Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(4), P. 1332 - 1355

Published: Jan. 1, 2024

Polyphenolic compounds have shown promising neuroprotective properties, making them a valuable resource for identifying prospective drug candidates to treat several neurological disorders (NDs).Numerous studies reported that polyphenols can disrupt the nuclear factor kappa B(NF-κB) pathway by inhibiting phosphorylation or ubiquitination of signaling molecules, which further prevents degradation IκB.Additionally, they prevent NF-κB translocation nucleus and pro-inflammatory cytokine production.Polyphenols such as curcumin, resveratrol, pterostilbene had significant inhibitory effects on NF-κB, treating NDs.Recent experimental findings suggest possess wide range pharmacological properties.Notably, much attention has been directed towards their potential therapeutic in NDs Alzheimer's disease (AD), Parkinson's (PD), cerebral ischemia, anxiety, depression, autism, spinal cord injury (SCI).Much preclinical data supporting neurotherapeutic benefits developed.Nevertheless, this study described significance agents, specifically emphasizing impact pathway.This article offers comprehensive analysis involvement NDs, including both clinical perspectives.

Language: Английский

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Antioxidant and Anti-Inflammatory Effects of Bioactive Compounds in Atherosclerosis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1379 - 1379

Published: Feb. 6, 2025

Atherosclerosis, a chronic inflammatory disease characterized by the accumulation of lipids and immune cells within arterial walls, remains leading cause cardiovascular morbidity mortality worldwide. Oxidative stress inflammation are central to its pathogenesis, driving endothelial dysfunction, foam cell formation, plaque instability. Emerging evidence highlights potential bioactive compounds with antioxidant anti-inflammatory properties mitigate these processes promote vascular health. This review explores mechanisms through which compounds-such as polyphenols, carotenoids, flavonoids, omega-3 fatty acids, coenzyme Q10, other natural compounds-modulate oxidative in atherosclerosis. It examines their effects on key molecular pathways, including inhibition reactive oxygen species (ROS) production, suppression nuclear factor-κB (NF-κB), modulation cytokines. By integrating current knowledge, this underscores therapeutic dietary supplemental complementary strategies for managing atherosclerosis, paving way future research clinical applications.

Language: Английский

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The botanical details, pharmacological activities and industrial applications of date seed (Phoenix dactylifera L.)

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

Language: Английский

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Altered Mitochondrial Function in MASLD: Key Features and Promising Therapeutic Approaches

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 906 - 906

Published: July 26, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty (NAFLD), encompasses a range of conditions from steatosis to steatohepatitis (NASH). Its prevalence, especially among patients with metabolic syndrome, highlights its growing global impact. The pathogenesis MASLD involves dysregulation, inflammation, oxidative stress, genetic factors and, notably, mitochondrial dysfunction. Recent studies underscore the critical role dysfunction in MASLD's progression. Therapeutically, enhancing function has gained interest, along lifestyle changes and pharmacological interventions targeting processes. FDA's approval resmetirom for metabolic-associated (MASH) fibrosis marks significant step. While represents progress, further research is essential understand MASLD-related fully. Innovative strategies like gene editing small-molecule modulators, alongside interventions, can potentially improve treatment. Drug repurposing new targets will advance therapy, addressing increasing burden. Therefore, this review aims provide better understanding identify more effective preventive treatment strategies.

Language: Английский

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Integrated in vitro, in silico, and in vivo approaches to elucidate the antidiabetic mechanisms of Cicer arietinum and Hordeum vulgare extract and secondary metabolites

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 24, 2025

Diabetes mellitus is a group of metabolic disorders that can lead to severe health problems, and the current treatments often have harmful side effects. Therefore, there growing interest in discovering new antidiabetic drugs with fewer adverse effects, natural products are promising source for this purpose. Cicer arietinum Hordeum vulgare plants high levels phytochemicals been shown therapeutic properties. This study investigates anti-diabetic potential C. H. seeds their secondary metabolites. We employed comprehensive approach combining vitro, silico, vivo methods evaluate efficacy compounds. Our findings reveal extracts (IC50 55.08 μg/mL) 115.8 ± 5 demonstrated stronger inhibitory effect on α-amylase compared acarbose (standard drug) 196.3 10 μg/mL). Similarly, both exhibited significant activity against α-glucosidase 100.2 μg/mL IC50 216.2 μg/mL, respectively) 246.5 To further investigate mechanism action, computational screening 194 from these was conducted, followed by molecular docking (PDB ID#1B2Y) α-Glucosidase ID# 5NN8) receptors. According binding affinities dynamics (MD) simulations, Medicagol, Euphol, Stigmasterol, Beta-Sitosterol emerged as candidates diabetes treatment. Molecular showed Medicagol strong inhibitor selected receptor proteins because ligand–protein complexes remained stabilized during entire simulation time 100 ns. In vitro analysis also confirmed stigmasterol, Euphol type 2 prevention via inhibition carbohydrates hydrolyzing enzymes. effects STZ-induced mice. Including reductions hyperlipidemia, hyperglycemia, insulin resistance. Histopathological revealed plant mitigated pancreatic liver damage. Additionally, enhanced antioxidant defenses increasing SOD, CAT, GSH levels, while decreasing MDA liver, kidneys, pancreas, highlighting protective role oxidative stress. These results support sources developing agents.

Language: Английский

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Coenzyme Q10: A Key Antioxidant in the Management of Diabetes-Induced Cardiovascular Complications—An Overview of Mechanisms and Clinical Evidence

International Journal of Endocrinology, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 13

Published: March 15, 2024

Background. Diabetes mellitus (DM) presents a significant global health challenge with considerable cardiovascular implications. Coenzyme Q10 (CoQ10) has gained recognition for its potential as natural antioxidant supplement in the management of diabetes and associated complications. Aim. This comprehensive review systematically examines scientific rationale underlying therapeutic properties CoQ10 mitigating impact consequences. The analysis encompasses preclinical trials (in vitro vivo) clinical studies evaluating efficacy mechanisms action CoQ10. Result & Discussion. Findings reveal that CoQ10, through potent anti-inflammatory attributes, demonstrates reducing oxidative stress, ameliorating lipid profiles, regulating blood pressure, which are crucial aspects managing diabetes-induced chemically represented C59H90O4, was administered capsule form human at doses 50, 100, 150, 200, 300 mg per day concentrations 10 20 μM sterile powder experimental investigations mg/kg mouse studies, according to published research. Clinical corroborate these findings, demonstrating improved glycemic control, pressure patients supplemented Conclusion. In conclusion, emerges promising intervention Its multifaceted impacts on Nrf2/Keap1/ARE pathway, metabolic regulation highlight an adjunct treatment related disorders. However, further extensive necessary fully establish assess synergistic effects other compounds.

Language: Английский

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Dietary Polyphenols, Food Processing and Gut Microbiome: Recent Findings on Bioavailability, Bioactivity, and Gut Microbiome Interplay

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1220 - 1220

Published: Oct. 10, 2024

Polyphenols are organic chemical compounds naturally present in plants, renowned for their anti-inflammatory, antioxidant, immunomodulatory, anticancer, and cardiovascular protective properties. Their bioactivity bioavailability can vary widely depending on the methods of food processing interactions with gut microbiome. These factors induce changes polyphenols, affecting ability to achieve intended health benefits. Thus, it is essential develop apply that optimize polyphenol content while maintaining bioavailability. This review aims explore how various techniques affect quantity, bioactivity, as well microbiome, which may ultimately determine effects.

Language: Английский

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Biomarkers of Oxidative and Radical Stress

Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 194 - 194

Published: Feb. 5, 2024

Reactive oxygen and nitrogen species (ROS/RNS) are generated as a result of normal intracellular metabolism [...]

Language: Английский

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Monitoring Glutathione Content of the Endoplasmic Reticulum under Scrap Leather-Induced Endoplasmic Reticulum Stress via an Endoplasmic Reticulum-Targeted Two-Photon Fluorescent Probe

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(45), P. 18132 - 18140

Published: Oct. 30, 2024

Maintaining tissue homeostasis necessitates the coordinated efforts of various cell types to regulate inflammation. Endoplasmic reticulum (ER) stress, a hallmark inflammation, exacerbates pathology in human diseases. Glutathione (GSH), pivotal regulator cellular redox balance, controls disulfide bond formation ER, thereby shielding cells from oxidative stress. In this study, we developed two-photon fluorescent probe, ER-GSH, with specific ER targeting and demonstrated its high sensitivity rapid response GSH. Experiments conducted on BV2 mice model neuroinflammation induced by scrap leather revealed that inflammatory reactions led stress substantial reduction GSH levels. Notably, anti-inflammatory drug NS-398 effectively inhibited inflammation maintaining These findings underscore potential therapeutic significance modulating levels alleviate impact neuroinflammation.

Language: Английский

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Anthocyanins and Type 2 Diabetes: An Update of Human Study and Clinical Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1674 - 1674

Published: May 29, 2024

Anthocyanins are phenolic compounds occurring in fruits and vegetables. Evidence from pre-clinical studies indicates their role glucose level regulation, gut microbiota improvement, inflammation reduction under diabetic conditions. Therefore, incorporating these research advancements into clinical practice would significantly improve the prevention management of type 2 diabetes. This narrative review provides a concise overview 18 findings recent published over last 5 years that investigate therapeutic effects dietary anthocyanins on Anthocyanin supplementation has been shown to have regulatory effect fasting blood levels, glycated hemoglobin, other diabetes-related indicators. Furthermore, increased anthocyanin dosages had more favorable implications for diabetes treatment. evidence an anthocyanin-rich diet can outcomes, especially at-risk groups. Future should focus optimal intervention duration, consider multiple biomarkers, analyze among well-controlled versus poorly controlled groups patients with

Language: Английский

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