COVID-19 and Male Infertility: Is There a Role for Antioxidants? DOI Creative Commons

Thomas Kalfas,

Aris Kaltsas, Evangelos N. Symeonidis

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(8), P. 1483 - 1483

Published: July 25, 2023

Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), jeopardizes male fertility because of the vulnerability reproductive system, especially testes. This study evaluates effects virus on testicular function and examines potential role antioxidants in mitigating damage oxidative stress (OS). A comprehensive PubMed search examined exocrine endocrine alteration, interplay between OS COVID-19-induced defects, benefit antioxidants. Although is rarely directly detectable sperm tissue, semen quality hormonal balance are affected patients, with some changes persisting throughout a spermatogenesis cycle. Testicular pathology deceased patients shows defects spermatogenesis, vascular changes, inflammation. Acute primary hypogonadism observed mainly severely infected cases. Elevated DNA fragmentation markers suggest redox imbalance as possible mechanism behind changes. COVID-19 vaccines appear to be safe for fertility, but efficacy improve after infection remains unproven due limited research. Given inconclusive evidence, careful evaluation men recovering from seeking improvement strongly recommended.

Language: Английский

Impact of hypoxia on male reproductive functions DOI
P. A. Oyedokun, Roland Eghoghosoa Akhigbe, Lydia Oluwatoyin Ajayi

et al.

Molecular and Cellular Biochemistry, Journal Year: 2022, Volume and Issue: 478(4), P. 875 - 885

Published: Sept. 15, 2022

Language: Английский

Citations

44
Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis DOI Creative Commons
Moses Agbomhere Hamed, Tunmise Maryanne Akhigbe, Adetomiwa Ezekiel Adeogun

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 24, 2023

Background Organophosphate (OP) pesticides have been associated with a decline in semen quality, although there are still considerable arguments about the magnitude of association. Objective This study provides systematic review and meta-analysis impacts OP on quality male reproductive hormones. Methods was conducted according to Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) protocols. Strategic search using combined text words as terms. The eligibility criteria were developed based Population, Exposure, Comparator, Outcome, Study designs (PECOS) framework. Relevant data extracted, risk bias evaluated by Office Health Assessment Translation (OHAT) tool, certainty evidence assessed Grading Recommendations Assessment, Development Evaluation (GRADE) Working Group guidelines. Quantitative performed Review Manager. Results A total 766 subjects (349 exposed 417 unexposed controls) included meta-analysis. There no significant difference ejaculate volume, seminal fluid sperm multiple anomaly index, sperm, leukocytes levels OP-exposed compared control. In addition, exposure did not significantly affect serum concentrations FSH, LH, testosterone who their counterparts. However, we found reduction count, concentration, progressive motility, normal morphology pesticides-exposed subjects. after subtype sensitivity analyses, reduce count. Also, analysis, alter motility. Conclusion demonstrates that reduced morphology, possibly via testosterone-independent mechanism.

Language: Английский

Citations

27
Promethazine induces testicular and epididymal toxicity via the upregulation of xanthine oxidase/uric acid-mediated oxidative stress signaling DOI
Moses Agbomhere Hamed, Roland Eghoghosoa Akhigbe,

Victor Olukayode Ekundina

et al.

Comparative Clinical Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

1
Impact of COVID 19 on erectile function DOI Creative Commons

Damilare Hakeem Adeyemi,

Adeyemi Fatai Odetayo, Moses Agbomhere Hamed

et al.

The Aging Male, Journal Year: 2022, Volume and Issue: 25(1), P. 202 - 216

Published: Aug. 4, 2022

Purpose: COVID-19, a novel infection, presented with several complications, including socioeconomical and reproductive health challenges such as erectile dysfunction (ED). The present review summarizes the available shreds of evidence on impact COVID-19 ED.Materials methods: All published peer-reviewed articles from onset outbreak to date, relating ED, were reviewed. Results: Available pieces that ED is consequence are convincing. share common risk factors disruption vascular integrity, cardiovascular disease (CVD), cytokine storm, diabetes, obesity, chronic kidney (CKD). also induces impaired pulmonary haemodynamics, increased ang II, testicular damage low serum testosterone, reduced arginine-dependent NO bioavailability promotes reactive oxygen species (ROS) generation endothelial dysfunction, resulting in ED. In addition, triggers psychological/mental stress suppresses testosterone-dependent dopamine concentration, which contributes incident ED.Conclusions: conclusion, exerts detrimental effect male function, function. This involves cascade events multiple pathways. As pandemic dwindles, identifying long-term effects COVID-19-induced proffering adequate effective measures militating against remains pertinent.

Language: Английский

Citations

36
Psychoactive drugs and male fertility: impacts and mechanisms DOI Creative Commons
Moses Agbomhere Hamed,

Victor Olukayode Ekundina,

Roland Eghoghosoa Akhigbe

et al.

Reproductive Biology and Endocrinology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 28, 2023

Abstract Although psychoactive drugs have their therapeutic values, they been implicated in the pathogenesis of male infertility. This study highlights reported to impair fertility, impacts, and associated mechanisms. Published data from scholarly peer-reviewed journals were used for present study. Papers assessed through AJOL, DOAJ, Google Scholar, PubMed/PubMed Central, Scopus using Medical Subjects Heading (MeSH) indexes relevant keywords. Psychoactive negatively affect reproductive functions, including sexual urge, androgen synthesis, spermatogenesis, sperm quality. These directly induce testicular toxicity by promoting ROS-dependent oxidative damage, inflammation, apoptosis, also suppress hypothalamic-pituitary–testicular axis. results suppression circulating androgen, impaired reduced In conclusion, drug abuse not only harms erectile function as well viz., testosterone concentration, quality, but it alters histoarchitecture a cascade events via multiple pathways. Therefore, offering adequate effective measures against drug-induced infertility remains pertinent.

Language: Английский

Citations

20
Evaluation of Female Infertility and Viral Diseases: A Systematic Review of Coronaviruses DOI

Mahla Javadzadeh,

Firouzeh Rakhshani Moghadam,

Elham Erfanifar

et al.

Sexuality and Disability, Journal Year: 2024, Volume and Issue: 42(3), P. 567 - 589

Published: July 26, 2024

Language: Английский

Citations

7
Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins DOI Creative Commons
Michal Ješeta, Anna Pospíšilová, Lenka Mekiňová

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(15), P. 2468 - 2468

Published: July 25, 2023

The compounds of seminal plasma have great potential as biomarkers male fertility and can be used a diagnostic tool for types azoospermia. Azoospermia occurs in approximately 1% the population, an effective therapy this form infertility, it is important to distinguish between obstructive non-obstructive Proteins serve diagnosing Considering various obstructions, combination multiple proteins advisable purposes. In context, testicular epididymal are particularly significant, they specific these tissues typically absent ejaculate during most obstructions. A more than analysis single protein. This group markers contains TEX101 ECM1 proteins, combined detections two bring output with high sensitivity specificity. Similar results were observed detection SPAG1. using from significantly improve existing approaches diagnosis causes infertility.

Language: Английский

Citations

14
Microbial Dysbiosis and Male Infertility: Understanding the Impact and Exploring Therapeutic Interventions DOI Open Access
Aris Kaltsas, Athanasios Zachariou,

Eleftheria Markou

et al.

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(10), P. 1491 - 1491

Published: Oct. 13, 2023

The human microbiota in the genital tract is pivotal for maintaining fertility, but its disruption can lead to male infertility. This study examines relationship between microbial dysbiosis and infertility, underscoring promise of precision medicine this field. Through a comprehensive review, research indicates signatures associated with such as altered bacterial diversity, dominance pathogenic species, imbalances microbiome. Key mechanisms linking infertility include inflammation, oxidative stress, sperm structural deterioration. Emerging strategies like targeted antimicrobial therapies, probiotics, prebiotics, fecal transplantation have shown potential adjusting enhance fertility. Notably, application medicine, which customizes treatments based on individual profiles specific causes emerges promising approach treatment outcomes. Ultimately, intricately linked embracing personalized rooted principles could be way forward addressing factors.

Language: Английский

Citations

14
Molecular mechanisms underpinning the protection against antiretroviral drug-induced sperm-endocrine aberrations and testicular toxicity: A review DOI
Roland Eghoghosoa Akhigbe, Tunmise Maryanne Akhigbe,

Precious Adeoye Oyedokun

et al.

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 128, P. 108629 - 108629

Published: May 31, 2024

Language: Английский

Citations

4
SARS-CoV-2 impairs male fertility by targeting semen quality and testosterone level: A systematic review and meta-analysis DOI Creative Commons

Victory Jesutoyosi Ashonibare,

P. J. Ashonibare,

Tunmise Maryanne Akhigbe

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(9), P. e0307396 - e0307396

Published: Sept. 9, 2024

Background Since the discovery of COVID-19 in December 2019, novel virus has spread globally causing significant medical and socio-economic burden. Although pandemic been curtailed, its attendant complication live on. A major global concern is adverse impact on male fertility. Aim This study was aimed to give an up date robust data regarding effect semen variables reproductive hormones. Materials methods Literature search performed according recommendations PRISMA. Out 852 studies collected, only 40 were eligible for inclusion assessing SARS-CoV-2 exerts quality androgens. More so, a SWOT analysis conducted. Results The present demonstrated that significantly reduced ejaculate volume, sperm count, concentration, viability, normal morphology, total progressive motility. Furthermore, led reduction circulating testosterone level, but rise oestrogen, prolactin, luteinizing hormone levels. These findings associated with decline testosterone/luteinizing ratio. Conclusions current provides compelling evidence may lower fertility by reducing through hormone-dependent mechanism; level increase oestrogen prolactin

Language: Английский

Citations

4