Aerobic exercise, an effective prevention and treatment for mild cognitive impairment DOI Creative Commons

Baiqing Huang,

Kang Chen, Ying Li

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Aug. 8, 2023

Aerobic exercise has emerged as a promising intervention for mild cognitive impairment (MCI), precursor to dementia. The therapeutic benefits of aerobic are multifaceted, encompassing both clinical and molecular domains. Clinically, been shown mitigate hypertension type 2 diabetes mellitus, conditions that significantly elevate the risk MCI. Moreover, it stimulates release nitric oxide, enhancing arterial elasticity reducing blood pressure. At level, is hypothesized modulates activation microglia astrocytes, cells crucial brain inflammation neurogenesis, respectively. It also suggested promotes factors such irisin, cathepsin B, CLU, GPLD1, which could enhance synaptic plasticity neuroprotection. Consequently, regular potentially prevent or reduce likelihood MCI development in elderly individuals. These mechanisms, however, hypotheses require further validation. mechanisms action intricate, research needed elucidate precise underpinnings develop targeted therapeutics

Language: Английский

Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders DOI Creative Commons

Elodie Kip,

Louise C. Parr‐Brownlie

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Feb. 15, 2023

Since the mid-20th century, Western societies have considered productivity and economic outcomes are more important than focusing on people's health wellbeing. This focus has created lifestyles with high stress levels, associated overconsumption of unhealthy foods little exercise, which negatively affect lives, subsequently lead to development pathologies, including neurodegenerative psychiatric disorders. Prioritizing a healthy lifestyle maintain wellbeing may slow onset or reduce severity pathologies. It is win-win for everyone; individuals. A balanced increasingly being adopted globally, many doctors encouraging meditation prescribing non-pharmaceutical interventions treat depression. In disorders, inflammatory response system brain (neuroinflammation) activated. Many risks factors now known be linked neuroinflammation such as stress, pollution, saturated trans fat diet. On other hand, studies habits anti-inflammatory products lower levels reduced risk Sharing protective critical so that individuals can make informed choices promote positive aging throughout their lifespan. Most strategies manage diseases palliative because neurodegeneration been progressing silently decades before symptoms appear. Here, we preventing by adopting an integrated "healthy" approach. review summarizes role

Language: Английский

Citations

41
Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction DOI Creative Commons
Marina Cefis,

Rémi Chaney,

Julien Wirtz

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: Oct. 5, 2023

Accumulating evidence supports that physical exercise (EX) is the most effective non-pharmacological strategy to improve brain health. EX prevents cognitive decline associated with age and decreases risk of developing neurodegenerative diseases psychiatric disorders. These positive effects can be attributed an increase in neurogenesis neuroplastic processes, leading learning memory improvement. At molecular level, there a solid consensus involve neurotrophin brain-derived neurotrophic factor (BDNF) as crucial molecule for on brain. However, even though incontestably leads beneficial processes through BDNF expression, cellular sources mechanisms underlying EX-induced cerebral overproduction are still being elucidated. In this context, present review offers summary different involved brain’s response EX, specific focus BDNF. It aims provide cohesive overview three main production: neuronal-dependent overexpression, elevation blood flow (hemodynamic hypothesis), exerkine signaling emanating from peripheral tissues (humoral response). By shedding light these intricate pathways, seeks contribute ongoing elucidation relationship between offering valuable insights into potential therapeutic implications health enhancement.

Language: Английский

Citations

41
Exercise Reshapes the Brain: Molecular, Cellular, and Structural Changes Associated with Cognitive Improvements DOI
Marcus Augusto‐Oliveira, Gabriela de Paula Arrifano,

Caio Gustavo Leal-Nazaré

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(12), P. 6950 - 6974

Published: July 31, 2023

Language: Английский

Citations

38
Does Exercise Attenuate Disease Progression in People With Parkinson’s Disease? A Systematic Review With Meta-Analyses DOI Creative Commons

Jiecheng A Li,

Marte B. Loevaas,

Catherine Guan

et al.

Neurorehabilitation and neural repair, Journal Year: 2023, Volume and Issue: 37(5), P. 328 - 352

Published: May 1, 2023

Introduction Exercise has many benefits for people with Parkinson’s disease (PD) and been suggested to modify PD progression, but robust evidence supporting this is lacking. Objective This systematic review (PROSPERO registration: CRD42020169999) investigated whether exercise may have neuroplastic effects indicative of attenuating progression. Methods Six databases were searched randomized controlled trials (RCTs) that compared the effect control (no or sham exercise) another form exercise, on indicators progression (eg, brain-derived neurotrophic factor [BDNF], brain activation, “off” Unified Disease Rating Scale [UPDRS] scores). Trial quality was assessed using Physiotherapy Evidence Database Scale. Random-effects meta-analyses performed where at least 3 comparable reported same outcome; remaining results synthesized narratively. Results Forty-nine involving 2104 participants included. Compared control, improved UPDRS motor scores (Hedge’s g −0.39, 95% CI: −0.65 −0.13, P = .003) BDNF concentration 0.54, 0.10-0.98, .02), low very certainty evidence, respectively. Narrative synthesis outcomes effects. The versus comparisons too heterogenous enable pooling results. Discussion provides limited an potential markers Further large RCTs are warranted explore differential by type, dose stage, should report a core set

Language: Английский

Citations

26
Risk factors and consequences of mental health problems in nurses: A scoping review of cohort studies DOI Creative Commons
Jiaxin Yang, Yamin Chen, Yusheng Tian

et al.

International Journal of Mental Health Nursing, Journal Year: 2024, Volume and Issue: 33(5), P. 1197 - 1211

Published: April 15, 2024

Abstract Mental health problems in nurses are prevalent and impairing. To date, no literature has comprehensively synthesised cohort evidence on mental among nurses. This scoping review aimed to synthesise the existing risk factors consequences of A systematic search was conducted PubMed, EMBASE, Epistemonikos database, Web Science, CINAHL, PsycINFO from inception March 2023. We identified 171 studies 16 countries, mostly (95.3%) high‐income economies. indicated that worldwide encountered significant challenges, including depression, cognitive impairment, anxiety, trauma/post‐traumatic stress disorder, burnout, sleep other negative problems. These were closely related various modifiable such as nurses' behaviours lifestyles, social support, workplace bullying violence, shift work, job demands, resources. Moreover, have effects their physical health, behaviour lifestyle, occupation organisation, intrapersonal factors. findings provided an enhanced understanding complexities nurses, shed light policy enactment alleviate impact Addressing should be a top priority.

Language: Английский

Citations

14
Endometriosis: A Comprehensive Analysis of the Pathophysiology, Treatment, and Nutritional Aspects, and Its Repercussions on the Quality of Life of Patients DOI Creative Commons
Gabriela Cano-Herrera, Sylvia Salmun Nehmad,

Jimena Ruiz de Chávez Gascón

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1476 - 1476

Published: July 4, 2024

Endometriosis is a chronic proinflammatory pathology characterized by the growth of tissue similar to endometrium outside uterus, affecting approximately 5 15% women worldwide. Suffering from endometriosis entails complex pathophysiological process, significantly impacting quality life and reproductive function affected women; therefore, it must be addressed in personalized comprehensive manner, as its management requires multidisciplinary approach. This article aims conduct literature review endometriosis, not only condition but also significant factor social, nutritional, mental well-being those who experience it. Emphasis placed on importance understanding assessing impact provide better more approach, integrating various alternatives strategic treatments for factors involved development. The aim complete overview pathophysiology patients, well current treatment options, both pharmacological alternative, order broaden perspective improve care patients with this disease.

Language: Английский

Citations

13
Accelerometer-derived ‘weekend warrior’ physical activity pattern and brain health DOI

Jiahao Min,

Zhi Cao,

Tingshan Duan

et al.

Nature Aging, Journal Year: 2024, Volume and Issue: 4(10), P. 1394 - 1402

Published: Aug. 21, 2024

Language: Английский

Citations

10
Mechanisms of comorbidity between Alzheimer's disease and pain DOI Creative Commons
Kaifang Yao, Shenjun Wang, Zhifang Xu

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(2)

Published: Feb. 1, 2025

ABSTRACT Clinical studies have revealed a significant correlation between pain and neurodegenerative diseases, particularly Alzheimer's disease (AD). However, due to cognitive speech impairments, AD patients, especially those in moderate severe stages, are often overlooked management. The challenges obtaining pain‐related information from this population exacerbate the issue. Although recent clinical research has increasingly recognized comorbidity of pain, pathological alterations interactive mechanisms underlying relationship remain inadequately explored. This review provides comprehensive analysis features with without comorbidity. It examines processes, including neuroinflammation, peripheral‐central immune interactions, neurotransmitter dynamics. Furthermore, it highlights current assessment management strategies patients. By offering theoretical framework, aims support development effective approaches serve as reference for interventions targeting AD‐associated pain. Highlights CP encompasses multiple interrelated biological pathways, such neurodegeneration inflammatory responses. damage neurons synapses patients influences brain regions responsible processing thereby reducing response. Neuroinflammation plays vital role both CP. Enhanced responses an impact on CNS promote sensitization. Common exist CP, influencing cognition, emotion, perception.

Language: Английский

Citations

1
Exercise and Neuroinflammation in Health and Disease DOI Creative Commons
Dae Yun Seo, Jun‐Won Heo,

Jeong Rim Ko

et al.

International Neurourology Journal, Journal Year: 2019, Volume and Issue: 23(Suppl 2), P. S82 - 92

Published: Nov. 28, 2019

Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson (PD), amyotrophic lateral sclerosis (ALS), multiple (MS). It induces microglia activation, mitochondrial dysfunction, the production nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), pro-inflammatory cytokines, reactive oxygen species. Exercise, which plays an important role in maintaining improving health, might be highly effective intervention for preventing neuroinflammation-related diseases. Thus, since exercise can improve neuroimmune response, we hypothesized that would attenuate In this review, will highlight (1) biological mechanisms underlie AD, PD, ALS, MS, neuroinflammation pathways associated with NF-κB, species, (2) neurodegenerative Keywords: Exercise; Neuroinflammation; Health; Disease

Language: Английский

Citations

60
Distinct non-inflammatory signature of microglia in post-mortem brain tissue of patients with major depressive disorder DOI
Gijsje J. L. Snijders,

Marjolein A. M. Sneeboer,

Alba Fernández-Andreu

et al.

Molecular Psychiatry, Journal Year: 2020, Volume and Issue: 26(7), P. 3336 - 3349

Published: Oct. 7, 2020

Language: Английский

Citations

55