Cancer Medicine,
Journal Year:
2025,
Volume and Issue:
14(5)
Published: March 1, 2025
The
increasing
incidence
of
gastric
cancer
(GC)
in
younger
populations,
coupled
with
population
aging,
has
highlighted
distinct
age-related
subtypes
unique
clinical
characteristics
and
outcomes.
Although
patients
tend
to
have
more
aggressive
tumors,
the
prognostic
factors
for
early-onset
(EOGC)
remain
underexplored.
This
study
is
dedicated
providing
a
comprehensive
in-depth
analysis
EOGC,
aiming
refine
personalized
treatment
strategies
under
precision
medicine
paradigm.
retrospective
encompassed
413
local
cohort
EOGC
8447
Surveillance,
Epidemiology,
End
Results
database
diagnosed
GC.
Survival
outcomes
were
assessed
using
Kaplan-Meier
survival
curves,
differences
between
groups
evaluated
log-rank
test.
Prognostic
identified
through
logistic
regression
Cox
proportional
hazards
models.
Mediation
was
conducted
assess
indirect
effects
on
prognosis.
Biomarker
comparisons
bone
metastasis
non-bone
Wilcoxon
test
significant
differences.
overall
cancer-specific
rates
group
significantly
lower
than
those
non-early-onset
(p
<
0.05).
However,
itself
not
an
independent
risk
factor
poor
revealed
that
adverse
impact
prognosis
predominantly
mediated
by
metastasis,
as
most
factor.
Furthermore,
emerged
predictor
patients,
potentially
linked
elevated
coagulation
markers,
increased
inflammation-related
cytokines,
imbalance
peripheral
blood
immune
cell
ratios.
Bone
contributes
EOGC.
demonstrate
suppression,
inflammation
activation,
coagulopathy,
highlighting
need
tailored
management
strategies.
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2024,
Volume and Issue:
150(5)
Published: May 7, 2024
Abstract
Background
Tumor
growth
is
closely
linked
to
the
activities
of
various
cells
in
tumor
microenvironment
(TME),
particularly
immune
cells.
During
progression,
circulating
monocytes
and
macrophages
are
recruited,
altering
TME
accelerating
growth.
These
adjust
their
functions
response
signals
from
stromal
Tumor-associated
(TAMs),
similar
M2
macrophages,
key
regulators
TME.
Methods
We
review
origins,
characteristics,
TAMs
within
This
analysis
includes
mechanisms
through
which
facilitate
evasion
promote
metastasis.
Additionally,
we
explore
potential
therapeutic
strategies
that
target
TAMs.
Results
instrumental
mediating
malignant
behaviors.
They
release
cytokines
inhibit
effector
attract
additional
immunosuppressive
primarily
T
cells,
inducing
exhaustion
directly,
influencing
activity
indirectly
cellular
interactions,
or
suppressing
checkpoints.
directly
involved
proliferation,
angiogenesis,
invasion,
Summary
Developing
innovative
tumor-targeted
therapies
immunotherapeutic
currently
a
promising
focus
oncology.
Given
pivotal
role
evasion,
several
approaches
have
been
devised
them.
include
leveraging
epigenetics,
metabolic
reprogramming,
engineering
repolarize
TAMs,
inhibiting
recruitment
activity,
using
as
drug
delivery
vehicles.
Although
some
these
remain
distant
clinical
application,
believe
future
targeting
will
offer
significant
benefits
cancer
patients.
Non-coding RNA Research,
Journal Year:
2024,
Volume and Issue:
9(3), P. 887 - 900
Published: April 4, 2024
In
the
intricate
field
of
cancer
biology,
researchers
are
increasingly
intrigued
by
emerging
role
exosomal
long
non-coding
RNAs
(lncRNAs)
due
to
their
multifaceted
interactions,
complex
modulation
mechanisms,
and
potential
therapeutic
applications.
These
lncRNAs,
carried
within
extracellular
vesicles,
play
a
vital
partin
tumorigenesis
disease
progression
facilitating
communication
networks
between
tumor
cells
local
microenvironment,
making
them
an
ideal
candidates
for
use
in
liquid
biopsy
approach.
However,
lncRNAs
remain
understudied
area,
especially
biology.
Therefore
this
review
aims
comprehensively
explore
dynamic
interplay
various
cellular
components,
including
interactions
with
tumor-stroma,
immune
modulation,
drug
resistance
mechanisms.
Understanding
regulatory
functions
these
processes
can
potentially
unveil
novel
diagnostic
markers
targets
cancer.
Additionally,
emergence
RNA-based
therapeutics
presents
exciting
opportunities
targeting
offering
innovative
strategies
combat
improve
treatment
outcomes.
Thus,
provides
insights
into
current
understanding
highlighting
crucial
roles,
evolving
landscape
interventions.
Furthermore,
we
have
also
discussed
advantage
exosomes
as
carriers
development
personalized
targeted
therapy
patients.
Cancers,
Journal Year:
2022,
Volume and Issue:
15(1), P. 286 - 286
Published: Dec. 31, 2022
Exosomes
are
nanovesicles
secreted
into
biofluids
by
various
cell
types
and
have
been
implicated
in
different
physiological
pathological
processes.
Interestingly,
a
plethora
of
studies
emphasized
the
mediating
role
exosomes
bidirectional
communication
between
donor
recipient
cells.
Among
cargoes
exosomes,
long
non-coding
RNAs
(lncRNAs)
identified
as
crucial
regulators
cancer
cells
immune
tumor
microenvironment
(TME)
that
can
interfere
with
innate
adaptive
responses
to
affect
therapeutic
efficiency.
Recently,
few
major
focused
on
exosomal
lncRNA-mediated
interaction
infiltrated
TME.
Nevertheless,
dearth
pertains
regulating
lncRNAs
is
still
early
stages.
Comprehensive
mechanisms
immunity
not
well
understood.
Herein,
we
provide
an
overview
immunomodulatory
function
treatment
resistance.
In
addition,
also
summarize
potential
strategies
toward
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 20, 2023
T
cells
play
a
crucial
role
in
the
regulation
of
immune
response
and
are
integral
to
efficacy
cancer
immunotherapy.
Because
immunotherapy
has
emerged
as
promising
treatment
for
cancer,
increasing
attention
been
focused
on
differentiation
function
response.
In
this
review,
we
describe
research
progress
T-cell
exhaustion
stemness
field
summarize
advances
potential
strategies
intervene
treat
chronic
infection
by
reversing
maintaining
stemness.
Moreover,
discuss
therapeutic
overcome
immunodeficiency
tumor
microenvironment
promote
continuous
breakthroughs
anticancer
activity
cells.
Journal for ImmunoTherapy of Cancer,
Journal Year:
2023,
Volume and Issue:
11(4), P. e006808 - e006808
Published: April 1, 2023
Background
Chordoma
is
an
extremely
rare,
locally
aggressive
malignant
bone
tumor
originating
from
undifferentiated
embryonic
remnants.
There
are
no
effective
therapeutic
strategies
for
chordoma.
Herein,
we
aimed
to
explore
cellular
interactions
within
the
chordoma
immune
microenvironment
and
provide
new
targets.
Methods
Spectrum
flow
cytometry
multiplex
immunofluorescence
(IF)
staining
were
used
investigate
of
Cell
Counting
Kit-8,
Edu,
clone
formation,
Transwell,
healing
assays
validate
functions.
Flow
Transwell
analyze
macrophage
phenotype
chemotaxis
alterations.
Immunohistochemistry,
IF,
western
blot,
PCR,
ELISA
molecular
expression.
An
organoid
model
a
xenograft
mouse
constructed
efficacy
maraviroc
(MVC).
Results
The
landscape
was
characterized,
observed
that
exhibits
typical
exclusion
phenotype.
However,
macrophages
infiltrating
zone
also
noted.
Through
functional
assays,
demonstrated
chordoma-secreted
CCL5
significantly
promoted
malignancy
progression,
recruitment,
M2
polarization.
In
turn,
markedly
enhanced
proliferation,
invasion,
migration
viability
knockdown
MVC
(CCL5/CCR5
inhibitor)
treatment
both
inhibited
progression
We
established
patient-derived
organoids,
wherein
exhibited
antitumor
effects,
especially
in
patient
4,
with
robust
killing
effect.
inhibits
growth
lung
metastasis
vivo.
Conclusions
Our
study
implicates
CCL5–CCR5
axis
plays
important
role
regulation
macrophages,
potential
target
Journal of Ethnopharmacology,
Journal Year:
2024,
Volume and Issue:
333, P. 118260 - 118260
Published: April 27, 2024
Wumei
Wan
(WMW),
a
traditional
Chinese
medicine
prescription,
has
been
proved
to
be
effective
in
treating
Colitis-associated
colorectal
cancer
(CAC),
but
it
not
proven
different
stages
of
CAC.
