European Journal of Neuroscience,
Journal Year:
2024,
Volume and Issue:
59(11), P. 2915 - 2954
Published: April 15, 2024
Alzheimer's
disease
(AD)
is
a
neurodegenerative
condition
that
exhibits
gradual
decline
in
cognitive
function
and
prevalent
among
significant
number
of
individuals
globally.
The
use
small
interfering
RNA
(siRNA)
molecules
interference
(RNAi)
presents
promising
therapeutic
strategy
for
AD.
Lipid
nanoparticles
(LNPs)
have
been
developed
as
delivery
vehicle
siRNA,
which
can
selectively
suppress
target
genes,
by
enhancing
cellular
uptake
safeguarding
siRNA
from
degradation.
Numerous
research
studies
exhibited
the
effectiveness
LNP-mediated
reducing
amyloid
beta
(Aβ)
levels
animal
models
feasibility
employing
approach
AD
emphasized
encouraging
outcomes
reported
clinical
other
medical
conditions.
has
emerged
to
slow
down
or
even
reverse
progression
targeting
synthesis
tau
phosphorylation
genes
linked
condition.
Improvement
mechanism
determination
most
suitable
targets
are
crucial
efficacious
management
This
review
focuses
on
through
LNPs
AD,
based
available
literature.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 7, 2024
Multicellular
organisms
are
composed
of
diverse
cell
types
that
must
coordinate
their
behaviors
through
communication.
Cell-cell
communication
(CCC)
is
essential
for
growth,
development,
differentiation,
tissue
and
organ
formation,
maintenance,
physiological
regulation.
Cells
communicate
direct
contact
or
at
a
distance
using
ligand-receptor
interactions.
So
cellular
encompasses
two
processes:
signal
conduction
generation
intercellular
transmission
signals,
transduction
reception
procession
signals.
Deciphering
networks
critical
understanding
metabolism.
First,
we
comprehensively
review
the
historical
milestones
in
CCC
studies,
followed
by
detailed
description
mechanisms
molecule
importance
main
signaling
pathways
they
mediate
maintaining
biological
functions.
Then
systematically
introduce
series
human
diseases
caused
abnormalities
progress
clinical
applications.
Finally,
summarize
various
methods
monitoring
interactions,
including
imaging,
proximity-based
chemical
labeling,
mechanical
force
analysis,
downstream
analysis
strategies,
single-cell
technologies.
These
aim
to
illustrate
how
functions
depend
on
these
interactions
complexity
regulatory
regulate
crucial
processes,
homeostasis,
immune
responses
diseases.
In
addition,
this
enhances
our
processes
occur
after
cell-cell
binding,
highlighting
its
application
discovering
new
therapeutic
targets
biomarkers
related
precision
medicine.
This
collective
provides
foundation
developing
targeted
drugs
personalized
treatments.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
16(1), P. 58 - 58
Published: Dec. 29, 2023
Alzheimer's
disease,
a
progressive
neurodegenerative
condition,
is
characterized
by
gradual
decline
in
cognitive
functions.
Current
treatment
approaches
primarily
involve
the
administration
of
medications
through
oral,
parenteral,
and
transdermal
routes,
aiming
to
improve
function
alleviate
symptoms.
However,
these
treatments
face
limitations,
such
as
low
bioavailability
inadequate
permeation.
Alternative
invasive
methods,
while
explored,
often
entail
discomfort
require
specialized
assistance.
Therefore,
development
non-invasive
efficient
delivery
system
crucial.
Intranasal
has
emerged
potential
solution,
although
it
constrained
unique
conditions
nasal
cavity.
An
innovative
approach
involves
use
nano-carriers
based
on
nanotechnology
for
intranasal
delivery.
This
strategy
overcome
current
limitations
providing
enhanced
bioavailability,
improved
permeation,
effective
traversal
blood-brain
barrier,
extended
retention
within
body,
precise
targeting
brain.
The
comprehensive
review
focuses
advancements
designing
various
types
nano-carriers,
including
polymeric
nanoparticles,
metal
lipid
liposomes,
nanoemulsions,
Quantum
dots,
dendrimers.
These
are
specifically
tailored
therapeutic
agents
aimed
at
combatting
disease.
In
summary,
utilization
systems
show
significant
surmounting
constraints
disease
strategies.
Nevertheless,
essential
acknowledge
regulatory
well
toxicity
concerns
associated
with
this
route;
meticulous
consideration
required
when
engineering
carrier.
underscores
revolutionize
management
highlights
importance
addressing
considerations
safe
implementations.
Embracing
could
lead
substantial
field
treatment.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(18), P. 3773 - 3773
Published: Sept. 9, 2022
The
link
between
oxidative
stress
and
environmental
factors
plays
an
important
role
in
chronic
degenerative
diseases;
therefore,
exogenous
antioxidants
could
be
effective
alternative
to
combat
disease
progression
and/or
most
significant
symptoms.
Curcuma
longa
L.
(CL),
commonly
known
as
turmeric,
is
mostly
composed
of
curcumin,
a
multivalent
molecule
described
having
antioxidant,
anti-inflammatory
neuroprotective
properties.
Poor
chemical
stability
low
oral
bioavailability
and,
consequently,
poor
absorption,
rapid
metabolism,
limited
tissue
distribution
are
major
restrictions
its
applicability.
advent
nanotechnology,
by
combining
nanosacale
with
multi-functionality
improvement,
offers
opportunity
overcome
these
limitations.
Therefore,
this
work,
poly-Ɛ-caprolactone
(PCL)
nanoparticles
were
developed
incorporate
the
methanolic
extract
CL,
their
bioactivity
was
assessed
comparison
free
or
encapsulated
curcumin.
Their
toxicity
evaluated
using
zebrafish
embryos
applying
Fish
Embryo
Acute
Toxicity
test,
following
recommended
OECD
guidelines.
protective
effect
against
paraquat-induced
damage
CL
extract,
PCL
nanoparticles,
evaluated.
This
herbicide
cause
greatly
affect
neuromotor
functions.
overall
results
indicate
that
CL-loaded
have
interesting
capacity
damage,
particularly
neuromuscular
development
goes
well
beyond
itself
other
antioxidants.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 916 - 916
Published: March 11, 2023
Alzheimer’s
disease
(AD),
as
a
neurodegenerative
disorder,
usually
develops
slowly
but
gradually
worsens.
It
accounts
for
approximately
70%
of
dementia
cases
worldwide,
and
is
recognized
by
WHO
public
health
priority.
Being
multifactorial
disease,
the
origins
AD
are
not
satisfactorily
understood.
Despite
huge
medical
expenditures
attempts
to
discover
new
pharmaceuticals
or
nanomedicines
in
recent
years,
there
no
cure
many
successful
treatments
available.
The
current
review
supports
introspection
on
latest
scientific
results
from
specialized
literature
regarding
molecular
cellular
mechanisms
brain
photobiomodulation,
complementary
method
with
implications
AD.
State-of-the-art
pharmaceutical
formulations,
development
nanoscale
materials,
bionanoformulations
applications
perspectives
highlighted.
Another
goal
this
was
speed
transition
completely
paradigms
multi-target
management
AD,
facilitate
remodeling
through
therapeutic
models
high-tech
light
lasers
integrative
nanomedicine
future.
In
conclusion,
insights
interdisciplinary
approach,
including
photobiomodulation
(PBM)
applied
human
clinical
trials,
combined
drug
delivery
systems
easily
overcome
protective
barriers,
could
open
avenues
rejuvenate
our
central
nervous
system,
most
fascinating
complex
organ.
Picosecond
transcranial
laser
stimulation
be
successfully
used
cross
blood-brain
barrier
together
nanotechnologies,
therapy.
Original,
smart
targeted
multifunctional
solutions
nanodrugs
may
soon
developed
treat
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(2), P. 151 - 151
Published: Jan. 19, 2023
Dementia,
most
often
associated
with
neurodegenerative
diseases,
affects
millions
of
people
worldwide,
predominantly
the
elderly.
Unfortunately,
no
treatment
is
still
available.
Therefore,
there
an
urgent
need
to
address
this
situation.
This
review
presents
state
art
drug
discovery
and
developments
in
targeting
dementia.
Several
approaches
are
discussed,
such
as
repurposing,
use
small
molecules,
phosphodiesterase
inhibitors.
Furthermore,
also
provides
insights
into
clinical
trials
these
molecules.
Emphasis
has
been
placed
on
molecules
multi-target-directed
ligands,
well
disease-modifying
therapies.
Finally,
attention
drawn
possibilities
applications
nanotechnology
managing
