The Potential Preventive Role of Dapagliflozin and Metformin Alone or in Combination on the Cisplatin-Induced Renal Damage in Adult Male Albino Rats DOI
Waseem Hassan, Mohamed G. Hamama,

Amal Abd El-Khalek Mahdy

et al.

Journal of Microscopy and Ultrastructure, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Language: Английский

Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems DOI Creative Commons
Pincha Devage Sameera Madushan Fernando,

Dong Ok Ko,

Mei Jing Piao

et al.

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 30(1)

Published: May 15, 2024

Physiological stress such as excessive reactive oxygen species (ROS) production may contribute normal fibroblasts activation into cancer‑associated fibroblasts, which serve a crucial role in certain types of cancer pancreatic, breast, liver and lung cancer. The present study aimed to examine the cytoprotective effects luteolin (3',4',5,7‑tetrahydroxyflavone) against hydrogen peroxide (H2O2)‑generated oxidative fibroblasts. To H2O2‑induced damages, cell viability, sub‑G1 population, nuclear staining with Hoechst 33342, lipid peroxidation comet assays were performed. evaluate on protein expression level apoptosis, western blot assay was assess antioxidant luteolin, detection ROS using H2DCFDA staining, O2‑ ·OH electron spin resonance spectrometer enzyme activity In cell‑free chemical system, scavenges superoxide anion hydroxyl radical generated by xanthine/xanthine oxidase Fenton reaction (FeSO4/H2O2). Furthermore, Chinese hamster (V79‑4) treated H2O2 showed significant increase cellular ROS. Intracellular levels damage components lipids DNA H2O2‑treated cells significantly decreased pretreatment. Luteolin increased impaired following treatment prevented H2O2‑mediated apoptosis. suppressed active caspase‑9 caspase‑3 while increasing Bcl‑2 decreasing Bax levels. Additionally, restored glutathione that reduced response H2O2. Moreover, enhanced expressions dismutase, catalase, peroxidase, heme oxygenase‑1. Overall, these results indicated inhibits upregulating enzymes.

Language: Английский

Citations

13
NRF2 in kidney physiology and disease DOI Creative Commons

Corry D. Bondi,

Hannah L. Hartman, Roderick J. Tan

et al.

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(5)

Published: Feb. 28, 2024

Abstract The role of NRF2 in kidney biology has received considerable interest over the past decade. transcriptionally controls genes responsible for cellular protection against oxidative and electrophilic stress anti‐inflammatory functions. is expressed throughout plays a salt water handling. In disease, animal studies show that protects tubulointerstitial damage reduces interstitial fibrosis tubular atrophy, may slow progression polycystic disease. However, proteinuric glomerular diseases controversial. Although inducer, bardoxolone methyl (CDDO‐Me), increases filtration rate humans, it not been shown to disease diabetic Alport syndrome. Furthermore, was associated with negative effects on fluid retention, proteinuria, blood pressure. Several replicate findings worsened proteinuria more rapid although controversy exists. It clear further study needed better understand kidney. This review summarizes available data clarify promise risks targeting activity

Language: Английский

Citations

12
Taxifolin Protects Against 5-Fluorouracil-Induced Cardiotoxicity in Mice Through Mitigating Oxidative Stress, Inflammation, and Apoptosis: Possible Involvement of Sirt1/Nrf2/HO-1 Signaling DOI
Mohammad H. Abukhalil, Zina M. Al‐Alami, Manal A. Alfwuaires

et al.

Cardiovascular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Language: Английский

Citations

1
Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin DOI Creative Commons
Lauren Thompson, Stacey M. Tuey,

Pamela González

et al.

AAPS Open, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 3, 2025

Abstract Objective Acute kidney injury (AKI) occurs in approximately one-third of patients treated with cisplatin and there is an outstanding need for mitigation strategies to decrease the frequency severity cisplatin-induced AKI. This study evaluated bardoxolone methyl (BARD) as a nephroprotectant multidose, tumor-bearing mouse model BARD attractive therapeutic intervention due its ability protect against nephrotoxicity by activating Nrf2 previous reports suggesting anti-tumorigenic effects. Methods In this study, CMT167 mice were four weekly doses or without survival, tumor growth, clinical histological measures Kidney and/or function quantification urinary molecule-1 (KIM-1) serum creatinine (SCr) levels well histopathology. Results Compared receiving alone, co-treatment significantly enhanced survival ( p = 0.01). Moreover, prevented elevation KIM-1 concentrations early one week after treatment < 0.01) – response that was observed throughout 4-week period. Cisplatin increased SCr weeks, which co-administration decreased burden compared vehicle-treated 0.05 two doses) not altered co-treatment. Conclusions Overall, results demonstrate has potential improve reduce cisplatin, it could be used mitigate

Language: Английский

Citations

0
Morroniside alleviates cisplatin-induced renal injury and gut dysbiosis via the gut–kidney axis and ferroptosis DOI
H Li, Ke Xu,

Wenhao Mao

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114430 - 114430

Published: March 17, 2025

Language: Английский

Citations

0
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei DOI
Lei Miao, Shuting Wang, Quan-Hao Wei

et al.

Phytochemistry, Journal Year: 2024, Volume and Issue: 219, P. 113984 - 113984

Published: Jan. 22, 2024

Language: Английский

Citations

3
Recruitment or activation of mast cells in the liver aggravates the accumulation of fibrosis in carbon tetrachloride-induced liver injury DOI
Mingkang Zhang,

Jinru Yang,

Yufan Yuan

et al.

Molecular Immunology, Journal Year: 2024, Volume and Issue: 170, P. 60 - 75

Published: April 15, 2024

Language: Английский

Citations

2
Dietary Probiotic Pediococcus acidilactici GKA4, Dead Probiotic GKA4, and Postbiotic GKA4 Improves Cisplatin-Induced AKI by Autophagy and Endoplasmic Reticulum Stress and Organic Ion Transporters DOI Open Access
Jaung‐Geng Lin, Wen‐Ping Jiang,

You‐Shan Tsai

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3532 - 3532

Published: Oct. 18, 2024

Background/Objectives: Acute kidney injury (AKI) syndrome is distinguished by a quick decline in renal excretory capacity and usually diagnosed the presence of elevated nitrogen metabolism end products and/or diminished urine output. AKI frequently occurs hospital patients, there are no existing specific treatments available to diminish its occurrence or expedite recovery. For an extended period food industry, Pediococcus acidilactici has been robust bacteriocin production, effectively inhibiting pathogen growth during fermentation storage. Methods: In this study, aim assess effectiveness P. GKA4, dead probiotic postbiotic GKA4 against cisplatin-induced animal model. The experimental protocol involves ten-day oral administration mice, with cisplatin intraperitoneal injection being given on seventh day induce AKI. Results: findings indicated significant alleviation histopathological changes serum biomarkers nephrotoxicity. expression levels HO-1 decreased Nrf-2 proteins. addition, significantly reduced apoptosis-related proteins (Bax, Bcl-2, caspase 3), autophagy-related (LC3B, p62, Beclin1), endoplasmic reticulum (ER) stress-related (GRP78, PERK, ATF-6, IRE1, CHOP, Caspase 12) tissues. Notably, also upregulated related organic anion transporters cation transporters. Conclusions: Overall, potential therapeutic benefits significant, particularly after treatment. This achieved modulating apoptosis, autophagy, ER stress, transporter alleviate oxidative stress.

Language: Английский

Citations

1
Renal Health Through Medicine–Food Homology: A Comprehensive Review of Botanical Micronutrients and Their Mechanisms DOI Open Access
Yi Zhao,

Jian‐Ye Song,

Ru Feng

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3530 - 3530

Published: Oct. 18, 2024

As an ancient concept and practice, "food as medicine" or "medicine-food homology" is receiving more attention these days. It a tradition in many regions to intake medicinal herbal food for potential health benefits various organs systems including the kidney. Kidney diseases usually lack targeted therapy face irreversible loss of function, leading dialysis dependence. most important organ endogenous metabolite exogenous nutrient excretion, status kidney could be closely related daily diet. Therefore, rich antioxidative, anti-inflammation micronutrients are ideal supplements protection. Recent studies have also discovered its impact on "gut-kidney" axis.

Language: Английский

Citations

1
Cisplatin induces acute liver injury by triggering caspase-3/GSDME-mediated cell pyroptosis DOI

Ping-Ping Wu,

Xiujin Shen,

Shusen Zheng

et al.

Hepatobiliary & pancreatic diseases international, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

0