Interaction of Phenanthroline-Containing Copper Complexes with Model Phospholipid Membranes DOI Creative Commons
Priscilla Freddi, Natalia Álvarez, Gianella Facchin

et al.

Inorganics, Journal Year: 2024, Volume and Issue: 12(12), P. 307 - 307

Published: Nov. 26, 2024

Medicinal Inorganic Chemistry has provided oncology with metallodrugs for cancer treatment, including several promising candidate drugs. In particular, copper(II) coordination compounds phenanthroline stand out as potential anticancer agents. this work, we used Differential Scanning Calorimetry and Electron Spin Resonance to investigate the interaction of copper complexes [Cu(phen)]2+ [Cu(L-dipeptide)(phenanthroline) (L-dipeptide: L-Ala-Gly L-Ala-Phe)) model lipid membranes (1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC, 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) sodium salt, DPPG). Our results showed that interact membrane models, fluidizing them. The presented a different localization than free ligand phen. dipeptide modulated complex in modifications induced physicochemical properties vesicles. A stronger DPPG anionic was observed, which mimic negatively charged surfaces, found on tumor cells.

Language: Английский

Recently Reported Biological Activities and Action Targets of Pt(II)- and Cu(II)-Based Complexes DOI Creative Commons
Cristhian Eduardo Maciel-Flores, Juan Antonio Lozano-Ãlvarez, Egla Yareth Bivián-Castro

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1066 - 1066

Published: Feb. 29, 2024

Most diseases that affect human beings across the world are now treated with drugs of organic origin. However, some these associated side effects, toxicity, and resistance phenomena. For treatment many illnesses, development new molecules pharmacological potential is an urgent matter. The biological activities metal complexes have been reported to antitumor, antimicrobial, anti-inflammatory, anti-infective antiparasitic amongst others. Metal effective because they possess unique properties. example, complex entity possesses activity, then formation coordination bonds between ions ligands controlled, provide it extraordinary mechanisms action characteristics such as d-orbitals, oxidation states, specific orientations; also exhibit good stability physicochemical properties water solubility. Platinum a transition widely used in design antineoplastic activities; however, platinum effects which made necessary search for, design, novel based on other metals. Copper biometal found living systems; demonstrated antitumoral, antimicrobial anti-inflammatory In this review, we consider open horizons Cu(II)- Pt(II)-based complexes, trends their synthesis, targets action.

Language: Английский

Citations

7

Copper(ii) Complexes Based on 2,2’-Bipyridine and 1,10-Phenanthroline as Potential Objects for Developing Antitumor Drugs DOI

Yu. A. Golubeva,

Е.В. Лидер

Journal of Structural Chemistry, Journal Year: 2024, Volume and Issue: 65(6), P. 1159 - 1209

Published: June 1, 2024

Language: Английский

Citations

6

Dinuclear copper(II) complexes with a bridging bis(chalcone) ligand reveal considerable in vitro cytotoxicity on human cancer cells and enhanced selectivity DOI
Zdeněk Trávnı́ček, Ján Vančo, Jan Belza

et al.

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 252, P. 112481 - 112481

Published: Jan. 4, 2024

Language: Английский

Citations

5

Experimental and Computational Studies on the Interaction of DNA with Hesperetin Schiff Base CuII Complexes DOI Open Access
Federico Pisanu, Anna Sykuła, Giuseppe Sciortino

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5283 - 5283

Published: May 13, 2024

The interactions with calf thymus DNA (CT-DNA) of three Schiff bases formed by the condensation hesperetin benzohydrazide (HHSB or L1H3), isoniazid (HIN L2H3), thiosemicarbazide (HTSC L3H3) and their CuII complexes (CuHHSB, CuHIN, CuHTSC general formula [CuLnH2(AcO)]) were evaluated in aqueous solution both experimentally theoretically. UV–Vis studies indicate that ligands exhibit hypochromism, which suggests helical ordering helix. intrinsic binding constants (Kb) Cu compounds CT-DNA, range (2.3–9.2) × 106, from to CuHHSB, higher than other copper-based potential drugs, suggesting π–π stacking interaction due presence aromatic rings favors binding. Thiazole orange (TO) assays confirmed displace TO site, quenching fluorescence emission. DFT calculations allow for an assessment equilibrium between [Cu(LnH2)(AcO)] [Cu(LnH2)(H2O)]+, tautomer binds CuII, amido (am) not imido (im), coordination mode HTSC (O−, N, S), instead NH2). docking intercalative is preferred over minor groove CT-DNA order [Cu(L1H2am)(AcO)] > [Cu(L2H2am)(AcO)] ≈ L1H3 [Cu(L3H2am)(AcO)], line experimental Kb constants, obtained spectroscopy. Moreover, dockings predict strength larger [Cu(L1H2am)(H2O)]+. Overall, results suggest when different enantiomers, tautomers, donor sets are possible a metal complex, computational approach should be recommended type and, general, macromolecules.

Language: Английский

Citations

5

Transition metal complexes: a new generation of anticancer drugs DOI
Ignácio E. León

Future Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 16(17), P. 1727 - 1730

Published: Aug. 9, 2024

Language: Английский

Citations

5

«Green-Ligand» in Metallodrugs Design—Cu(II) Complex with Phytic Acid: Synthetic Approach, EPR-Spectroscopy, and Antimycobacterial Activity DOI Creative Commons
К. А. Кошенскова,

Natalia V. Makarenko,

F.M. Dolgushin

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 313 - 313

Published: Jan. 15, 2025

The interaction of sodium phytate hydrate C6H18O24P6·xNa·yH2O (phytNa) with Cu(OAc)2·H2O and 1,10-phenanthroline (phen) led to the anionic tetranuclear complex [Cu4(H2O)4(phen)4(phyt)]·2Na+·2NH4+·32H2O (1), structure latter was determined by X-ray diffraction analysis. 1 is completely deprotonated; six phosphate− fragments (with atoms P1–P6) are characterized different spatial arrangements relative cyclohexane ring (1a5e conformation), which determines two types coordination complexing agents—P1 P3, P4, P6 have monodentate, while P2 P5 bidentately bound Cu2+ cations. molecular anion stabilized a set strong intramolecular hydrogen bonds involving coordinated water molecules. Aromatic systems phen ligands chelating copper ions participate in intermolecular π-π interactions, further contributing their association. At supramolecular level, endless stacks formed, voids ammonium cations molecules present. stability presence human serum albumin (HSA) investigated using Electron Paramagnetic Resonance (EPR) spectroscopy. Continuous wave (CW) EPR spectra water/glycerol frozen solution clearly indicate an exchange-coupled Cu(II)-Cu(II) dimeric unit, as well Cu(II) monomer-like signal arising from spins sufficiently distant each other, comparable contributions signals. In at 1:1 ratio (1 albumin), spectrum changes significantly, primarily due reduced contribution S = fraction showing dipole–dipole splitting. biological activity vitro against non-pathogenic (model for Mycobacterium tuberculosis) strain Mycolicibacterium smegmatis first-line drug tuberculosis treatment, rifampicin.

Language: Английский

Citations

0

Evaluation of biomolecular interactions and in vitro cytotoxic activity of mononuclear and polymeric copper(ii)-based complexes against triple-negative breast cancer cells DOI

Imtiyaz Ahmad Mantoo,

Chandra Prakash Prasad, Imtiyaz Yousuf

et al.

New Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In vitro biomolecular & cytotoxic assessment of a mononuclear polymeric copper based chemotherutic agents.

Language: Английский

Citations

0

Copper(II) Cyclopeptides with High ROS-Mediated Cytotoxicity DOI
Sonia Boga, David Bouzada, Roi Lopez-Blanco

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Cu(II) coordination complexes are emerging as promising anticancer agents due to their ability induce oxidative stress through reactive oxygen species (ROS) generation. In this study, we synthesized and characterized two novel metallopeptide systems, 1/Cu(II) 2/Cu(II), derived from the oligocationic bipyridyl cyclopeptides 1 2, designed enhance transport of into cells increase ROS levels. Spectroscopic electrochemical analyses confirmed formation stable in aqueous media. Inductively coupled plasma mass spectrometry (ICP-MS) studies demonstrated that both metallopeptides significantly intracellular accumulation NCI/ADR-RES cancer cells, highlighting role efficient transporters. Additionally, generation assays revealed induces a substantial levels, supporting hypothesis stress-induced cytotoxicity. Cell-viability further 2/Cu(II) exhibit strong activity number cell lines, with IC50 values lower than those free cyclopeptide counterparts or alone, showing an order higher cisplatin. Finally, molecular modeling provided insights structural stability environment within complexes. These findings suggest these cyclometallopeptide systems hold potential metal-based therapeutic agents, leveraging key strategies for treatment.

Language: Английский

Citations

0

Cu(I) chelators: Useful tools to reveal and control Cu(I) homeostasis and toxicity DOI Creative Commons
Charlène Esmieu, Sarah Hostachy, Christelle Hureau

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216684 - 216684

Published: April 24, 2025

Language: Английский

Citations

0

Synthesis and Investigations of the Antitumor Effects of First-Row Transition Metal(II) Complexes Supported by Two Fluorinated and Non-Fluorinated β-Diketonates DOI Open Access
Maura Pellei, Jo’ Del Gobbo,

Miriam Caviglia

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2038 - 2038

Published: Feb. 7, 2024

The 3d transition metal (Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)) complexes, supported by anions of sterically demanding β-diketones, 1,3-dimesitylpropane-1,3-dione (HLMes) 1,3-bis(3,5-bis(trifluoromethyl)phenyl)-3-hydroxyprop-2-en-1-one (HLCF3), were synthesized evaluated for their antitumor activity. To assess the biological effects substituents on phenyl moieties, we also investigated analogous metal(II) complexes anion less bulky 1,3-diphenylpropane-1,3-dione (HLPh) ligand. compounds [Cu(LCF3)2], [Cu(LMes)2] ([Zn(LMes)2]) characterized X-ray crystallography. [Cu(LCF3)2] crystallizes with an apical molecule solvent (THF) features a rare square pyramidal geometry at center. copper(II) zinc(II) diketonate ligands, derived from deprotonated (HLMes), adopt planar or tetrahedral metal, respectively. We properties newly against series human tumor cell lines different solid tumors. Except iron derivatives, cellular studies revealed noteworthy properties, even towards cancer cells endowed poor sensitivity to reference drug cisplatin.

Language: Английский

Citations

2