Glymphatic system impairment in Alzheimer’s disease: associations with perivascular space volume and cognitive function

European Radiology, Journal Year: 2023, Volume and Issue: 34(2), P. 1314 - 1323

Published: Aug. 23, 2023

Language: Английский

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Altered Brain Glymphatic Flow at Diffusion-Tensor MRI in Rapid Eye Movement Sleep Behavior Disorder

Radiology, Journal Year: 2023, Volume and Issue: 307(5)

Published: May 9, 2023

Background Brain glymphatic dysfunction may contribute to the development of α-synucleinopathies. Yet, noninvasive imaging and quantification remain lacking. Purpose To examine function brain in isolated rapid eye movement sleep behavior disorder (RBD) its relevance phenoconversion with use diffusion-tensor (DTI) analysis along perivascular space (ALPS). Materials Methods This prospective study included consecutive participants diagnosed RBD, age- sex-matched control participants, Parkinson disease (PD) who were enrolled examined between May 2017 April 2020. All underwent 3.0-T MRI including DTI, susceptibility-weighted susceptibility map–weighted imaging, and/or dopamine transporter using iodine 123–2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane SPECT at time participation. Phenoconversion status α-synucleinopathies was unknown MRI. Participants regularly followed up monitored for any signs The ALPS index reflecting activity calculated by a ratio diffusivities x-axis projection association neural fibers perpendicular them compared according groups Kruskal-Wallis Mann-Whitney U tests. risk RBD evaluated Cox proportional hazards model. Results Twenty (12 men; median age, 73 years [IQR, 66–76 years]), 20 PD included. lower group versus controls (1.53 vs 1.72; P = .001) but showed no evidence difference (1.49; .68). conversion decreased an increasing (hazard ratio, 0.57 per 0.1 increase [95% CI: 0.35, 0.93]; .03). Conclusion DTI-ALPS demonstrated more severe reduction individuals © RSNA, 2023 Supplemental material is available this article. See also editorial Filippi Balestrino issue.

Language: Английский

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Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method

Magnetic Resonance in Medical Sciences, Journal Year: 2024, Volume and Issue: 23(3), P. 268 - 290

Published: Jan. 1, 2024

More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.

Language: Английский

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Neuroimaging uncovers distinct relationships of glymphatic dysfunction and motor symptoms in Parkinson’s disease

Journal of Neurology, Journal Year: 2023, Volume and Issue: 270(5), P. 2649 - 2658

Published: March 1, 2023

Language: Английский

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Regional Glymphatic Abnormality in Behavioral Variant Frontotemporal Dementia

Annals of Neurology, Journal Year: 2023, Volume and Issue: 94(3), P. 442 - 456

Published: May 27, 2023

Glymphatic function has not yet been explored in behavioral variant frontotemporal dementia (bvFTD). The spatial correlation between regional glymphatic and bvFTD remains unknown.

Language: Английский

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Perivascular Spaces, Glymphatic System and MR

Frontiers in Neurology, Journal Year: 2022, Volume and Issue: 13

Published: May 3, 2022

The importance of the perivascular space (PVS) as one imaging markers cerebral small vessel disease (CSVD) has been widely appreciated by neuroradiologists. PVS surrounds blood vessels in brain and a signal consistent with cerebrospinal fluid (CSF) on MR. In variety physio-pathological statuses, may expand. discovery glymphatic system provided revolutionary perspective to elucidate its pathophysiological mechanisms. Research function pathogenesis this become prevalent topic among It is now believed that carries out similar functions lymphatic other parts body plays an important role removal metabolic waste maintenance homeostatic circulation brain. article, we will briefly describe composition system, influencing factors, MR manifestations related technological advances. aim research provide reference for future clinical studies system.

Language: Английский

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Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson’s Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 12928 - 12928

Published: Oct. 26, 2022

Parkinson’s disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative and the most prevalent disorder after Alzheimer’s with high incidence rate in elderly population. PD highly multifactorial etiology has complex wide-ranging pathogenic mechanisms. Environmental exposures genetic predisposition are prominent risk factors. However, current evidence suggests that an intimate link may exist between factor of sleep disturbance pathogenesis. characterized by pathological hallmarks alpha-synuclein aggregations dopaminergic neuron degeneration substantia nigra. The loss dopamine-producing neurons results both motor non-motor symptoms, commonly, bradykinesia, tremor, rigidity, psychiatric disorders, disorders gastrointestinal problems. Factors exacerbate accumulation dopamine include neuroinflammation glymphatic system impairment. Extracellular can induce inflammatory response which lead to neural cell death inhibition neurogenesis. functions optimally remove extracellular brain solutes during therefore disruption be crucial progression as well factor. This literature review interprets analyses data from experimental epidemiological studies determine recent advances establishing relationship dysfunction, disturbance, pathogenesis progression. addresses limitations surrounding ability affirm causal improved clearance increased quality prevention management. Furthermore, this proposes potential therapeutic approaches could utilize protective mechanism sleep, promote reduce symptom severity patients.

Language: Английский

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Diffusion along perivascular spaces provides evidence interlinking compromised glymphatic function with aging in Parkinson's disease

CNS Neuroscience & Therapeutics, Journal Year: 2022, Volume and Issue: 29(1), P. 111 - 121

Published: Oct. 2, 2022

The aim of the study was to evaluate glymphatic function and its related factors in patients with Parkinson's disease (PD) PD different ages using diffusion tensor image analysis along perivascular space (DTI-ALPS) method.Medical records imaging data 93 idiopathic 42 age- sex-matched healthy controls (HCs) were retrospectively reviewed analyzed. diffusivity spaces, projection fibers, association fibers calculated on (DTI) acquire (ALPS) index.PD exhibited a reduced ALPS index compared HCs. Negative correlations between clinical information including age, age at onset, sleep scale 2nd version (PDSS-2) scores, history diabetes mellitus revealed group. Besides, negative correlation severity motor symptoms identified subgroup aged 65 above, rather than younger ones.The results demonstrate that index, potential noninvasive measure compromised activity, is involved pathophysiology PD, especially ones those disorders.

Language: Английский

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Relationships Between the Deposition of Amyloid-β and Tau Protein and Glymphatic System Activity in Alzheimer’s Disease: Diffusion Tensor Image Study

Journal of Alzheimer s Disease, Journal Year: 2022, Volume and Issue: 90(1), P. 295 - 303

Published: Sept. 16, 2022

Amyloid-β (Aβ) and tau protein accumulation in the brain is thought to be one of causes Alzheimer's disease (AD). Recent study found that glymphatic system was waste drainage promoting elimination Aβ protein.We evaluated relationships between activity deposition.Subjects were 21 patients with AD 36 healthy subjects who underwent diffusion tensor imaging (DTI) scan positron emission tomography (PET) using tracer: 11C-PiB tau/inflammatory 18F-THK5351. We computed image analysis along perivascular space (DTI-ALPS) index as proxy activity, estimated DTI-ALPS protein/inflammatory deposition.We significant negative correlations standard uptake value ratio (SUVR) bilateral temporal left parietal cortices posterior cingulate gyrus all subjects. Further, we detected SUVR 18F-THK5351 right cortex participants, too.Our data suggested a good biomarker for evaluation deposition neuroinflammation, this marker might effective estimate activity.

Language: Английский

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Diffusion-weighted image analysis along the perivascular space (DWI–ALPS) for evaluating interstitial fluid status: age dependence in normal subjects

Japanese Journal of Radiology, Journal Year: 2022, Volume and Issue: 40(9), P. 894 - 902

Published: April 27, 2022

The purpose of this study was to evaluate the interstitial fluid status in a wide range age groups using diffusion-weighted image analysis along perivascular space (DWI-ALPS) method, which is simplified variation diffusion tensor (DTI-ALPS).This retrospective included data from 128 patients who underwent clinical magnetic resonance imaging (MRI) studies, including DWI, and were found have no abnormal findings brain on MRI. Three motion-probing gradients DWI applied an orthogonal direction plane. Apparent coefficient images x-, y-, z-axes retrospectively generated, composite color created locate projection association fiber area slice body lateral ventricle. ALPS indices calculated, correlations with evaluated linear second-degree regression analysis. Linear also performed for subgroup older than 40 years. In addition, variance (ANOVA) test among generations performed.The between index showed correlation -0.20 all group -0.51 0.39. ANOVA that 40's generation statistically significant higher value compared other except 30's generation. While, 70's lower generations.The DWI-APLS method distribution peaked This finding normal subjects may be fundamental disease cases. We tried glymphatic system results

Language: Английский

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