Cytoprotective effects of iridoids from Gaultheria spp. berries in gastric and intestinal epithelial cells after in vitro digestion DOI Creative Commons

Luise Amelie Lauer,

Daniel Mieres‐Castro, Victor Schmalle

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 57, P. 103587 - 103587

Published: Jan. 6, 2024

Reactive oxygen species may induce oxidation of macromolecules in foods and during digestion the gastrointestinal tract, negatively impacting human health. Antioxidants present plant foods, including carotenoids, tocochromanols, ascorbic acid, as well (poly)phenols iridoids, counteract macromolecules. The aims study were to determine contents acid from Gaultheria spp. berries investigate cytoprotective antioxidant activities fruit extracts monotropein esters berries. Moreover, underlying mechanisms action epithelial cells after vitro was also investigated. content ranged 3 24 mg/100 g fw, carotenoids 9 56 μg/100 total tocochromanols 0.29 0.45 fw. pre-incubation gastric (AGS) intestinal (Caco-2) with significantly increased viability stressed 10 mM H2O2 100 AAPH, respectively, compared control cells. Furthermore, digested relative mRNA Nrf2/Keap1/ARE signaling pathway enzymes such superoxide dismutase (SOD), glutathione peroxidase (GPX) reductase, catalase (CAT). Caco-2 protein expression GPX, CAT, Keap1, Nrf2, incremented SOD activity In conclusion, protect against oxidative stress digestive processes.

Language: Английский

Broccoli: A Multi-Faceted Vegetable for Health: An In-Depth Review of Its Nutritional Attributes, Antimicrobial Abilities, and Anti-inflammatory Properties DOI Creative Commons
Rahamat Unissa Syed, Sivakumar S. Moni, Mohammed Khaled Bin Break

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(7), P. 1157 - 1157

Published: July 7, 2023

Broccoli, Brassica oleracea var. italica, has recently gained considerable attention due to its remarkable nutritional composition and numerous health benefits. In this review, the aspects of broccoli are examined, highlighting rich nutrient content essential bioactive compounds. The cruciferous vegetable is a source several important nutrients, including fiber, vitamins (A, C, K), minerals (calcium, potassium, iron), antioxidants. It also been shown contain compounds such as glucosinolates, sulforaphane, indole-3-carbinol, all which have significant health-promoting effects. These chemicals known potent antioxidant, anti-inflammatory, anticancer This review article aims comprehensively examine diverse spectrum nutrients contained in explore medicinal potential promote human health.

Language: Английский

Citations

40
Extraction, structural characterization, and antioxidant activity of polysaccharides from three microalgae DOI

Yang Zhao,

Chun Han,

Yangyingdong Wu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 931, P. 172567 - 172567

Published: April 20, 2024

Language: Английский

Citations

15
Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii) DOI Open Access
Preeti Sarkar, Alessandra Pecorelli, Brittany Woodby

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 1035 - 1035

Published: Feb. 19, 2023

Food-derived bioactive peptides (BAPs) obtained from edible insect-protein hold multiple activities promising the potential to target complex pathological mechanisms responsible for chronic health conditions such as hypertension development. In this study, enzymatic protein hydrolysates non-mulberry silkworm Antheraea assama (Muga) and Philosomia ricini (Eri) pupae, specifically Alcalase (A. assama) Papain (P. ricini) after 60 240 min, exhibited highest ACE-inhibitory antioxidant properties. The hydrolysates’ fractions (<3, 3–10 >10 kDa), Alc_M60min_F3 (≤3 kDa) Pap_E240min_F3 showed activities, respectively. Further RP-HPLC purified sub-fractions F4 F6 ACE inhibition well potent anti-oxinflammatory in lipopolysaccharide (LPS)-treated endothelial cells. Indeed, peptide were effective preventing p65 nuclear translocation 3 h of LPS stimulation along with p38 MAPK phosphorylation HUVEC addition, pretreatment significantly prevented LPS-induced upregulation COX-2 expression IL-1β secretion, while NRF2 (nuclear factor erythroid 2-related 2)-regulated enzymes HO-1 NQO1 was induced by both fractions. derived pupae have potentialities be explored nutritional approaches against related cardiovascular diseases.

Language: Английский

Citations

17
Advancements in nanotechnology for the delivery of phytochemicals DOI
Divya Chauhan, Pavan Kumar Yadav, Nazneen Sultana

et al.

Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: 22(4), P. 385 - 398

Published: April 24, 2024

Language: Английский

Citations

7
Exploring the Antioxidant and Anti-Inflammatory Potential of Saffron (Crocus sativus) Tepals Extract within the Circular Bioeconomy DOI Creative Commons
Luisa Frusciante, Michela Geminiani,

Behnaz Shabab

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1082 - 1082

Published: Sept. 4, 2024

Repurposing saffron (

Language: Английский

Citations

7
Antioxidant, anti-amylase, anti-lipase, and efficiency of Satureja fatty acid on the anti-inflammatory parameters in lipopolysaccharide-stimulated macrophage through Nrf2/NF-kB/NADH oxidase pathway DOI Creative Commons

Elham Obeidnejad,

Gholamreza Kavoosi, Mohammad Jamal Saharkhiz

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 31, 2024

Abstract Satureja is an aromatic plant that used for flavoring, perfume, and food manufacturing due to its pleasant essential oil. Modern medicine research revealed several biological activities of oil, including antifungal, antibacterial, antiviral, antioxidant, anticancer, anti-inflammatory. However, the functional properties fatty acid have not been explored. This study examined profile, lipid nutritional quality, anti-amylase, anti-lipase capacities . The efficiency on anti-oxidative anti-inflammatory parameters in LPS-induced macrophage through Nrf2/NF-kB/NADH oxidase pathway was examined. whole extract prepared with chloroform/methanol/water solution. Fatty acids methyl ester from were methanol/sulfuric reagent. profile analyzed using gas chromatography-mass spectrometry. Total antioxidant determined by ABTS decolorization. Lipase amylase monitoring decomposition p -nitrophenyl butyrate starch. cell line grown DMEM media presence acid. hydrogen peroxide production treated cells monitored FOX NADH activity measured breakdown. expression NOX, NF-kB, NRF2, tested real-time PCR. main components linolenic (24.67–37.32%), palmitic (10.65–20.29%), linoleic (8.31–13.39%), oleic (4.42–14.35%), stearic (2.76–8.77%) palmitoleic (1.77–4.95%). Given omega-3 PUFA (23.58–37.32%), SFA (21.53–26.70%), omega-6 (10.86–16.14%), omega-9 MUFA omega-7 (1.77–4.95%) comprise majority acids. has a promising unsaturation index (120.77–164.27), PUFA/MUFA (2.07–6.41), hypocholesterolemic (2.44–3.47), health-promoting (2.03–2.42), PUFA/SFA (1.37–1.94), nutritive value (0.53–1.71), MUFA/SFA (0.30–0.80) omega-6/omega-3 (0.34–0.65), atherogenicity (0.41–0.49), thrombogenicity (0.17–0.27). displayed strong capacity (with IC 50 ranging 354 428 µg/mL), anti-amylase 370 390 µg/mL). LPS induced NF-kB synthesis cells. In LPS-stimulated macrophages, reduced NOX expression, peroxide, increased NRF2 at 0.04 mg/mL. conclusion, potent anti-lipase, activities. mechanisms lowering oxidative stress markers depended down-regulating superoxide-producing enzymes gene protein levels. polyunsaturated could be recommended healthy products combined dietary therapy treat obesity, diabetes, stress.

Language: Английский

Citations

5
Serving up health: How phytochemicals transform food into medicine in the battle against cancer DOI Creative Commons
Eshita Sharma, Manju Tewari,

Priyanka Sati

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: 5(5), P. 1866 - 1908

Published: July 7, 2024

Abstract The escalating global cancer burden underscores the urgent need for more effective therapeutic strategies. Phytochemicals, naturally occurring compounds in plants, have garnered attention their potential chemoprevention and chemotherapy. Their ability to modulate molecular mechanisms influence cell signaling pathways offers a promising avenue management. This review aims synthesize current knowledge on phytochemicals’ chemopreventive chemotherapeutic potential, focusing of action impacts involved cancer. A systematic literature search was conducted across major databases, including PubMed/Medline, Web Science, Scopus, Google Scholar. strategy uses Medical Subject Headings (MeSH) free‐text terms using Boolean operators capture relevant studies. Inclusion criteria targeted original research reviews effects phytochemicals cancer, with specific focus mechanisms. flavonoids, polyphenols, terpenoids, demonstrated significant anticancer properties by inducing cycle arrest, apoptosis, autophagy. They critical pathways, such as cyclooxygenase‐2, nuclear factor kappa B, various growth factor‐related rectify epigenetic alterations, contributing effects. Phytochemicals represent valuable resource developing novel prevention treatment strategies; actions underscore combat. Further is warranted translate these findings into clinical applications, optimizing phytochemical‐based interventions

Language: Английский

Citations

5
Conjugation, Prodrug, and Co-Administration Strategies in Support of Nanotechnologies to Improve the Therapeutic Efficacy of Phytochemicals in the Central Nervous System DOI Creative Commons
Giovanna Rassu, Milena Sorrenti, Laura Catenacci

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1578 - 1578

Published: May 23, 2023

Phytochemicals, produced as secondary plant metabolites, have shown interesting potential therapeutic activities against neurodegenerative diseases and cancer. Unfortunately, poor bioavailability rapid metabolic processes compromise their use, several strategies are currently proposed for overcoming these issues. The present review summarises enhancing the central nervous system's phytochemical efficacy. Particular attention has been paid to use of phytochemicals in combination with other drugs (co-administrations) or administration prodrugs conjugates, particularly when approaches supported by nanotechnologies exploiting conjugation appropriate targeting molecules. These aspects described polyphenols essential oil components, which can improve loading nanocarriers, be part nanocarriers designed targeted co-delivery achieve synergistic anti-glioma anti-neurodegenerative effects. vitro models, able simulate blood-brain barrier, neurodegeneration glioma, useful optimizing innovative formulations before vivo via intravenous, oral, nasal routes, is also summarised. Among compounds, quercetin, curcumin, resveratrol, ferulic acid, geraniol, cinnamaldehyde efficaciously formulated attain brain-targeting characteristics, may therefore therapeutically glioma diseases.

Language: Английский

Citations

12
Beyond Glucose: The Dual Assault of Oxidative and ER Stress in Diabetic Disorders DOI

Tamsheel Fatima Roohi,

Syed Faizan, Zahoor Ahmad Parray

et al.

High Blood Pressure & Cardiovascular Prevention, Journal Year: 2023, Volume and Issue: 30(6), P. 513 - 531

Published: Dec. 2, 2023

Language: Английский

Citations

11
In silico evaluation of potential breast cancer receptor antagonists from GC-MS and HPLC identified compounds in Pleurotus ostreatus extracts DOI Creative Commons
Magdalene Eno Effiong, Mercy Bella-Omunagbe, Israel Sunmola Afolabi

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(33), P. 23744 - 23771

Published: Jan. 1, 2024

Introduction: Pharmacotherapeutic targets for breast cancer include the estrogen receptor (ER), progesterone (PR), and human epidermal growth factor (EGFR). Inhibitors of these receptors could be interesting therapeutic candidates treatment management (BC). Aim: This study used GC-MS HPLC to identify bioactive compounds in Pleurotus ostreatus (P. ostreatus) extracts applied silico methods potent EGFR, ER, PR inhibitors from as potential drug candidates. Method: were chemicals P. aqueous (PO-A), methanol (PO-M), ethanol (PO-E), chloroform (PO-C), n-hexane (PO-H). The PR, EGFR model optimization molecular docking compounds/control binding pocket simulated using AutoDock Vina PyRx. drug-likeness, pharmacokinetic, pharmacodynamic features prospective leads all anticipated. Result: results indicated existence 29 PO-A, 36 PO-M PO-E, 42 PO-C, 22 PO-H extracts. With only o-tolylamino-acetic acid (4-nitro-benzylidene)-hydrazide (-7.5 kcal mol-1) ethanolic extract bind receptor. on other hand, identified several with higher affinities than control. Ergotaman-3',6',18-trione (-8.1 mol-1), 5,10-diethoxy-2,3,7,8-tetrahydro-1H,6H-dipyrrolo[1,2-a:1',2'-d]pyrazine (-7.8 extract; (-8.4 had better affinity compared (-7.7 mol-1). Likewise, ergotaman-3',6',18-trione (-9.7 phenol, 2,4-bis(1,1-dimethyl ethyl) (-8.2 control, gefitinib (-7.9 regards EGFR. None or outperformed control any proteins. Phenols flavonoids such quercetin, luteolin, rutin, chrysin, apigenin, ellagic acid, naringenin their Conclusion: class phenols lead molecules due ability strongly proteins' receptors. These showed promising drug-like properties; they safe new creating anticancer medicines.

Language: Английский

Citations

4