Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications DOI Open Access
Yuhan Qin, Yong Qiao, Dong Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 141, P. 111872 - 111872

Published: July 7, 2021

Ferroptosis is a type of regulated cell death driven by iron dependent accumulation cellular reactive oxygen species (ROS) when glutathione (GSH)-dependent lipid peroxidation repair systems are compromised. Nuclear receptor co-activator 4 (NCOA4)-mediated selective autophagy ferritin, termed ferritinophagy, involves the regulation ferroptosis. Emerging evidence has revealed that ferritinophagy and ferroptosis exert significant role in occurrence development cardiovascular disease. In present review, we aimed to brief overview focusing on underlying mechanism regulations involved. We summarize discuss relevant research progress diseases accompanied with potential applications modulators treatment ferroptosis-associated diseases.

Language: Английский

Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors DOI Creative Commons
Jorn de Jong, Jasper E. Bos, Sander J. Wezenberg

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(13), P. 8530 - 8574

Published: June 21, 2023

Anionic species are omnipresent and involved in many important biological processes. A large number of artificial anion receptors has therefore been developed. Some these capable mediating transmembrane transport. However, where transport proteins can respond to stimuli their surroundings, creation synthetic with stimuli-responsive functions poses a major challenge. Herein, we give full overview the stimulus-controlled that have developed thus far, including application membrane In addition potential operation as carriers, use recognition motifs forming responsive membrane-spanning channels is discussed. With this review article, intend increase interest among scientists working on host–guest complexes dynamic functional systems order stimulate further developments.

Language: Английский

Citations

44

Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications DOI
Xianbo Wu, Yuqing Li, Mei Wen

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(5), P. 2643 - 2692

Published: Jan. 1, 2024

This review discusses the structures and engineering strategies of nanocatalysts, highlighting their underlying mechanisms applications in cancer immunotherapy.

Language: Английский

Citations

36

Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer DOI
Ana Podolski-Renić, Ana Čipak Gašparović, Andreia Valente

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 270, P. 116363 - 116363

Published: March 29, 2024

Language: Английский

Citations

23

Tumor microenvironment responsive nanozymes for multimodal imaging of tumors DOI Creative Commons
Heng Wang, Wenrui Ouyang, Hongxing Liu

et al.

Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100032 - 100032

Published: Jan. 29, 2024

Nanozymes exhibit immense potential and promising prospects in the realm of diagnostic imaging tumor therapy, owing to their inherent physicochemical properties enzymatic activities. With further development application nanotechnology, nanozymes are expected become an important tool field medicine, providing new solutions for disease diagnosis treatment. This review provides overview recent studies over past five years on capable responding microenvironment (TME) multimodal imaging, with a focus hypoxia, acid pH, excess GSH ROS. In addition, we present current status several common related contrast agents, such as MRI/CT, MRI/PET, MRI/SPECT, PET/CT. Moreover, some thoughts challenges, future development, clinical translation microenvironment-responsive shared. aims provide up-to-date theranostic nanomedicine reference those who fields, promote progress this interdisciplinary subject, accelerate translation.

Language: Английский

Citations

20

Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications DOI Open Access
Yuhan Qin, Yong Qiao, Dong Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 141, P. 111872 - 111872

Published: July 7, 2021

Ferroptosis is a type of regulated cell death driven by iron dependent accumulation cellular reactive oxygen species (ROS) when glutathione (GSH)-dependent lipid peroxidation repair systems are compromised. Nuclear receptor co-activator 4 (NCOA4)-mediated selective autophagy ferritin, termed ferritinophagy, involves the regulation ferroptosis. Emerging evidence has revealed that ferritinophagy and ferroptosis exert significant role in occurrence development cardiovascular disease. In present review, we aimed to brief overview focusing on underlying mechanism regulations involved. We summarize discuss relevant research progress diseases accompanied with potential applications modulators treatment ferroptosis-associated diseases.

Language: Английский

Citations

92