Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

Cellular & Molecular Biology Letters, Journal Year: 2022, Volume and Issue: 27(1)

Published: Aug. 19, 2022

Human mesenchymal stem cells (MSCs) are primary multipotent capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role MSCs in tissue homeostasis, aging-related diseases, cellular therapy is clinically suggested. As aging a universal problem that has large socioeconomic effects, an improved understanding the concepts can direct public policies reduce its adverse impacts on healthcare system humanity. Several studies have been carried out over several years to understand phenomenon different factors affecting human aging. A reduced ability adult cell populations reproduce regenerate one main contributors process. In this context, senescence major challenge front advancement. Many factors, ranging from genetic metabolic pathways extrinsic through various signaling pathways, involved regulating mechanism MSC senescence. To better reverse senescence, review highlights underlying mechanisms signs discusses strategies combat

Language: Английский

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Antioxidant Supplementation in Oxidative Stress-Related Diseases: What Have We Learned from Studies on Alpha-Tocopherol?

Antioxidants, Journal Year: 2022, Volume and Issue: 11(12), P. 2322 - 2322

Published: Nov. 24, 2022

Oxidative stress has been proposed as a key contributor to lifestyle- and age-related diseases. Because free radicals play an important role in various processes such immune responses cellular signaling, the body possesses arsenal of different enzymatic non-enzymatic antioxidant defense mechanisms. is, among others, result imbalance between production reactive oxygen species (ROS) mechanisms including vitamin E (α-tocopherol) antioxidant. Dietary vitamins, C E, can also be taken supplements. It postulated that increasing levels through supplementation may delay and/or ameliorate outcomes diseases have linked oxidative stress. Although supported by many animal experiments observational studies, randomized clinical trials humans failed demonstrate any benefit from supplementation. Nevertheless, possible explanations for this discrepancy remain underreported. This review aims provide overview recent developments novel research techniques used clarify existing controversy on benefits health disease, focusing α-tocopherol Based currently available literature, we propose examining difference activity capacity, considering catabolism antioxidants, will crucial knowledge preventative therapeutical use stress-related

Language: Английский

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LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion

Cell Reports, Journal Year: 2024, Volume and Issue: 43(5), P. 114102 - 114102

Published: April 17, 2024

Although dysregulated cholesterol metabolism predisposes aging tissues to inflammation and a plethora of diseases, the underlying molecular mechanism remains poorly defined. Here, we show that metabolic genotoxic stresses, convergently acting through liver X nuclear receptor, upregulate CD38 promote lysosomal efflux, leading nicotinamide adenine dinucleotide (NAD

Language: Английский

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Effects of polyphenols and their metabolites on age-related diseases

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 214, P. 115674 - 115674

Published: July 4, 2023

Language: Английский

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7β-Hydroxycholesterol and 7-ketocholesterol: New oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2023, Volume and Issue: 232, P. 106345 - 106345

Published: June 5, 2023

Language: Английский

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Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 25, 2024

The pathogenesis of age-related macular degeneration (AMD), a degenerative retinopathy, remains unclear. Administration anti-vascular endothelial growth factor agents, antioxidants, fundus lasers, photodynamic therapy, and transpupillary warming has proven effective in alleviating symptoms; however, these interventions cannot prevent or reverse AMD. Increasing evidence suggests that AMD risk is linked to changes the composition, abundance, diversity gut microbiota (GM). Activation multiple signaling pathways by GM metabolites, including lipopolysaccharides, oxysterols, short-chain fatty acids (SCFAs), bile (BAs), influences retinal physiology. Traditional Chinese medicine (TCM), known for its multi-component multi-target advantages, can help treat altering composition regulating levels certain substances, such as reducing increasing SCFA BA contents. This review explores correlation between two provide new perspectives on treating with TCM.

Language: Английский

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Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

The proportion of the elderly population is gradually increasing as a result medical care advances, leading to subsequent surge in geriatric diseases that significantly impact quality life and pose substantial healthcare burden. Sarcopenia, characterized by age-related decline skeletal muscle mass quality, affects considerable portion older adults, particularly elderly, can adverse outcomes such frailty, fractures, bedridden, hospitalization, even mortality. Skeletal aging accompanied underlying metabolic changes. Therefore, elucidating these profiles specific mechanisms holds promise for informing prevention treatment strategies sarcopenia. This review provides comprehensive overview key metabolites identified current clinical studies on sarcopenia their potential pathophysiological alterations activity. Besides, we examine therapeutic from perspective focused regulation.

Language: Английский

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The role of cannabidiol in aging

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115074 - 115074

Published: July 6, 2023

Aging is usually considered a key risk factor associated with multiple diseases, such as neurodegenerative cardiovascular diseases and cancer. Furthermore, the burden of age-related has become global challenge. It great significance to search for drugs extend lifespan healthspan. Cannabidiol (CBD), natural nontoxic phytocannabinoid, been regarded potential candidate drug antiaging. An increasing number studies have suggested that CBD could benefit healthy longevity. Herein, we summarized effect on aging analyzed possible mechanism. All these conclusions may provide perspective further study aging.

Language: Английский

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Oxysterols, age-related-diseases and nutritherapy: focus on 7-ketocholesterol and 7β-hydroxycholesterol

Prostaglandins & Other Lipid Mediators, Journal Year: 2025, Volume and Issue: unknown, P. 106993 - 106993

Published: April 1, 2025

Language: Английский

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A comprehensive molecular analysis of cannabidiol: From solid state to antioxidant potential

Computational and Theoretical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 114890 - 114890

Published: Sept. 1, 2024

Language: Английский

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