Does Insulin Resistance (IR) Have an Impact on The Reproductive and Fertility Potential in Polycystic Ovary Syndrome (PCOS) Women? : Review Article DOI Creative Commons
Muhjah Falah Hassan,

Mufedah Ali Jawad,

Rabab Zahir Al-yasiry

et al.

Maaen Journal for Medical Sciences, Journal Year: 2023, Volume and Issue: 2(1)

Published: April 20, 2023

Backgrounds: Polycystic ovary syndrome is the most common endocrine and reproductive disorder in reproductive-age women. Among pathological changes that are responsible for development of polycystic (PCOS), hyperinsulinemia due to increased insulin resistance (IR) usually associated with a higher rate ovulatory dysfunction sub-fertility. In addition, those women have poor quality oocytes low fertilization capability embryos. So, has role function fertility potential age Conclusion: Females PCOS exhibit an extreme difficulty achieving either successful spontaneous or assisted pregnancy. Hyperinsulinemia / should be well understood as can possible order achieve effective treatment plan increase chance uncomplicated

Language: Английский

Targeting ferroptosis for the treatment of female reproductive system disorders DOI
Rui Ye, Yiming Mao,

Yingxue Fei

et al.

Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0
Antioxidant Defense Expressed as Glutathione Status and Keap1-Nrf2 System Action in Relation to Anthropometric Parameters and Body Composition in Young Women with Polycystic Ovary Syndrome DOI Creative Commons
Magdalena Chełchowska, Justyna Jurczewska, Joanna Gajewska

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 730 - 730

Published: March 16, 2023

Metabolic disorders present in women with polycystic ovary syndrome (PCOS) and the associated risk of obesity may result increased oxidative stress reproductive failure. Therefore, we evaluated concentrations reduced glutathione (GSH), oxidized (GSSG), peroxidase (GPx), reductase (GR), as well nuclear factor erythroid 2-related 2 (Nrf2) Kelch-like ECH-associating protein1 (Keap1) serum 56 PCOS divided according to visceral subcutaneous fat surface ratio (VAT/SAT) waist-to-hip (WHR) values. Antioxidant parameter levels were measured by competitive inhibition enzyme immunoassay technique. As VAT/SAT WHR increased, observed significantly higher GSSG Keap1 protein a lower value GSSG/GSH (R-index), which is considered an index cellular redox (p < 0.05). Negative correlations found between R-index body weight, BMI, WHR, ratio, total fat; positive links free mass water. Opposite associations noted level aforementioned composition parameters. Oxidative characterized depleted reduced-to-oxidized anthropometric parameters PCOS. In particular, abdominal expressed and/or seems have negative impact on status, lead disruption many biological cell processes. The association suggests that elevated changes dependent Nrf2 activation promote antioxidant expression. Although GSH/GSSG appear be good indicators studies larger group patients should continue confirm these among

Language: Английский

Citations

9
Impact of Smoking and Obesity on the Selected Peptide Hormones and Metabolic Parameters in the Blood of Women with Polycystic Ovary Syndrome—Preliminary Study DOI Open Access
Justyna Niepsuj, Agnieszka Piwowar, Grzegorz Franik

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8713 - 8713

Published: Aug. 9, 2024

We investigated the effects of tobacco smoke exposure and abnormal body weight on selected peptide hormones their association with metabolic hormonal disorders in women polycystic ovary syndrome (PCOS). The study group included 88 PCOS 28 without disease. In PCOS, chemerin, lipocalin, apelin concentrations were influenced by overweight obesity status, highest observed those a mass index (BMI) ≥ 30.0. Exposure to significantly increased only lipocalin-2 concentration. disease itself did not affect apelin. Additionally, we found positive correlation between chemerin concentration fasting glucose, insulin, triglycerides levels, while negative was high-density lipoprotein (HDL-C) smoking subgroup, positively correlated free testosterone androgen negatively associated sex hormone-binding globulin Our findings indicate that has stronger impact than highlighting important role control such individuals. However, appears be an additional factor intensifies adipose tissue.

Language: Английский

Citations

2
Molecular Research on Polycystic Ovary Syndrome (PCOS) DOI Creative Commons
Simona Daniele,

Elisa Chelucci,

Giorgia Scarfò

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1358 - 1358

Published: May 4, 2023

Polycystic ovary syndrome (PCOS) is an endocrine systemic disorder with a prevalence of between 5% and 20% that commonly affects childbearing-aged women [...].

Language: Английский

Citations

3
Evaluation of Selected Oxidant/Antioxidant Parameters in Patients with Relapsing-Remitting Multiple Sclerosis Undergoing Disease-Modifying Therapies DOI Creative Commons
Anna Bizoń, Justyna Chojdak-Łukasiewicz, Aleksandra Kołtuniuk

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(12), P. 2416 - 2416

Published: Dec. 7, 2022

The aim of this study was to evaluate oxidative stress parameters, specifically the concentration advanced oxidation protein products (AOPP) and ferric-reducing antioxidant power (FRAP), in serum patients with relapsing-remitting multiple sclerosis (RRMS). We also analyzed relationships between each parameter selected clinical/laboratory multiple-sclerosis-related parameters. group comprised 204 RRMS 29 healthy, age-matched controls. AOPP significantly higher than ROC analysis showed ability distinguish controls (the value AUC 94.8%, a sensitivity 89.69% specificity 89.3%). FRAP were male female patients. Correlations found laboratory markers inflammation. differed subgroups treated particular medications. Our findings indicate an increase patients, possibly linked chronic Gender type treatment affected stress.

Language: Английский

Citations

5
Anti-Müllerian hormone and HOMA-IR in different phenotypes of polycystic ovary syndrome on insulin resistance DOI Open Access
Murat ÖNAL, Halime ÇALI ÖZTÜRK

Anatolian Current Medical Journal, Journal Year: 2023, Volume and Issue: 5(4), P. 376 - 382

Published: Oct. 27, 2023

Aims: To examine the link between serum anti-mullerian hormone (AMH) levels and homeostatic model assessment of insulin resistance (HOMA-IR) in different phenotypes polycystic ovary syndrome (PCOS). Methods: This retrospective study included 120 patients aged 18-30 who visited our polyclinics June 2021 December 2022. Patients were divided into four groups based on Rotterdam criteria for PCOS phenotypes. A control group 24 individuals was also included. Clinical data, hormonal profiles, metabolic parameters obtained from medical records. Results: There significant differences AMH, follicle stimulating (FSH), luteinizing (LH), high-density lipoprotein (HDL) among group. AMH highest phenotype 1 (oligo/anovulation + hyperandrogenism ovaries) lowest FSH 4 LH 2 hyperandrogenism). HOMA-IR 1. However, there no or phenotypes. Conclusion: Our found level but HOMA-IR. suggests may not distinguish differ significantly

Language: Английский

Citations

2
The Concentration of Follistatin and Activin A in Serum and Selected Biochemical Parameters in Women with Polycystic Ovary Syndrome: Stratification by Tobacco Smoke Exposure, Insulin Resistance, and Overweight/Obesity DOI Open Access
Justyna Niepsuj, Agnieszka Piwowar, Grzegorz Franik

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(17), P. 5316 - 5316

Published: Sept. 8, 2024

Background/Objectives: The aim of the study was to investigate concentrations follistatin and activin A in serum women with polycystic ovary syndrome (PCOS) assess their relationship selected biochemical parameters, specifically stratifying analysis based on tobacco smoke, insulin resistance, abnormal weight. Methods: research carried out within a cohort 88 (60 28 without PCOS). Results: We observed significant differences (p < 0.05) between PCOS stratified by homeostatic model assessment for resistance (HOMA-IR) values. These were consistent across both smoking non-smoking subgroups PCOS. Similar results when comparing normal-weight those overweight or obesity. Additionally, significantly increased higher body mass index (BMI) HOMA-IR values Moreover, we identified negative correlation (r = −0.30; p 0.023) cotinine levels Anti-Müllerian hormone. Among PCOS, noted decreased sex hormone-binding globulin high-density lipoproteins, alongside fasting glucose, insulin, HOMA-IR, free androgen Conclusions: Our findings suggest that are more strongly influenced disruptions glucose metabolism BMI than smoke exposure. changes pronounced level.

Language: Английский

Citations

0
Does Insulin Resistance (IR) Have an Impact on The Reproductive and Fertility Potential in Polycystic Ovary Syndrome (PCOS) Women? : Review Article DOI Creative Commons
Muhjah Falah Hassan,

Mufedah Ali Jawad,

Rabab Zahir Al-yasiry

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 2(1)

Published: April 20, 2023

Backgrounds: Polycystic ovary syndrome is the most common endocrine and reproductive disorder in reproductive-age women. Among pathological changes that are responsible for development of polycystic (PCOS), hyperinsulinemia due to increased insulin resistance (IR) usually associated with a higher rate ovulatory dysfunction sub-fertility. In addition, those women have poor quality oocytes low fertilization capability embryos. So, has role function fertility potential age Conclusion: Females PCOS exhibit an extreme difficulty achieving either successful spontaneous or assisted pregnancy. Hyperinsulinemia / should be well understood as can possible order achieve effective treatment plan increase chance uncomplicated

Language: Английский

Citations

1
Does Insulin Resistance (IR) Have an Impact on The Reproductive and Fertility Potential in Polycystic Ovary Syndrome (PCOS) Women? : Review Article DOI Creative Commons
Muhjah Falah Hassan,

Mufedah Ali Jawad,

Rabab Zahir Al-yasiry

et al.

Maaen Journal for Medical Sciences, Journal Year: 2023, Volume and Issue: 2(1)

Published: April 20, 2023

Backgrounds: Polycystic ovary syndrome is the most common endocrine and reproductive disorder in reproductive-age women. Among pathological changes that are responsible for development of polycystic (PCOS), hyperinsulinemia due to increased insulin resistance (IR) usually associated with a higher rate ovulatory dysfunction sub-fertility. In addition, those women have poor quality oocytes low fertilization capability embryos. So, has role function fertility potential age Conclusion: Females PCOS exhibit an extreme difficulty achieving either successful spontaneous or assisted pregnancy. Hyperinsulinemia / should be well understood as can possible order achieve effective treatment plan increase chance uncomplicated

Language: Английский

Citations

0