40Hz Auditory Entrainment Promotes Synchronization Between Frontal and Parietal Regions of the Brain DOI
Mojtaba Lahijanian, Hamid Aghajan

Published: May 9, 2023

Gamma oscillations are known to play a critical role in memory and cognition tasks. The quality of neural activity this oscillatory band is impaired due Alzheimer's disease (AD) dementia. Recently, promoting gamma through sensory stimulation has shown promising therapeutic results reducing structural cognitive symptoms AD. Further analysis on the effects entrainment brain's could help better understand mechanisms underlying observed improvements optimize protocols for achieving outcome. In study, we investigate 40Hz auditory brain synchronizing frontoparietal based electroencephalogram data recorded from cohort elderly participants with complaints. We that entrained encompasses entire scalp most responsive regions frontal parietal lobes. addition, synchronized synchronization correlated strength entrainment. other word, highly sites cortices present between these two regions. Long distance across can improve functional connectivity disrupted network-level coordination responsible high-level operations.

Language: Английский

Auditory or Audiovisual Stimulation Ameliorates Cognitive Impairment and Neuropathology in ApoE4 Knock-In Mice DOI Open Access
Harry Jung,

Yeonkyeong Lee,

Sang‐Hwa Lee

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 938 - 938

Published: Jan. 4, 2023

We hypothesized that auditory stimulation could reduce the progression of Alzheimer’s disease (AD), and audiovisual have additional effects through multisensory integration. exposed 12 month old Apoetm1.1(APOE*4)Adiuj mice (a mouse model sporadic AD) to (A) or (AV) at 40 Hz for 14 days in a soundproof chamber system (no stimulation, N). Behavioral tests were performed before after each session, their brain tissues assessed amyloid-beta expression apoptotic cell death, days. Furthermore, levels acetylcholine apoptosis-related proteins analyzed. In Y-maze test, percentage relative alternation was significantly higher group A than N mice. Amyloid-beta TUNEL positivity hippocampal CA3 region lower AV (p < 0.05). Acetylcholine Compared mice, proapoptotic Bax caspase-3 A, antiapoptotic protein Bcl-2 AV. early-stage AD, improved cognitive performance neuropathology.

Language: Английский

Citations

7
Forty-Hertz audiovisual stimulation does not have a promoting effect on visual threshold and visual spatial memory DOI Creative Commons

Pin-Cheng Hsiung,

Po-­Jang Hsieh

Journal of Vision, Journal Year: 2024, Volume and Issue: 24(2), P. 8 - 8

Published: Feb. 23, 2024

Previous research has demonstrated that 40-Hz audiovisual stimulation can improve pathological conditions and promote cognitive function in mouse models of Alzheimer's disease. However, limited been conducted on humans, the results have inconsistent. In our study, we divided participants into an experimental group a control to investigate whether could enhance performance visual threshold tasks working memory task. Experiment 1, used light bulb as stimulus source found general practice effect, but no difference between groups. 2, computer screen set frequency 48 Hz. 3 , audio sources, simultaneously applying both auditory modalities. Both experiments only revealed disappearance effects (48-Hz) group. 4 focused testing spatial memory, did not identify any significant differences or within 5, tested various frequencies; yet again, were found. Based comprehensive results, conclude does promoting effect memory.

Language: Английский

Citations

2
Rhythmic gamma frequency light flickering ameliorates stress-related behaviors and cognitive deficits by modulating neuroinflammatory response through IL-12-Mediated cytokines production in chronic stress-induced mice DOI

Junqi Yao,

Liming Zhang,

Chunkui Zhang

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 121, P. 213 - 228

Published: July 21, 2024

Language: Английский

Citations

2
The gamma rhythm as a guardian of brain health DOI Creative Commons

Ana Maria Ichim,

Harald Bârzan,

Vasile V. Moca

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Nov. 20, 2024

Gamma oscillations in brain activity (30–150 Hz) have been studied for over 80 years. Although the past three decades significant progress has made to try understand their functional role, a definitive answer regarding causal implication perception, cognition, and behavior still lies ahead of us. Here, we first review basic neural mechanisms that give rise gamma then focus on two main pillars exploration. The pillar examines major theories role information processing brain, also highlighting critical viewpoints. second reviews novel research direction proposes therapeutic oscillations, namely entrainment using sensory stimulation (GENUS). We extensively discuss both positive findings issues reproducibility GENUS. Going beyond gamma, propose third exploration, where generated endogenously by cortical circuits, is essential maintenance healthy circuit function. four classes interneurons, those expressing parvalbumin (PV), vasointestinal peptide (VIP), somatostatin (SST), nitric oxide synthase (NOS) take advantage endogenous perform active vasomotor control maintains homeostasis neuronal tissue. According this hypothesis, which call GAMER (GAmma MEdiated ciRcuit maintenance), act as ‘servicing’ rhythm enables efficient translation into vascular responses are optimal neurometabolic processes. an extension GENUS, rather than entrained plays fundamental role. Finally, several experiments test hypothesis.

Language: Английский

Citations

1
Sensory stimulation enhances visual working memory capacity DOI Creative Commons
Indre Pileckyte, Salvador Soto‐Faraco

Communications Psychology, Journal Year: 2024, Volume and Issue: 2(1)

Published: Nov. 18, 2024

Language: Английский

Citations

1
40 Hz sensory entrainment: Is real-time EEG a good indicator of future cognitive improvement? DOI

Prangya Parimita Sahu,

Yu‐Hui Lo, Philip Tseng

et al.

Neurological Sciences, Journal Year: 2023, Volume and Issue: 45(3), P. 1271 - 1274

Published: Oct. 31, 2023

Language: Английский

Citations

2
40 Hz Visual Stimulation Increases Neuronal Gamma Activity in NREM and REM Sleep DOI
Laura Hainke, James Dowsett, Manuel Spitschan

et al.

Published: Jan. 1, 2024

Background: Visual stimulation at 40 Hz is being tested as a non-invasive approach against neurodegeneration and cognitive decline in Alzheimer's Disease (AD). Applying it during sleep could increase convenience take advantage of the role neurotoxic molecule clearance, one posited mechanism for beneficial effects stimulation. The feasibility, however, unclear.Methods: 30 healthy participants underwent control experimental night polysomnography laboratory. visual was delivered through custom mask wakefulness (W), NREM stages 2 3, REM sleep.Findings: As expected, EEG spectral power increased all four condition, compared to control. It highest W similar across 2, REM, with large medium effect sizes, respectively. Steady-State Visually Evoked Potential (SSVEP) analyses time domain Signal-to-Noise Ratios confirmed specificity effect. Secondary revealed that intervention did not impair objective subjective quality beyond "first effect".Interpretation: effectively neuronal gamma activity frequency without degrading sleep. These findings lay grounds improving gamma-band sensory scalable, non-pharmaceutical add-on AD.Funding: NEUROTECH Innovation Network (IGSSE); DFG DO 2460/1-1; Max Planck Society.Declaration Interest: LH, MS, JD report no conflicts interest. JP receives consulting fees from Uniqure, involved patent application Epovariants, on advisory board Sinapps2, member following societies: DGPPN, DGGPP, DZPG, AND DZNE.Ethical Approval: study approved by ethical committee Technical University Munich complies Declaration Helsinki. Written informed consent obtained each participant. Participants were compensated 100 € upon completion.

Language: Английский

Citations

0
40 Hz Visual Stimulation During Sleep Evokes Neuronal Gamma Activity in NREM and REM Stages DOI Creative Commons
Laura Hainke, James Dowsett, Manuel Spitschan

et al.

SLEEP, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Study Objectives Visual stimulation (VS) at 40 Hz is being tested as a non-invasive approach against dementias such Alzheimer’s disease. Applying it during sleep could increase the convenience, duration, and efficacy of stimulation. Here, we feasibility VS in proof-of-concept study. Methods Thirty healthy participants underwent one control experimental night polysomnography laboratory. was delivered wakefulness (W), NREM stages 2 3, REM sleep. Results As expected, EEG spectral power increased all four condition, compared to control. It highest W similar across 2, REM, with large medium effect sizes, respectively. Steady-state visually evoked potential (SSVEP) analyses time domain confirmed specificity effect. Secondary revealed that intervention did not impair objective subjective quality beyond first-night Conclusions effectively neuronal gamma activity frequency without degrading quality, supporting this approach. These findings lay groundwork for optimizing gamma-band sensory tool causally study cognitive functions scalable, dementias.

Language: Английский

Citations

0
Imperceptible gamma-band sensory stimulation enhances episodic memory retrieval DOI Creative Commons
Benjamin Griffiths,

Daniel E. Weinert,

Ole Jensen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 25, 2023

Abstract Enhanced gamma activity (30-100Hz) coincides with the successful recall of episodic memories, but it remains unknown whether this oscillatory is a cause or consequence retrieval process. To address question, we asked human participants to complete paired associates memory task while undergoing sensory stimulation (at 65Hz, 43.3Hz and 32.5Hz). We observed that 65Hz 32.5Hz enhances compared baseline condition without stimulation. No similar effect was following Notably, almost all could perceive stimulation, only small proportion (∼10%) visual flicker, suggesting acts as an imperceptible intervention enhance recall. understand dual action on recall, built three pyramidal-interneuronal network (PING) models drove them using same protocols in behavioural task. The results be reproduced by stimulating endogenous ∼32Hz oscillation, not ∼65Hz oscillation nor oscillation. These suggest harmonically entraining ∼32.5Hz Based these findings, propose “slow” oscillations play causal role retrieval.

Language: Английский

Citations

1
Relaxing environments make people with high neuroticism more concentrated: An EEG study of auditory steady-state response DOI Creative Commons

Ayana Hashizume,

Masataka Yamamoto,

Hisanao Nakadai

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 15, 2024

Abstract Considering that new ways of working are increasing in modern society, where people can choose their own workspace, workers must understand the most suitable environment for concentration. Personality is crucial determining a and focused each individual. However, few studies have investigated relationship between personality environment, which it easy to concentrate using objective methods. We explored whether differences exist easily, depending on personalities. measured concentration auditory steady-state response, brain response sound. For Big Five factors, we compared after presenting videos simulating both relaxed tense environments with scores. The results indicated negative correlation neuroticism scores environment. People lower concentrated more while those higher These findings not only assist employees choosing workspace but also may support educational settings such as schools universities.

Language: Английский

Citations

0