The
multidisciplinary
approach
in
the
management
of
polytrauma
patients
is
utmost
importance
for
proper
evaluation
and
treatment
injuries
different
body
systems,
as
second
most
common
cause
death
these
occurs
due
to
treatable
injuries.The
aim
this
article
highlight
correct
through
a
review
current
literature.In
article,
we
present
literature
widely
used
systematic
approach.We
discuss
ABCDE
sequence
ATLS
protocol,
prioritizing
airway
control,
breathing
assessment,
circulation
hemorrhage
neurological
patient
exposure
injury
identification.After
stabilization
identified
injuries,
detailed
secondary
assessment
crucial.The
emphasizes
specialized
team
provide
care
optimize
outcomes
complex
clinical
situation.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(22), P. 16316 - 16316
Published: Nov. 14, 2023
Glioblastoma
is
the
most
common
malignant
primary
central
nervous
system
tumor
and
one
of
debilitating
cancers.
The
prognosis
patients
with
glioblastoma
remains
poor,
management
this
tumor,
both
in
its
recurrent
forms,
suboptimal.
Despite
tremendous
efforts
that
are
being
put
forward
by
research
community
to
discover
novel
efficacious
therapeutic
agents
modalities,
no
major
paradigm
shifts
have
been
established
field
last
decade.
However,
does
not
mirror
abundance
relevant
findings
discoveries
made
preclinical
research.
Hence,
developing
utilizing
appropriate
models
faithfully
recapitulate
characteristics
behavior
human
utmost
importance.
Herein,
we
offer
a
holistic
picture
evolution
glioblastoma.
We
further
elaborate
on
commonly
used
vitro
vivo
models,
delving
into
their
development,
favorable
characteristics,
shortcomings,
areas
potential
improvement,
which
aids
researchers
designing
future
experiments
suitable
models.
Additionally,
review
explores
progress
fields
humanized
immunotolerant
mouse
genetically
engineered
animal
3D
microfluidics
highlights
promising
avenues
for
Sensors,
Journal Year:
2024,
Volume and Issue:
24(9), P. 2865 - 2865
Published: April 30, 2024
Glioblastoma,
an
aggressive
primary
brain
tumor,
poses
a
significant
challenge
owing
to
its
dynamic
and
intricate
tumor
microenvironment.
This
review
investigates
the
innovative
integration
of
biosensor-enhanced
organ-on-a-chip
(OOC)
models
as
novel
strategy
for
in-depth
exploration
glioblastoma
microenvironment
dynamics.
In
recent
years,
transformative
approach
incorporating
biosensors
into
OOC
platforms
has
enabled
real-time
monitoring
analysis
cellular
behaviors
within
controlled
Conventional
in
vitro
vivo
exhibit
inherent
limitations
accurately
replicating
complex
nature
progression.
addresses
existing
research
gap
by
pioneering
models,
providing
comprehensive
platform
investigating
The
applications
this
combined
studying
dynamics
are
critically
scrutinized,
emphasizing
potential
bridge
between
simplistic
conditions.
Furthermore,
article
discusses
implications
elucidating
features
microenvironment,
encompassing
cell
migration,
proliferation,
interactions.
By
furnishing
insights,
these
significantly
contribute
unraveling
biology
glioblastoma,
thereby
influencing
development
more
accurate
diagnostic
therapeutic
strategies.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 13, 2024
Glioblastoma
(GBM)
is
an
aggressive
form
of
cancer,
comprising
≈80%
malignant
brain
tumors.
However,
there
are
no
effective
treatments
for
GBM
due
to
its
heterogeneity
and
the
presence
blood-brain
barrier
(BBB),
which
restricts
delivery
therapeutics
brain.
Despite
in
vitro
models
contributing
understanding
GBM,
conventional
2D
oversimplify
complex
tumor
microenvironment.
Organ-on-a-chip
(OoC)
have
emerged
as
promising
platforms
that
recapitulate
human
tissue
physiology,
enabling
disease
modeling,
drug
screening,
personalized
medicine.
There
a
sudden
increase
GBM-on-a-chip
can
significantly
advance
knowledge
etiology
revolutionize
development
by
reducing
animal
testing
enhancing
translation
clinic.
In
this
review,
overview
their
applications
reported
screening
discussed
current
challenges
potential
future
directions
models.
Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(1), P. 93 - 93
Published: Jan. 18, 2024
GBM
is
the
most
aggressive
and
common
form
of
primary
brain
cancer
with
a
dismal
prognosis.
Current
treatments
have
not
improved
patient
survival,
due
to
propensity
for
tumor
cell
adaptation
immune
evasion,
leading
persistent
progression
disease.
In
recent
years,
microenvironment
(TME)
has
been
identified
as
critical
regulator
these
pro-tumorigenic
changes,
providing
complex
array
biomolecular
biophysical
signals
that
facilitate
evasion
strategies
by
modulating
cells,
stromal
populations.
Efforts
unravel
TME
interactions
are
necessary
improve
therapy.
Immunotherapy
promising
treatment
strategy
utilizes
patient’s
own
system
eradication
exhibited
exciting
results
in
many
types;
however,
highly
immunosuppressive
between
populations
continue
present
challenges.
order
elucidate
interactions,
novel
bioengineering
models
being
employed
decipher
mechanisms
immunologically
“cold”
GBMs.
Additionally,
data
leveraged
develop
engineering
bolster
immunotherapy
efficacy.
This
review
presents
an
in-depth
analysis
well
systems
used
underlying
improving
current
therapies.
Small Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: June 3, 2025
Glioma,
a
highly
aggressive
brain
tumor,
presents
significant
challenges
in
understanding
its
complex
pathophysiology
and
developing
effective
treatments.
This
review
critically
examines
the
current
glioma
modeling
platforms,
including
2D
culture,
3D
cultures,
glioma‐on‐a‐chip
(GoC)
models,
animal
with
focus
on
their
applications
recapitulating
tumor
microenvironment
evaluating
treatment
effectiveness.
Particular
attention
is
given
to
microfluidic
GoC
which
offer
unique
capabilities
mimic
pathophysiological
complexity
of
glioblastoma,
interactions
blood–brain
barrier
(BBB)
vascularization.
Recent
advancements
these
models
are
explored,
highlighting
potential
for
clinical
translation
through
improved
drug
permeability
central
nervous
system,
progress,
therapeutic
responses.
In
end,
discusses
perspective
establishes
key
criteria
designing
robust
clinically
relevant
models.
By
addressing
future
opportunities,
critical
role
platforms
bridging
gap
between
preclinical
research
outcomes
emphasized,
offering
promising
approach
more
personalized
therapies.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
174, P. 116496 - 116496
Published: March 26, 2024
Two
novel
hybrid
compounds,
CON1
and
CON2,
have
been
developed
by
combining
sclareol
(SC)
doxorubicin
(DOX)
into
a
single
molecular
entity.
These
compounds
1:1
molar
ratio
of
covalently
linked
SC
DOX.
They
demonstrated
promising
anticancer
properties,
especially
in
glioblastoma
cells,
also
shown
potential
treating
multidrug-resistant
(MDR)
cancer
cells
that
express
the
P-glycoprotein
(P-gp)
membrane
transporter.
CON2
form
nanoparticles,
as
confirmed
Zetasizer,
transmission
electron
microscopy
(TEM),
chemical
modeling.
TEM
showed
can
be
found
specifically
cytoplasm,
different
organelles,
nucleus,
nucleolus.
To
examine
U87
cell
line,
its
corresponding
U87-TxR
well
patient-derived
astrocytoma
grade
3
(ASC),
were
used,
while
normal
human
lung
fibroblasts
used
to
determine
selectivity.
exhibited
better
resistance
selectivity
profiles
than
DOX,
showing
less
cytotoxicity,
evidenced
real-time
analysis,
DNA
damage
determination,
death
induction,
mitochondrial
respiration,
depolarization
studies.
Cell
cycle
analysis
β-galactosidase
activity
assay
suggested
die
senescence
following
treatment.
Overall,
great
they
features
are
candidates
for
additional
preclinical
clinical
studies
on
glioblastoma.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Oct. 2, 2024
Our
previous
article
entitled
"Proteomics
and
its
applications
in
breast
cancer",
proposed
a
Breast
Cancer
Continuum
Concept
(BCCC),
including
Cell
as
well
Proteomic
Concept.
cancer-on-chip
(BCoC),
cancer
liquid
biopsy-on-chip
(BCLBoC),
metastasis-on-chip
(BCMoC)
models
successfully
recapitulate
reproduce
FEBS Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 12, 2024
Understanding
the
intricate
mechanisms
underlying
brain-related
diseases
hinges
on
unraveling
pivotal
role
of
blood-brain
barrier
(BBB),
an
essential
dynamic
interface
crucial
for
maintaining
brain
equilibrium.
This
review
offers
a
comprehensive
analysis
BBB
physiology,
delving
into
its
cellular
and
molecular
components
while
exploring
wide
range
in
vivo
vitro
models.
Notably,
recent
advancements
3D
cell
culture
techniques
are
explicitly
discussed,
as
they
have
significantly
improved
fidelity
modeling
by
enabling
replication
physiologically
relevant
environments
under
flow
conditions.
Special
attention
is
given
to
aspects
models,
alongside
discussions
advances
stem
technologies,
providing
valuable
insights
generating
robust
systems
modeling.
The
diverse
array
types
used
modeling,
depending
their
sources,
meticulously
examined
this
review,
scrutinizing
respective
derivation
protocols
implications.
By
synthesizing
approaches,
sheds
light
improvements
models
capture
physiological
conditions,
aiding
understanding
interactions
health
disease
conditions
foster
clinical
developments.