Clinical and Translational Medicine,
Journal Year:
2023,
Volume and Issue:
13(8)
Published: Aug. 1, 2023
Abstract
Messenger
ribonucleic
acid
(mRNA)
vaccines
are
a
relatively
new
class
of
that
have
shown
great
promise
in
the
immunotherapy
wide
variety
infectious
diseases
and
cancer.
In
past
2
years,
SARS‐CoV‐2
mRNA
contributed
tremendously
against
SARS‐CoV2,
which
has
prompted
arrival
vaccine
research
boom,
especially
cancer
vaccines.
Compared
with
conventional
vaccines,
significant
advantages,
including
efficient
production
protective
immune
responses,
low
side
effects
lower
cost
acquisition.
this
review,
we
elaborated
on
development
as
well
potential
biological
mechanisms
latest
progress
various
tumour
treatments,
discussed
challenges
future
directions
for
field.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 6099 - 6099
Published: June 1, 2024
Michael
acceptors
represent
a
class
of
compounds
with
potential
anti-cancer
properties.
They
act
by
binding
to
nucleophilic
sites
in
biological
molecules,
thereby
disrupting
cancer
cell
function
and
inducing
death.
This
mode
action,
as
well
their
ability
be
modified
targeted,
makes
them
promising
avenue
for
advancing
therapy.
We
are
investigating
the
molecular
mechanisms
underlying
interactions
cells,
particular
interfere
cellular
processes
induce
apoptosis.
The
properties
not
accidental
but
due
chemical
structure
reactivity.
electrophilic
nature
these
allows
selectively
target
residues
on
disease-associated
proteins,
resulting
significant
therapeutic
benefits
minimal
toxicity
various
diseases.
opens
up
new
perspectives
development
more
effective
precise
drugs.
Nevertheless,
further
studies
essential
fully
understand
impact
our
discoveries
translate
into
clinical
practice.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(2), P. 190 - 190
Published: Feb. 4, 2024
Lung
cancer
is
one
of
the
most
lethal
malignancies
worldwide.
Peroxisome
proliferator-activated
receptor
gamma
(PPARγ,
NR1C3)
a
ligand-activated
transcriptional
factor
that
governs
expression
genes
involved
in
glucolipid
metabolism,
energy
homeostasis,
cell
differentiation,
and
inflammation.
Multiple
studies
have
demonstrated
PPARγ
activation
exerts
anti-tumor
effects
lung
through
regulation
lipid
induction
apoptosis,
cycle
arrest,
as
well
inhibition
invasion
migration.
Interestingly,
may
pro-tumor
on
cells
tumor
microenvironment,
especially
myeloid
cells.
Recent
clinical
data
has
substantiated
potential
agonists
therapeutic
agents
for
cancer.
Additionally,
also
show
synergistic
with
traditional
chemotherapy
radiotherapy.
However,
application
remains
limited
due
to
presence
adverse
side
effects.
Thus,
further
research
trials
are
necessary
comprehensively
explore
actions
both
stromal
evaluate
vivo
toxicity.
This
review
aims
consolidate
molecular
mechanism
modulators
discuss
their
prospects
challenges
tackling
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5659 - 5659
Published: May 23, 2024
Cannabinoids,
the
bioactive
compounds
found
in
Cannabis
sativa,
have
been
used
for
medicinal
purposes
centuries,
with
early
discoveries
dating
back
to
BC
era
(BCE).
However,
increased
recreational
use
of
cannabis
has
led
a
negative
perception
its
and
food
applications,
resulting
legal
restrictions
many
regions
worldwide.
Recently,
cannabinoids,
notably
Δ9-tetrahydrocannabinol
(THC)
cannabidiol
(CBD),
gained
renewed
interest
medical
field
due
their
anti-cancer
properties.
These
properties
include
inhibition
tumour
growth
cell
invasion,
anti-inflammatory
effects,
induction
autophagy
apoptosis.
As
result,
cannabinoids
treat
chemotherapy-associated
side
like
nausea,
vomiting,
pain,
increased,
there
suggestions
implement
large-scale
cancer
therapy.
these
compounds’
cellular
molecular
mechanisms
action
still
need
be
fully
understood.
This
review
explores
recent
evidence
CBD’s
efficacy
as
an
agent,
which
is
non-psychoactive
The
current
will
also
provide
understanding
common
different
cancers.
Studies
shown
that
activity
can
receptor-dependent
(CB1,
CB2,
TRPV,
PPARs)
or
receptor-independent
induced
through
mechanisms,
such
ceramide
biosynthesis,
ER
stress,
subsequent
It
projected
form
basis
therapeutic
applications
CBD.
Therefore,
it
essential
understand
developing
optimizing
pre-clinical
CBD-based
therapies.
Cells,
Journal Year:
2022,
Volume and Issue:
11(20), P. 3215 - 3215
Published: Oct. 13, 2022
Peroxisome
proliferator-activated
receptor-γ
(PPAR-γ)
has
emerged
as
one
of
the
most
extensively
studied
transcription
factors
since
its
discovery
in
1990,
highlighting
importance
etiology
and
treatment
numerous
diseases
involving
various
types
cancer,
type
2
diabetes
mellitus,
autoimmune,
dermatological
cardiovascular
disorders.
Ligands
are
regarded
key
determinant
for
tissue-specific
activation
PPAR-γ.
However,
mechanism
governing
this
process
is
merely
a
contradictory
debate
which
yet
to
be
systematically
researched.
Either
these
receptors
get
weakly
activated
by
endogenous
or
natural
ligands
leads
direct
over-activation
synthetic
ligands,
serving
complete
full
agonists.
Therefore,
fine-tuning
on
action
PPAR-γ
more
subtle
modulation
can
rewarding
approach
might
open
new
avenues
several
diseases.
In
recent
era,
researchers
have
sought
develop
safer
partial
agonists
order
dodge
toxicity
induced
agonists,
akin
balanced
activation.
With
particular
reference
review
concentrates
therapeutic
role
especially
cancer
treatment.
Additionally,
timely
examination
their
efficacy
other
disease-fate
decisions
been
also
discussed.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 12, 2023
Peroxisome
proliferator-activated
receptors
(PPARs)
have
been
extensively
studied
for
over
3
decades
and
consist
of
three
isotypes,
including
PPARα,
γ,
β/δ,
that
were
originally
considered
key
metabolic
regulators
controlling
energy
homeostasis
in
the
body.
Cancer
has
become
a
leading
cause
human
mortality
worldwide,
role
peroxisome
cancer
is
increasingly
being
investigated,
especially
deep
molecular
mechanisms
effective
therapies.
are
an
important
class
lipid
sensors
involved
regulation
multiple
pathways
cell
fate.
They
can
regulate
progression
different
tissues
by
activating
endogenous
or
synthetic
compounds.
This
review
emphasizes
significance
knowledge
tumor
microenvironment,
metabolism,
anti-cancer
treatment
summarizing
recent
research
on
receptors.
In
general,
either
promote
suppress
types
microenvironments.
The
emergence
this
difference
depends
various
factors,
receptor
type,
stage.
Simultaneously,
effect
therapy
based
drug-targeted
PPARs
differs
even
opposes
among
homotypes
types.
Therefore,
current
status
challenges
use
agonists
antagonists
further
explored
review.
