The Biflavonoid Agathisflavone Regulates Microglial and Astrocytic Inflammatory Profiles via Glucocorticoid Receptor DOI Creative Commons

Áurea Maria Alves Nunes Almeida,

Cleonice Creusa dos Santos,

Daniele Takahashi

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1014 - 1014

Published: Feb. 22, 2025

Nuclear receptors such as glucocorticoid (GRs) are transcription factors with prominent regulatory effects on neuroinflammation. Agathisflavone is a biflavonoid that demonstrates neurogenic, neuroprotective, anti-inflammatory, antioxidant, and pro-myelinogenic in vitro. This study investigated whether the control of glial reactivity by agathisflavone mediated GRs. Primary cultures astrocytes microglia were induced to neuroinflammation lipopolysaccharides (LPSs) exposed or not presence absence mifepristone, GR antagonist. The morphology evaluated immunofluorescence against calcium-binding ionized adapter (Iba-1) CD68. astrocyte fibrillary acidic protein (GFAP). inflammatory profile was RT-qPCR. Molecular docking performed characterize interactions. Microglial branching increased response agathisflavone, an effect inhibited mifepristone. CD68 GFAP expression decreased but pro-inflammatory cytokine IL-1β IL-10. increase IL-10 mRNA silico analysis showed binds pocket at receptor. These interactions stronger than dexamethasone, monomer apigenin. results indicate involved inflammation, contributing elucidation molecular mechanisms agathisflavone's nervous system.

Language: Английский

Flavonoids and their role in oxidative stress, inflammation, and human diseases DOI Creative Commons
Klaudia Jomová, Suliman Yousef Alomar,

Richard Valko

et al.

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111489 - 111489

Published: March 1, 2025

Oxidative stress and chronic inflammation are important drivers in the pathogenesis progression of many diseases, such as cancers breast, kidney, lung, others, autoimmune diseases (rheumatoid arthritis), cardiovascular (hypertension, atherosclerosis, arrhythmia), neurodegenerative (Alzheimer's disease, Parkinson's Huntington's disease), mental disorders (depression, schizophrenia, bipolar disorder), gastrointestinal (inflammatory bowel colorectal cancer), other disorders. With increasing demand for less toxic more tolerable therapies, flavonoids have potential to effectively modulate responsiveness conventional therapy radiotherapy. Flavonoids polyphenolic compounds found fruits, vegetables, grains, plant-derived beverages. Six twelve structurally different flavonoid subgroups dietary significance include anthocyanidins (e.g. pelargonidin, cyanidin), flavan-3-ols epicatechin, epigallocatechin), flavonols quercetin, kaempferol), flavones luteolin, baicalein), flavanones hesperetin, naringenin), isoflavones (daidzein, genistein). The health benefits related their structural characteristics, number position hydroxyl groups presence C2=C3 double bonds, which predetermine ability chelate metal ions, terminate ROS radicals formed by Fenton reaction), interact with biological targets trigger a response. Based on these can exert both antioxidant or prooxidant properties, activity ROS-scavenging enzymes expression activation proinflammatory cytokines (e.g., interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α)), induce apoptosis autophagy, target key signaling pathways, nuclear factor erythroid 2-related 2 (Nrf2) Bcl-2 family proteins. This review aims briefly discuss mutually interconnected aspects oxidative inflammatory mechanisms, lipid peroxidation, protein oxidation, DNA damage, mechanism resolution inflammation. major part this article discusses role alleviating inflammation, two common components human diseases. results epidemiological studies also presented.

Language: Английский

Citations

5
In Vitro and In Vivo Antioxidant and Immune Stimulation Activity of Wheat Product Extracts DOI Open Access
Beatrice Mengoni, Federica Armeli, Emily Schifano

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 302 - 302

Published: Jan. 16, 2025

Inflammation and oxidative stress are the main pathogenetic pathways involved in development of several chronic degenerative diseases. Our study is aimed at assessing antioxidant anti-inflammatory activity hydroalcoholic extracts obtained from wheat its derivatives. The content total phenolic flavonoid compounds were carried out by ABTS DPPH assays. ability to promote microglia polarization towards an phenotype was evaluated analyzing increased expression markers real-time qPCR immunofluorescence Antioxidant all C. elegans ROS levels enzymes GST-4 SOD-3 fluorescence experiments. key genes innate immune response resistance pathways-daf-16, sek-1, pmk-1-was qPCR. Wheat showed polarize cells phenotype, even after addition LPS. An detected both Caenorhabditis nematode, where also implemented anti-stress resilience stimulated immunity. present shows that seeds, flour, chaff, pasta as well activities may be considered prospective positive health agents for preparation functional foods. Moreover, valorization by-products agricultural agro-industrial would have significant implications terms circular economy.

Language: Английский

Citations

3
Synthesis of Naringenin and Senecioic Acid Ester Derivatives and Biological Evaluation of the Astrocyte Antioxidant Mechanism and Reactivity After Inflammatory Stimulus DOI Open Access
Janaína Ribeiro Pereira Soares,

Cleonice Creusa dos Santos,

Lucas Matheus Gonçalves de Oliveira

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2215 - 2215

Published: Feb. 28, 2025

The imbalance between the overproduction of reactive species and antioxidant mechanisms can result in astrogliosis oxidative stress associated with neurodegeneration. Based on described activity naturally occurring flavonoids, this study evaluated flavonoid naringenin senecioic acid ester derivatives cortical astrocytes. Naringenin (S)-naringenin were purified from Citrus paradisi, them 7,4-O-disenecioic naringenin, (S)-7,4-O-disenecioic 7-O-senecioic synthesized tested for by free-radical scavenging reaction DPPH. flavonoids' toxicity glutathione (GS) depletion determined rat astrocyte cultures; effects astrocytes' reactivity was expression glial fibrillary acidic protein (GFAP) measuring nitric oxide (NO) production astrocytes treated lipopolysaccharide (LPS, 1 µg/mL/24 h). compounds (1-10 μM) presented effects, (S)-7,4'-O-disenecioic most effective. (1-100 not toxic to astrocytes, also promoting an effect increasing GSH. Moreover, 7-O-senecioc mitigated induced LPS, reducing GFAP NO production. These findings indicate that present a pharmacological potential as anti-inflammatory brain diseases via modulation response.

Language: Английский

Citations

2
Exploring the efficacious constituents and underlying mechanisms of sini decoction for sepsis treatment through network pharmacology and multi-omics DOI
Yang Gu, Ziying Li,

Han Li

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 123, P. 155212 - 155212

Published: Nov. 12, 2023

Language: Английский

Citations

27
Electrospraying and electrospinning of tannic acid-loaded zein: Characterization and antioxidant effects in astrocyte culture exposed to E. coli lipopolysaccharide DOI
Karina Pereira Luduvico, Marjana Radünz, Helen Cristina dos Santos Hackbart

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131433 - 131433

Published: April 6, 2024

Language: Английский

Citations

10
Application of natural products in regulating ferroptosis in human diseases DOI

Liyan Deng,

Wen Tian, Lianxiang Luo

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155384 - 155384

Published: Jan. 28, 2024

Language: Английский

Citations

9
Iron toxicity, ferroptosis and microbiota in Parkinson’s disease: Implications for novel targets DOI
Fernanda V. Carvalho,

Harold E. Landis,

Bruk Getachew

et al.

Advances in neurotoxicology, Journal Year: 2024, Volume and Issue: unknown, P. 105 - 132

Published: Jan. 1, 2024

Language: Английский

Citations

9
Newer Therapeutic Approaches in Treating Alzheimer’s Disease: A Comprehensive Review DOI Creative Commons

Radhakrishna Reddi Sree,

Manjunath Kalyan,

Nikhilesh Anand

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5148 - 5171

Published: Feb. 3, 2025

Alzheimer's disease (AD) is an aging-related irreversible neurodegenerative affecting mostly the elderly population. The main pathological features of AD are extracellular Aβ plaques generated by APP cleavage through amyloidogenic pathway, intracellular neurofibrillary tangles (NFT) resulting from hyperphosphorylated tau proteins, and cholinergic neurodegeneration. However, actual causes unknown, but several studies suggest hereditary mutations in PSEN1 -2, APOE4, APP, TAU genes major perpetrators. In order to understand etiology pathogenesis AD, various hypotheses proposed. These include following hypotheses: amyloid accumulation, tauopathy, inflammation, oxidative stress, mitochondrial dysfunction, glutamate/excitotoxicity, deficiency, gut dysbiosis. Currently approved therapeutic interventions donepezil, galantamine, rivastigmine, which cholinesterase inhibitors (ChEIs), memantine, N-methyl-d-aspartate (NMDA) antagonist. treatment strategies focus on only symptomatic management attenuating symptoms not regeneration neurons or clearance Tau. This review focuses pathophysiology, novel targets, disease-altering treatments such as α-secretase modulators, active immunotherapy, passive natural antioxidant products, nanomaterials, antiamyloid therapy, aggregation inhibitors, transplantation fecal microbiota stem cells, microtubule stabilizers that clinical trials still under investigation.

Language: Английский

Citations

1
Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression DOI

Spandana Rajendra Kopalli,

Tapan Behl,

Ashishkumar Kyada

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

Citations

1
Post-traumatic stress disorder, diabetes mellitus, and alpha-lipoic acid DOI Creative Commons
Victoria Serhiyenko, O.М. Chemerys,

S.Y. Holovach

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 21(1), P. 82 - 94

Published: Feb. 23, 2025

Post-traumatic stress disorder (PTSD) is a prognostic factor for the development of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), increases risk cardiometabolic pathologies and neurodegenerative diseases. At same time, T2DM MetS can also cause major neurosis-like psychiatric symptoms characteristic PTSD. Their influence manifested through negative effects on central nervous system, in particular Oxidative chronic low-grade inflammation play an important role pathophysiology PTSD, MetS, T2DM, making them main therapeutic targets. Targeted oxidative stress, mitochondrial metabolism disorders, use antioxidants, α-lipoic acid (ALA), positively affect not only course comorbidities but manifestations In vitro vivo studies have demonstrated that ALA modulates number pathways associated with stress. addition, results clinical trials confirm antioxidant mechanism action patients obesity, 1 2. The neuroprotective activity being actively studied proving promising as approach treatment PTSD Despite significant potential ALA, its application limited by several barriers. particular, lack standardized protocols, well detailed assessment effectiveness alone. pharmacokinetic profile remains limited, which one factors hinder use. this context, there are certain prospects transportation systems based nanoparticles, potentially solve these problems. technologies so­lid lipid nanoparticles such niosomes, liposomes, nanostructured carriers micelles provide possibility local or systemic ALA. However, further preclinical needed to definitively determine feasibility search was conducted Scopus, Science Direct (from Elsevier) PubMed, including MEDLINE databases. keywords used were “α-lipoic acid”, “post-traumatic disorder”, “diabetes mellitus”, “metabolic syndrome”. A manual bibliography publications identify study could be found during online search.

Language: Английский

Citations

1