Mitigative and neuroprotective effects of Lavandula angustifolia essential oil on serotonin syndrome-induced neurotoxicity in male albino rats DOI

Manal A. Babaker,

Naema Ibolgasm Alazabi,

Shimaa A. Haredy

et al.

Drug and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Feb. 2, 2025

The term serotonin syndrome (SS) is a potentially life-threatening devastating condition triggered by the excessive accumulation of serotonin, often due to an overdose or concurrent use multiple serotonergic drugs. Lavandula angustifolia (lavender), known plant from Lamiaceae family, very rich in essential oils, minerals, and tannins. This study aimed elucidate detrimental effects SS on brain evaluate neuroprotective potential L. oil. Male rats were randomly divided into following groups: control (Group 1); angustifolia-treated 2); ondansetron-treated high-dose 3); sertraline-treated 4); low-dose ondansetron + 5); 6); sertraline 7); 8). Neurotransmitter levels, dopamine metabolites, expressed cytokines quantified. Additionally, histological assessment hippocampus was performed. results revealed significant disruptions neurotransmitter amino acid levels within across treated groups. Notably, group presented pronounced increases 5-HIAA, proinflammatory cytokines, resulting neurotoxicity alterations hippocampus. Conversely, treatment with significantly attenuated these neurotoxic effects. findings suggest that confers neuroprotection against deleterious SS, particularly counteracting impact combined 5-HT3 receptor antagonists reuptake inhibitors These highlight as natural therapeutic agent for mitigating SS-induced neurotoxicity.

Language: Английский

Electrospraying and electrospinning of tannic acid-loaded zein: Characterization and antioxidant effects in astrocyte culture exposed to E. coli lipopolysaccharide DOI
Karina Pereira Luduvico, Marjana Radünz, Helen Cristina dos Santos Hackbart

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131433 - 131433

Published: April 6, 2024

Language: Английский

Citations

10
Iron toxicity, ferroptosis and microbiota in Parkinson’s disease: Implications for novel targets DOI
Fernanda V. Carvalho,

Harold E. Landis,

Bruk Getachew

et al.

Advances in neurotoxicology, Journal Year: 2024, Volume and Issue: unknown, P. 105 - 132

Published: Jan. 1, 2024

Language: Английский

Citations

9
Newer Therapeutic Approaches in Treating Alzheimer’s Disease: A Comprehensive Review DOI Creative Commons

Radhakrishna Reddi Sree,

Manjunath Kalyan,

Nikhilesh Anand

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5148 - 5171

Published: Feb. 3, 2025

Alzheimer's disease (AD) is an aging-related irreversible neurodegenerative affecting mostly the elderly population. The main pathological features of AD are extracellular Aβ plaques generated by APP cleavage through amyloidogenic pathway, intracellular neurofibrillary tangles (NFT) resulting from hyperphosphorylated tau proteins, and cholinergic neurodegeneration. However, actual causes unknown, but several studies suggest hereditary mutations in PSEN1 -2, APOE4, APP, TAU genes major perpetrators. In order to understand etiology pathogenesis AD, various hypotheses proposed. These include following hypotheses: amyloid accumulation, tauopathy, inflammation, oxidative stress, mitochondrial dysfunction, glutamate/excitotoxicity, deficiency, gut dysbiosis. Currently approved therapeutic interventions donepezil, galantamine, rivastigmine, which cholinesterase inhibitors (ChEIs), memantine, N-methyl-d-aspartate (NMDA) antagonist. treatment strategies focus on only symptomatic management attenuating symptoms not regeneration neurons or clearance Tau. This review focuses pathophysiology, novel targets, disease-altering treatments such as α-secretase modulators, active immunotherapy, passive natural antioxidant products, nanomaterials, antiamyloid therapy, aggregation inhibitors, transplantation fecal microbiota stem cells, microtubule stabilizers that clinical trials still under investigation.

Language: Английский

Citations

1
Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression DOI

Spandana Rajendra Kopalli,

Tapan Behl,

Ashishkumar Kyada

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

Citations

1
Post-traumatic stress disorder, diabetes mellitus, and alpha-lipoic acid DOI Creative Commons
Victoria Serhiyenko, O.М. Chemerys,

S.Y. Holovach

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 21(1), P. 82 - 94

Published: Feb. 23, 2025

Post-traumatic stress disorder (PTSD) is a prognostic factor for the development of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), increases risk cardiometabolic pathologies and neurodegenerative diseases. At same time, T2DM MetS can also cause major neurosis-like psychiatric symptoms characteristic PTSD. Their influence manifested through negative effects on central nervous system, in particular Oxidative chronic low-grade inflammation play an important role pathophysiology PTSD, MetS, T2DM, making them main therapeutic targets. Targeted oxidative stress, mitochondrial metabolism disorders, use antioxidants, α-lipoic acid (ALA), positively affect not only course comorbidities but manifestations In vitro vivo studies have demonstrated that ALA modulates number pathways associated with stress. addition, results clinical trials confirm antioxidant mechanism action patients obesity, 1 2. The neuroprotective activity being actively studied proving promising as approach treatment PTSD Despite significant potential ALA, its application limited by several barriers. particular, lack standardized protocols, well detailed assessment effectiveness alone. pharmacokinetic profile remains limited, which one factors hinder use. this context, there are certain prospects transportation systems based nanoparticles, potentially solve these problems. technologies so­lid lipid nanoparticles such niosomes, liposomes, nanostructured carriers micelles provide possibility local or systemic ALA. However, further preclinical needed to definitively determine feasibility search was conducted Scopus, Science Direct (from Elsevier) PubMed, including MEDLINE databases. keywords used were “α-lipoic acid”, “post-traumatic disorder”, “diabetes mellitus”, “metabolic syndrome”. A manual bibliography publications identify study could be found during online search.

Language: Английский

Citations

1
Synthesis of Naringenin and Senecioic Acid Ester Derivatives and Biological Evaluation of the Astrocyte Antioxidant Mechanism and Reactivity After Inflammatory Stimulus DOI Open Access
Janaína Ribeiro Pereira Soares,

Cleonice Creusa dos Santos,

Lucas Matheus Gonçalves de Oliveira

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2215 - 2215

Published: Feb. 28, 2025

The imbalance between the overproduction of reactive species and antioxidant mechanisms can result in astrogliosis oxidative stress associated with neurodegeneration. Based on described activity naturally occurring flavonoids, this study evaluated flavonoid naringenin senecioic acid ester derivatives cortical astrocytes. Naringenin (S)-naringenin were purified from Citrus paradisi, them 7,4-O-disenecioic naringenin, (S)-7,4-O-disenecioic 7-O-senecioic synthesized tested for by free-radical scavenging reaction DPPH. flavonoids' toxicity glutathione (GS) depletion determined rat astrocyte cultures; effects astrocytes' reactivity was expression glial fibrillary acidic protein (GFAP) measuring nitric oxide (NO) production astrocytes treated lipopolysaccharide (LPS, 1 µg/mL/24 h). compounds (1-10 μM) presented effects, (S)-7,4'-O-disenecioic most effective. (1-100 not toxic to astrocytes, also promoting an effect increasing GSH. Moreover, 7-O-senecioc mitigated induced LPS, reducing GFAP NO production. These findings indicate that present a pharmacological potential as anti-inflammatory brain diseases via modulation response.

Language: Английский

Citations

1
Exploring the efficacious constituents and underlying mechanisms of sini decoction for sepsis treatment through network pharmacology and multi-omics DOI
Yang Gu, Ziying Li,

Han Li

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 123, P. 155212 - 155212

Published: Nov. 12, 2023

Language: Английский

Citations

21
Molecular Mechanisms of the Anti-Inflammatory Effects of Epigallocatechin 3-Gallate (EGCG) in LPS-Activated BV-2 Microglia Cells DOI Creative Commons
Ashley Payne,

Equar Taka,

Getinet M. Adinew

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(4), P. 632 - 632

Published: April 7, 2023

Chronic neuroinflammation is associated with many neurodegenerative diseases, such as Alzheimer's. Microglia are the brain's primary immune cells, and when activated, they release various proinflammatory cytokines. Several natural compounds anti-inflammatory antioxidant properties, epigallocatechin 3-gallate (EGCG), may provide a promising strategy for inflammation-related diseases involving activated microglia cells. The objective of current study was to examine molecular targets underlying effects EGCG in BV-2 cells were grown, stimulated, treated EGCG. Cytotoxicity nitric oxide (NO) production evaluated. Immunoassay, PCR array, WES™ Technology utilized evaluate inflammatory, neuroprotective modulators well signaling pathways involved mechanistic action neuroinflammation. Our findings showed that significantly inhibited mediator NO LPS-stimulated In addition, ELISA analysis revealed decreases cytokine IL-6 while it increases TNF-α. array downregulated MIF, CCL-2, CSF2. It also upregulated IL-3, IL-11, TNFS10. Furthermore, inflammatory mRNA expression mTOR, NF-κB2, STAT1, Akt3, CCL5, SMAD3 upregulating Ins2, Pld2, A20/TNFAIP3, GAB1. Additionally, reduced relative protein Akt3. These suggest be used its prevent diseases.

Language: Английский

Citations

19
Application of natural products in regulating ferroptosis in human diseases DOI

Liyan Deng,

Wen Tian, Lianxiang Luo

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155384 - 155384

Published: Jan. 28, 2024

Language: Английский

Citations

7
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway DOI Creative Commons
Yi Zhou,

Jiale Yan,

Limin Qiao

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 183 - 183

Published: Jan. 31, 2024

As a pivotal player in spermatogenesis, the blood-testis barrier (BTB) made from junction apparatus coexisting Sertoli cells (SCs) is impaired with an increase age and ultimately induces spermatogenic dysfunction or even infertility. It has been corroborated that bone marrow mesenchymal stem cell (BMSC) transplantation can efficiently repair regenerate testicular function. vital mediators of cell-to-cell communication, MSC-derived exosomes (Exos) directly serve as therapeutic agents for tissue regeneration. However, value BMSC-Exos aging-induced BTB damage remains to be confirmed. In this study, we explored old porcine testes had defective autophagy, which aggravated disruption SCs. could decrease ROS production NLRP3 inflammasome activation but enhanced autophagy tight (TJ) function D-gal-triggered aging SCs mouse model testes, according vitro vivo experiments. Furthermore, rapamycin, NAC, MCC950, IL-1Ra restored TJ D-gal-stimulated SCs, while BMSC-Exos’ stimulatory effect on was inhibited by chloroquine. Moreover, treatment D-gal-induced means AMPK/mTOR signal transduction pathway. These findings uncovered through present study enhance improving via signaling pathway, thereby suppressing activation.

Language: Английский

Citations

7