Journal of Cancer Research and Clinical Oncology, Journal Year: 2023, Volume and Issue: 149(12), P. 10781 - 10796
Published: June 14, 2023
Language: Английский
Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1255 - 1255
Published: June 11, 2023
Genetic, developmental, biochemical, and environmental variables interact intricately to produce sex differences. The significance of differences in cancer susceptibility is being clarified by numerous studies. Epidemiological research registries have revealed over the past few years that there are definite variations incidence, progression, survival. However, oxidative stress mitochondrial dysfunction also a significant impact on response treatment neoplastic diseases. Young women may be more protected from than men because most proteins implicated regulation redox state function under control sexual hormones. In this review, we describe how hormones activity antioxidant enzymes mitochondria, as well they affect several molecular pathways underlie gender-related discrepancies been identified better understood, which lead effective precision medicine vital information options for both males females with illnesses.
Language: Английский
Citations
31
Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(12), P. 5700 - 5723
Published: Sept. 25, 2023
Abstract Galangin is an important flavonoid with natural activity, that abundant in galangal and propolis. Currently, various biological activities of galangin have been disclosed, including anti‐inflammation, antibacterial effect, anti‐oxidative stress aging, anti‐fibrosis, antihypertensive effect. Based on the above bioactivities, more attention has paid to role neurodegenerative diseases, rheumatoid arthritis, osteoarthritis, osteoporosis, skin cancer. In this paper, sources, pharmacokinetics, therapeutic potential against diseases were systematically reviewed by collecting summarizing relevant literature. addition, molecular mechanism new preparation treatment related are also discussed, broaden application prospect provide reference for its clinical application. Furthermore, it should be noted current toxicity studies insufficient, evidence needed support possibility as a functional food.
Language: Английский
Citations
27
Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 913 - 913
Published: Feb. 23, 2024
Melanoma progression is a multistep evolution from common melanocytic nevus through radial superficial growth phase, the invasive vertical phase finally leading to metastatic dissemination into distant organs. aggressiveness largely depends on propensity metastasize, which means capacity escape physiological microenvironment since tissue damage due primary melanoma lesions generally modest. Physiologically, epidermal melanocytes are attached basement membrane, and their adhesion/migration under control of surrounding keratinocytes. Thus, compartment represents first responsible for spread. This complex process involves cell-cell contact broad range secreted bioactive molecules. Invasion, or at beginning microinvasion, implies breakdown dermo-epidermal membrane followed by migration neoplastic cells in papillary dermis. Correspondingly, several experimental evidences documented structural functional rearrangement entire neoplasm that some way reflects atypia tumor cells. Lastly, must support proliferation survival outside normal epidermal-melanin units. task presumably mostly delegated fibroblasts ultimately self-autonomous review will discuss remodeling occurs epidermis during formation as well skin changes occur independently hyperproliferation having possible pro-tumoral features.
Language: Английский
Citations
5
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2024
This comprehensive review navigates the complex relationship between cellular aging, senescence, and cancer, unraveling determinants of fate. Beginning with an overview aging's significance in explores processes, changes, molecular pathways influencing senescence. The senescence as a dual mechanism acting suppressor contributor, focusing on its impact therapy response. highlights opportunities for cancer therapies that target further examines senescence-associated secretory phenotype strategies to modulate aging influence tumor behavior. Additionally, mechanisms escape cells, emphasizing their prognosis resistance therapy. article addresses current advances, unexplored aspects, future perspectives understanding cancer.
Language: Английский
Citations
5
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102403 - 102403
Published: July 2, 2024
Language: Английский
Citations
4
Cell Death and Differentiation, Journal Year: 2024, Volume and Issue: 31(8), P. 957 - 969
Published: April 22, 2024
Abstract Our skin provides a physical and immunological barrier against dehydration environmental insults ranging from microbial attacks, toxins UV irradiation to wounding. Proper functioning of the largely depends on interplay between keratinocytes- epithelial cells skin- immune cells. Two spatially distinct populations keratinocyte stem (SCs) maintain epidermal function hair follicle. These SCs are inherently long-lived, but cell death can occur within their niches impacts functionality. The default programme in is apoptosis, an orderly non-inflammatory suicide programme. However, recent findings shedding light significance various modes regulated necrotic death, which lytic provoke inflammation local environment. While presence dying was generally regarded as mere consequence inflammation, human dermatological conditions experimental mouse models aberrant control demonstrated that programmes keratinocytes (KCs) drive even tumour initiation. When die, they need be removed by phagocytosis KCs non-professional phagocytes apoptotic with important implications for SC capacities. It becoming apparent heightened activity, modalities differentially impact different niches. Here, we describe how functionally affect along relevance injury repair, inflammatory disorders cancer.
Language: Английский
Citations
3
Aging, Journal Year: 2024, Volume and Issue: 16(16), P. 11824 - 11842
Published: June 20, 2024
Melanoma is a highly malignant skin tumor with poor prognosis. Circadian rhythm closely related to melanoma pathogenesis. This study aimed identify key circadian genes (CRGs) in and explore their potential as diagnostic prognostic biomarkers. Microarray data of tissues normal skins were obtained. Differentially expressed identified weighted gene co-expression network analysis (WGCNA) was performed screen hub associated melanoma. By overlapping known CRGs, 125 melanoma-related CRGs identified. Functional enrichment revealed these mainly involved other cancer-related pathways. Three machine learning algorithms including LASSO regression, support vector machine-recursive feature elimination (SVM-RFE), random forest utilized select CRGs. Six (ABCC2, CA14, EGR3, FBXW7, LDHB, PSEN2) for diagnosis Diagnostic values evaluated by ROC training validation sets. Prognostic assessed survival multivariate Cox regression model constructed. The could effectively stratify patients into high- low-risk groups significantly different survival. A nomogram integrating clinical variables risk score built predict 3-, 5- 10-year overall patients. In summary, six pathogenesis may serve promising facilitate personalized prognosis evaluation
Language: Английский
Citations
2
Aging Cell, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 7, 2024
Abstract Cellular senescence is an established cause of cell and tissue aging. Senescent cells have been shown to increase in multiple organs during aging, including the skin. Here we hypothesized that senescent residing skin can spread distant organs, thereby accelerating systemic aging processes. To explore this hypothesis, initially observed several markers mice. Subsequently, conducted experiments wherein fibroblasts were transplanted into dermis young mice assessed various age‐associated parameters. Our findings reveal presence dermal layer leads increased both proximal distal host tissues, alongside frailty, impaired musculoskeletal function. Additionally, there was a significant decline cognitive function, concomitant with expression senescence‐associated within hippocampus brain area. These results support concept accumulation exert remote effects on other brain, potentially explaining links between disorders diseases and, contributing physical associated
Language: Английский
Citations
2
Journal of Cancer, Journal Year: 2023, Volume and Issue: 15(1), P. 1 - 19
Published: Dec. 5, 2023
In recent years, accumulating evidence from preclinical and clinical studies consistently indicated that physical activity/exercise plays a crucial role in reducing the incidence recurrence of various malignancies, by exerting beneficial modulation cancer hallmarks.Moreover, activity is suggested to attenuate certain adverse effects anticancer therapy, including reduction cardiovascular toxicity symptoms related depression anxiety, among others, while preserving muscular strength.In case melanoma, relationship with has been critically debated.Historically, several cohort meta-analyses reported positive association between melanoma risk.This was primarily attributed outdoor activities may expose skin UV radiation, well-known risk factor for melanocyte transformation.However, more does not support such recognizes both prevention progression.Nevertheless, sun protection recommended during training minimize radiation exposure.This narrative review summarizes data about on hallmarks.Specifically, experimental concerning (i) invasion metastasis, (ii) reprogramming energy metabolism, (iii) angiogenesis, (iv) resistance cell death, (v) evasion immune destruction, (vi) tumor-promoting inflammation.
Language: Английский
Citations
5
Journal of Cancer Research and Clinical Oncology, Journal Year: 2023, Volume and Issue: 149(12), P. 10781 - 10796
Published: June 14, 2023
Language: Английский
Citations
0