Cryopreservation of bioflavonoid-rich plant sources and bioflavonoid-microcapsules: emerging technologies for preserving bioactivity and enhancing nutraceutical applications

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 14, 2023

Bioflavonoids are natural polyphenolic secondary metabolites that medicinal. These compounds possess antitumor, cardioprotective, anti-inflammatory, antimicrobial, antiviral, and anti-psoriasis properties to mention a few. Plant species contain bioflavonoids should be preserved as such. Also, the bioactivity of neutraceutical is compromised following extraction due their sensitivity environmental factors like light, pH, temperature. In other words, bioflavonoids’ shelf-life affected. Scientists noticed have low solubility properties, poor absorption, bioavailability consumption. Researchers came up with methods encapsulate in order circumvent challenges above also mask unpleasant these chemicals may have. Besides, scientists cryopreserve plant bioflavonoids. this review, we discuss cryopreservation bioflavonoid microencapsulation focusing mainly on vitrification, slow freezing, freeze-drying techniques. addition, highlight techniques, medicinal challenges, future perspectives Regardless uniqueness preserve sources bioactivity, there reported. Freeze-drying technology costly. Cryoprotectants damage integrity cells, say least. working very hard overcome challenges. Encapsulating via coaxial electrospray then cryopreserving micro/nanocapsules produced can interesting.

Language: Английский

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A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

ACS Omega, Journal Year: 2024, Volume and Issue: 9(9), P. 10030 - 10048

Published: Feb. 22, 2024

Skin cancer (SC) poses a global threat to the healthcare system and is expected increase significantly over next two decades if not diagnosed at an early stage. Early diagnosis crucial for successful treatment, as disease becomes more challenging cure it progresses. However, identifying new drugs, achieving clinical success, overcoming drug resistance remain significant challenges. To overcome these obstacles provide effective understand causes of skin cancer, how cells grow divide, factors that affect cell growth, occurs. In this review, we have explained various therapeutic approaches SC treatment via ligands, targeted photosensitizers, natural synthetic drugs SC, epigenetic approach management melanoma, photodynamic therapy, therapy BRAF-mutated melanoma. This article also provides detailed summary are in managing melanoma reducing occurrence stages focuses on current status future prospects therapies available cancer.

Language: Английский

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Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

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Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways

Molecules, Journal Year: 2022, Volume and Issue: 27(13), P. 4304 - 4304

Published: July 4, 2022

Plant bioactive compounds, particularly apigenin, have therapeutic potential and functional activities that aid in the prevention of infectious diseases many mammalian bodies promote tumor growth inhibition. Apigenin is a flavonoid with low toxicities numerous properties due to which it has been considered as traditional medicine for decades. shows synergistic effects combined treatment sorafenib HepG2 human cell line (HCC) less time statistically reduces viability cells, migration, gene expression apoptosis. The combination anti-cancerous drugs apigenin shown health promoting against various cancers. It can prevent mobility, maintain cycle stimulate immune system. also suppresses mTOR activity raises UVB-induced phagocytosis cancerous proliferation growth. high safety threshold, active (anti-cancer) doses be gained by consuming vegetable rich diet. boosted autophagosome formation, decreased activated autophagy preventing PI3K pathway, specifically cells. This paper provides an updated overview apigenin's beneficial anti-inflammatory, antibacterial, antiviral, anticancer effects, making step right direction therapeutics. study critically analyzed effect on cancer signaling pathways including PI3K/AKT/MTOR, JAK/STAT, NF-κB ERK/MAPK pathways.

Language: Английский

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Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 241, P. 124508 - 124508

Published: April 20, 2023

Language: Английский

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Anticancer Mechanism of Flavonoids on High-Grade Adult-Type Diffuse Gliomas

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 797 - 797

Published: Feb. 4, 2023

High-grade adult-type diffuse gliomas are the most common and deadliest malignant adult tumors of central nervous system. Despite advancements in multimodality treatment high-grade gliomas, five-year survival rates still remain poor. The biggest challenge treating is intra-tumor heterogeneity feature glioma tumors. Introducing dietary flavonoids to current strategies crucial overcome this challenge, as can target several molecular targets. This review discusses anticancer mechanism (quercetin, rutin, chrysin, apigenin, naringenin, silibinin, EGCG, genistein, biochanin A C3G) through targeting molecules associated with cell proliferation, apoptosis, oxidative stress, cycle arrest, migration, invasion, autophagy DNA repair. In addition, targeted by such Bax, Bcl-2, MMP-2, MMP-9, caspase-8, caspase-3, p53, p38, Erk, JNK, beclin-1 LC3B were also discussed. Moreover, clinical relevance flavonoid targets discussed comparison small inhibitors: ralimetinib, AMG232, marimastat, hydroxychloroquine chloroquine. positive pre-clinical results, further investigations studies warranted substantiate efficacy safety use on patients.

Language: Английский

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Assessing the antioxidant properties of Naringin and Rutin and investigating their oxidative DNA damage effects in breast cancer

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 3, 2024

Abstract This work examines the capacity of Naringin and Rutin to influence DNA damage response (DDR) pathway by investigating their interactions with key DDR proteins, including PARP-1, ATM, ATR, CHK1, WEE1. Through a combination in silico molecular docking vitro evaluations, we investigated cytotoxic genotoxic effects these compounds on MDA-MB-231 cells, comparing them normal human fibroblast cells (2DD) quiescent (QFC). The research found that had strong affinities for indicating specifically regulate pathways cancer cells. Both exhibited preferential cytotoxicity towards while preserving vitality 2DD as demonstrated experiments conducted at dose 10 µM. comet performed particularly QFC provide valuable information impact Rutin, highlighting targeted initiation need use precise cell models appropriately evaluate toxicity genotoxicity is emphasized this discrepancy. In addition, ADMET drug-likeness investigations have pharmacological potential compounds; however, they also pointed out necessity optimization improve therapeutic profiles. antioxidant capabilities were assessed using DPPH free radical scavenging assays concentration results confirmed both role reducing oxidative stress, hence enhancing anticancer effects. Overall, show medicines modulating treatment. They exhibit selective sparing possess properties. analysis enhances our understanding uses natural chemicals treatment, supporting more mechanisms action clinical effectiveness.

Language: Английский

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Bee Pollen Extracts: Chemical Composition, Antioxidant Properties, and Effect on the Growth of Selected Probiotic and Pathogenic Bacteria

Antioxidants, Journal Year: 2022, Volume and Issue: 11(5), P. 959 - 959

Published: May 12, 2022

This paper evaluated the chemical and biological properties of bee pollen samples from Romania. Firstly, alcoholic extracts (BPEs) were obtained raw harvested by Apis mellifera carpatica bees. The composition BPE was determination total phenol content flavonoid content, UHPLC-DAD-ESI/MS analysis phenolic compounds, GC-MS fatty acids, esters, terpenes. Additionally, antioxidant activity Trolox Equivalent Antioxidant Capacity method. Furthermore, (antimicrobial cytotoxic activity). BP studied in this had significant acid moderate acid, ester, terpene content. P1, P2, P4 have highest TPC TFC levels, best activity. All BPEs antimicrobial on pathogenic strains isolated clinic or standard strains. A synergistic effect observed along with soluble compounds L. rhamnosus MF9 E. faecalis 2M17 against some (clinical) and, considering tumour proliferation inhibitory activity, makes a potential prebiotic antitumour agent for gut environment.

Language: Английский

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Development of Pegylated Nano‐Phytosome Formulation with Oleuropein and Rutin to Compare Anti‐Colonic Cancer Activity with Olea Europaea Leaves Extract

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(8)

Published: July 27, 2023

Olive leaf extract is a valuable source of phenolic compounds; primarily, oleuropein (major component) and rutin. This natural olive has potential use as therapeutic agent for cancer treatment. However, its clinical application hindered by poor pharmacokinetics low stability. To overcome these limitations, this study aimed to enhance the anticancer activity stability rutin loading them into PEGylated Nano-phytosomes. The developed Nano-phytosomes exhibited favorable characteristics in terms size, charge, Notably, anticolonic Pegylated loaded with (IC50=0.14 μM) (IC50=0.44 surpassed that pure alone. outcome highlights advantageous impact augment These results present promising pathway future development effective options passive tumor-targeted therapy, given their improved efficacy.

Language: Английский

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Nutritive value, biological properties, health benefits and applications of Tetrapleura tetraptera: An updated comprehensive review

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27834 - e27834

Published: March 1, 2024

Due to the health benefits that medicinal plants present, they are applied in traditional healthcare developing and developed countries alike. Tetrapleura tetraptera, a flowering plant mostly found western part of Africa has an essential chemical composition gives it nutritive value capacities. This review aims highlight nutritional attributes, biological properties, benefits, applications T. tetraptera. The fruit been revealed possess about 58.48–63. 86% carbohydrates, 251.22–288.62 mg/g potassium, 182.11–200.02 calcium, 322.00–342.00 manganese, 0.02–4.69 vitamins. Also, active phytochemical compounds including phenols (3.51 ± 0.03 mgGAE/g), flavonoids (0.87 mgQE/g), saponins (4.27 mgDE/g), tannins (23.87 0.44 mg/100 g), alkaloids (5.03 0.15% w/w) have discovered plant's abundant phytochemicals account for its antioxidant, antimicrobial, anti-inflammatory, anti-diabetic, anti-parasitic, anti-proliferative activities. These properties turn translate lower blood pressure, enhanced immune system, malaria treatment, diabetes hypertension management, cancer prevention. health-promoting assets tetraptera underscore beverage production, food preservation flavoring, feed supplementation, pharmaceutical formulations. data gathered this piece is crucial industrial processing creation potent products functional foods with superior attributes.

Language: Английский

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