Redox signaling at the crossroads of human health and disease

MedComm, Journal Year: 2022, Volume and Issue: 3(2)

Published: March 31, 2022

Abstract Redox biology is at the core of life sciences, accompanied by close correlation redox processes with biological activities. homeostasis a prerequisite for human health, in which physiological levels nonradical reactive oxygen species (ROS) function as primary second messengers to modulate signaling orchestrating multiple sensors. However, excessive ROS accumulation, termed oxidative stress (OS), leads biomolecule damage and subsequent occurrence various diseases such type 2 diabetes, atherosclerosis, cancer. Herein, starting evolution biology, we reveal roles multifaceted modulators mediate sustain homeostasis. In addition, also emphasize detailed OS mechanisms involved initiation development several important diseases. double‐edged sword disease progression suggest two different therapeutic strategies treat redox‐relevant diseases, targeting sources redox‐related effectors manipulate will largely promote precision medicine. Therefore, comprehensive understanding networks under pathological conditions facilitate medicine benefit patients

Language: Английский

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Nitrotyrosine, Nitrated Lipoproteins, and Cardiovascular Dysfunction in Patients with Type 2 Diabetes: What Do We Know and What Remains to Be Explained?

Antioxidants, Journal Year: 2022, Volume and Issue: 11(5), P. 856 - 856

Published: April 27, 2022

Diabetes mellitus (DM) is a strong risk factor for the development of cardiovascular diseases (CVDs), which are most important cause morbidity and mortality in population patients living with DM. DM associated lipid metabolism disorders characterized by decrease high-density lipoprotein blood concentration, an increase triglyceride presence modified lipoproteins not routinely measured clinical practice. Nitrated produced nitration tyrosyl residues apolipoproteins myeloperoxidase. There some evidence from research conducted showing that nitrated may play role dysfunction, but this issue requires further investigation. It was found HDL particles caspase-3 paraoxonase-1 activity, as well activity cholesterol transport via ABCA1, reduces protective effect on system. Less information has been collected about LDL particles. Thus far, much more obtained relationship nitrotyrosine expression factors dysfunction. The purpose paper to provide extensive review literature present current state knowledge association between dysfunction system, especially Moreover, directions future area were discussed.

Language: Английский

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Cigarette Smoke-Induced Respiratory Response: Insights into Cellular Processes and Biomarkers

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1210 - 1210

Published: June 3, 2023

Cigarette smoke (CS) poses a significant risk factor for respiratory, vascular, and organ diseases owing to its high content of harmful chemicals reactive oxygen species (ROS). These substances are known induce oxidative stress, inflammation, apoptosis, senescence due their exposure environmental pollutants the presence enzymes. The lung is particularly susceptible stress. Persistent stress caused by chronic CS can lead respiratory such as obstructive pulmonary disease (COPD), fibrosis (PF), cancer. Avoiding pollutants, like cigarette air pollution, help mitigate A comprehensive understanding impact on lungs requires future research. This includes identifying strategies preventing treating well investigating underlying mechanisms behind Thus, this review aims investigate cellular processes induced CS, specifically senescence, associated biomarkers. Furthermore, will delve into alveolar response provoked emphasizing roles potential therapeutic target markers in inflammation

Language: Английский

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Endothelial and vascular smooth muscle dysfunction in hypertension

Biochemical Pharmacology, Journal Year: 2022, Volume and Issue: 205, P. 115263 - 115263

Published: Sept. 26, 2022

Language: Английский

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The Role of Oxidative Stress and Antioxidants in Cardiovascular Comorbidities in COPD

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1196 - 1196

Published: May 31, 2023

Oxidative stress driven by several environmental and local airway factors associated with chronic obstructive bronchiolitis, a hallmark feature of COPD, plays crucial role in disease pathomechanisms. Unbalance between oxidants antioxidant defense mechanisms amplifies the inflammatory processes, worsens cardiovascular health, contributes to COPD-related dysfunctions mortality. The current review summarizes recent developments our understanding different contributing oxidative its countermeasures, special attention those that link systemic processes. Major regulatory orchestrating these pathways are also introduced, some suggestions for further research field.

Language: Английский

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Targeting Non-Eosinophilic Immunological Pathways in COPD and AECOPD: Current Insights and Therapeutic Strategies

International Journal of COPD, Journal Year: 2025, Volume and Issue: Volume 20, P. 511 - 532

Published: March 1, 2025

COPD is a multifactorial illness characterized by long-term restriction of airflow and an inflammatory reaction in the lungs. The associated emphysema leads to breakdown alveolar proteins abnormal expansion lung air spaces. Chronic bronchitis caused same disease can result increased deposition structural proteins, narrowing airways, excessive mucus secretion leading acute exacerbation (AECOPD). most commonly prescribed medications for it, such as glucocorticoids bronchodilators, provide important therapeutic benefits, but they also have negative side effects, including immunosuppression infection. Therefore, it necessary develop treatment that specifically target immune system molecular components. This review focuses on non-eosinophilic aspects immunological modulation management. Since, existing literature extensively covers eosinophilic inflammation, this aims fill gap examining alternative pathways their implications. findings suggest targeting specific responses may enhance efficacy while minimizing adverse effects with traditional therapies. In summary, emphasizes importance advancing research into mechanisms COPD, prescribing development novel therapies more effectively manage disease.

Language: Английский

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Emerging trends and hotspots in chronic obstructive pulmonary disease and oxidative stress: a bibliometric and visualized analysis from 2010 to 2024

Journal of Thoracic Disease, Journal Year: 2025, Volume and Issue: 17(3), P. 1228 - 1248

Published: March 1, 2025

Chronic obstructive pulmonary disease (COPD) is a long-term respiratory condition defined by ongoing symptoms and restricted airflow, resulting in high rates of morbidity, mortality, disability for this condition. Due to the incomplete understanding its pathogenesis, no permanent curative measures or specific drugs are available. In recent years, multitude research has highlighted substantial influence oxidative stress on development COPD; however, there been deficiency bibliometric analyses focusing trends hotspots field. Therefore, our study aimed at presenting emerging related COPD stress. Publications concerning were obtained from Web Science Core Collection database, covering period 2010 2024. On July 25, 2024, all relevant data downloaded, followed process screening analysis. The analysis incorporated 1,308 articles 440 reviews, involving contributions 1,034 researchers affiliated with 512 institutions across 64 countries published total 548 journals. Through series using five visualization tools, we identified top 5 most productive countries, institutions, journals, highly co-cited journals field We also 12 citation clusters, 10 influential authors, authors articles, 11 keyword established 20 keywords, observed evolution reference bursts. This first quantitatively capture progress research, results show marked upward trend years terms Developing novel effective antioxidants becoming future direction treatment. Besides antioxidant therapy, exposure (to air pollution), cigarette smoke, mitochondrial dysfunction emerged as prominent hotspots. extensive offers significant insights into exploration publications purpose support enhance scientific investigators

Language: Английский

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Targeting respiratory virus-induced reactive oxygen species in airways diseases

European Respiratory Review, Journal Year: 2025, Volume and Issue: 34(176), P. 240169 - 240169

Published: April 1, 2025

The immune response to virus infection in the respiratory tract must be carefully balanced achieve pathogen clearance without excessive immunopathology. For chronic diseases where there is ongoing inflammation, such as asthma and COPD, airway balance perturbed, viral frequently worsens (exacerbates) these conditions. Reactive oxygen species (ROS) are critical induction propagation of when appropriately regulated, ROS vital cell signalling molecules contribute innate immunity. However, extended periods high concentration can cause cellular damage that dysregulates antiviral immunity promotes inflammation. Traditional antioxidant therapeutics have had limited success treating inflammatory exacerbations or owing nonspecific pharmacology poorly understood pharmacokinetic properties. These drawbacks could addressed with novel drug delivery technologies pharmacological agents. This review summarises current research on imbalances during infection, discusses commercially available mitochondrial drugs progressed clinical trial assesses approaches for airways. Additionally, it provides a perspective future into targeting treatment disease.

Language: Английский

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Redox Regulation of cAMP-Dependent Protein Kinase and Its Role in Health and Disease

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 655 - 655

Published: April 16, 2025

Protein kinase A (PKA) is a key regulator of cellular signaling that regulates physiological processes such as metabolism, cell proliferation, and neuronal function. While its activation by the second messenger 3′,5′-cyclic adenosine triphosphate (cAMP) well characterized, recent research highlights additional regulatory mechanisms, particularly oxidative post-translational modifications, influence PKA’s structure, activity, substrate specificity. Both catalytic subunits PKA are susceptible to redox which have been shown play important roles in regulation functions, including cardiac contractility, lipid immune response. Likewise, redox-dependent modulation has implicated numerous diseases, cardiovascular disorders, diabetes, neurodegenerative conditions, making it potential therapeutic target. However, mechanisms crosstalk between redox- PKA-dependent remain poorly understood. This review examines structural functional PKA, with focus on modifications their impact signaling. deeper understanding these may provide new strategies for targeting stress disease restoring balanced cells.

Language: Английский

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Association between frailty status and risk of chronic lung disease: an analysis based on two national prospective cohorts

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: Nov. 9, 2024

The association between the frailty index (FI) and risk of chronic lung diseases (CLDs) remains unexplored, warranting further research.

Language: Английский

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