Effects of moderate ethanol exposure on risk factors for cardiovascular disease and colorectal cancer in adult Wistar rats DOI Creative Commons

Anna J Kwon,

Lani Morales,

Louise Chatagnier

et al.

Alcohol, Journal Year: 2024, Volume and Issue: 117, P. 55 - 63

Published: March 24, 2024

While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate use these conditions produced mixed results. The purpose this study was investigate factors associated with development CVDs CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned either an ethanol group, which consisted voluntary access a 20% (v/v) solution alternate days, or water control group (n = 12/group) 13 weeks. Blood samples collected analyze levels albumin, glucose, adiponectin, lipids, oxidized low-density lipoprotein cholesterol, high-density cholesterol (HDL-C), apolipoprotein A1 (apoA1), C-reactive protein (CRP), high-mobility box 1 (HMGB-1), tumor necrosis factor-alpha (TNF-α), thyroxine, thyroid-stimulating hormone, 8-oxo-2'-deoxyguanosine (8-oxo-dG), liver function enzymes, antioxidant capacity. Colonic gene expression related colon carcinogenesis also assessed. Ethanol-treated found significantly higher HDL-C apoA1 compared controls. Moderate led lower CRP trend decrease HMGB-1, TNF-α, 8-oxo-dG levels. In ethanol-exposed colonic superoxide dismutase upregulated while aldehyde dehydrogenase 2 showed increase group. These results indicate that adopting approach could potentially improve health biomarkers CVD by increasing activity reducing DNA damage inflammatory activity.

Language: Английский

The Role of Reactive Oxygen Species in Colorectal Cancer Initiation and Progression: Perspectives on Theranostic Approaches DOI Open Access

Teresa Catalano,

Federico Selvaggi, Roberto Cotellese

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 752 - 752

Published: Feb. 22, 2025

Altered levels of reactive oxygen species (ROS) are recognized as one the key factors in mediating tumor cell survival tissue microenvironment, where they play a role initiation, progression and recurrence/relapse colorectal cancer (CRC). Tumor cells can adapt to oxidative stress (OS) using genetic or metabolic reprogramming long short term. In addition, defend themselves through positive regulation antioxidant molecules, enhancing ROS-driven proliferation. Balanced eustress influence chemotherapy resistance, allowing survive treatment. Secondary effects include increased ROS production redox stress, which kill eliminate drug resistance. Anticancer treatments based on manipulating could represent gold standard CRC therapy. Therefore, exploring modulation response OS deregulated signaling pathways may lead development new personalized overcome therapy this review, we explore initiation their diagnostic implications biomarkers disease. Furthermore, focused involvement different therapeutic options, such surgery, radiotherapy, theranostic imaging, immunotherapy other precision medicine approaches.

Language: Английский

Citations

1
Exercise and survival benefit in cancer patients: evidence from a comprehensive meta-analysis DOI Creative Commons
Zoltán Ungvári, Mónika Fekete, Péter Varga

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

Citations

1
Natural Products as Dietary Agents for the Prevention and Mitigation of Oxidative Damage and Inflammation in the Intestinal Barrier DOI Creative Commons
Carlos Martins‐Gomes, Fernando M. Nunes, Amélia M. Silva

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(1), P. 65 - 65

Published: Jan. 1, 2024

Food intake is a basic need to sustain life, but foodborne pathogens and food-related xenobiotics are also the main health concerns regarding intestinal barrier homeostasis. With predominant role in well-being of entire human body, homeostasis strictly regulated by epithelial immune cells. These cells intervenients oxidative stress inflammation-related diseases tract, triggered, for example, genetic/epigenetic factors, food additives, pesticides, drugs, pathogens, their metabolites. Nevertheless, diet can be seen as solution problem, mainly via inclusion functional foods or nutraceuticals that may act antioxidant/anti-inflammatory agents prevent mitigate acute chronic damage inflammation. A literature analysis recent advances this topic highlights significant Nrf2 (nuclear factor erythroid 2-related 2) NF-kB kappa-light-chain-enhancer activated B cells) pathways these biological processes, with many natural products phytochemicals targeting endogenous antioxidant systems cytokine production balance. In review, we summarized discussed studies using vitro vivo models tract used reproduce inflammatory events, well modulators NK-kB pathways.

Language: Английский

Citations

8
Costunolide ameliorates MNNG-induced chronic atrophic gastritis through inhibiting oxidative stress and DNA damage via activation of Nrf2 DOI
Ruixuan Wang,

Youdong Zhao,

Lei Zhou

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155581 - 155581

Published: April 2, 2024

Language: Английский

Citations

8
Atherosclerosis, Diabetes Mellitus, and Cancer: Common Epidemiology, Shared Mechanisms, and Future Management DOI Open Access
Vasiliki Katsi, Ilias Papakonstantinou, Konstantinos Tsioufis

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11786 - 11786

Published: July 22, 2023

The involvement of cardiovascular disease in cancer onset and development represents a contemporary interest basic science. It has been recognized, from the most recent research, that metabolic syndrome-related conditions, ranging atherosclerosis to diabetes, elicit many pathways regulating lipid metabolism signaling are also linked same framework multiple potential mechanisms for inducing cancer. Otherwise, dyslipidemia endothelial cell dysfunction may present common or even interdependent changes, similar oncogenic molecules elevated forms However, whether atherosclerotic provides signals promote pre-clinical proliferation malignant cells is an issue requires further understanding, though more questions presented with every answer. Here, we highlight molecular point causal link between glucose homeostasis knowledge these breakthrough pave way application new therapeutic targets implementing interventions clinical practice.

Language: Английский

Citations

16
Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms DOI
Ahmed Aj. Jabbar, Zaenah Zuhair Alamri, Mahmood Ameen Abdulla

et al.

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(6), P. 2702 - 2719

Published: Sept. 29, 2023

Language: Английский

Citations

15
Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer DOI Creative Commons
Natalia Kurowska, Marcel Madej, Barbara Strzałka‐Mrozik

et al.

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 46(1), P. 121 - 139

Published: Dec. 23, 2023

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and responsible for approximately million deaths each year. The current standard care surgical resection lesion chemotherapy with 5-fluorouracil (5-FU). However, concern increasing incidence in an increasingly younger patient population ability CRC cells to develop resistance 5-FU. In this review, we discuss effects thymoquinone (TQ), main bioactive components Nigella sativa seeds, on CRC, a particular focus use TQ combination therapy other chemotherapeutic agents. exhibits anti-CRC activity by inducing proapoptotic effect inhibiting proliferation, primarily through its regulation signaling pathways crucial tumor progression oxidative stress. can be used synergistically agents enhance their anticancer influence expression genes important development. These data appear relevant co-treatment We believe that suitable candidate consideration chemoprevention adjuvant but further studies, including clinical trials, are needed confirm safety efficacy treatment cancer.

Language: Английский

Citations

14
Gold nanoparticles (AuNPs) decrease the viability of cervical cancer cells by inducing the BAX gene and activating antioxidant enzymes DOI

Noor Alhuda Kamil Shareef,

Farshid Zandsalimi, Gholamreza Tavoosidana

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Feb. 8, 2024

Language: Английский

Citations

6
Recent advances and molecular mechanisms of TGF-β signaling in colorectal cancer, with focus on bioactive compounds targeting DOI Open Access
Saad Bakrim, Naoufal El Hachlafi,

Asaad Khalid

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 116886 - 116886

Published: June 29, 2024

Colorectal cancer (CRC) is one of the most significant forms human cancer. It characterized by its heterogeneity because several molecular factors are involved in contiguity and can link it to others without having a linear correlation. Among influencing tumor transformation CRC, transforming growth factor-beta (TGF-β) plays key promoter role. This factor associated with colorectal tumors very high prognosis: increases survival, invasion, metastasis CRC cells, thus functioning as an oncogene. The inhibition this constitute major therapeutic route for treatment. Various chemical drugs including synthetic molecules biotherapies have been developed TGF-β inhibitors. Moreover, scientific community has recently shown interest screening natural inhibiting CRC. In context, we carried out review article using computerized databases, such PubMed, Google Scholar, Springer Link, Science Direct, Cochrane Library, Embase, Web Science, Scopus, highlight mechanism induction progression current advances pharmacodynamic effects bioactive substances targeting

Language: Английский

Citations

6
Advances in and Perspectives on Transgenic Technology and CRISPR-Cas9 Gene Editing in Broccoli DOI Open Access
Li Zhang,

Su-Fang Meng,

Yumei Liu

et al.

Genes, Journal Year: 2024, Volume and Issue: 15(6), P. 668 - 668

Published: May 23, 2024

Broccoli, a popular international Brassica oleracea crop, is an important export vegetable in China. Broccoli not only rich protein, vitamins, and minerals but also has anticancer antiviral activities. Recently, Agrobacterium-mediated transformation system been established optimized broccoli, transgenic CRISPR-Cas9 gene editing techniques have applied to improve broccoli quality, postharvest shelf life, glucoraphanin accumulation, disease stress resistance, among other factors. The construction application of genetic technology systems led rapid development worldwide, which good for functional identification some potential traits broccoli. This review comprehensively summarizes the progress over past four decades. Moreover, it explores future integration digital smart technologies into processes, thus demonstrating promise even more sophisticated targeted crop improvements. As field continues evolve, these innovations are expected play pivotal role sustainable production enhancement its nutritional health benefits.

Language: Английский

Citations

5