composed biodegradable natural polymers significantly improve administration, which why these materials attracted attention. Chitosan possesses wide variety properties functions pharmaceutical well healthcare industries. Drug encapsulation transport within body are two its important features. Moreover, chitosan can enhance efficacy by facilitating interaction target cells. Based on physicochemical properties, potentially be synthesized into nanoparticles, this review summarizes advances applications orally delivered nanoparticle interventions.

Language: Английский

Citations

25
Cell Membrane‐Coated Nanoparticles: A New Frontier in Immunomodulation DOI Creative Commons
Nimeet Desai, Vishakha Tambe, Prasad Pofali

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(8)

Published: May 31, 2024

Immune dysregulation is a pivotal factor in the onset and progression of various diseases. In cancer, immune system's inability to discern eliminate abnormal cells leads uncontrolled tumor growth. When faced with resilient pathogens or harmful toxins, system encounters challenges clearance neutralization. Achieving delicate balance pro‐inflammatory anti‐inflammatory signals essential managing range disorders Like other biomedical research domains, nanotechnology has provided innovative approaches for rebalancing host immunity. Among plethora nanotechnology‐based interventions, concept cell membrane‐coated nanoparticles holds significant potential immunomodulatory applications owing their biomimetic properties that allow precise interaction compromised system. This review thoroughly examines novel nanosystems modulation. The exploration covers crucial elements, including origins characteristics membranes, methods employed procurement coating, physicochemical/biological characterization techniques, enhancement therapeutic efficacy via functionalization. Subsequently, case studies‐based analysis utilizing these bioinspired tackling different conditions caused by disturbance been comprehensively discussed.

Language: Английский

Citations

12
Cell membrane-coated nanoparticles for targeting carcinogenic bacteria DOI
Lei Sun, Dan Wang,

Kailin Feng

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 209, P. 115320 - 115320

Published: April 21, 2024

Language: Английский

Citations

9
Supercharged precision killers: Genetically engineered biomimetic drugs of screened metalloantibiotics against Acinetobacter baumanni DOI Creative Commons
Xianyuan Wei, Bin Xue, Shuangchen Ruan

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(12)

Published: March 22, 2024

To eliminate multidrug-resistant bacteria of Acinetobacter baumannii , we screened 1100 Food and Drug Administration–approved small molecule drugs accessed the broxyquinoline (Bq) efficacy in combination with various metal ions. Antibacterial tests demonstrated that prepared Zn(Bq) 2 complex showed ultralow minimum inhibitory concentration ~0.21 micrograms per milliliter no resistance after 30 passages. We then constructed nano zeolitic imidazolate framework-8 (ZIF-8) as a drug carrier also incorporated photosensitizer chlorin e6 (Ce6) to trace boost antibacterial effect. further ensure stable targeted delivery, genetically engineered outer membrane vesicles (OMVs) ability selectively target A. . By coating ZnBq/Ce6@ZIF-8 core these OMV, resulted (ZnBq/Ce6@ZIF-8@OMV) exhibited exceptional killing (>99.9999999%) In addition, vitro vivo were respectively carried out inspect remarkable this previously unknown nanodrug eradicating infections, including biofilms meningitis.

Language: Английский

Citations

7
Biomimetic Metal–Organic Framework Gated Nanoplatform for Sonodynamic Therapy against Extensively Drug Resistant Bacterial Lung Infection DOI Creative Commons
Jianling Huang,

Xiuwen Hong,

Sixi Chen

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: July 4, 2024

Novel antimicrobial strategies are urgently needed to treat extensively drug-resistant (XDR) bacterial infections due the high mortality rate and lack of effective therapeutic agents. Herein, nanoengineered human umbilical cord mesenchymal stem cells (hUC-MSCs), named PMZMU, designed as a sonosensitizer for synergistic sonodynamic-nano-antimicrobial therapy against gram-negative XDR bacteria. PMZMU is composed targeting peptide (UBI

Language: Английский

Citations

5
Cell membrane nanomaterials composed of phospholipids and glycoproteins for drug delivery in inflammatory bowel disease: A review DOI
Pengyu Lei,

Haiyang Yu,

Jiahui Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 249, P. 126000 - 126000

Published: July 31, 2023

Language: Английский

Citations

12
Recent advances in cell membrane camouflaged nanotherapeutics for the treatment of bacterial infection DOI

Yinan Jia,

Li Zhang, Junhua Xu

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(4), P. 042006 - 042006

Published: May 2, 2024

Abstract Infectious diseases caused by bacterial infections are common in clinical practice. Cell membrane coating nanotechnology represents a pioneering approach for the delivery of therapeutic agents without being cleared immune system meantime. And mechanism infection treatment should be divided into two parts: suppression pathogenic bacteria and excessive response. The membrane-coated nanoparticles exert anti-bacterial function neutralizing exotoxins endotoxins, some other proteins. Inflammation, second procedure infection, can also suppressed through targeting inflamed site, neutralization toxins, pro-inflammatory cytokines. platelet affect complement process to suppress inflammation. Membrane-coated treat combined action membranes nanoparticles, diagnose imaging, forming theranostic system. Several strategies have been discovered enhance anti-bacterial/anti-inflammatory capability, such as synthesizing material electroporation, pretreating with corresponding pathogen, hybridization, or incorporating genetic modification, lipid insertion, click chemistry. Here we aim provide comprehensive overview current knowledge regarding application preventing well addressing existing uncertainties misconceptions.

Language: Английский

Citations

4
Synthesis and Characterization of SiO2 Nanoparticles for Application as Nanoadsorbent to Clean Wastewater DOI Open Access
Nora Elizondo Villarreal,

Eleazar Gándara-Martínez,

Manuel García-Méndez

et al.

Coatings, Journal Year: 2024, Volume and Issue: 14(7), P. 919 - 919

Published: July 22, 2024

By way of the sol–gel chemical synthesis method, it is possible to synthesize SiO2 nanoparticles with a defined specific particle size, surface area, and crystal structure that can be effectively used as nanoadsorbent remove various organic dyes. were synthesized by method using sodium silicate (Na2SiO3) green without tetraethyl orthosilicate (TEOS) precursor, which very expensive highly toxic. This process involves formation colloidal suspension (sol) solid gelation form network in continuous liquid phase (gel). In addition, requires controlled atmospheres. XRD indicates presence an amorphous diffraction angle 2θ = 23°, associated SiO2. UV-Vis spectroscopy reveals absorbance value region 200 nm 300 nm, nanoparticles. The application dyes was measured, found best performance those pH 7, showing 97% removal 20 mg 60 min. Therefore, nanoadsorbent, low-cost scalable for methylene blue aqueous medium.

Language: Английский

Citations

4