Overcoming cancer chemotherapy resistance by the induction of ferroptosis

Drug Resistance Updates, Journal Year: 2022, Volume and Issue: 66, P. 100916 - 100916

Published: Dec. 29, 2022

Language: Английский

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Erythrocyte metabolism

Acta Physiologica, Journal Year: 2024, Volume and Issue: 240(3)

Published: Jan. 25, 2024

Abstract Our aim is to present an updated overview of the erythrocyte metabolism highlighting its richness and complexity. We have manually collected connected available biochemical pathways integrated them into a functional metabolic map. The focus this map on main consisting glycolysis, pentose phosphate pathway, redox metabolism, oxygen purine/nucleoside membrane transport. Other recently emerging are also curated, like methionine salvage glyoxalase system, carnitine lands cycle, as well remnants carboxylic acid metabolism. An additional goal review dynamics providing key numbers used perform basic quantitative analyses. By synthesizing experimental computational data, we conclude that foundations Additionally, can sense levels oxidative stress adjusting mechanics, function. In conclusion, fine‐tuning controls one most important biological processes, is, loading, transport, delivery.

Language: Английский

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Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: April 9, 2024

Abstract The latest findings in iron metabolism and the newly uncovered process of ferroptosis have paved way for new potential strategies anti-leukemia treatments. In current project, we reviewed summarized role nanomedicine treatment diagnosis leukemia through a comparison made between traditional approaches applied via existing investigations about molecular mechanisms involved various anti-tumor application nanotechnology other novel technologies may provide direction ferroptosis-driven therapies. article explores targeting ferroptosis, form regulated cell death, as therapeutic strategy leukemia. It discusses its how can enhance delivery efficacy ferroptosis-inducing agents. not only highlights promise ferroptosis-targeted therapies revolutionizing treatment, but also calls further research to overcome challenges fully realize clinical this innovative approach. Finally, it opportunities applications ferroptosis.

Language: Английский

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Ferroptosis: From regulation of lipid peroxidation to the treatment of diseases

Cell Biology and Toxicology, Journal Year: 2022, Volume and Issue: 39(3), P. 827 - 851

Published: Dec. 2, 2022

Language: Английский

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The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 15, 2023

Arachidonic and adrenic acids in the membrane play key roles ferroptosis. Here, we reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular phospholipid metabolism contributes to ferroptosis resistance. A metabolic drug screen reveals darapladib, an inhibitor of Lp-PLA2, synergistically induces presence GPX4 inhibitors. We show darapladib is able enhance under lipoprotein-deficient or serum-free conditions. Furthermore, find Lp-PLA2 located cytoplasm suppresses ferroptosis, suggesting a critical role for Lp-PLA2. Lipidomic analyses treatment deletion PLA2G7, which encodes generally enriches phosphatidylethanolamine species reduces lysophosphatidylethanolamine species. Moreover, combination with PACMA31 efficiently inhibits tumour growth xenograft model. Our study suggests inhibition potential therapeutic strategy cancer treatment.

Language: Английский

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Berberine modulates gut microbiota to attenuate cerebral ferroptosis induced by ischemia-reperfusion in mice

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 953, P. 175782 - 175782

Published: May 26, 2023

Ferroptosis was reported to be involved in cerebral ischemia-reperfusion injury (CIRI), on which the effects of berberine (BBR) remain unclear. Moreover, based critical role gut microbiota pleiotropic actions BBR, we hypothesized that BBR can suppress CIRI-induced ferroptosis by modulating microbiota. In this study, results showed obviously attenuated behavioral deficits CIRI mice, accompanied with improved survival rate and neuron damages, as phenocopied dirty cage experiment. The typical morphological changes ferroptotic cells biomarkers were BBR- its fecal microbiota-treated reduced malondialdehyde reactive oxygen species, increased glutathione (GSH). found alter mice decreased abundance Muribaculaceae, Erysipelotrichaceae, Helicobacteraceae, Streptococcaceae Tannerellaceae, but elevated Bacteroidaceae Enterobacteriaceae. KEGG analysis 16S rRNA indicated multiple metabolic pathways including GSH metabolism, altered BBR. Oppositely, antibiotics administration counteracted protective properties Summarily, study revealed therapeutic potential via inhibiting neuronal ferroptosis, upregulated peroxidase 1 (GPX1) possibly involved. BBR-modulated shown play underlying mechanism.

Language: Английский

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Oxidative stress is two‐sided in the treatment of acute myeloid leukemia

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(9)

Published: May 1, 2024

Abstract Introduction Oxidative stress caused by elevated ROS, as a novel therapeutic mechanism, has been implicated in various tumors including AML. AML cells are chronically under oxidative stress, yet overreliance on ROS production makes tumor increasingly vulnerable to further damage. Reducing the cytotoxic effect of normal while killing leukemia stem cell (LSC) with high levels reactive oxygen species is new challenge for therapy leukemia. Methods By searching literature databases, we summarized recent relevant studies. The relationship genes, signaling pathways, and transcription factors, correlation bone marrow microenvironment autophagy were summarized. In addition, summarize current status research therapeutics. Finally, discuss progress redox resistance Results This review discusses evidence showing link between reactions progression compiles latest findings that will facilitate future biological studies effects associated treatment. Conclusion We believe exploiting this unique property may provide way prevent relapse drug resistance.

Language: Английский

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Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress and NRF2 signaling pathway

Chemico-Biological Interactions, Journal Year: 2022, Volume and Issue: 362, P. 110004 - 110004

Published: June 2, 2022

Language: Английский

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Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 2, 2024

Ferroptosis induces significant changes in mitochondrial morphology, including membrane condensation, volume reduction, cristae alteration, and outer rupture, affecting function cellular fate. Recent reports have described the intrinsic iron metabolism its intricate connection to ferroptosis, a kind of cell death characterized by dependence oxidative stress regulation. Furthermore, updated molecular insights elucidated significance mitochondria ferroptosis implications various cancers. In context cancer therapy, understanding dual role anastasis chemoresistance is crucial. Targeting pathways involved may enhance efficacy inducers, providing synergistic approach overcome chemoresistance. Research into how DNA damage response (DDR) proteins, metabolic changes, redox states interact during can offer new designing combinatorial therapeutic regimens against several cancers associated with stemness. These treatments could potentially inhibit while simultaneously inducing thereby reducing likelihood cells evading developing resistance chemotherapy. The objective this study explore interplay between anastasis, EMT chemoresistance, immunotherapeutics better understand their collective impact on therapy outcomes. We searched public research databases google scholar, PubMed, relemed, national library medicine related topic. review, we discussed tricarboxylic acid cycle glycolysis implicated modulating adding complexity regulatory mechanisms. Additionally, reactive oxygen species (ROS) electron transport chain (ETC) has garnered attention. Lipid metabolism, particularly involving GPX4 System Xc- plays both progression cancer. There need investigate clinical Integrating strategies targeting exploring potential synergy immunotherapy represent promising avenues for advancing chemoresistant treatment. Understanding among mitochondria, ROS, vital oncology, revolutionizing personalized treatment drug development.

Language: Английский

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Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills

Antioxidants and Redox Signaling, Journal Year: 2023, Volume and Issue: 40(1-3), P. 40 - 85

Published: May 3, 2023

The multifactorial nature of the mechanisms implicated in cancer development still represents a major issue for success established antitumor therapies. discovery ferroptosis, novel form programmed cell death distinct from apoptosis, along with identification molecular pathways activated during its execution, has led to uncovering molecules characterized by ferroptosis-inducing properties.

Language: Английский

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