Proteomic profiling of human plasma extracellular vesicles identifies PF4 and C1R as novel biomarker in sarcopenia DOI Creative Commons
Paula Aparicio, David Navarrete‐Villanueva, Alba Gómez‐Cabello

et al.

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2024, Volume and Issue: 15(5), P. 1883 - 1897

Published: July 15, 2024

Abstract Background Sarcopenia, the gradual and generalized loss of muscle mass function with ageing, is one major health problems in older adults, given its high prevalence substantial socioeconomic implications. Despite extensive efforts to reach consensus on definition diagnostic tests cut‐offs for sarcopenia, there an urgent unmet need non‐invasive, specific sensitive biomarkers disease. Extracellular vesicles (EVs) are present different biofluids including plasma, whose cargo reflects cellular physiology. This work analysed EV proteome sarcopenia robust patients search differentially contained proteins that can be used diagnose Methods Plasma small EVs (sEVs) from a total 29 controls (aged 73.4 ± 5.6 years; 11 men 18 women) 49 sarcopenic 82.3 5.4 15 34 aged 65 years were isolated their was by proteomics. Proteins concentration sEVs between further validated using ELISA. The these candidates correlated EWGSOP2 low strength physical performance, receiver operating characteristic (ROC) curve analyses carried out evaluate power, sensitivity specificity. Results Proteomic analysis identified 157 both samples. Among them, 48 had never been reported ExoCarta nor Vesiclepedia databases. Statistical revealed eight significantly groups: PF4 (log2 FC = 4.806), OIT3 −1.161), MMRN1 −1.982), MASP1 −0.627), C1R 1.830), SVEP1 1.295), VCAN (FC 0.937) SPTB 1.243). platelet factor 4 (PF4) showed lowest while Complement C1r subcomponent (C1R) increased most patients, being results confirmed ELISA ( P 1.07E‐09 0.001287, respectively). concentrations candidate currently used. ROC area under 0.8921 0.7476 C1R, respectively. Choosing optimal PF4, 80% 85.71% specificity reached cut‐off value would allow diagnosis 75% 66.67% Conclusions Our support determination as plasma open door investigate role content pathogeny

Language: Английский

Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis DOI
Joshua Bennett, Arthur G. Pratt, Richard Dodds

et al.

Nature Reviews Rheumatology, Journal Year: 2023, Volume and Issue: 19(4), P. 239 - 251

Published: Feb. 17, 2023

Language: Английский

Citations

78
The Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy DOI Creative Commons
Huiling Chen, Xiaojing Huang, Meiyuan Dong

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2023, Volume and Issue: Volume 16, P. 1541 - 1554

Published: May 1, 2023

Abstract: Diabetes and sarcopenia are emerging as serious public health issues. Sarcopenia, an age-related disorder characterized by loss of skeletal muscle mass function, is recognized a new complication in elderly patients with type 2 diabetes mellitus (T2DM). Type insulin resistance, chronic inflammation, accumulation advanced glycation products increased oxidative stress, which can negatively affect mass, strength function leading to sarcopenia. There mutual interrelationship between T2DM light pathophysiology mechanism long-term outcome. will accelerate the decline turn lead glucose metabolism disorders, reduced physical activity risk diabetes. However, specific involved has not been thoroughly studied. Therefore, this review aims explore therapeutic strategy related provide insight for future investigations, great significance improving quality life concurrently reducing incidence complications. Keywords: mellitus, sarcopenia, gut microbiota,

Language: Английский

Citations

58
Fiber-Type Shifting in Sarcopenia of Old Age: Proteomic Profiling of the Contractile Apparatus of Skeletal Muscles DOI Open Access
Paul Dowling, Stephen Gargan, Dieter Swandulla

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2415 - 2415

Published: Jan. 26, 2023

The progressive loss of skeletal muscle mass and concomitant reduction in contractile strength plays a central role frailty syndrome. Age-related neuronal impairments are closely associated with sarcopenia the elderly, which is characterized by severe muscular atrophy that can considerably lessen overall quality life at old age. Mass-spectrometry-based proteomic surveys senescent human muscles, as well animal models sarcopenia, have decisively improved our understanding molecular cellular consequences fiber-type shifting during aging. This review outlines spectrometric identification proteome-wide changes atrophying focus on proteins potential markers distribution patterns. observed trend fast-to-slow transitions individual muscles aging process most likely linked to preferential susceptibility fast-twitching fibers atrophy. Studies models, including mostly aged rodent confirmed shifting. analysis fast versus slow isoforms key proteins, such myosin heavy chains, light actins, troponins tropomyosins, suggests them suitable bioanalytical tools

Language: Английский

Citations

48
Improving sarcopenia in older adults: a systematic review and meta-analysis of randomized controlled trials of whey protein supplementation with or without resistance training DOI Creative Commons
Ming-Lin Li, Fei Zhang,

Han-Yong Luo

et al.

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(4), P. 100184 - 100184

Published: Feb. 12, 2024

The aim of the study was to comprehensively analyze effects whey protein (WP)-enriched supplement intake with or without resistance training (RT) in older patients, either from community hospital, who were diagnosed sarcopenia according EWGSOP AWGS criteria.

Language: Английский

Citations

18
Associations of CBC-Derived inflammatory indicators with sarcopenia and mortality in adults: evidence from Nhanes 1999 ∼ 2006 DOI Creative Commons
Botang Guo,

Xinqing Liu,

Qi Si

et al.

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 16, 2024

Abstract Background It has been proposed that inflammation plays a role in the development of sarcopenia. This study aimed to investigate links complete blood cell count (CBC) parameters and CBC-derived inflammatory indicators with sarcopenia mortality. Methods Data pertaining were extracted from 1999–2006 National Health Nutrition Examination Survey (NHANES), mortality events ascertained through Death Index up December 31, 2019. The assessed this included neutrophil-to-lymphocyte ratio (NLR), derived (dNLR), monocyte-to-lymphocyte (MLR), neutrophil-monocyte lymphocyte (NMLR), systemic response index (SIRI), immune-inflammation (SII). prognostic significance these was evaluated using random survival forests (RSF) analysis. Results encompassed cohort 12,689 individuals, among whom 1,725 diagnosed Among individuals sarcopenia, 782 experienced all-cause mortality, 195 succumbed cardiovascular causes. Following adjustment for confounding variables, it observed elevated levels NLR, dNLR, NMLR, SIRI, SII associated an increased prevalence participants those highest quartile NLR (HR = 1.336 [1.095–1.631]), dNLR 1.274 [1.046–1.550]), MLR 1.619 [1.290–2.032]), NMLR 1.390 [1.132–1.707]), SIRI 1.501 [1.210–1.862]) exhibited risk compared lowest inflammation-derived indicators. These associations similarly 1.874 [1.169–3.003] MLR, HR 1.838 [1.175–2.878] SIRI). RSF analysis indicated predictive power both Conclusions Our findings underscore association between adults Of note, emerged as most robust predictor population.

Language: Английский

Citations

17
Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study DOI Creative Commons
Lin Shi, Liang Zhang, Dan Zhang

et al.

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 24, 2023

Chronic inflammatory responses have been reported to be associated with low muscle mass and systemic immune-inflammation index(SII) is a novel indicator of inflammation. The purpose our study was clarify the relationship between SII mass.This cross-sectional based on National Health Nutrition Examination Survey (2011-2018). calculated as platelet count × neutrophil count/lymphocyte count. Appendicular skeletal index used define mass. individuals were divided into four groups by quartile (Q1-Q4). Multivariate weighted logistic regression analysis, smooth curve fitting subgroup analysis investigate sarcopenia. Subgroup demographic clinical variables.There 10,367 enrolled in final analysis. overall mean age 39.39 years 49.17% males. prevalence population 8.77%. indicated near-linear In multivariate odds ratio (OR) Q4 1.28 (95% CI, 1.16-1.40) for when compared lowest SII. still increased risk independently.The levels an large population. Our understanding inflammation Anti-inflammation therapy may important

Language: Английский

Citations

30
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity DOI
Gregory Livshits, Alexander Kalinkovich

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 86, P. 101852 - 101852

Published: Jan. 13, 2023

Language: Английский

Citations

29
Correlation between sarcopenia and esophageal cancer: a narrative review DOI Creative Commons
Shenglan Li,

Kaiqiang Xie,

Xiaoxiong Xiao

et al.

World Journal of Surgical Oncology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 24, 2024

Abstract Background In recent years, the research on relationship between sarcopenia before and after treatment of esophageal cancer, as well its impact prognosis has increased rapidly, which aroused people’s attention to disease patients with cancer complicated sarcopenia. This review examines prevalence in (before surgery or chemotherapy) cancer. Moreover, we summarized potential pathogenesis pharmacologic non-pharmacologic therapies. Methods A narrative was performed PubMed Web Science using keywords (“esophageal cancer” “esophageal neoplasm” “neoplasm, esophageal” “esophagus neoplasms” esophagus” “neoplasms, “cancer “cancer, “cancers, cancers” cancers”) (“sarcopenia” “muscular atrophy” “aging” “senescence” “biological aging” “aging, biological” “atrophies, muscular” “atrophy, atrophies” muscle” “muscle atrophies”). Studies reporting were analyzed. Results The results suggest that average 46.3% ± 19.6% ranging from 14.4 81% can be an important predictor poor Patients suffer due their nutritional deficiencies, reduced physical activity, chemotherapy, effects certain inflammatory factors pathways. When classic diagnostic values for such skeletal muscle index (SMI) are not available clinically, it is also feasible predict simpler metrics, calf circumference (CC), five-count sit-up test (5-CST), six-minute walk distance (6MWD). Conclusions Identifying mechanism implementing appropriate interventions may hold key improving these patients.

Language: Английский

Citations

10
Association between composite dietary antioxidant index and metabolic dysfunction associated steatotic liver disease: result from NHANES, 2017-2020 DOI Creative Commons

Zhaofu Zhang,

Hao Wang, Youpeng Chen

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 22, 2024

Background The development of metabolic dysfunction associated steatotic liver disease (MASLD) has been with lipid accumulation, oxidative stress, endoplasmic reticulum and lipotoxicity. Composite Dietary Antioxidant Index (CDAI) is a comprehensive score representing an individual intake various dietary antioxidants, including vitamin A, C, E, selenium, zinc, carotenoids. This study investigated the association between CDAI MASLD. Materials methods Clinical demographic data, as well ultrasound transient elastography measurements at baseline, were collected from National Health Nutrition Examination Survey 2017–2020 (NHANES 2017–2020). controlled attenuation parameter was utilized to diagnose presence hepatic steatosis categorize individuals into those without Liver stiffness measured by elastography, subjects classified advanced fibrosis. Results included 5,884 adults, whom 3,433 diagnosed MASLD, resulting in weighted prevalence 57.3%. After adjusting for covariates, odds ratios MASLD 0.96 (95% CI: 0.82, 1.12) second quartile, 0.80 0.68, 0.95) third quartile 0.60 0.49, 0.73) fourth respectively. CDAI, however, not significantly Conclusion These findings suggested that scores on linearly negatively United States adults.

Language: Английский

Citations

10
Association between the systemic immune-inflammation index and sarcopenia: a systematic review and meta-analysis DOI Creative Commons

Siye Xie,

Qi Wu

Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)

Published: May 28, 2024

Sarcopenia is associated with increased morbidity and mortality. The systemic immune-inflammation index (SII) has been correlated to a variety of disorders. present study conducted systematic review meta-analysis investigate the relationship between SII sarcopenia.

Language: Английский

Citations

9