Enhanced Recovery of Phenolic and Tocopherolic Compounds from Walnut (Juglans Regia L.) Male Flowers Based on Process Optimization of Ultrasonic Assisted-Extraction: Phytochemical Profile and Biological Activities

Antioxidants, Journal Year: 2021, Volume and Issue: 10(4), P. 607 - 607

Published: April 15, 2021

The extraction of bioactive compounds present in walnut (Juglans regia L.) male flowers (WMFs) was performed based on an experimental design using ultrasonic-assisted extraction. Solvent nature, time, and water content were selected as variables, phenolic, flavonoidic, condensed tannins contents antioxidant properties evaluated. Acetone the solvent with highest performance, extracts obtained this displaying increased concentration activities. For several high content, individual polyphenolic tocopherolic evaluated by means LC-MS LC-MS/MS. best conditions for (2.86 mg gallic acid equivalents/g WMF) (29.4 µg/g acetone 40% (N20) 20% (N15), respectively. Although total tocopherol concentrations lower than other Juglans parts, most quantity provided highly biologically active δ-tocopherol (84%). Significant quantities quercetin (101.9 µg/g), hyperoside (2662.9 quercitrin (405.7 isoquercitrin (1293.7 µg/g) determined WMF (N20). Both inhibited enzymatic activity α-glucosidase tyrosinase; however, inhibition observed N20, extract higher content. Conversely, N15 had anticancerous cell lines used, a moderate selectivity towards cancerous phenotype being both extracts. At non-cytotoxic concentrations, displayed good activities cellular cultures, decreasing basal H2O2-induced oxidative stress. This is first characterization hydrophilic lipophilic phytochemicals outcomes our study reveal that have strong biological activities, thus justifying further research to demonstrate their usefulness food, pharmaceutical, and/or cosmetic industries.

Language: Английский

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Mediterranean Diet and the Emotional Well-Being of Students of the Campus of Melilla (University of Granada)

Nutrients, Journal Year: 2020, Volume and Issue: 12(6), P. 1826 - 1826

Published: June 19, 2020

A certain link exists between the consumption of particular groups food and well-being. In this study, we analyzed in depth relationship strict adherence to Mediterranean diet (MD) emotional well-being through a descriptive, exploratory, transversal, correlational study students from Campus Melilla, University Granada, Spain. The sample consisted 272 individuals. Adherence MD was measured with PREvención con DIetaMEDiterránea (PREDIMED) questionnaire, (both positive negative affection) Spanish version Positive Negative Affect Schedule (PANAS), state perceived health Short Form-36 (SF36), degree physical activity using International Physical Activity Questionnaire Form (IPAQ-SF). found be significantly related (β = 0.018, p 0.009). 0.192, < 0.001), mental role 0.346, 0.155, 0.007) were predictive factors state. Conversely, not significant. Various components independently connected results suggest that adopting nutritional pattern such as is linked an improvement

Language: Английский

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Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut (Juglans regia L.) Septum Extract Rich in Bioactive Compounds

Antioxidants, Journal Year: 2021, Volume and Issue: 10(1), P. 119 - 119

Published: Jan. 15, 2021

The antitussive, antioxidant, and anti-inflammatory effects of a walnut (Juglans regia L.) septum extract (WSE), rich in bioactive compounds were investigated using the citric acid aerosol-induced cough experimental model rodents. Wistar male rats treated orally for three days with distilled water (control), codeine (reference), WSE graded doses. On third day, all exposed to aerosols, number coughs being recorded. Each animal was sacrificed after exposure, blood lung tissue samples collected histopathological analysis assessment oxidative stress inflammatory biomarkers. results experiment showed significant antitussive effect WSE, superior codeine. This activity could be due cellular protective via stimulation antioxidant enzyme system decrease IL-6 CXC-R1 concentration WSE-treated animals. confirmed by biochemical assays analysis. is first scientific study reporting septum, new potential source non-opioid drug candidates, valuable by-product that used treatment respiratory diseases.

Language: Английский

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Antioxidants in Age-Related Diseases and Anti-Aging Strategies

Antioxidants, Journal Year: 2022, Volume and Issue: 11(10), P. 1868 - 1868

Published: Sept. 21, 2022

Aging is an intricate process and important risk factor in the development advancement of many disorders [...].

Language: Английский

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Dietary Factors and Pancreatic Cancer Risk: An Umbrella Review of Meta-Analyses of Prospective Observational Studies

Advances in Nutrition, Journal Year: 2023, Volume and Issue: 14(3), P. 451 - 464

Published: Feb. 26, 2023

Dietary factors may be associated with the occurrence of pancreatic cancer. This umbrella review aimed to and grade evidence for associations between dietary cancer risk. We searched PubMed, EMBASE, Web Science, Scopus, Cochrane Database Systematic Reviews, CINAHL eligible literature. included meta-analyses randomized controlled trials (RCTs) or prospective observational studies. used AMSTAR-2, a measurement tool assess systematic reviews, evaluate methodological quality meta-analyses. For each association, we calculated summary effect size, 95% CI, heterogeneity, number cases, prediction interval, small-study effect, excess significance bias. The protocol this was registered in PROSPERO database (CRD42022333669). 41 studies describing 59 None retrieved RCTs. No association supported by convincing highly suggestive evidence; however, there positive fructose intake There weak an inverse nuts adherence Mediterranean diet incidence, higher red meat heavy alcohol incidence. remaining 54 were nonsignificant. Consistent American Institute Cancer Research review, found that regular consumption reduced fructose, meat, lower risk Emerging As some rated as most considered nonsignificant, further are needed investigate role

Language: Английский

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Effect of a 12-Week Almond-Enriched Diet on Biomarkers of Cognitive Performance, Mood, and Cardiometabolic Health in Older Overweight Adults

Nutrients, Journal Year: 2020, Volume and Issue: 12(4), P. 1180 - 1180

Published: April 23, 2020

Long term nut consumption is associated with reduced risk of coronary heart disease and better cognitive function. This study examined supplementing habitual diets almonds or carbohydrate-rich snack foods (providing 15% energy) on biomarkers cardiovascular metabolic health, mood performance. Participants (overweight/obese, 50-80 years) were randomised to an almond-enriched diet (AED) isocaloric nut-free (NFD) for 12 weeks. Body weight, blood lipids, glucose, insulin, pressure (BP), arterial stiffness, cell adhesions molecules, C reactive protein (CRP), mood, performance (working memory primary outcome), dietary profiles energy intake/expenditure measured at baseline Week in 128 participants (n = 63 AED, n 65 NFD). Compared NFD, AED was altered macro micronutrient profiles, but no differences intake expenditure. The significantly triglycerides SBP there other changes cardiometabolic biomarkers, inclusion the improves aspects health without affecting overweight/obese adults.

Language: Английский

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The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review

Molecules, Journal Year: 2021, Volume and Issue: 26(11), P. 3406 - 3406

Published: June 4, 2021

In both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. However, the physiological differences between common in terms how they react metabolically high-fat diets need be considered. Here, we review factors that may affect translatability mechanistic research paying special attention effects on outcomes. We draw dissociation metabolic syndrome dyslipidemia rodents, unlike state humans, where two commonly occur. also discuss differential vulnerability species macronutrients diet. Findings from studies are better interpreted as modeling specific aspects dysfunction. conclude an opportunity explore why some protected detrimental high-fat-diet-induced dysfunction, translate these findings into benefits human health.

Language: Английский

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Astounding the synergistic interplay of walnuts in combating inflammation and oxidative damage

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 119, P. 106292 - 106292

Published: June 14, 2024

Language: Английский

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Unveiling the Impact of Peanut Consumption on Telomere Length in Young and Healthy Individuals: Insights from the ARISTOTLE Study: A Randomized Clinical Trial

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 467 - 467

Published: April 14, 2025

Diet is a potential modulator of telomere length (TL), but the impact individual dietary components, such as nuts, on TL in young, healthy individuals remains underexplored. Peanuts are rich bioactive compounds that may influence TL. Therefore, to fill this gap knowledge, study aimed investigate effect peanut consumption specific population. Fifty-eight were randomized one three different intervention groups for 6 months each: (1) 25 g/day skin-roasted peanuts (SRP); (2) 32 butter (PB); (3) control (CB) (based oil). was measured by quantitative real-time PCR saliva at baseline and end intervention. Our findings revealed significant between-group differences changes, particularly between SRP CB over (mean difference: 0.53; 95% CI: 0.01, 1.05; p-value = 0.048). No difference observed PB 0.12; –0.42, 0.66; 0.66). This provides novel insights into maintenance young individuals. The highlight benefits incorporating diet means promoting cellular health longevity. Further research warranted elucidate underlying mechanisms validate these across diverse populations longer time frames.

Language: Английский

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Lutein and Zeaxanthin Are Positively Associated with Visual–Spatial Functioning in Older Adults: An fMRI Study

Nutrients, Journal Year: 2018, Volume and Issue: 10(4), P. 458 - 458

Published: April 7, 2018

Lutein (L) and zeaxanthin (Z) are two xanthophyll carotenoids that have antioxidant anti-inflammatory properties. Previous work has demonstrated their importance for eye health preventing diseases such as age-related macular degeneration. An emerging literature base also the of L Z in cognition, neural structure, efficiency. The present study aimed to better understand mechanisms by which relate particular, visual–spatial processing decision-making older adults. We hypothesized markers higher levels would be associated with efficiency during a task. were assessed via standard measurement blood serum retinal concentrations. Visual–spatial judgment line orientation task (JLO) completed functional magnetic resonance imaging (fMRI) scan. results individuals concentrations showed decreased blood-oxygen-level dependent (BOLD) signal performance (i.e., “neural efficiency”) key areas perception, processing, decision-making, motor coordination, including lateral occipital cortex, pole, superior middle temporal gyri, parietal lobule, frontal pre- post-central gyri. To our knowledge, this is first investigation relationship at level using vivo methodology. Our findings suggest may impact brain cognition adults enhancing neurobiological variety regions support visual perception decision-making.

Language: Английский

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