EVENTOS ADVERSOS RELACIONADOS AO USO DO IBUPROFENO NO BRASIL DOI Open Access

Marcus Fernando da Silva Praxedes

Published: June 11, 2024

The multidisciplinary approach in the management of polytrauma patients is utmost importance for proper evaluation and treatment injuries different body systems, as second most common cause death these occurs due to treatable injuries.The aim this article highlight correct through a review current literature.In article, we present literature widely used systematic approach.We discuss ABCDE sequence ATLS protocol, prioritizing airway control, breathing assessment, circulation hemorrhage neurological patient exposure injury identification.After stabilization identified injuries, detailed secondary assessment crucial.The emphasizes specialized team provide care optimize outcomes complex clinical situation.

Language: Английский

Preclinical Models and Technologies in Glioblastoma Research: Evolution, Current State, and Future Avenues DOI Open Access
Hasan Slika, Ziya Karimov,

Paolo Alimonti

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16316 - 16316

Published: Nov. 14, 2023

Glioblastoma is the most common malignant primary central nervous system tumor and one of debilitating cancers. The prognosis patients with glioblastoma remains poor, management this tumor, both in its recurrent forms, suboptimal. Despite tremendous efforts that are being put forward by research community to discover novel efficacious therapeutic agents modalities, no major paradigm shifts have been established field last decade. However, does not mirror abundance relevant findings discoveries made preclinical research. Hence, developing utilizing appropriate models faithfully recapitulate characteristics behavior human utmost importance. Herein, we offer a holistic picture evolution glioblastoma. We further elaborate on commonly used vitro vivo models, delving into their development, favorable characteristics, shortcomings, areas potential improvement, which aids researchers designing future experiments suitable models. Additionally, review explores progress fields humanized immunotolerant mouse genetically engineered animal 3D microfluidics highlights promising avenues for

Language: Английский

Citations

20
Understanding current experimental models of glioblastoma-brain microenvironment interactions DOI
Niket Yadav, Benjamin Purow

Journal of Neuro-Oncology, Journal Year: 2024, Volume and Issue: 166(2), P. 213 - 229

Published: Jan. 1, 2024

Language: Английский

Citations

5
Biosensor-Enhanced Organ-on-a-Chip Models for Investigating Glioblastoma Tumor Microenvironment Dynamics DOI Creative Commons
Gayathree Thenuwara, Bilal Javed, Baljit Singh

et al.

Sensors, Journal Year: 2024, Volume and Issue: 24(9), P. 2865 - 2865

Published: April 30, 2024

Glioblastoma, an aggressive primary brain tumor, poses a significant challenge owing to its dynamic and intricate tumor microenvironment. This review investigates the innovative integration of biosensor-enhanced organ-on-a-chip (OOC) models as novel strategy for in-depth exploration glioblastoma microenvironment dynamics. In recent years, transformative approach incorporating biosensors into OOC platforms has enabled real-time monitoring analysis cellular behaviors within controlled Conventional in vitro vivo exhibit inherent limitations accurately replicating complex nature progression. addresses existing research gap by pioneering models, providing comprehensive platform investigating The applications this combined studying dynamics are critically scrutinized, emphasizing potential bridge between simplistic conditions. Furthermore, article discusses implications elucidating features microenvironment, encompassing cell migration, proliferation, interactions. By furnishing insights, these significantly contribute unraveling biology glioblastoma, thereby influencing development more accurate diagnostic therapeutic strategies.

Language: Английский

Citations

5
Recent Developments in Glioblastoma‐On‐A‐Chip for Advanced Drug Screening Applications DOI Open Access
Surjendu Maity, Tamanna Bhuyan, Christopher M. Jewell

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Glioblastoma (GBM) is an aggressive form of cancer, comprising ≈80% malignant brain tumors. However, there are no effective treatments for GBM due to its heterogeneity and the presence blood-brain barrier (BBB), which restricts delivery therapeutics brain. Despite in vitro models contributing understanding GBM, conventional 2D oversimplify complex tumor microenvironment. Organ-on-a-chip (OoC) have emerged as promising platforms that recapitulate human tissue physiology, enabling disease modeling, drug screening, personalized medicine. There a sudden increase GBM-on-a-chip can significantly advance knowledge etiology revolutionize development by reducing animal testing enhancing translation clinic. In this review, overview their applications reported screening discussed current challenges potential future directions models.

Language: Английский

Citations

5
Biophysical Control of the Glioblastoma Immunosuppressive Microenvironment: Opportunities for Immunotherapy DOI Creative Commons

Landon Teer,

Kavitha Yaddanapudi, Joseph Chen

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(1), P. 93 - 93

Published: Jan. 18, 2024

GBM is the most aggressive and common form of primary brain cancer with a dismal prognosis. Current treatments have not improved patient survival, due to propensity for tumor cell adaptation immune evasion, leading persistent progression disease. In recent years, microenvironment (TME) has been identified as critical regulator these pro-tumorigenic changes, providing complex array biomolecular biophysical signals that facilitate evasion strategies by modulating cells, stromal populations. Efforts unravel TME interactions are necessary improve therapy. Immunotherapy promising treatment strategy utilizes patient’s own system eradication exhibited exciting results in many types; however, highly immunosuppressive between populations continue present challenges. order elucidate interactions, novel bioengineering models being employed decipher mechanisms immunologically “cold” GBMs. Additionally, data leveraged develop engineering bolster immunotherapy efficacy. This review presents an in-depth analysis well systems used underlying improving current therapies.

Language: Английский

Citations

3
Evolution of Preclinical Models for Glioblastoma Modelling and Drug Screening DOI Creative Commons
Grace Thomas, Ruman Rahman

Current Oncology Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

Citations

0
Bridging the Gap: How Organ‐on‐a‐Chip Technology Facilitates the Battle against Glioma DOI Creative Commons
Su Liu, Zhenyu Gong,

Dairan Zhou

et al.

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

Glioma, a highly aggressive brain tumor, presents significant challenges in understanding its complex pathophysiology and developing effective treatments. This review critically examines the current glioma modeling platforms, including 2D culture, 3D cultures, glioma‐on‐a‐chip (GoC) models, animal with focus on their applications recapitulating tumor microenvironment evaluating treatment effectiveness. Particular attention is given to microfluidic GoC which offer unique capabilities mimic pathophysiological complexity of glioblastoma, interactions blood–brain barrier (BBB) vascularization. Recent advancements these models are explored, highlighting potential for clinical translation through improved drug permeability central nervous system, progress, therapeutic responses. In end, discusses perspective establishes key criteria designing robust clinically relevant models. By addressing future opportunities, critical role platforms bridging gap between preclinical research outcomes emphasized, offering promising approach more personalized therapies.

Language: Английский

Citations

0
Novel hybrid compounds of sclareol and doxorubicin as potential anticancer nanotherapy for glioblastoma DOI Open Access
Ana Stepanović, Nataša Terzić, Aleksandra Korać

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116496 - 116496

Published: March 26, 2024

Two novel hybrid compounds, CON1 and CON2, have been developed by combining sclareol (SC) doxorubicin (DOX) into a single molecular entity. These compounds 1:1 molar ratio of covalently linked SC DOX. They demonstrated promising anticancer properties, especially in glioblastoma cells, also shown potential treating multidrug-resistant (MDR) cancer cells that express the P-glycoprotein (P-gp) membrane transporter. CON2 form nanoparticles, as confirmed Zetasizer, transmission electron microscopy (TEM), chemical modeling. TEM showed can be found specifically cytoplasm, different organelles, nucleus, nucleolus. To examine U87 cell line, its corresponding U87-TxR well patient-derived astrocytoma grade 3 (ASC), were used, while normal human lung fibroblasts used to determine selectivity. exhibited better resistance selectivity profiles than DOX, showing less cytotoxicity, evidenced real-time analysis, DNA damage determination, death induction, mitochondrial respiration, depolarization studies. Cell cycle analysis β-galactosidase activity assay suggested die senescence following treatment. Overall, great they features are candidates for additional preclinical clinical studies on glioblastoma.

Language: Английский

Citations

2
Tumor-on-chip platforms for breast cancer continuum concept modeling DOI Creative Commons

Anca-Narcisa Neagu,

Danielle Whitham, Pathea Bruno

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 2, 2024

Our previous article entitled "Proteomics and its applications in breast cancer", proposed a Breast Cancer Continuum Concept (BCCC), including Cell as well Proteomic Concept. cancer-on-chip (BCoC), cancer liquid biopsy-on-chip (BCLBoC), metastasis-on-chip (BCMoC) models successfully recapitulate reproduce

Language: Английский

Citations

1
A guide for blood–brain barrier models DOI Open Access

Yomna Soliman,

Jana Al‐khodor,

Gülnaz Yildirim Köken

et al.

FEBS Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Understanding the intricate mechanisms underlying brain-related diseases hinges on unraveling pivotal role of blood-brain barrier (BBB), an essential dynamic interface crucial for maintaining brain equilibrium. This review offers a comprehensive analysis BBB physiology, delving into its cellular and molecular components while exploring wide range in vivo vitro models. Notably, recent advancements 3D cell culture techniques are explicitly discussed, as they have significantly improved fidelity modeling by enabling replication physiologically relevant environments under flow conditions. Special attention is given to aspects models, alongside discussions advances stem technologies, providing valuable insights generating robust systems modeling. The diverse array types used modeling, depending their sources, meticulously examined this review, scrutinizing respective derivation protocols implications. By synthesizing approaches, sheds light improvements models capture physiological conditions, aiding understanding interactions health disease conditions foster clinical developments.

Language: Английский

Citations

1