Selenium Mitigates Caerulein and LPS-induced Severe Acute Pancreatitis by Inhibiting MAPK, NF-κB, and STAT3 Signaling via the Nrf2/HO-1 Pathway

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

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GSH and Ferroptosis: Side-by-Side Partners in the Fight against Tumors

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 697 - 697

Published: June 6, 2024

Glutathione (GSH), a prominent antioxidant in organisms, exhibits diverse biological functions and is crucial safeguarding cells against oxidative harm upholding stable redox milieu. The metabolism of GSH implicated numerous diseases, particularly the progression malignant tumors. Consequently, therapeutic strategies targeting regulation synthesis to modulate levels represent promising avenue for future research. This study aimed elucidate intricate relationship between ferroptosis, highlighting how modulation can impact cellular susceptibility ferroptosis consequently influence development tumors other diseases. paper provides comprehensive overview physiological GSH, including its structural characteristics, physicochemical properties, sources, metabolic pathways, as well investigate molecular mechanisms underlying potential interventions. Unraveling role holds promise individuals afflicted with

Language: Английский

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A Review of the Therapeutic Potential of Sulfur Compounds in Allium sativum

Measurement Food, Journal Year: 2024, Volume and Issue: 15, P. 100195 - 100195

Published: Aug. 28, 2024

Language: Английский

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Enhanced methanogenesis and efficient ciprofloxacin degradation via nZVI@LDH in an electricity-driven anaerobic bioreactor: A biotic-abiotic hybrid system for ROS regulation and ARGs mitigation

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137348 - 137348

Published: Jan. 1, 2025

Language: Английский

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A ROS-responsive TPP-modified tanshinone IIA micelle improves DOX-induced heart failure

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 672, P. 125318 - 125318

Published: Feb. 5, 2025

Language: Английский

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Exploring the Future of Metal‐Based Anticancer Agents: A Comprehensive Review of Ruthenium‐Based Complexes

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(9)

Published: March 1, 2025

Abstract Ruthenium complexes are gaining recognition in oncology as promising alternatives to the traditionally used platinum‐based anticancer agents. Unlike Pt agents, they can better differentiate between healthy and malignant cells, minimizing adverse side effects. They exhibit advantageous properties such thermodynamic kinetic stability, increased water solubility, enhanced cellular absorption, superior selectivity cytotoxicity for tumors, decreased toxicity cells. has been make having structural variability ability undergo ligand exchange. effective against metastatic tumor cells interact with components; their significant charges large cavities allow efficient molecule encapsulation. These being explored enhance efficacy enzymatic research targeted therapies. The manifold biochemical of ruthenium induce cell apoptosis through various signaling pathways them candidates future Despite successful testing some these clinical trials, none have commercially available. Continued aims unlock full potential cancer treatment. This review covers a few findings past 6 years on ligated organic moieties antineoplastic

Language: Английский

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Glutathione-Dependent Pathways in Cancer Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8423 - 8423

Published: Aug. 1, 2024

The most abundant tripeptide—glutathione (GSH)—and the major GSH-related enzymes—glutathione peroxidases (GPxs) and glutathione S-transferases (GSTs)—are highly significant in regulation of tumor cell viability, initiation development, its progression, drug resistance. high level GSH synthesis different cancer types depends not only on increasing expression key enzymes γ-glutamyl cycle but also changes transport velocity precursor amino acids. ability GPxs to reduce hydroperoxides is used for cellular each member GPx family has a mechanism action site maintaining redox balance. GSTs catalyze conjugation electrophilic substances reduction organic take part signaling pathways. By catalyzing S-glutathionylation target proteins, are involved processes, including metabolism (e.g., glycolysis PPP), signal transduction, transcription regulation, development resistance anticancer drugs. In this review, recent findings synthesis, roles functions GPxs, GST isoforms discussed, along with search inhibitors treatment.

Language: Английский

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The Role of Dietary Antioxidants, Food Supplements and Functional Foods for Energy Enhancement in Healthcare Professionals

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1508 - 1508

Published: Dec. 10, 2024

Healthcare professionals frequently experience significant work overload, which often leads to substantial physical and psychological stress. This stress is closely linked increased oxidative a corresponding decline in energy levels. scoping review investigates the potential impact of dietary antioxidants food supplements conjunction with diet controlling these negative effects. Through an analysis biochemical pathways involved metabolism, paper emphasizes effectiveness targeted interventions. Key antioxidants, such as vitamins C E, polyphenols, carotenoids, are evaluated for their ability counteract enhance Additionally, assesses various supplements, including omega-3 fatty acids, coenzyme Q10, ginseng, mechanisms action enhancement. Practical guidelines incorporating energy-boost strategies into routine healthcare provided, emphasizing importance modifications reducing improving overall well-being performance high-stress environments. The concludes by suggesting directions future research validate findings explore new interventions that may further support under overload.

Language: Английский

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Ionizing radiation induces neurotoxicity in Xenopus laevis embryos through neuroactive ligand-receptor interaction pathway

Environmental Research, Journal Year: 2024, Volume and Issue: 256, P. 119237 - 119237

Published: May 27, 2024

Language: Английский

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Prolactin is an Endogenous Antioxidant Factor in Astrocytes That Limits Oxidative Stress-Induced Astrocytic Cell Death via the STAT3/NRF2 Signaling Pathway

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(7), P. 1879 - 1901

Published: May 17, 2024

Abstract Oxidative stress-induced death of neurons and astrocytes contributes to the pathogenesis numerous neurodegenerative diseases. While significant progress has been made in identifying neuroprotective molecules against neuronal oxidative damage, little is known about their counterparts for astrocytes. Prolactin (PRL), a hormone stimulate astroglial proliferation, viability, cytokine expression, exhibits antioxidant effects neurons. However, its role protecting from stress remains unexplored. Here, we investigated effect PRL hydrogen peroxide (H 2 O )-induced insult primary cortical astrocyte cultures. Incubation with led increased enzymatic activity superoxide dismutase (SOD) glutathione peroxidase (GPX), resulting higher total capacity. Concomitantly, prevented H -induced cell death, reactive oxygen species accumulation, protein lipid oxidation. The protective upon can be explained by activation both signal transducer activator transcription 3 (STAT3) NFE2 like bZIP factor (NRF2) transduction cascades. We demonstrated that induced nuclear translocation transcriptional upregulation Nrf2 , concurrently NRF2-dependent genes heme oxygenase 1, Sod1, Sod2 Gpx1 . Pharmacological blockade STAT3 suppressed PRL-induced Sod1 mRNA, SOD GPX activities. Furthermore, genetic ablation receptor susceptibility while diminishing intrinsic Overall, these findings unveil as potent protects insult, which may contribute brain neuroprotection.

Language: Английский

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