Connexin 43: An Interface Connecting Neuroinflammation to Depression DOI Creative Commons
Hong Jiang, Yi Zhang, Zhen‐Zhen Wang

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1820 - 1820

Published: Feb. 15, 2023

Major depressive disorder (MDD) is a leading chronic mental illness worldwide, characterized by anhedonia, pessimism and even suicidal thoughts. Connexin 43 (Cx43), mainly distributed in astrocytes of the brain, far most widely ubiquitously expressed connexin almost all vital organs. Cx43 forms gap junction channels which mediate energy exchange effectively maintain physiological homeostasis. Increasing evidence suggests crucial role pathogenesis MDD. Neuroinflammation one common pathological features central nervous system dysfunctions. Inflammatory factors are abnormally elevated patients with depression closely related to nearly links depression. After activating inflammatory pathway release uptake glutamate adenosine triphosphate, through synaptic cleft, would be affected. In this review, we have summarized association between neuroinflammation, cornerstones linking inflammation depression, abnormalities We also discuss significant will help explore new antidepressant drug targets.

Language: Английский

The Microbiota–Gut–Brain Axis in Psychiatric Disorders DOI Open Access
Aleksandra Góralczyk-Bińkowska, Dagmara Szmajda‐Krygier, Elżbieta Kozłowska

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11245 - 11245

Published: Sept. 24, 2022

Modulating the gut microbiome and its influence on human health is subject of intense research. The microbiota could be associated not only with gastroenterological diseases but also psychiatric disorders. importance factors such as stress, mode delivery, role probiotics, circadian clock system, diet, occupational environmental exposure in relationship between brain function through bidirectional communication, described "the microbiome-gut-brain axis", especially underlined. In this review, we discuss link intestinal host response involving different pathways nervous system (e.g., neurotransmitters, endocrine immunological mechanisms, or bacterial metabolites). We review alterations their results development disorders, including major depressive disorder (MDD), schizophrenia (SCZ), bipolar (BD), autism spectrum (ASD), attention-deficit hyperactivity (ADHD).

Language: Английский

Citations

237
Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism DOI
Jiafeng Xia, Longxian Lv, Boqiang Liu

et al.

Microbiology Spectrum, Journal Year: 2022, Volume and Issue: 10(1)

Published: Feb. 2, 2022

Our work revealed that A. muciniphila attenuated APAP-induced liver injury by alleviating oxidative stress and inflammation in the liver, its hepatoprotective effect was accompanied activation of PI3K/Akt pathway mediated regulation composition metabolic function intestinal microbiota. This finding suggested microbial community is a non-negligible impact on drug metabolism probiotic administration could be potential therapy for drug-induced injury.

Language: Английский

Citations

117
Role of the gut microbiome in three major psychiatric disorders DOI Creative Commons
Jenny Borkent, Magdalini Ioannou, Jon D. Laman

et al.

Psychological Medicine, Journal Year: 2022, Volume and Issue: 52(7), P. 1222 - 1242

Published: May 1, 2022

Abstract Major depressive disorder (MDD), bipolar (BD) and schizophrenia-spectrum disorders (SSD) are heterogeneous psychiatric disorders, which place significant burden on patient's well-being global health. Disruptions in the gut-microbiome may play a role these disorders. This review presents current data composition of human gastrointestinal microbiota, its interaction mechanisms gut–brain axis MDD, BD SSD. Diversity metrics microbial relative abundance differed across studies. More studies reported inconsistent findings ( n = 7) or no differences 8) than who lower α -diversity 5). The most consistent were higher abundances genera Streptococcus , Lactobacillus Eggerthella butyrate producing Faecalibacterium patients with All three increased associated symptom severity. Confounders, such as medication use life style have not been accounted for. So far, results probiotics trials inconsistent. Most traditional widely used (consisting Bifidobacterium spp. spp.) safe, however, they do correct potential microbiota disbalances Findings prebiotics faecal transplantation (FMT) too limited to draw definitive conclusions. Disease-specific pro/prebiotic treatment even FMT could be auspicious interventions for prevention therapy should investigated future trials.

Language: Английский

Citations

86
The interplay between sleep and gut microbiota DOI
Mengqi Han, Shiying Yuan, Jiancheng Zhang

et al.

Brain Research Bulletin, Journal Year: 2022, Volume and Issue: 180, P. 131 - 146

Published: Jan. 13, 2022

Language: Английский

Citations

80
Anti-Inflammatory, Antioxidant, and Neuroprotective Effects of Polyphenols—Polyphenols as an Element of Diet Therapy in Depressive Disorders DOI Open Access

Anna Winiarska‐Mieczan,

Małgorzata Kwiecień, Karolina Jachimowicz-Rogowska

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2258 - 2258

Published: Jan. 23, 2023

Depressive disorders can affect up to 350 million people worldwide, and in developed countries, the percentage of patients with depressive may be as high 10%. During depression, activation pro-inflammatory pathways, mitochondrial dysfunction, increased markers oxidative stress, a reduction antioxidant effectiveness body are observed. It is estimated that approximately 30% depressed do not respond traditional pharmacological treatments. However, more attention being paid influence active ingredients food on course risk neurological disorders, including depression. The possibility using foods containing polyphenols an element diet therapy depression was analyzed review. whether consumption products such could alleviate or prevent progression it also considered. Results from preclinical studies demonstrate potential phenolic compounds have reduce behaviors by regulating factors related neuroinflammation, modulation intestinal microbiota.

Language: Английский

Citations

54
Allergic Diseases and Mental Health DOI

Alexandra E. Conway,

Marylee Verdi,

Navya Kartha

et al.

The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2024, Volume and Issue: 12(9), P. 2298 - 2309

Published: June 7, 2024

Language: Английский

Citations

17
Bifidobacterium longum 1714 improves sleep quality and aspects of well-being in healthy adults: a randomized, double-blind, placebo-controlled clinical trial DOI Creative Commons
Elaine Patterson, Hern‐Tze Tina Tan,

David Groeger

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 14, 2024

Abstract Stress and sleep are linked with overall well-being. Bifidobacterium longum 1714 has been shown to influence stress responses modulate neural during social stress, quality examination in healthy adults. Here, we explored the ability of this strain alter adults using subjective objective measures. Eighty-nine (18–45y) impaired assessed Pittsburgh Sleep Quality Index (PSQI) a global score ≥ 5 were randomized receive B. or placebo daily for eight weeks. Assessing effect on PSQI was primary objective. Secondary objectives well-being subjectively parameters actigraphy objectively. While improved both groups, significantly component ( p < 0.05) daytime dysfunction due sleepiness after 4 weeks functioning energy/vitality 8 weeks, compared placebo. No significant measures observed. The had mild sleep, demonstrated by faster improvement at week placebo, although improvements similar groups. increased line previous work that showed modulated activity which correlated enhanced vitality/reduced mental fatigue (ClinicalTrials.gov: NCT04167475).

Language: Английский

Citations

16
The (neuro)inflammatory system in anxiety disorders and PTSD: Potential treatment targets DOI Creative Commons
Anupam Sah, Nicolas Singewald

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108825 - 108825

Published: Feb. 1, 2025

Language: Английский

Citations

2
Regulation of body weight: Lessons learned from bariatric surgery DOI Creative Commons
Vance L. Albaugh, Yanlin He,

Heike Münzberg

et al.

Molecular Metabolism, Journal Year: 2022, Volume and Issue: 68, P. 101517 - 101517

Published: May 26, 2022

Bariatric or weight loss surgery is currently the most effective treatment for obesity and metabolic disease. Unlike dieting pharmacology, its beneficial effects are sustained over decades in patients, mortality among lowest major surgery. Because there not nearly enough surgeons to implement bariatric on a global scale, intensive research efforts have begun identify mechanisms of action molecular level order replace with targeted behavioral pharmacological treatments. To date, however, no consensus as critical involved. The purpose this non-systematic review evaluate existing evidence specific inter-organ signaling pathways that play roles surgery-induced benefits, focus Roux-en-Y gastric bypass (RYGB) vertical sleeve gastrectomy (VSG), both humans rodents. Gut-brain communication brain targets food intake control energy balance regulation complex redundant. Although relatively young science has generated number hypotheses, clear unique mechanism yet emerged. It seems increasingly likely broad physiological produced by do involve single mechanism, but rather multiple pathways. Besides need improve better validate surgeries animals, advanced techniques, including inducible, tissue-specific knockout models, use humanized traits will be necessary. State-of-the-art genetically-guided neural identification techniques should used more selectively manipulate function-specific

Language: Английский

Citations

48
Protective Effect of Anthocyanins against Neurodegenerative Diseases through the Microbial-Intestinal-Brain Axis: A Critical Review DOI Open Access

Hao Zhong,

Jie Xu,

Mengyu Yang

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 496 - 496

Published: Jan. 18, 2023

With the increase in human mean age, prevalence of neurodegenerative diseases (NDs) also rises. This negatively affects mental and physiological health. In recent years, evidence has revealed that anthocyanins could regulate functioning central nervous system (CNS) through microbiome-gut-brain axis, which provides a new perspective for treating NDs. this review, protective effects mechanisms against NDs are summarized, especially interaction between intestinal microbiota, microbial-intestinal-brain axis is comprehensively discussed. Moreover, achieve therapeutic purpose by regulating microflora certain metabolites (protocateic acid, vanillic etc.). particular, inhibitory effect tryptophan metabolism on some neurotransmitters induction blood-brain barrier permeability butyrate production preventive Overall, it suggested may be novel mechanism

Language: Английский

Citations

31