Polymers,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1567 - 1567
Published: June 1, 2024
PETG
(poly(ethylene
glycol-co-cyclohexane-1,4-dimethanol
terephthalate))
is
an
amorphous
copolymer,
biocompatible,
recyclable,
and
versatile.
Nowadays,
it
being
actively
researched
for
biomedical
applications.
However,
proposals
of
as
a
platform
the
loading
bioactive
compounds
from
natural
extract
are
scarce,
well
effect
supercritical
impregnation
on
this
polymer.
In
work,
filaments
with
Olea
europaea
leaf
was
investigated,
evaluating
pressure
(100–400
bar),
temperature
(35–55
°C),
depressurization
rate
(5–50
bar
min−1)
expansion
degree,
antioxidant
activity,
mechanical
properties
resulting
filaments.
degree
ranged
~3
to
120%,
ranging
2.28
17.96
g
per
100
polymer,
corresponding
oxidation
inhibition
values
7.65
66.55%,
respectively.
The
binary
interaction
between
most
affected
these
properties.
depended
greatly
process
variables.
Tensile
strength
were
similar
or
lower
than
untreated
Young’s
modulus
elongation
at
break
decreased
below
~1000
MPa
~10%,
respectively,
after
scCO2
treatment
impregnation.
extent
decrease
operational
parameters.
Therefore,
higher
activity
different
degrees
obtained
by
adjusting
processing
conditions.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 275 - 275
Published: Jan. 13, 2025
Type
2
diabetes
mellitus
(T2DM),
a
serious
metabolic
disorder,
is
worldwide
health
problem
due
to
the
alarming
rise
in
prevalence
and
elevated
morbidity
mortality.
Chronic
hyperglycemia,
insulin
resistance,
ineffective
effect
secretion
are
hallmarks
of
T2DM,
leading
many
secondary
complications.
These
include,
particular,
cardiovascular
disorders,
diabetic
neuropathy,
nephropathy
retinopathy,
foot,
osteoporosis,
liver
damage,
susceptibility
infections
some
cancers.
Polyphenols
such
as
flavonoids,
phenolic
acids,
stilbenes,
tannins,
lignans
constitute
an
extensive
heterogeneous
group
phytochemicals
fresh
fruits,
vegetables
their
products.
Various
vitro
studies,
animal
model
studies
available
clinical
trials
revealed
that
flavonoids
(e.g.,
quercetin,
kaempferol,
rutin,
epicatechin,
genistein,
daidzein,
anthocyanins),
acids
chlorogenic,
caffeic,
ellagic,
gallic
curcumin),
stilbenes
resveratrol),
tannins
procyanidin
B2,
seaweed
phlorotannins),
pinoresinol)
have
ability
lower
enhance
sensitivity
improve
secretion,
scavenge
reactive
oxygen
species,
reduce
chronic
inflammation,
modulate
gut
microbiota,
alleviate
complications
T2DM.
The
interaction
between
polyphenols
conventional
antidiabetic
drugs
offers
promising
strategy
management
treatment
especially
advanced
disease
stages.
Synergistic
effects
with
been
documented,
but
also
antagonistic
interactions
may
impair
drug
efficacy.
Therefore,
additional
research
required
clarify
mutual
order
use
knowledge
applications.
Nevertheless,
dietary
can
be
successfully
applied
part
supportive
for
they
both
obvious
symptoms
European journal of medical research,
Journal Year:
2025,
Volume and Issue:
30(1)
Published: Jan. 7, 2025
Diabetic
foot
infections
(DFIs)
are
a
significant
complication
in
diabetes
mellitus,
leading
to
increased
morbidity,
hospitalizations,
and
healthcare
burdens.
The
growing
prevalence
of
antibiotic-resistant
pathogens
has
reduced
the
efficacy
conventional
treatments,
highlighting
need
for
alternative
therapeutic
strategies.
Natural
products,
known
their
antimicrobial,
anti-inflammatory,
wound-healing
properties,
have
garnered
attention
as
potential
treatments
DFIs.
This
review
examines
key
natural
compounds,
including
eugenol,
thymol,
carvacrol,
curcumin,
Aloe
vera,
mechanisms
action
combating
diabetic
infections.
We
analyze
antimicrobial
these
ability
inhibit
biofilm
formation,
role
wound
healing.
also
explores
challenges
integrating
products
into
clinical
practice
use
alongside
or
place
traditional
antibiotic
therapies.
Our
findings
suggest
that
could
play
crucial
developing
sustainable
effective
treatment
strategies
DFIs,
especially
face
rising
resistance.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(1), P. 116 - 116
Published: Jan. 20, 2025
In
addition
to
the
immature
edible
flower
heads,
cultivation
of
globe
artichoke
(Cynara
cardunculus
L.
var.
scolymus
(L.)
Fiori)
generates
substantial
quantities
by-products,
including
leaves,
stems,
and
roots,
which
constitute
potential
sources
bioactive
compounds
prebiotic
dietary
fiber.
Preserving
agricultural
biodiversity
promoting
socioeconomic
development
are
essential
for
enhancing
domestic
production
fostering
innovation.
search
new
biomolecules
with
antioxidant
properties,
this
research
focused
on
a
landrace
at
risk
genetic
erosion,
still
cultivated
in
northern
part
Lazio
region,
known
as
“Carciofo
Ortano”.
To
investigate
properties
various
tissues
from
Ortano”
landrace,
methanolic
extracts
were
prepared
main
secondary
leaves
representative
genotypes
landrace.
Additionally,
obtained
same
four
landraces/clones
included
varietal
platform
PGI
Romanesco
del
Lazio”,
served
reference
genotypes:
Campagnano,
Castellammare,
C3,
Grato
1.
The
these
assessed
using
FRAP,
ABTS,
DPPH
assays,
total
phenolic
content
(TPC).
stem
head
two
1
clone,
have
higher
content,
demonstrated
highest
activity.
These
therefore
studied
their
chemical
profile
HPLC-DAD
SPME-GC/MS
analysis.
investigated
vitro
capacity
differentiated
SH-SY5Y
cells,
assessing
effects
ROS
levels
restoration
GSH
levels.
Furthermore,
vivo
beneficial
counteracting
oxidative
stress
evaluated
high
sucrose-fed
Drosophila
melanogaster,
is
typical
hallmark
hyperglycemic
status.
Overall,
results
indicated
that
inflorescences
along
byproducts
its
cultivation,
raw
materials
containing
whose
can
be
exploited
further
applications
pharmaceutical
medical
sectors.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1143 - 1143
Published: Sept. 22, 2024
Anthocyanins,
a
class
of
flavonoid
compounds
responsible
for
the
vibrant
colors
many
fruits
and
vegetables,
have
received
considerable
attention
in
recent
years
due
to
their
potential
health
benefits.
This
review,
focusing
on
evidence
from
both
vitro
vivo
studies,
provides
comprehensive
overview
current
state
knowledge
regarding
health-promoting
properties
anthocyanins.
The
chemical
structure
diversity
anthocyanins,
bioavailability,
mechanisms
action
at
cellular
molecular
level
are
examined.
Research
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective
effects
anthocyanins
is
critically
reviewed.
Special
emphasis
placed
role
prevention
treatment
chronic
diseases
such
as
cardiovascular
diseases,
diabetes,
neurodegenerative
diseases.
review
also
discusses
challenges
translating
findings
highlights
importance
considering
dose,
metabolism
when
assessing
therapeutic
concludes
with
identification
gaps
research
suggestions
future
directions
anthocyanin
including
need
more
long-term
clinical
trials
investigations
into
synergistic
other
phytochemicals.
analysis
promising
promoting
human
valuable
insights
researchers,
professionals,
nutraceutical
industry.
study
new
insights,
it
comprehensively
investigates
dual
anti-inflammatory
anticancer
models.
By
uncovering
biological
variety
natural
sources,
this
not
only
expands
our
these
level,
but
enhances
relevance
through
validation.
Furthermore,
innovative
use
may
lead
important
advances
application
future.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(6), P. 060501 - 060501
Published: Oct. 10, 2024
The
pursuit
of
sustainable
bioinspired
materials
for
regenerative
medicine
demands
a
nuanced
balance
between
scientific
advancement,
ethical
considerations,
and
environmental
consciousness.
This
abstract
encapsulates
comprehensive
perspective
paper
exploring
the
intricate
dynamics
toxicology,
impact,
concerns
within
realm
materials.
As
landscape
evolves,
ensuring
biocompatibility
safety
these
emerges
as
pivotal
challenge.
Our
delves
into
multidimensional
aspects
toxicity
assessment,
encompassing
cytotoxicity,
genotoxicity,
immunotoxicity
analyses.
Additionally,
we
shed
light
on
complexities
evaluating
impact
materials,
discussing
methodologies
such
life
cycle
biodegradability
testing,
design
approaches.
Amid
endeavors,
emphasize
paramount
importance
considerations
in
material
development,
navigating
web
international
regulations
frameworks
guiding
medical
Furthermore,
our
underscores
envisioned
future
directions
challenges
toxicology
techniques,
computational
modeling,
holistic
evaluation,
aiming
understanding
synergistic
interplay
stewardship,
deliberation.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5222 - 5222
Published: May 10, 2024
Flavonoids,
a
variety
of
plant
secondary
metabolites,
are
known
for
their
diverse
biological
activities.
Isoflavones
subgroup
flavonoids
that
have
gained
attention
potential
health
benefits.
Puerarin
is
one
the
bioactive
isoflavones
found
in
Kudzu
root
and
Pueraria
genus,
which
widely
used
alternative
Chinese
medicine,
has
been
to
be
effective
treating
chronic
conditions
like
cardiovascular
diseases,
liver
gastric
respiratory
diabetes,
Alzheimer’s
disease,
cancer.
extensively
researched
both
scientific
clinical
studies
over
past
few
years.
The
purpose
this
review
provide
an
up-to-date
exploration
puerarin
biosynthesis,
most
common
extraction
methods,
analytical
techniques,
effects,
new
perspective
medical
pharmaceutical
research
development.
