The Structures, Functions, and Roles of Class III HDACs (Sirtuins) in Neuropsychiatric Diseases DOI Creative Commons
Robin Bonomi,

William Riordan,

Juri G. Gelovani

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1644 - 1644

Published: Oct. 2, 2024

Over the past two decades, epigenetic regulation has become a rapidly growing and influential field in biology medicine. One key mechanism involves acetylation deacetylation of lysine residues on histone core proteins other critical that regulate gene expression cellular signaling. Although deacetylases (HDACs) have received significant attention, roles individual HDAC isoforms pathogenesis psychiatric diseases still require further research. This is particularly true with regard to sirtuins, class III HDACs. Sirtuins unique functional activity normal neurophysiology, as well mechanisms addiction, mood disorders, neuropsychiatric abnormalities. review aims elucidate differences catalytic structure function seven sirtuins they relate psychiatry.

Language: Английский

Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far? DOI Creative Commons
Abdullah Al Mamun, Chuxiao Shao, Peiwu Geng

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(4), P. 1332 - 1355

Published: Jan. 1, 2024

Polyphenolic compounds have shown promising neuroprotective properties, making them a valuable resource for identifying prospective drug candidates to treat several neurological disorders (NDs).Numerous studies reported that polyphenols can disrupt the nuclear factor kappa B(NF-κB) pathway by inhibiting phosphorylation or ubiquitination of signaling molecules, which further prevents degradation IκB.Additionally, they prevent NF-κB translocation nucleus and pro-inflammatory cytokine production.Polyphenols such as curcumin, resveratrol, pterostilbene had significant inhibitory effects on NF-κB, treating NDs.Recent experimental findings suggest possess wide range pharmacological properties.Notably, much attention has been directed towards their potential therapeutic in NDs Alzheimer's disease (AD), Parkinson's (PD), cerebral ischemia, anxiety, depression, autism, spinal cord injury (SCI).Much preclinical data supporting neurotherapeutic benefits developed.Nevertheless, this study described significance agents, specifically emphasizing impact pathway.This article offers comprehensive analysis involvement NDs, including both clinical perspectives.

Language: Английский

Citations

27
Sirtuin dysregulation in Parkinson's disease: Implications of acetylation and deacetylation processes DOI
Sonia Dhiman, Ashi Mannan, Ayushi Taneja

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 342, P. 122537 - 122537

Published: Feb. 29, 2024

Language: Английский

Citations

10
Maternal Resveratrol Supplementation Attenuates Prenatal Stress Impacts on Anxiety- and Depressive-like Behaviors by Regulating Bdnf Transcripts Expression in the Brains of Adult Male Offspring Rats DOI Creative Commons

Gerardo Vera-Juárez,

Edgar Ricardo Vázquez-Martínez, Raquel Gómez‐Pliego

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 210 - 210

Published: Feb. 19, 2025

Prenatal stress has been reported to harm the physiological and biochemical functions of brain offspring, potentially resulting in anxiety- depression-like behaviors later life. Trans-Resveratrol (RESV) is known for its anti-inflammatory, anxiolytic, antidepressant properties. However, whether administering RESV during pregnancy can counteract induced by maternal unknown. This study aimed assess protective potential against molecular behavioral changes prenatal stress. During pregnancy, dams received 50 mg/kg BW/day orally. They underwent a movement restriction forty-five minutes, three times day, addition being exposed artificial light 24 h before delivery. The male offspring were left undisturbed until early adulthood, at which point they assessments, including open field test, elevated plus maze, forced swim test. Subsequently, euthanized, hippocampus prefrontal cortex extracted RT-qPCR analysis measure Bdnf mRNA expression. By weaning, results showed that led reduced weight gain and, increased these effects attenuated supplementation. findings suggest prevent modulating

Language: Английский

Citations

1
Resveratrol Improves Cognitive Function in Post-stroke Depression Rats by Repressing Inflammatory Reactions and Oxidative Stress via the Nrf2/HO-1 Pathway DOI

Yanjuan Bai,

Rubo Sui, Lei Zhang

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 541, P. 50 - 63

Published: Jan. 24, 2024

Language: Английский

Citations

6
Piceid Octanoate Protects Retinal Cells against Oxidative Damage by Regulating the Sirtuin 1/Poly-ADP-Ribose Polymerase 1 Axis In Vitro and in rd10 Mice DOI Creative Commons
Seyed Mohamadmehdi Moshtaghion, Estefanía Caballano‐Infantes, Álvaro Plaza Reyes

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 201 - 201

Published: Feb. 4, 2024

Retinitis pigmentosa is a common cause of inherited blindness in adults, which many cases associated with an increase the formation reactive oxygen species (ROS) that induces DNA damage, triggering Poly-ADP-Ribose Polymerase 1 (PARP1) activation and leading to parthanatos-mediated cell death. Previous studies have shown resveratrol (RSV) promising molecule can mitigate PARP1 overactivity, but its low bioavailability limitation for medical use. This study examined impact synthesized new acylated RSV prodrug, piceid octanoate (PIC-OCT), 661W line against H2O2 oxidative stress rd10 mice. PIC-OCT possesses better ADME profile than RSV. In response H2O2, cells pretreated preserved viability more 38% by significantly promoting SIRT1 nuclear translocation, preserving NAD+/NADH ratio, suppressing intracellular ROS formation. These effects result from expressing antioxidant genes, maintaining mitochondrial function, reducing expression, preventing AIF translocation. mice, inhibited PAR-polymer formation, increased reduced TUNEL-positive retinal outer layer, ERGs, enhanced light chamber activity (all p values < 0.05). Our findings corroborate protects photoreceptors modulating SIRT1/PARP1 axis models degeneration.

Language: Английский

Citations

6
Certain Fermented Foods and Their Possible Health Effects with a Focus on Bioactive Compounds and Microorganisms DOI Creative Commons
Gülsüm Deveci, Elif Çelik, Duygu Ağagündüz

et al.

Fermentation, Journal Year: 2023, Volume and Issue: 9(11), P. 923 - 923

Published: Oct. 24, 2023

Fermented foods refer to beverages or made by carefully regulated microbial growth and the enzymatic conversion of dietary components. have recently become more popular. Studies on fermented suggest types bacteria bioactive peptides involved in this process, revealing linkages that may impacts human health. By identifying studies relationships impressions been associated with obesity, cardiovascular disease, type 2 diabetes. In article, dairy products, vegetables fruits, legumes, meats, grains are included. Two elements particular emphasized when discussing fermentation all these foods: chemicals generated during microorganisms fermentation. Organic acids, peptides, conjugated linoleic acid, biogenic amines, isoflavones, phytoestrogens, nattokinase a few compounds included review. Also, certain such as Lactobacillus, Bifidobacterium, Streptococcus, Bacillus species, which utilized process mentioned. The effects both substances including anti-fungal antioxidant properties; modulation intestinal microbiota; anti-inflammatory, antidiabetes, anti-obesity, anticancer, antihypertension protection cognitive function explained

Language: Английский

Citations

13
Resveratrol and Neuroinflammation: Total-Scale Analysis of the Scientific Literature DOI Creative Commons
Michele Goulart dos Santos,

Diele Bopsin da Luz,

Fernanda Barros de Miranda

et al.

Nutraceuticals, Journal Year: 2024, Volume and Issue: 4(2), P. 165 - 180

Published: March 22, 2024

Neuroinflammation plays a crucial role in the development of various neurological diseases, including neurodegenerative disorders, leading to significant neuronal dysfunction. Current treatments involve use non-steroidal anti-inflammatory drugs and steroids; however, they are associated with serious adverse effects, limiting their efficacy. Exploring natural products properties appears promising, resveratrol, polyphenol found plants, standing out for its potential benefits. Studies on resveratrol have been increasing recent years, analyzing profile this knowledge area can bring benefits scientific community. Therefore, study conducted bibliometric analyses, using “resveratrol AND neuroinflammation” as search terms Web Science Core Collection database. The analysis, performed VOSviewer software version 1.6.18, encompasses 323 publications. Key studies include “resveratrol”, “neuroinflammation”, “oxidative stress”, China number Federal University Rio Grande do Sul Brazil emerges institution highest contribution, phase 2 clinical was most cited. These results provide an overview global research landscape related neuroinflammation, aiding decision making future publications advancing understanding field.

Language: Английский

Citations

4
Oxytocin attenuates neuroinflammation-induced anxiety through restoration of excitation and inhibition balance in the anterior cingulate cortex in mice DOI

Cui-na Shi,

Xin-miao Wu,

Yuzhu Gao

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 362, P. 341 - 355

Published: May 29, 2024

Language: Английский

Citations

4
Understanding Role of Maternal Separation in Depression, Anxiety,and Pain Behaviour: A Mini Review of Preclinical Research With Focus on Neuroinflammatory Pathways DOI Open Access
Shima Mohammadi, Alieh Bashghareh, Leila Karimi‐Zandi

et al.

International Journal of Developmental Neuroscience, Journal Year: 2025, Volume and Issue: 85(1)

Published: Feb. 1, 2025

Contact between mother and child is essential for the proper development of an infant's physiological systems, brain maturation behavioural outcomes. Early life stress (ELS), which includes factors such as inadequate parental care childhood abuse, significantly increases risk developing neuropsychiatric disorders, including anxiety depression. This review examines impact maternal separation (MS) on depression, pain behaviour, with a particular emphasis neuroinflammatory pathways. Experiences ELS can adversely affect neurotransmitter systems associated neural circuits that are crucial processing painful stimuli regulating Stressful experiences trigger inflammatory processes in brain, initiating immune responses cells stimulating production pro-inflammatory cytokines. In mammals, MS serves significant stressor activates hypothalamic-pituitary-adrenal (HPA) axis other stress-related leading to increased challenges heightened sensitivity adulthood due systemic inflammation. Key mediators, IL-1β, IL-6 TNF-α, play critical roles pathological pain, while activation microglia releases mediators contribute neurological dysfunction pathophysiology stress, depression anxiety. Moreover, therapeutics targeting oxidative inflammation have shown promise alleviating affective disorders following MS. discusses potential pathways, primary focus mechanisms therapeutic strategies may mitigate adverse effects There pressing need further research elucidate underlying pathways identify effective interventions improve mental health outcomes individuals affected by

Language: Английский

Citations

0
Hippocampal microRNA-181a overexpression participates in anxiety and ethanol related behaviors via regulating the expression of SIRT-1 DOI
Amine Bahí

Physiology & Behavior, Journal Year: 2025, Volume and Issue: unknown, P. 114839 - 114839

Published: Feb. 1, 2025

Language: Английский

Citations

0