Traditional Chinese Medicine in Alzheimer's Disease: From the Perspective of GSK-3β and Tau Hyperphosphorylation DOI Creative Commons
Mei Wang, Wendi Huang, Juan Huang

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 13, P. 100543 - 100543

Published: Nov. 6, 2024

Language: Английский

Insights from insulin resistance pathways: Therapeutic approaches against Alzheimer associated diabetes mellitus DOI
Ayesha Fauzi, Ewen Se Thoe, Yin-Quan Tang

et al.

Journal of Diabetes and its Complications, Journal Year: 2023, Volume and Issue: 37(11), P. 108629 - 108629

Published: Oct. 18, 2023

Language: Английский

Citations

9
Plasma Insulin Predicts Early Amyloid-β Pathology Changes in Alzheimer’s Disease DOI
Yuhan Chen, Zhibo Wang,

Xipeng Liu

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 100(1), P. 321 - 332

Published: June 7, 2024

Evidence suggests that type 2 diabetes (T2D) is an independent risk factor for Alzheimer's disease (AD), sharing similar pathophysiological traits like impaired insulin signaling.

Language: Английский

Citations

2
Rosmarinic Acid Improves Cognitive Abilities and Glucose Metabolism in Aged C57Bl/6N Mice While Disrupting Lipid Profile in Young Adults in a Sex-Dependent Fashion DOI Open Access
Chiara Musillo, Letizia Giona, Michael Ristow

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3366 - 3366

Published: July 28, 2023

A growing body of evidence suggests that regular consumption natural products might promote healthy aging; however, their mechanisms action are still unclear. Rosmarinic acid (RA) is a polyphenol holding anti-inflammatory, antioxidant and neuroprotective properties. The aim this study was to characterise the efficacy an oral administration RA in promoting healthspan mouse model physiological aging. Aged C57Bl/6 male female (24-month-old) mice were either administered with (500 mg/Kg) or vehicle drinking bottles for 52 days while 3-month-old receiving same treatment used as controls. All subjects assessed cognitive abilities Morris water maze (MWM) emotionality elevated-plus test (EPM). Brain-derived Neurotrophic Factor (BDNF) protein levels evaluated hippocampus. Since interaction between metabolic signals cerebral functions plays pivotal role etiopathogenesis decline, glycaemic lipid profiles also assessed. enhanced learning memory 24-month-old mice, effect associated improved glucose homeostasis. By contrast, profile disrupted young adults. This worse control males reduced BDNF females, suggesting powerful sex-dependent effects raising note caution adult subjects.

Language: Английский

Citations

5
Dendrobium nobile Lindl. alkaloid decreases Tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β pathway in vitro and in vivo DOI
Juan Huang, Nanqu Huang, Yu Qiu

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 322, P. 117592 - 117592

Published: Dec. 12, 2023

Language: Английский

Citations

5
Editorial: Investigating the impact of bioactive metabolites and extracts in human health and disease DOI Creative Commons
Sanjeev Kumar, Vibhav Gautam, Bhim Pratap Singh

et al.

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: Aug. 7, 2023

EDITORIAL article Front. Mol. Biosci., 07 August 2023Sec. Molecular Diagnostics and Therapeutics Volume 10 - 2023 | https://doi.org/10.3389/fmolb.2023.1244316

Language: Английский

Citations

4
Diversity of amyloid beta peptide actions DOI

Sona Mardanyan,

Svetlana Sharoyan, Alvard Antonyan

et al.

Reviews in the Neurosciences, Journal Year: 2024, Volume and Issue: 35(4), P. 387 - 398

Published: Jan. 28, 2024

Fibril formation by amyloidogenic proteins and peptides is considered the cause of a number incurable diseases. One most known amyloid diseases Alzheimer's disease (AD). Traditionally, beta Aβ40 Aβ42 (Aβs) are as main causes AD foremost targets in fight. The efforts pharmacology aimed at reducing Aβs concentration to prevent their accumulation, aggregation, senile plaques, neuronal death, neurodegeneration. However, publications have demonstrated certain beneficial physiological effects Aβs. Simultaneously, it indicated that turn into pathological due development body. accumulation C- N-terminal truncated under diverse conditions supposed play role development. significance transformation glutamate residue positions 3 or 11 catalyzed glutaminyl cyclase making them more degradation resistant, hydrophobic, prone well participation dipeptidyl peptidase IV these transformations discussed. experimental data presented confirm maintenance physiological, nonaggregated state plant preparations. In conclusion, this review suggests fight against AD, instead removing Aβs, preference should be given treatment common Glutaminyl can treatment. Flavonoids preparations possess antiamyloidogenic propensity proposed neuroprotective, anticancer, antidiabetic food additives.

Language: Английский

Citations

1
Effects of antidiabetic agents on platelet characteristics with implications in Alzheimer's disease: Mendelian randomization and colocalization study DOI Creative Commons
Zhipeng Xie, Yijie Liu, Min Huang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e30909 - e30909

Published: May 1, 2024

Observational studies have found a potential link between the use of thiazolidinediones (TZDs) and lower risk Alzheimer's disease (AD) development. Platelets were great source amyloid-β (Aβ) involved in development AD. This study aimed to assess correlation antidiabetic agents platelet characteristics, hoping provide mechanism TZDs neuroprotection

Language: Английский

Citations

1
Tannins-enriched fraction of TeMac™ Protects Against Aluminum Chloride Induced Alzheimer’s Disease-like Pathology By Modulating Aberrant Insulin Resistance and Alleviating Oxidative Stress In Diabetic Rats DOI
Bruno Dupon Ambamba Akamba,

Fils Armand Ella,

Dany Joël Ngassa Ngoumen

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118653 - 118653

Published: Aug. 1, 2024

Language: Английский

Citations

1
The role of AMPKα subunit in Alzheimer's disease: In-depth analysis and future prospects DOI Creative Commons

Lingqiong Xia,

Jianhua Chen, Juan Huang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e34254 - e34254

Published: July 1, 2024

The AMP-activated protein kinase α (AMPKα) subunit is the catalytic in AMPK complex, playing a crucial role activation. It has two isoforms: AMPKα1 and AMPKα2. Emerging evidence suggests that AMPKα exhibits subtype-specific effects Alzheimer's disease (AD). This review discusses of pathogenesis AD, including its impact on β-amyloid (Aβ) pathology, Tau metabolic disorders, inflammation, mitochondrial dysfunction, inflammasome pyroptosis. Additionally, it reviews distinct roles isoforms, AMPKα2, which may provide more precise targets for future drug development AD.

Language: Английский

Citations

1
Synthesis, Characterization, and Biological Activities of Ag-Au Nanoparticles Using Heliotropium eichwaldi L. Extract as a Reducing and Stabilizing Agent DOI
Naila Sher, Mushtaq Ahmed, Nadia Mushtaq

et al.

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(4), P. 4532 - 4550

Published: May 22, 2024

Language: Английский

Citations

0