Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(10), P. 2845 - 2916

Published: July 13, 2024

Abstract Several efforts have been extensively accomplished for the amelioration of cancer treatments using different types new drugs and less invasives therapies in comparison with traditional therapeutic modalities, which are widely associated numerous drawbacks, such as drug resistance, non-selectivity high costs, restraining their clinical response. The application natural compounds prevention treatment cells has attracted significant attention from pharmaceuticals scientific communities over past decades. Although use nanotechnology therapy is still preliminary stages, nanotherapeutics demonstrated to decrease various limitations related compounds, physical/chemical instability, poor aqueous solubility, low bioavailability. Despite emerged a promise improve bioavailability there limited trials performed challenges required pre-clinical trials, production at an industrial level, assurance long-term stability, physiological barriers safety regulatory issues. This review highlights most recent advances nanocarriers secreted plants, bacteria, fungi, marine organisms, well role on cell signaling pathways anticancer treatments. Additionally, status main regarding loaded applications were also discussed. Graphical abstract

Language: Английский

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Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention

Pharmaceuticals, Journal Year: 2021, Volume and Issue: 14(11), P. 1069 - 1069

Published: Oct. 22, 2021

Cancer is a complex ailment orchestrated by numerous intrinsic and extrinsic pathways. Recent research has displayed deep interest in developing plant-based cancer therapeutics for better management of the disease limited side effects. A wide range plant-derived compounds have been reported their anticancer potential quest finding an effective therapeutic approach. Rutin (vitamin P) low-molecular weight flavonoid glycoside (polyphenolic compound), abundantly present various vegetables, fruits (especially berries citrus fruits), medicinal herbs. Numerous studies delineated several pharmacological properties rutin such as its antiprotozoal, antibacterial, anti-inflammatory, antitumor, antiviral, antiallergic, vasoactive, cytoprotective, antispasmodic, hypolipidemic, antihypertensive, antiplatelet properties. Specifically, rutin-mediated anticancerous activities cancerous cell lines, but most common scientific evidence, encompassing molecular processes interactions, including apoptosis pathway regulation, aberrant signaling pathways, oncogenic genes, not thoroughly studied. In this direction, we attempted to project regulation carcinomas. Additionally, also incorporated advanced that uncovered notable modulation key cellular functions via interaction with mRNAs, major emphasis on elucidating direct miRNA targets well process needed transform these approaches novel interventions treatment cancers.

Language: Английский

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Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10479 - 10479

Published: Sept. 9, 2022

In recent years, interest in natural products such as alternative sources of pharmaceuticals for numerous chronic diseases, including tumors, has been renewed. Propolis, a product collected by honeybees, and polyphenolic/flavonoid propolis-related components modulate all steps the cancer progression process. Anticancer activity propolis its compounds relies on various mechanisms: cell-cycle arrest attenuation cells proliferation, reduction number stem cells, induction apoptosis, modulation oncogene signaling pathways, inhibition matrix metalloproteinases, prevention metastasis, anti-angiogenesis, anti-inflammatory effects accompanied tumor microenvironment (by modifying macrophage activation polarization), epigenetic regulation, antiviral bactericidal activities, gut microbiota, chemotherapy-induced deleterious side effects. Ingredients from also ”sensitize“ to chemotherapeutic agents, likely blocking transcription factor nuclear kappa-light-chain-enhancer activated B (NF-κB). this review, we summarize current knowledge related flavonoids other polyphenolic growth metastasizing ability, discuss possible molecular cellular mechanisms involved inflammatory pathways processes that affect survival, invasion, angiogenesis, metastasis tumor.

Language: Английский

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Current advances on the therapeutic potential of pinocembrin: An updated review

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 157, P. 114032 - 114032

Published: Dec. 6, 2022

Pinocembrin (5,7-dihydroxyflavone) is a major flavonoid found in many plants, fungi and hive products, mainly honey propolis. Several vitro preclinical studies revealed numerous pharmacological activities of pinocembrin including antioxidant, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective anticancer activities. Here, we comprehensively review critically analyze the carried out on pinocembrin. We also discuss its potential mechanisms action, bioavailability, toxicity, clinical investigations. The wide therapeutic window makes it promising drug candidate for applications. recommend some future perspectives to improve pharmacokinetic pharmacodynamic properties better delivery that may lead new advances.

Language: Английский

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Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways

Journal of bone oncology, Journal Year: 2022, Volume and Issue: 33, P. 100415 - 100415

Published: Feb. 2, 2022

Language: Английский

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Anticancer Mechanism of Flavonoids on High-Grade Adult-Type Diffuse Gliomas

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 797 - 797

Published: Feb. 4, 2023

High-grade adult-type diffuse gliomas are the most common and deadliest malignant adult tumors of central nervous system. Despite advancements in multimodality treatment high-grade gliomas, five-year survival rates still remain poor. The biggest challenge treating is intra-tumor heterogeneity feature glioma tumors. Introducing dietary flavonoids to current strategies crucial overcome this challenge, as can target several molecular targets. This review discusses anticancer mechanism (quercetin, rutin, chrysin, apigenin, naringenin, silibinin, EGCG, genistein, biochanin A C3G) through targeting molecules associated with cell proliferation, apoptosis, oxidative stress, cycle arrest, migration, invasion, autophagy DNA repair. In addition, targeted by such Bax, Bcl-2, MMP-2, MMP-9, caspase-8, caspase-3, p53, p38, Erk, JNK, beclin-1 LC3B were also discussed. Moreover, clinical relevance flavonoid targets discussed comparison small inhibitors: ralimetinib, AMG232, marimastat, hydroxychloroquine chloroquine. positive pre-clinical results, further investigations studies warranted substantiate efficacy safety use on patients.

Language: Английский

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Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment

Cancers, Journal Year: 2024, Volume and Issue: 16(12), P. 2171 - 2171

Published: June 7, 2024

Cancer cells show altered antioxidant defense systems, dysregulated redox signaling, and increased generation of reactive oxygen species (ROS). Targeting cancer through ROS-mediated mechanisms has emerged as a significant therapeutic strategy due to its implications in progression, survival, resistance. Extensive research focused on selective H2O2 for cell killing by employing various strategies such metal-based prodrugs, photodynamic therapy, enzyme-based nano-particle mediated approaches, chemical modulators, combination therapies. Many these H2O2-amplifying approaches have demonstrated promising anticancer effects selectivity preclinical investigations. They selectively induce cytotoxicity while sparing normal cells, sensitize resistant modulate the tumor microenvironment. However, challenges remain achieving selectivity, addressing heterogeneity, ensuring efficient delivery, managing safety toxicity. To address those issues, H2O2-generating agents been combined with other treatments leading optimized This review focuses agents/approaches that kill via H2O2-mediated mechanisms. Different categories compounds generate are summarized, their underlying function elucidated, clinical studies well recent advancements discussed, prospects targeted utility explored. By understanding potential compounds, researchers can pave way development effective personalized treatments.

Language: Английский

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Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 15

Published: June 8, 2022

Stroke is one of the leading causes death and disability worldwide. Autophagy a conserved cellular catabolic pathway that maintains homeostasis by removal damaged proteins organelles, which critical for maintenance energy function cells. Accumulating evidence demonstrates autophagy plays important roles in pathophysiological mechanisms under ischemic stroke. Previous investigations show serves as "double-edged sword" stroke it can either promote survival neuronal cells or induce cell special conditions. Following stroke, activated inhibited several types brain, including neurons, astrocytes, microglia, well microvascular endothelial cells, involves inflammatory activation, modulation microglial phenotypes, blood-brain barrier permeability. However, exact underlying role are not fully understood. This review focuses on recent advances regarding potential molecular different types. The focus also discussing effect its possible mechanisms. In addition, therapeutic strategies targeting reviewed.

Language: Английский

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Advances in mitophagy and mitochondrial apoptosis pathway-related drugs in glioblastoma treatment

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 30, 2023

Glioblastoma (GBM) is the most common malignant tumor of central nervous system (CNS). It a leading cause death among patients with intracranial tumors. GBM exhibits intra- and inter-tumor heterogeneity, to drug resistance eventual recurrence. Conventional treatments for include maximum surgical resection glioma tissue, temozolomide administration, radiotherapy, but these methods do not effectively halt cancer progression. Therefore, development novel treatment identification new therapeutic targets are urgently required. In recent years, studies have shown that drugs related mitophagy mitochondrial apoptosis pathways can promote glioblastoma cells by inducing damage, impairing adenosine triphosphate (ATP) synthesis, depleting large amounts ATP. Some also modern nano-drug delivery technology targeting mitochondria achieve better release deeper tissue penetration, suggesting could be target intervention therapy. The combination autophagy nanotechnology promising approach treating GBM.This article reviews current status therapy GBM, pathways, potential as treatment, latest developments pertaining directions future research.

Language: Английский

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Analysis of some flavonoids for inhibitory mechanism against cancer target phosphatidylinositol 3-kinase (PI3K) using computational tool

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 13, 2023

Cancer has been one of the leading causes mortality worldwide over past few years. Some progress made in development more effective cancer therapeutics, resulting improved survival rates. However, desired outcome form successful treatment is yet to be achieved. There high demand for innovative, inexpensive, and anticancer treatments using natural resources. Natural compounds have increasingly discovered used therapy owing their molecular diversity, novel biofunctionality, minimal side effects. These can utilized as chemopreventive agents because they efficiently inhibit cell growth, control cycle progression, block several tumor-promoting signaling pathways. PI3K an important upstream protein PI3K-Akt-mTOR pathway a well-established therapeutic target. This study aimed explore small molecules, flavonoids, viz. quercetin, luteolin, kaempferol, genistein, wogonin, daidzein, flavopiridol PI3Kγ kinase activity inhibition. In this study, binding pose, interacting residues, interactions, energies, dissociation constants were investigated. Our results showed that these flavonoids bound well with adequate strength scores energy ranging from (−8.19 −8.97 Kcal/mol). Among explored ligands, highest Kcal/mol, dock score (−44.40), constant term, pKd 6.58 against PI3Kγ. Based on above results, stability most promising ligand, flavopiridol, was evaluated by dynamics simulations 200 ns, confirming stable complex. suggests among selected specifically may act potential inhibitors could alternative pathway, providing new insights into rational drug discovery research therapy.

Language: Английский

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