The Ketogenic Diet and Cardiovascular Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3368 - 3368

Published: July 28, 2023

The most common and increasing causes of death worldwide are cardiovascular diseases (CVD). Taking into account the fact that diet is a key factor, it worth exploring this aspect CVD prevention therapy. aim article to assess potential ketogenic in treatment CVD. comprehensive, meticulous analysis literature area, taking recent studies currently available. has been shown have multifaceted effect on Among other aspects, beneficial blood lipid profile, even compared diets. It shows strong anti-inflammatory cardioprotective potential, which due, among factors, properties state ketosis, elimination simple sugars, restriction total carbohydrates supply omega-3 fatty acids. In addition, ketone bodies provide "rescue fuel" for diseased heart by affecting its metabolism. They also function vascular endothelium, including improving inhibiting premature ageing. pressure risk factors through, weight loss. evidence cited often superior standard diets, making likely advantages over dietary models diseases. There legitimate need further research area.

Language: Английский

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Advances in Research on Type 2 Diabetes Mellitus Targets and Therapeutic Agents

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13381 - 13381

Published: Aug. 29, 2023

Diabetes mellitus is a chronic multifaceted disease with multiple potential complications, the treatment of which can only delay and prolong terminal stage disease, i.e., type 2 diabetes (T2DM). The World Health Organization predicts that will be seventh leading cause death by 2030. Although many antidiabetic medicines have been successfully developed in recent years, such as GLP-1 receptor agonists SGLT-2 inhibitors, single-target drugs are gradually failing to meet therapeutic requirements owing individual variability, diversity pathogenesis, organismal resistance. Therefore, there remains need investigate pathogenesis T2DM more depth, identify targets, provide improved glycemic control solutions. This review presents an overview mechanisms action development latest agents targeting years. It also discusses emerging target-based therapies new targets emerged within last three aim our theoretical basis for further advancement targeted T2DM.

Language: Английский

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Revised definition of obesity in Asian Indians living in India

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102989 - 102989

Published: Jan. 1, 2025

Language: Английский

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The Effects of Ketogenic Diet on Insulin Sensitivity and Weight Loss, Which Came First: The Chicken or the Egg?

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3120 - 3120

Published: July 12, 2023

The ketogenic diet (KD) is, nowadays, considered an interesting nutritional approach for weight loss and improvement in insulin resistance. Nevertheless, most of the studies available literature do not allow a clear distinction between its effects on sensitivity per se, induced by KDs sensitivity. In this review, we discuss scientific evidence direct mediated glycemic status humans, describing KD's biochemical background underlying mechanisms.

Language: Английский

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Effect of the Ketogenic Diet on the Prophylaxis and Treatment of Diabetes Mellitus: A Review of the Meta-Analyses and Clinical Trials

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 500 - 500

Published: Jan. 18, 2023

The exponentially growing frequency of diagnosing diabetes mellitus means that a verification the previous dietetic approach to treating disease seems justified. simultaneous growth interest in ketogenic diet and development knowledge this field have contributed increasingly frequent application treatment. This paper also deals with issue; its aim includes an extensive analysis influence on prophylaxis treatment diabetes. has been prepared based wide, meticulous available literature subject. Among other findings, favorable effect nutrition model demonstrated values glycated hemoglobin, glucose, insulin, or metabolic parameters patients. pharmacotherapy type 1 2 presented compared standard nutritional management plan recommended for disease. Further research is needed field, especially studies long follow-up period. discussed articles report interesting therapeutic advantages comparison diets.

Language: Английский

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Effect of Dietary Approaches on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review with Network Meta-Analysis of Randomized Trials

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3156 - 3156

Published: July 15, 2023

Background: Dietary patterns play a critical role in diabetes management, while the best dietary pattern for Type 2 (T2DM) patients is still unclear. The aim of this network meta-analysis was to compare impacts various approaches on glycemic control T2DM patients. Methods: Relevant studies were retrieved from PubMed, Embase, Web Knowledge, Cochrane Central Register Controlled Trials (CENTRAL), and other additional records (1949 31 July 2022). Eligible RCTs those comparing different against each or diet individuals with at least 6 months. We assessed risk bias included tool confidence estimates Grading Recommendations Assessment, Development, Evaluation approach meta-analyses. In order determine pooled effect relative other, we performed (NMA) interventions both HbA1c fasting glucose, which enabled us estimate intervention effects by combing direct indirect trial evidence. Results: Forty-two comprising 4809 NMA, 10 (low-carbohydrate, moderate-carbohydrate, ketogenic, low-fat, high-protein, Mediterranean, Vegetarian/Vegan, low index, recommended, diets). total, 83.3% lower had some concerns. Findings NMA revealed that low-carbohydrate, low-fat diets significantly effective reducing (viz., −0.73 (−1.19, −0.28), −0.69 (−1.32, −0.06), −1.82 (−2.93, −0.71)), glucose −1.30 (−1.92, −0.67), −1.26 (−2.26, −0.27), −0.95 (−1.51, −0.38), −0.89 (−1.60, −0.18) −0.75 (−1.24, −0.27)) compared diet. clustered ranking plot combined outcomes indicated index promising controlling glucose. univariate meta-regressions showed mean reductions only related weight change subjects. Conclusions: For patients, ketogenic diet, Mediterranean moderate-carbohydrate options. Although study found superior, further high-quality long-term are needed strengthen its credibility.

Language: Английский

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Ketogenic diet and cardiovascular risk – state of the art review

Current Problems in Cardiology, Journal Year: 2024, Volume and Issue: 49(3), P. 102402 - 102402

Published: Jan. 21, 2024

The ketogenic diet is based on extreme carbohydrate intake reduction and replacing the remaining with fat has become a popular dietary pattern used for weight loss. relationship between cardiovascular risk controversial topic. This publication aimed to present evidence factors mortality. does not fulfill criteria of healthy diet. It presents potential rapid short-term body mass, triglycerides level, Hb1Ac, blood pressure. Its efficacy loss above-mentioned metabolic changes significant in long-term observations. In terms mortality, low-carb more beneficial than very low-carbohydrate (including diet). There still scarce comparing Mediterranean Other safety concerns patients such as adverse events related ketosis, fat-free mass loss, or pharmacological interactions should be also taken into consideration future research.

Language: Английский

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Expert consensus on nutrition and lower-carbohydrate diets: An evidence- and equity-based approach to dietary guidance

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 29, 2024

There is a substantial body of clinical evidence supporting the beneficial effects lower-carbohydrate dietary patterns on multiple established risk factors associated with insulin resistance and cardiovascular diseases in adult populations. Nutrition health researchers, practitioners, stakeholders gathered for, “The Scientific Forum Nutrition, Wellness, Lower-Carbohydrate Diets: An Evidence- Equity-Based Approach to Dietary Guidance” discuss base around diets, outcomes, guidance. Consensus statements were agreed upon identify current areas scientific agreement spotlight gaps research, education, practice help define prioritize future pathways. Given considering that most American adults are living at least one nutrition-related chronic disease, there was consensus including pattern as part Guidelines for Americans could promote equity among general population.

Language: Английский

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Role of lifestyle and glucagon‐like peptide‐1 receptor agonists for weight loss in obesity, type 2 diabetes and steatotic liver diseases

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 59(S1)

Published: May 30, 2024

Summary Background The current obesity pandemic has given rise to associated comorbidities and complications, including type 2 diabetes metabolic dysfunction‐associated steatotic liver disease (MASLD). During the last decade, certain glucagon‐like peptide 1 receptor agonists (GLP‐1RA), originally developed as antihyperglycemic drugs, also demonstrated efficacy for weight loss. Aims To review shared pathophysiologic features of common diseases compare therapeutic strategies reduce body related complications. Methods We performed an extensive literature research describe effects lifestyle modification, first‐generation anti‐obesity GLP‐1RA on loss in humans with obesity, MASLD. Results Until recently, treatment been limited which offer moderate degree sustainability few approved drugs are either short term use or forms obesity. Some significantly decrease caloric intake weight. Liraglutide semaglutide have therefore treating people They lead a reduction hepatic fat content inflammation biopsy‐confirmed Possible limitations comprise adverse effects, adherence persistence. Conclusion Certain superior modification inducing markedly changed portfolio additional beneficial disease.

Language: Английский

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Ketogenic Diets for Body Weight Loss: A Comparison with Other Diets

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 965 - 965

Published: March 10, 2025

With the prevalence of obesity and overweight increasing at an alarming rate, more researchers are focused on identifying effective weight loss strategies. The ketogenic diet (KD), used as a treatment in epilepsy management for over 100 years, is additionally gaining popularity method. Although its efficacy well documented, areas where it may be beneficial to other dietary approaches need carefully examined. objective this paper identify potential benefits KD alternative strategies based comprehensive literature review. It has been shown that bioenergetically efficient than strategies, inter alia owing effect curtailing hunger, improving satiety decreasing appetite (influence hunger hormones sensation hunger), inducing faster initial (associated with lower glycogen levels reduced water retention), controlling glycaemia insulinemia (directly attributable low-carbohydrate nature indirectly described). These effects accompanied by improved insulin sensitivity, inflammation (through ketone bodies avoidance pro-inflammatory sugars), pharmacological control (the diet’s mechanisms similar those medication but without side effects), positive impacts psychological factors food addiction. Based authors’ review latest research, reasonable conclude that, due these many additional health benefits, advantageous diet-based This important hypothesis deserves further exploration, which could achieved including outcome measures future clinical trials, especially when comparing different diets equal caloric value.

Language: Английский

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