Effects of Turmeric Powder on Aflatoxin M1 and Aflatoxicol Excretion in Milk from Dairy Cows Exposed to Aflatoxin B1 at the EU Maximum Tolerable Levels

Toxins, Journal Year: 2022, Volume and Issue: 14(7), P. 430 - 430

Published: June 24, 2022

Due to the climatic change, an increase in aflatoxin B1 (AFB1) maize contamination has been reported Europe. As alternative mineral binders, natural phytogenic compounds are increasingly used counteract negative effects of AFB1 farm animals. In cows, even low dietary concentrations may result milk excretion genotoxic carcinogen metabolite M1 (AFM1). this study, we tested ability turmeric powder (TP), extract from Curcuma longa (CL) rich curcumin and curcuminoids, reducing AFM1 mammary Holstein–Friesian cows. Both active principles inhibit hepatic synthesis interact with drug transporters involved absorption excretion. A crossover design was applied two groups cows (n = 4 each) a 4-day washout. Animals received diet contaminated levels (5 ± 1 µg/kg) for 10 days TP supplementation (20 g/head/day). treatment had no impact on yield, composition or somatic cell count. Despite tendency toward lower average content last four (below EU limits), statistically significant differences group occurred. Since bioavailability be major issue, further investigations different CL preparations warranted.

Language: Английский

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Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 258 - 258

Published: Feb. 20, 2024

Heat stress represents a pervasive global concern with far-reaching implications for the reproductive efficiency of both animal and human populations. An extensive body published research on heat effects utilizes controlled experimental environments to expose cells tissues its disruptive influence physiological aspects phenotypic traits, encompassing parameters such as sperm quality, motility, viability, overall competence. Beyond these immediate effects, has been linked embryo losses, compromised oocyte development, even infertility across diverse species. One primary mechanisms underlying adverse outcomes is elevation reactive oxygen species (ROS) levels precipitating oxidative apoptosis within mammalian cells. Oxidative are recognized pivotal biological factors through which exerts impact male female In concerted effort mitigate detrimental consequences stress, supplementation antioxidants, in natural synthetic forms, explored potential intervention strategy. Furthermore, possess inherent self-protective that come into play during episodes aiding their survival. This comprehensive review delves multifaceted traits elucidates intricate molecular underpinning cells, compromise normal function. Additionally, we provide succinct overview antioxidant interventions highlight genetic biomarkers capabilities, collectively offering promising avenues ameliorating negative by restraining stress.

Language: Английский

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The Effect of Adding Different Levels of Curcumin and Its Nanoparticles to Extender on Post-Thaw Quality of Cryopreserved Rabbit Sperm

Animals, Journal Year: 2020, Volume and Issue: 10(9), P. 1508 - 1508

Published: Aug. 26, 2020

The cryopreservation process adversely affects sperm function and quality traits, causing some changes at biochemical structural levels, due to mechanical, thermal, osmotic, oxidative damage. Supplementation with curcumin nanoparticles could prevent even revert this effect enhance the post/thawed in rabbit. study amid explore of (CU) (CUNPs) supplementation semen extender on rabbit quality. Twelve fertile, healthy bucks were included, ejaculates collected using artificial vaginas. Rabbit pooled was cryopreserved tris-yolk fructose (TYF) without any supplement (control group) or supplemented CU levels 0.5, 1 1.5 µg/mL (CU0.5, CU1.0, CU1.5, respectively) CUNPs 1, (CUNPs0.5, CUNPs1.0, CUNPs1.5, packed straws (0.25 mL) stored liquid nitrogen (-196 °C). Results revealed that CUNPs1.5 had a positive influence (p < 0.05) post-thawing progressive motility, viability, membrane integrity as compared other groups. Percentages dead sperm, abnormalities, early apoptotic, necrotic cells reduced treatments. Using significantly improved total antioxidant capacity (TAC), GPx, while MDA POC CU1.5 comparison SOD values enhanced CUNPs1.0 relation Conclusively, addition its can improve post-thawed via redox signaling reduce apoptosis process.

Language: Английский

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Supplemental dietary curcumin improves testicular hemodynamics, testosterone levels, and semen quality in Baladi bucks in the non-breeding season

Theriogenology, Journal Year: 2022, Volume and Issue: 188, P. 100 - 107

Published: May 27, 2022

Language: Английский

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The impact of curcumin on livestock and poultry animal's performance and management of insect pests

Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10

Published: Feb. 3, 2023

Plant-based natural products are alternative to antibiotics that can be employed as growth promoters in livestock and poultry production attractive alternatives synthetic chemical insecticides for insect pest management. Curcumin is a polyphenol compound from the rhizomes of turmeric ( Curcuma spp .) has been suggested have number therapeutic benefits treatment human diseases. It also credited its nutritional pesticide properties improving performances controlling pests. Recent studies reported curcumin an excellent feed additive contributing animal disease resistance. Also, they detailed curcumin's growth-inhibiting insecticidal activity reducing agricultural pests vector-borne This review aims highlight role increasing development animals We discuss challenges knowledge gaps concerning use commercialization repellent.

Language: Английский

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Fenpropathrin provoked kidney damage via controlling the NLRP3/Caspase-1/GSDMD–mediated pyroptosis: The palliative role of curcumin-loaded chitosan nanoparticles

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 484, P. 116869 - 116869

Published: Feb. 19, 2024

Language: Английский

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Nanocurcumin and curcumin prevent N, N'-methylenebisacrylamide-induced liver damage and promotion of hepatic cancer cell growth

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: May 18, 2022

Acrylamide (AC) is an environmental contaminant with cancer-promoting and cytotoxic properties, while curcumin (Cur.) a phytochemical documented anticancer cytoprotective efficacy. Nanoparticle formulations can increase the efficacy of phytochemicals, so we examined hepatoprotective efficacies nanocurcumin (N.Cur). Curcumin reduced HepG2 Huh-7 cancer cell viability increased apoptosis in presence absence AC, AC alone promoted proliferation. Furthermore, was greater than that curcumin. In mice, greatly hepatic expression CYP2E1, P53, cleaved caspase-3, COL1A1 as well serum alanine aminotransferase aspartate activities. These effects were reversed by Nanocurcumin also histopathology fibrosis caused AC-induced glycogen depletion. formulation efficiencies

Language: Английский

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Curcumin as a Potential Antioxidant in Stress Regulation of Terrestrial, Avian, and Aquatic Animals: A Review

Antioxidants, Journal Year: 2023, Volume and Issue: 12(9), P. 1700 - 1700

Published: Aug. 31, 2023

Stress has brought about a variety of harmful impacts on different animals, leading to difficulties in the management animal husbandry and aquaculture. Curcumin been recognized as potential component ameliorate adverse influence stress induced by toxicity, inflammation, diseases, thermal effect, so on. In detail, this compound is known offer various outstanding functions, including antibacterial properties, antioxidant effects, immune response recovery, behavioral restoration animals under conditions. However, curcumin still some limitations, owing its low bioavailability. This review summarizes latest updates regulatory effects terms terrestrial, avian, aquatic animals.

Language: Английский

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A dynamic transcriptional cell atlas of testes development after birth in Hu sheep

BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 12, 2025

Testes development is a fundamental process in sexual and reproduction. The testes undergo dramatic structural changes during development, including the proliferation differentiation of somatic cells such as Sertoli cells, Leydig myoid well maturation spermatogonia. However, little known about onset spermatogenesis cell spermatogonial niche large animals. We used single-cell RNA sequencing (scRNA-seq) to profile nearly 100,000 from Hu sheep across seven developmental stages (birth, prepuberty, puberty, adulthood). constructed transcriptomic atlases identified distinct subtypes, revealing dynamic gene expression patterns spermatogenesis. Notably, we observed that two states converge into mature population puberty. Additionally, common prepubertal progenitor for with transitioning through immature before reaching maturity. Our study provides comprehensive atlas key insights regulatory mechanisms birth adulthood. These findings offer new perspectives on testicular mammals support future research reproductive biology breeding strategies.

Language: Английский

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Effects of Curcumin on Growth Performance, Ruminal Fermentation, Rumen Microbial Protein Synthesis, and Serum Antioxidant Capacity in Housed Growing Lambs

Animals, Journal Year: 2023, Volume and Issue: 13(9), P. 1439 - 1439

Published: April 23, 2023

This experiment was conducted to investigate growth performance, ruminal fermentation, rumen microbial protein synthesis, and serum antioxidant capacity with different doses of curcumin (CUR) included in the diet housed growing lambs. Forty-eight four-month-old Dorper × Thin-tailed Han F1 crossbred male lambs (body weight = 20.89 ± 1.15 kg, age 120 10 days; mean SD) were randomly divided into four groups for a single-factor, completely randomized experiment. Treatments comprised following: basal supplemented 0 (Control), 300 mg/kg (300 CUR), 600 (600 or 900 (900 CUR) CUR, respectively. The results showed that dietary CUR increased average daily gain (ADG), group evidenced highest value. There no significant effects on dry matter intake (DMI) DMI/ADG. Lambs higher totals volatile fatty acids (VFA) acetate than other groups, while decreased valerate observed supplementary CUR. pH ammonia N (NH3-N) concentration increasing greatest effect group. quadratic found pectinase, carboxymethyl cellulose, protease, value populations total bacteria Ruminococcus albus also responded quadratically, methanogens, protozoan, Fibrobacter succinogenes linearly receiving additional Prevotella ruminicola population. Microbial (MCP) synthesis promoted by As supplementation increased, activity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) enhanced, In conclusion, improved enhanced activity, as well promoting performance

Language: Английский

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