Rabeprazole suppressed gastric intestinal metaplasia through activation of GPX4-mediated ferroptosis DOI Creative Commons
Jing Xie,

Xinhua Liang,

Fangfang Xie

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 7, 2024

Background Gastric intestinal metaplasia is a common pathological feature in patients with Helicobacter pylori ( H. ) infection. Rabeprazole was widely used as the first-line regimen for infectious treatment. The objective of this study to explore mechanism rabeprazole gastric Methods Real-time PCR, Western blotting (WB) and ROS analysis were conducted confirm that could induce ferroptosis suppress metaplasia. Cellular fraction, luciferase chromatin immunoprecipitation (ChIP) identify underlying modulated ferroptosis. Results Herein, we found treatment led inhibit CDX2 MUC2 expression, alleviating metaplasia, which attributed enhanced characterized by decreased GPX4 expression. Inhibition ferrostatin-1 (Fer-1) reverse expression caused rabeprazole. Mechanically, CREB phosphorylation nuclear translocation, further binding promoter, reducing transactivity. Moreover, endogenous PKA interacted CREB, interaction drastically destroyed response Most importantly, observed pylori- infected comparison HC control. Conclusion These findings suggested induced reduce epithelial cells through PKA/CREB cascade signaling, implying targeting be promising strategy improving during -infected patients.

Language: Английский

Overcoming cancer chemotherapy resistance by the induction of ferroptosis DOI
Yumin Wang,

Xiaorui Wu,

Ren Zhao

et al.

Drug Resistance Updates, Journal Year: 2022, Volume and Issue: 66, P. 100916 - 100916

Published: Dec. 29, 2022

Language: Английский

Citations

165
Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases DOI Open Access
Ying Liu, Wei Ding, Jianxun Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114993 - 114993

Published: June 9, 2023

Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality worldwide seriously threatens human health life. Cardiomyocyte death considered the pathological basis of various CVDs, including myocardial infarction, heart failure, aortic dissection. Multiple mechanisms, such as ferroptosis, necrosis, apoptosis, contribute cardiomyocyte death. Among them, ferroptosis an iron-dependent form programmed cell that plays vital role in physiological processes, from development aging immunity CVD. The dysregulation has been shown be closely associated with CVD progression, yet its underlying mechanisms are still not fully understood. In recent years, growing amount evidence suggests non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular involved regulation thus affecting progression. Some ncRNAs also exhibit potential value biomarker and/or therapeutic target for patients this review, we systematically summarize findings on their We focus clinical applications diagnostic prognostic biomarkers well targets treatment. DATA AVAILABILITY: No new data were created or analyzed study. Data sharing applicable article.

Language: Английский

Citations

51
Ferroptosis in Cancer: Mechanisms, Therapeutic Strategies, and Clinical Implications DOI

Mina Pourhabib Mamaghani,

Seyedeh Nasibeh Mousavikia,

Hosein Azimian

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155907 - 155907

Published: March 12, 2025

Language: Английский

Citations

2
POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer DOI Creative Commons
Jingyun Wang,

Qiaoyu Jia,

Shuqin Jiang

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: Jan. 25, 2024

Abstract Objective This study investigated the effect and mechanism of POU6F1 lncRNA-CASC2 on ferroptosis gastric cancer (GC) cells. Methods GC cells treated with erastin RSL3 were detected for ferroptosis, reactive oxygen species (ROS) level, cell viability. The expression levels POU6F1, lncRNA-CASC2, SOCS2, ferroptosis-related molecules (GPX4 SLC7A11) also measured. regulations among FMR1, SLC7A11 determined. Subcutaneous tumor models established, in which expressions Ki-67, GPX4 by immunohistochemistry. Results patients decreased had lower survival rate. Overexpression or proliferation GSH cells, addition to increasing total iron, Fe2+, MDA, ROS levels. directly binds promoter promote its transcription. LncRNA-CASC2 can target FMR1 increase SOCS2 mRNA stability ubiquitination degradation activate signaling. Knockdown inhibited sensitivity reversed effects overexpression Conclusion Transcription factor expression, while upregulated increases targeting thereby inhibiting signaling inhibit progression.

Language: Английский

Citations

9
Micronutrients/miRs/ATP networking in mitochondria: Clinical intervention with ferroptosis, cuproptosis, and calcium burden DOI
Siva Prasad Panda, Adarsh Kesharwani

Mitochondrion, Journal Year: 2023, Volume and Issue: 71, P. 1 - 16

Published: May 11, 2023

Language: Английский

Citations

17
Ferroptosis and circular RNAs: new horizons in cancer therapy. DOI
Asif Ahmad Bhat,

Neelima Kukreti,

Muhammad Afzal

et al.

PubMed, Journal Year: 2024, Volume and Issue: 23, P. 570 - 599

Published: Jan. 1, 2024

Cancer poses intricate challenges to treatment due its complexity and diversity. Ferroptosis circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators pivotal influencers ferroptosis in cell lines. The results underscore significance modulating pathways that impact crucial aspects development, including survival, proliferation, metastasis. A detailed analysis delineates these pathways, shedding light on mechanisms through which influence ferroptosis. Building upon recent experimental findings, study evaluates potential targeting induce By identifying specific associated with etiology cancer, this paves way for development targeted therapeutics exploit vulnerabilities cells. This review consolidates existing understanding circRNAs, emphasizing role therapy providing impetus ongoing research dynamic field. See also graphical abstract(Fig. 1).

Language: Английский

Citations

7
The potential role and mechanism of circRNAs in Ferroptosis: A comprehensive review DOI
Javad Arabpour,

Kimia Rezaei,

Javad Yaghmoorian Khojini

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155203 - 155203

Published: Feb. 9, 2024

Language: Английский

Citations

5
Helicobacter pylori upregulates circPGD and promotes development of gastric cancer DOI Creative Commons

Wenjun Zhao,

Zhendong Yao,

Jia Cao

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(2)

Published: Feb. 26, 2024

Abstract Purpose Helicobacter pylori ( H. ) has unique biochemical traits and pathogenic mechanisms, which make it a substantial cause of gastrointestinal cancers. Circular RNAs (circRNAs) have concurrently been identified as an important participating factor in the pathophysiology several different However, underlying processes putative interactions between circRNAs received very little attention. To address this issue, we explored interaction to investigate how they might jointly contribute occurrence development gastric cancer. Methods Changes circPGD expression were detected using qRT-PCR. Cell proliferation migration changes assayed by colony formation, CCK-8 assay transwell assay. Apoptosis was measured flow cytometry. Western blot conducted detect cell migration, apoptosis, inflammation-associated proteins. QRT-PCR used measure factors. Results We found that induced increased infected human cells facilitated cancer progression three ways promoting enhancing inflammatory response, inhibiting apoptosis. Conclusions CircPGD appears play role -related may thus be viable, novel target for therapeutic intervention.

Language: Английский

Citations

5
Ferroptosis resistance in cancer: recent advances and future perspectives DOI
Zhang Xing, Xiang Li, Xia Ran

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 219, P. 115933 - 115933

Published: Nov. 22, 2023

Language: Английский

Citations

12
The role of metal ions in the occurrence, progression, drug resistance, and biological characteristics of gastric cancer DOI Creative Commons

Pengtuo Xiao,

Changfeng Li, Yuanda Liu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 2, 2024

Metal ions exert pivotal functions within the human body, encompassing essential roles in upholding cell structure, gene expression regulation, and catalytic enzyme activity. Additionally, they significantly influence various pathways implicated divergent mechanisms of death. Among prevailing malignant tumors digestive tract worldwide, gastric cancer stands prominent, exhibiting persistent high mortality rates. A compelling body evidence reveals conspicuous ion irregularities tumor tissues, cancer. Notably, metal have been observed to elicit distinct contributions progression, drug resistance, biological attributes This review consolidates pertinent literature on involvement etiology advancement Particular attention is directed towards ions, namely, Na, K, Mg, Ca, Fe, Cu, Zn, Mn, elucidating their initiation progression cancer, cellular demise processes, resistance phenomena, therapeutic approaches.

Language: Английский

Citations

4