The Role of Non-coding RNAs in Alzheimer’s Disease: Pathogenesis, Novel Biomarkers, and Potential Therapeutic Targets DOI
Othman Saleh, Khaled Albakri,

Abdalrahmn Altiti

et al.

CNS & Neurological Disorders - Drug Targets, Journal Year: 2023, Volume and Issue: 23(6), P. 731 - 745

Published: May 22, 2023

Long non-coding RNAs (IncRNAs) are regulatory RNA transcripts that have recently been associated with the onset of many neurodegenerative illnesses, including Alzheimer's disease (AD). Several IncRNAs found to be AD pathophysiology, each a distinct mechanism. In this review, we focused on role in pathogenesis and their potential as novel biomarkers therapeutic targets. Searching for relevant articles was done using PubMed Cochrane library databases. Studies had published full text English order considered. Some were upregulated, while others downregulated. Dysregulation expression may contribute pathogenesis. Their effects manifest synthesis beta-amyloid (Aβ) plaques increases, thereby altering neuronal plasticity, inducing inflammation, promoting apoptosis. Despite need more investigations, could potentially increase sensitivity early detection AD. Until now, there has no effective treatment Hence, InRNAs promising molecules serve Although several dysregulated AD-associated lncRNAs discovered, functional characterization most is still lacking.

Language: Английский

ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease DOI
Riya Thapa, Ehssan Moglad, Muhammad Afzal

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102327 - 102327

Published: May 10, 2024

Language: Английский

Citations

14
Circulating and extracellular vesicle-derived microRNAs as biomarkers in bone-related diseases DOI Creative Commons

Julika Huber,

Michael T. Longaker, Natalina Quarto

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: May 24, 2023

MicroRNAs (miRNA) are small non-coding RNA molecules that regulate posttranscriptional gene expression by repressing messengerRNA-targets. MiRNAs abundant in many cell types and secreted into extracellular fluids, protected from degradation packaging vesicles. These circulating miRNAs easily accessible, disease-specific sensitive to changes, which makes them ideal biomarkers for diagnostic, prognostic, predictive or monitoring purposes. Specific miRNA signatures can be reflective of disease status development indicators poor treatment response. This is especially important malignant diseases, as the ease accessibility circumvents need invasive tissue biopsy. In osteogenesis, act either osteo-enhancing osteo-repressing targeting key transcription factors signaling pathways. review highlights role vesicle-derived bone-related with a specific focus on osteoporosis osteosarcoma. To this end, comprehensive literature search has been performed. The first part discusses history biology miRNAs, followed description different an update current knowledge bone related diseases. Finally, limitations biomarker research future perspectives will presented.

Language: Английский

Citations

13
Intrinsic factors behind long‐COVID: I. Prevalence of the extracellular vesicles DOI
Yousra A. El‐Maradny, Alberto Rubio‐Casillas, Vladimir N. Uversky

et al.

Journal of Cellular Biochemistry, Journal Year: 2023, Volume and Issue: 124(5), P. 656 - 673

Published: May 1, 2023

Abstract It can be argued that the severity of COVID‐19 has decreased in many countries. This could a result broad coverage population by vaccination campaigns, which often reached an almost compulsory status places. Furthermore, significant roles were played multiple mutations body virus, led to emergence several new SARS‐CoV‐2 variants with enhanced infectivity but dramatically reduced pathogenicity. However, challenges associated development various side effects and their persistence for long periods exceeding 20 months as infection, or taking available vaccines against it, are spreading horizontally vertically number repercussions. For example, World Health Organization announced there more than 17 million registered cases long‐COVID (also known post‑COVID syndrome) European Union countries alone. using PubMed search engine, one find 10 000 articles have been published focusing exclusively on long‐COVID. In light these enormous ever‐increasing numbers articles, most descriptive symptoms, need know reasons behind this phenomenon raises important questions. Is caused continued presence virus one/several its components recovering individual time, urges respond way leads development? Or some latent limited related patients themselves? is it sum both? Many observations support positive answer first question, whereas others back second question typically without releasing fundamental reason/signal it. Whatever is, seems real widespread remain unclear. report opens series we will try shed underlying causes phenomenon.

Language: Английский

Citations

11
Epigenetic Modifications Associated With Wildland–Urban Interface (WUI) Firefighting DOI Creative Commons
Jaclyn M. Goodrich, Melissa Furlong, Derek J. Urwin

et al.

Environmental and Molecular Mutagenesis, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

ABSTRACT Wildland–urban interface (WUI) firefighting involves exposure to burning vegetation, structures, and other human‐made hazards, often without respiratory protection. Response activities can last for long periods of time, spanning multiple days or weeks. Epigenetic modifications, including microRNA (miRNA) expression DNA methylation, are responsive toxicant exposures part the development cancers diseases. modifications have not been studied in relation WUI fires. Firefighters ( n = 99) from southern California, 79 firefighters who responded at least one fire, provided blood samples baseline approximately 10 months later. We quantified relative abundance 800 miRNAs using nCounter Human v3 miRNA panel leukocyte methylation throughout genome via Infinium EPIC array. used linear mixed models compare each across time locus, adjusting potential confounders. In analysis among all firefighters, 65 were significantly different follow‐up compared a false discovery rate 5%. Results similar when restricted with recorded fire during interim period, although only 50 significant. Expression hsa‐miR‐518c‐3p, tumor suppressor, was associated response (fold change 0.77, 95% CI [0.69, 0.87]). analysis, no statistically significant changes over identified. summary, wildfire season altered but did substantially impact methylation.

Language: Английский

Citations

0
Vascular Dementia: from Pathogenesis to Treatment DOI Creative Commons
Mingyue Cui, Leilei Wang, Tingting Wang

et al.

Journal of Contemporary Medical Practice, Journal Year: 2025, Volume and Issue: 7(2), P. 164 - 169

Published: Feb. 28, 2025

Vascular dementia is the second most common type of and a preventable disease, but its complex etiology difficult diagnosis make it occupy high status in field neuroscience geriatrics. At present, modern medicine mainly takes oral donepezil other drugs to control vascular risk factors improve cognitive function (non-) drugs; summarizes epidemiology, related factors, pathogenesis, treatment plan future direction dementia.

Language: Английский

Citations

0
Cognitive dysfunction associated with COVID-19: Prognostic role of circulating biomarkers and microRNAs DOI Creative Commons

Marissa Alvarez,

Erick Trent,

Bruno de Souza Gonçalves

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Oct. 4, 2022

COVID-19 is renowned as a multi-organ disease having subacute and long-term effects with broad spectrum of clinical manifestations. The evolving scientific evidence demonstrates that the frequency cognitive impairment after high it crucial to explore more research implement proper diagnostic treatment strategies. Several central nervous system complications have been reported comorbidities COVID-19. changes in function associated neurodegenerative diseases develop slowly over time are only diagnosed at an already advanced stage molecular pathology. Hence, understanding common links between will broaden our knowledge help strategizing prognostic therapeutic approaches. present review focuses on diverse highlight importance major circulating biomarkers microRNAs (miRNAs) progression severity. literature analysis showed proteins function, such Glial fibrillary acidic protein, neurofilament light chain, p-tau 181, Ubiquitin C-terminal hydrolase L1, S100 calcium-binding protein B, Neuron-specific enolase various inflammatory cytokines, were significantly altered patients. Furthermore, among miRNAs pivotal roles diseases, miR-146a, miR-155, Let-7b, miR-31, miR-16 miR-21 shown significant dysregulation Thus consolidates important findings from numerous studies unravel underlying mechanism neurological sequelae possible association circulatory biomarkers, which may serve predictors targets future research.

Language: Английский

Citations

18
Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease DOI Open Access

Lyudmila P. Dolgacheva,

В. П. Зинченко, Н. В. Гончаров

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 13043 - 13043

Published: Oct. 27, 2022

An increasing number of the population all around world suffer from age-associated neurodegenerative diseases including Parkinson's disease (PD). This disorder presents different signs genetic, epigenetic and environmental origin, molecular, cellular intracellular dysfunction. At molecular level, α-synuclein (αSyn) was identified as principal molecule constituting Lewy bodies (LB). The gut microbiota participates in pathogenesis PD may contribute to loss dopaminergic neurons through mitochondrial most important pathogenetic link is an imbalance Ca2+ ions, which associated with redox cells increased generation reactive oxygen species (ROS). In this review, factors that cause these disorders their cause-and-effect relationships are considered. As a constituent factors, example organophosphates (OPs) also reviewed. role endothelial damage discussed, 'triple hit hypothesis' proposed modification Braak's dual one. absence effective therapies for diseases, more evidence emerging about positive impact nutritional structure healthy lifestyle on state blood vessels risk developing diseases.

Language: Английский

Citations

17
Epigenetic Biomarkers in Alzheimer's Disease: Diagnostic and Prognostic Relevance DOI
Tapan Behl,

Ashishkumar Kyada,

R Roopashree

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102556 - 102556

Published: Oct. 30, 2024

Language: Английский

Citations

3
Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction DOI Creative Commons
Yu-Shen Yang,

Shi-Ling He,

Wei-can Chen

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Oct. 13, 2022

Postoperative cognitive dysfunction (POCD), especially in elderly patients, is a serious complication characterized by impairment of and sensory modalities after surgery. The pathogenesis POCD mainly includes neuroinflammation, neuronal apoptosis, oxidative stress, accumulation Aβ, tau hyperphosphorylation; however, the exact mechanism remains unclear. Non-coding RNA (ncRNA) may play an important role POCD. Some evidence suggests that microRNA, long ncRNA, circular can regulate POCD-related processes, making them promising biomarkers diagnosis, treatment, prognosis. This article reviews crosstalk between ncRNAs POCD, systematically discusses diagnosis Additionally, we explored possible mechanisms ncRNA-associated providing new knowledge for developing ncRNA-based treatments

Language: Английский

Citations

14
Bioinformatic identification of potential biomarkers and therapeutic targets in carotid atherosclerosis and vascular dementia DOI Creative Commons

Dong-shi Li,

Zhixin Huang,

Yingyi Dai

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 10, 2023

Vascular disease is the second most common cause of dementia. The prevalence vascular dementia (VaD) has increased over past decade. However, there are no licensed treatments for this disease. Carotid atherosclerosis (CAS) highly prevalent and main ischemic stroke VaD. We studied co-expressed genes to understand relationships between CAS VaD further reveal potential biomarkers therapeutic targets VaD.CAS differentially expressed (DEGs) were identified through bioinformatic analysis Gene Expression Omnibus (GEO) datasets GSE43292 GSE122063, respectively. Furthermore, a variety target prediction methods network approaches used assess protein-protein interaction (PPI) networks, Ontology (GO) terms, pathway enrichment DEGs, top 7 hub genes, coupled with corresponding predicted miRNAs involved in VaD, assessed as well.A total 60 upregulated DEGs 159 downregulated identified, which high degree connectivity selected. Overexpression these was associated Finally, miRNAs. hsa-miR-567 hsa-miR-4652-5p may be significantly

Language: Английский

Citations

8